The prevention and treatment of missing data in clinical trials

Inference and missing data

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Statistical Analysis with Missing Data

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Handling drop‐out in longitudinal studies

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Responsible Research: A Systems Approach to Protecting Research Participants

Federman, D. D., Hanna, K. E., & Rodriguez, L. L. (2013) · Cited by 218 · see citing works

Interpreting Incomplete Data in Studies of Diet and Weight Loss

Ware, J. H. (2003) · New England Journal of Medicine · doi:10.1056/nejme030054 · Cited by 205 · see citing works

Undue Inducement: Nonsense on Stilts?

Emanuel, E. J. (2005) · The American Journal of Bioethics · doi:10.1080/15265160500244959 · Cited by 191 · see citing works

The Prevention and Treatment of Missing Data in Clinical Trials: An FDA Perspective on the Importance of Dealing With It

O’Neill, R. T., & Temple, R. (2012) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2011.340 · Cited by 164 · see citing works

Dropout Rates in Placebo-Controlled and Active-Control Clinical Trials of Antipsychotic Drugs

Kemmler, G., Hummer, M., Widschwendter, C. G., & Fleischhacker, W. W. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.12.1305 · Cited by 146 · see citing works

Meta-Analysis of Randomized Controlled Trials of Statins Versus Placebo in Patients With Heart Failure

Lipinski, M. J., Cauthen, C. A., Biondi‐Zoccai, G., Abbate, A., Vrtovec, B., Khan, B. V., & Vetrovec, G. W. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.07.055 · Cited by 99 · see citing works

The design and conduct of clinical trials to limit missing data

Little, R. J. A., Cohen, M. L., Dickersin, K., Emerson, S. S., Farrar, J. T., Neaton, J. D., Shih, W. J., Siegel, J. P., & Stern, H. S. (2012) · Statistics in Medicine · doi:10.1002/sim.5519 · Cited by 70 · see citing works

Have last-observation-carried-forward analyses caused us to favour more toxic dementia therapies over less toxic alternatives? A systematic review.

Molnar, F., Man‐Son‐Hing, M., Hutton, B., & Fergusson, D. A. (2009) · PubMed Central · Cited by 65 · see citing works

Dropout Rates in Randomized Clinical Trials of Antipsychotics: A Meta-analysis Comparing First- and Second-Generation Drugs and an Examination of the Role of Trial Design Features

Rabinowitz, J., Levine, S. Z., Barkai, O., & Davidov, O. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn005 · Cited by 64 · see citing works

Time-to-Event Analyses for Long-Term Treatments — The APPROVe Trial

Lagakos, S. W. (2006) · New England Journal of Medicine · doi:10.1056/nejmp068137 · Cited by 63 · see citing works

Meta-Analysis of Dropout Rates in SSRIs Versus Placebo in Randomized Clinical Trials of PTSD

Lurie, I., & Levine, S. Z. (2010) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0b013e3181cc41b6 · Cited by 31 · see citing works

Impact of Missing Data Due to Dropouts on Estimates of the Treatment Effect in a Randomized Trial of Antiretroviral Therapy for HIV-Infected Individuals

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Statistical inference with missing data

Rueda, M. D. M. (2008) · Model Assisted Statistics and Applications · doi:10.3233/mas-2008-3201 · Cited by 22 · see citing works

New Concepts in the Invasive and Non Invasive Evaluation of Remodelling of the Right Ventricle and Pulmonary Vasculature in Pulmonary Arterial Hypertension

Domingo, E., Aguilar, R., López‐Meseguer, M., et al. (2009) · The Open Respiratory Medicine Journal · doi:10.2174/1874306400903010031 · Cited by 12 · see citing works

Impact of Missing Data Due to Dropouts on Estimates of the Treatment Effect in a Ranomized Trial of Antiretroviral Therapy for HIV-Infected Individuals

Raboud, J., Montaner, J., Thorne, A., et al. (1996) · Cited by 10 · see citing works

SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials

Chan, A.-W., Tetzlaff, J. M., Gotzsche, P. C., Altman, D. G., Mann, H., Berlin, J. A., Dickersin, K., Hrobjartsson, A., Schulz, K. F., Parulekar, W. R., et al. (2013) · BMJ · doi:10.1136/bmj.e7586 · Cited by 6,251 · see citing works

Edoxaban versus warfarin in patients with atrial fibrillation

Giugliano, R. P., Ruff, C. T., Braunwald, E., Murphy, S. A., Wiviott, S. D., Halperin, J. L., Waldo, A. L., Ezekowitz, M. D., Weitz, J. I., Špinar, J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1310907 · Cited by 5,164 · see citing works

Using Big Data to Emulate a Target Trial When a Randomized Trial Is Not Available: Table 1.

Hernán, M. A., & Robins, J. M. (2016) · American Journal of Epidemiology · doi:10.1093/aje/kwv254 · Cited by 3,115 · see citing works

Transcatheter Mitral-Valve Repair in Patients with Heart Failure

Stone, G. W., Lindenfeld, J., Abraham, W. T., Kar, S., Lim, D. S., Mishell, J. M., Whisenant, B., Grayburn, P. A., Rinaldi, M., Kapadia, S. R., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1806640 · Cited by 3,017 · see citing works

Long-term cognitive impairment after critical illness

Pandharipande, P. P., Girard, T. D., Jackson, J. C., Morandi, A., Thompson, J. L., Pun, B. T., Brummel, N. E., Hughes, C. G., Vasilevskis, E. E., Shintani, A. K., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1301372 · Cited by 2,842 · see citing works

When and how should multiple imputation be used for handling missing data in randomised clinical trials – a practical guide with flowcharts

Jakobsen, J. C., Gluud, C., Wetterslev, J., & Winkel, P. (2017) · BMC Medical Research Methodology · doi:10.1186/s12874-017-0442-1 · Cited by 2,747 · see citing works

A tutorial on sensitivity analyses in clinical trials: the what, why, when and how

Thabane, L., Mbuagbaw, L., Zhang, S., Samaan, Z., Marcucci, M., Ye, C., Thabane, M., Giangregorio, L., Dennis, B., Kosa, D., et al. (2013) · BMC Medical Research Methodology · doi:10.1186/1471-2288-13-92 · Cited by 893 · see citing works

Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin

Bolinder, J., Ljunggren, Ö., Kullberg, J., Johansson, L., Wilding, J., Langkilde, A. M., Sugg, J., & Parikh, S. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2260 · Cited by 867 · see citing works

Thresholds for statistical and clinical significance in systematic reviews with meta-analytic methods

Jakobsen, J. C., Wetterslev, J., Winkel, P., Lange, T., & Gluud, C. (2014) · BMC Medical Research Methodology · doi:10.1186/1471-2288-14-120 · Cited by 704 · see citing works

A Guide to Handling Missing Data in Cost-Effectiveness Analysis Conducted Within Randomised Controlled Trials

Faria, R., Gomes, M., Epstein, D., & White, I. R. (2014) · PharmacoEconomics · doi:10.1007/s40273-014-0193-3 · Cited by 673 · see citing works

Per-Protocol Analyses of Pragmatic Trials

Hernán, M. A., & Robins, J. M. (2017) · New England Journal of Medicine · doi:10.1056/nejmsm1605385 · Cited by 660 · see citing works

An integrated palliative and respiratory care service for patients with advanced disease and refractory breathlessness: a randomised controlled trial

Higginson, I. J., Bausewein, C., Reilly, C. C., Gao, W., Gysels, M., Dzingina, M., McCrone, P., Booth, S., Jolley, C. J., & Moxham, J. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(14)70226-7 · Cited by 605 · see citing works

Efficacy and safety of alirocumab vs ezetimibe in statin-intolerant patients, with a statin rechallenge arm: The ODYSSEY ALTERNATIVE randomized trial

Moriarty, P. M., Thompson, P. D., Cannon, C. P., Guyton, J. R., Bergeron, J., Zieve, F. J., Bruckert, E., Jacobson, T. A., Kopecky, S. L., Baccara-Dinet, M. T., et al. (2015) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2015.08.006 · Cited by 470 · see citing works

Differential dropout and bias in randomised controlled trials: when it matters and when it may not

Bell, M. L., Kenward, M. G., Fairclough, D. L., & Horton, N. J. (2013) · BMJ · doi:10.1136/bmj.e8668 · Cited by 460 · see citing works

Handling missing data in RCTs; a review of the top medical journals

Bell, M. L., Fiero, M., Horton, N. J., & Hsu, C.-H. (2014) · BMC Medical Research Methodology · doi:10.1186/1471-2288-14-118 · Cited by 395 · see citing works

Handling missing data in clinical research

Heymans, M. W., & Twisk, J. W. R. (2022) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2022.08.016 · Cited by 399 · see citing works

Challenges in the design and interpretation of Noninferiority trials

Mauri, L., & D’Agostino, R. B. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1510063 · Cited by 395 · see citing works

Effect of Longer-Interval vs Standard Dosing of Zoledronic Acid on Skeletal Events in Patients With Bone Metastases: A Randomized Clinical Trial

Himelstein, A. L., Foster, J. C., Khatcheressian, J. L., Roberts, J. D., Seisler, D. K., Novotny, P. J., Qin, R., Go, R. S., Grubbs, S. S., O’Connor, T., et al. (2017) · JAMA · doi:10.1001/jama.2016.19425 · Cited by 356 · see citing works

Optimizing Treatment of Complicated Grief: A Randomized Clinical Trial

Shear, M. K., Reynolds, C. F., Simon, N. M., Zisook, S., Wang, Y., Mauro, C., Duan, N., Lebowitz, B., & Skritskaya, N. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.0892 · Cited by 349 · see citing works

Mindfulness-based stress reduction compared with cognitive behavioral therapy for the treatment of insomnia comorbid with cancer: a randomized, partially blinded, noninferiority trial

Garland, S. N., Carlson, L. E., Stephens, A. J., Antle, M. C., Samuels, C., & Campbell, T. S. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2012.47.7265 · Cited by 329 · see citing works

Fallacies of last observation carried forward analyses

Lachin, J. M. (2016) · Clinical Trials · doi:10.1177/1740774515602688 · Cited by 328 · see citing works

Health Care Hotspotting — A Randomized, Controlled Trial

Finkelstein, A., Zhou, A., Taubman, S., & Doyle, J. (2020) · New England Journal of Medicine · doi:10.1056/nejmsa1906848 · Cited by 320 · see citing works

Study design of ASPirin in Reducing Events in the Elderly (ASPREE): A randomized, controlled trial

(2013) · Contemporary Clinical Trials · doi:10.1016/j.cct.2013.09.014 · Cited by 310 · see citing works

Perioperative Rosuvastatin in Cardiac Surgery

Zheng, Z., Jayaram, R., Jiang, L., Emberson, J., Zhao, Y., Li, Q., Du, J., Guarguagli, S., Hill, M., Chen, Z., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1507750 · Cited by 322 · see citing works

SPIRIT 2013: new guidance for content of clinical trial protocols

Chan, A.-W., Tetzlaff, J. M., Altman, D. G., Dickersin, K., & Moher, D. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62160-6 · Cited by 298 · see citing works

Treatment of Complicated Grief in Elderly Persons: A Randomized Clinical Trial

Shear, M. K., Wang, Y., Skritskaya, N., Duan, N., Mauro, C., & Ghesquiere, A. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1242 · Cited by 276 · see citing works

Missing data is poorly handled and reported in prediction model studies using machine learning: A literature review

Nijman, S., Leeuwenberg, A., Beekers, I., Verkouter, I., Jacobs, J., Bots, M., Asselbergs, F., Moons, K., & Debray, T. (2022) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2021.11.023 · Cited by 269 · see citing works

Lisdexamfetamine Dimesylate for Adults with Moderate to Severe Binge Eating Disorder: Results of Two Pivotal Phase 3 Randomized Controlled Trials

McElroy, S. L., Hudson, J., Ferreira-Cornwell, M. C., Radewonuk, J., Whitaker, T., & Gasior, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.275 · Cited by 254 · see citing works

Cardiovascular outcome trials of glucose-lowering drugs or strategies in type 2 diabetes

Holman, R. R., Sourij, H., & Califf, R. M. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60794-7 · Cited by 227 · see citing works

Association between adherence to pharmacotherapy and outcomes in type 2 diabetes: a meta-analysis

Khunti, K., Seidu, S., Kunutsor, S., & Davies, M. (2017) · Diabetes Care · doi:10.2337/dc16-1925 · Cited by 231 · see citing works

Comparative efficacy and acceptability of first-generation and second-generation antidepressants in the acute treatment of major depression: protocol for a network meta-analysis

Furukawa, T. A., Salanti, G., Atkinson, L. Z., Leucht, S., Ruhe, H. G., Turner, E. H., Chaimani, A., Ogawa, Y., Takeshima, N., Hayasaka, Y., et al. (2016) · BMJ Open · doi:10.1136/bmjopen-2015-010919 · Cited by 214 · see citing works

Missing data: A statistical framework for practice

Carpenter, J. R., & Smuk, M. (2021) · Biometrical Journal · doi:10.1002/bimj.202000196 · Cited by 198 · see citing works

Missing Data in Alcohol Clinical Trials: A Comparison of Methods

Hallgren, K. A., & Witkiewitz, K. (2013) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.12205 · Cited by 176 · see citing works

Efficacy and safety of alirocumab, a monoclonal antibody to PCSK9, in statin-intolerant patients: design and rationale of ODYSSEY ALTERNATIVE, a randomized phase 3 trial

Moriarty, P. M., Jacobson, T. A., Bruckert, E., Thompson, P. D., Guyton, J. R., Baccara-Dinet, M. T., & Gipe, D. (2014) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2014.09.007 · Cited by 154 · see citing works

SPIRIT 2025 explanation and elaboration: updated guideline for protocols of randomised trials

Hróbjartsson, A., Boutron, I., Hopewell, S., Moher, D., Schulz, K. F., Collins, G. S., Tunn, R., Aggarwal, R., Berkwits, M., Berlin, J. A., et al. (2025) · BMJ · doi:10.1136/bmj-2024-081660 · Cited by 171 · see citing works

School-based gardening, cooking and nutrition intervention increased vegetable intake but did not reduce BMI: Texas sprouts - a cluster randomized controlled trial

Davis, J. N., Pérez, A., Asigbee, F. M., Landry, M. J., Vandyousefi, S., Ghaddar, R., Hoover, A., Jeans, M., Nikah, K., Fischer, B., et al. (2021) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-021-01087-x · Cited by 136 · see citing works

Rationale and Design of TransplantLines: A Prospective Cohort Study and Biobank of Solid Organ Transplant Recipients

Eisenga, M. F., Gomes-Neto, A. W., van Londen, M., Ziengs, A. L., Douwes, R. M., Stam, S. P., Osté, M. C. J., Knobbe, T. J., Hessels, N. R., Buunk, A. M., et al. (2018) · BMJ Open · doi:10.1136/bmjopen-2018-024502 · Cited by 141 · see citing works

Inconsistent Definitions for Intention-To-Treat in Relation to Missing Outcome Data: Systematic Review of the Methods Literature

Alshurafa, M., Briel, M., Akl, E. A., Haines, T., Moayyedi, P., Gentles, S. J., Rios, L., Tran, C., Bhatnagar, N., Lamontagne, F., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049163 · Cited by 126 · see citing works

The Mediating Role of Acceptance in Multidisciplinary Cognitive-Behavioral Therapy for Chronic Pain

Åkerblom, S., Perrin, S., Rivano Fischer, M., & McCracken, L. M. (2015) · The Journal of Pain · doi:10.1016/j.jpain.2015.03.007 · Cited by 129 · see citing works

EFFECTIVENESS OF DIALECTICAL BEHAVIOR THERAPY VERSUS COLLABORATIVE ASSESSMENT AND MANAGEMENT OF SUICIDALITY TREATMENT FOR REDUCTION OF SELF-HARM IN ADULTS WITH BORDERLINE PERSONALITY TRAITS AND DISORDER-A RANDOMIZED OBSERVER-BLINDED CLINICAL TRIAL: Research Article: Effectiveness of DBT versus CAMS on Reducing Self-Harm

Andreasson, K., Krogh, J., Wenneberg, C., Jessen, H. K. L., Krakauer, K., Gluud, C., Thomsen, R. R., Randers, L., & Nordentoft, M. (2016) · Depression and Anxiety · doi:10.1002/da.22472 · Cited by 124 · see citing works

Nurse practitioners can effectively deliver pain coping skills training to osteoarthritis patients with chronic pain: A randomized, controlled trial

Broderick, J. E., Keefe, F. J., Bruckenthal, P., Junghaenel, D. U., Schneider, S., Schwartz, J. E., Kaell, A. T., Caldwell, D. S., McKee, D., Reed, S., et al. (2014) · Pain · doi:10.1016/j.pain.2014.05.024 · Cited by 118 · see citing works

A CONSORT-Compliant, Randomized, Double-Blind, Placebo-Controlled Pilot Trial of Purified Anthocyanin in Patients With Nonalcoholic Fatty Liver Disease

Zhang, P.-W., Chen, F.-X., Li, D., Ling, W.-H., & Guo, H.-H. (2015) · Medicine · doi:10.1097/md.0000000000000758 · Cited by 116 · see citing works

Where Have All the Rodents Gone? The Effects of Attrition in Experimental Research on Cancer and Stroke

Holman, C., Piper, S. K., Grittner, U., Diamantaras, A. A., Kimmelman, J., Siegerink, B., & Dirnagl, U. (2016) · PLOS Biology · doi:10.1371/journal.pbio.1002331 · Cited by 114 · see citing works

The Selective Labels Problem

Lakkaraju, H., Kleinberg, J., Leskovec, J., Ludwig, J., & Mullainathan, S. (2017) · Proceedings of the 23rd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining · doi:10.1145/3097983.3098066 · Cited by 110 · see citing works

Pedometer step count targets during pulmonary rehabilitation in chronic obstructive pulmonary disease. A randomized controlled trial

Nolan, C. M., Maddocks, M., Canavan, J. L., Jones, S. E., Delogu, V., Kaliaraju, D., Banya, W., Kon, S. S. C., Polkey, M. I., & Man, W. D.-C. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201607-1372oc · Cited by 104 · see citing works

The Impact of Antidepressant Dose and Class on Treatment Response in Pediatric Anxiety Disorders: A Meta-Analysis

Strawn, J. R., Mills, J. A., Sauley, B. A., & Welge, J. A. (2018) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2018.01.015 · Cited by 98 · see citing works

A Pilot RCT of Psychodynamic Group Art Therapy for Patients in Acute Psychotic Episodes: Feasibility, Impact on Symptoms and Mentalising Capacity

Montag, C., Haase, L., Seidel, D., Bayerl, M., Gallinat, J., Herrmann, U., & Dannecker, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112348 · Cited by 97 · see citing works

Bias and Precision of the “Multiple Imputation, Then Deletion” Method for Dealing With Missing Outcome Data

Sullivan, T. R., Salter, A. B., Ryan, P., & Lee, K. J. (2015) · American Journal of Epidemiology · doi:10.1093/aje/kwv100 · Cited by 86 · see citing works

Analysis of randomised trials with long-term follow-up

Herbert, R. D., Kasza, J., & Bø, K. (2018) · BMC Medical Research Methodology · doi:10.1186/s12874-018-0499-5 · Cited by 80 · see citing works

Enduring effects of psychological treatments for anxiety disorders: Meta-analysis of follow-up studies

Bandelow, B., Sagebiel, A., Belz, M., Görlich, Y., Michaelis, S., & Wedekind, D. (2018) · The British Journal of Psychiatry · doi:10.1192/bjp.2018.49 · Cited by 70 · see citing works

Initial severity of depression and efficacy of cognitive–behavioural therapy: Individual-participant data meta-analysis of pill-placebo-controlled trials

Furukawa, T. A., Weitz, E. S., Tanaka, S., Hollon, S. D., Hofmann, S. G., Andersson, G., Twisk, J., DeRubeis, R. J., Dimidjian, S., Hegerl, U., et al. (2017) · British Journal of Psychiatry · doi:10.1192/bjp.bp.116.187773 · Cited by 73 · see citing works

Wish You Were Here": examining characteristics, outcomes, and statistical solutions for missing cases in web-based psychotherapeutic trials

Karin, E., Dear, B. F., Heller, G. Z., Crane, M. F., & Titov, N. (2018) · JMIR Mental Health · doi:10.2196/mental.8363 · Cited by 67 · see citing works

High-throughput target trial emulation for Alzheimer’s disease drug repurposing with real-world data

Zang, C., Zhang, H., Xu, J., Zhang, H., Fouladvand, S., Havaldar, S., Cheng, F., Chen, K., Chen, Y., Glicksberg, B. S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43929-1 · Cited by 69 · see citing works

Randomized controlled trial of internet-delivered cognitive behaviour therapy comparing standard weekly versus optional weekly therapist support

Hadjistavropoulos, H. D., Schneider, L. H., Edmonds, M., Karin, E., Nugent, M. N., Dirkse, D., Dear, B. F., & Titov, N. (2017) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2017.09.006 · Cited by 71 · see citing works

Imagery enhancements increase the effectiveness of cognitive behavioural group therapy for social anxiety disorder: A benchmarking study

McEvoy, P. M., Erceg-Hurn, D. M., Saulsman, L. M., & Thibodeau, M. A. (2015) · Behaviour Research and Therapy · doi:10.1016/j.brat.2014.12.011 · Cited by 69 · see citing works

Estimating and reporting treatment effects in clinical trials for weight management: using estimands to interpret effects of intercurrent events and missing data.

Wharton, S., Astrup, A., Endahl, L., Lean, M. E. J., Satylganova, A., Skovgaard, D., Wadden, T. A., & Wilding, J. P. H. (2021) · International Journal of Obesity · doi:10.1038/s41366-020-00733-x · Cited by 58 · see citing works

Methods to analyze treatment effects in the presence of missing data for a continuous heavy drinking outcome measure when participants drop out from treatment in alcohol clinical trials

Witkiewitz, K., Falk, D. E., Kranzler, H. R., Litten, R. Z., Hallgren, K. A., O'Malley, S. S., Anton, R. F., & Workgroup, I. C. W. T. A. C. T. I. (. (2014) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.12543 · Cited by 60 · see citing works

The pain course: a randomised controlled trial comparing a remote-delivered chronic pain management program when provided in online and workbook formats

Dear, B. F., Gandy, M., Karin, E., Ricciardi, T., Fogliati, V. J., McDonald, S., Staples, L. G., Perry, K. N., Sharpe, L., Nicholas, M. K., et al. (2017) · Pain · doi:10.1097/j.pain.0000000000000916 · Cited by 57 · see citing works

Comparing Standard Versus Prosocial Internet Support Groups for Patients With Breast Cancer: A Randomized Controlled Trial of the Helper Therapy Principle

Lepore, S. J., Buzaglo, J. S., Lieberman, M. A., Golant, M., Greener, J. R., & Davey, A. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2014.57.0093 · Cited by 58 · see citing works

Reporting missing participant data in randomised trials: systematic survey of the methodological literature and a proposed guide

Akl, E. A., Shawwa, K., Kahale, L. A., Agoritsas, T., Brignardello-Petersen, R., Busse, J. W., Carrasco–Labra, A., Ebrahim, S., Johnston, B. C., Neumann, I., et al. (2015) · BMJ Open · doi:10.1136/bmjopen-2015-008431 · Cited by 52 · see citing works

Aberrant microRNA expression in patients with painful peripheral neuropathies

Leinders, M., Üçeyler, N., Thomann, A., & Sommer, C. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.07.041 · Cited by 57 · see citing works

Clinical trial registration was associated with lower risk of bias compared with non-registered trials among trials included in systematic reviews

Lindsley, K., Fusco, N., Li, T., Scholten, R., & Hooft, L. (2022) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2022.01.012 · Cited by 52 · see citing works

Adherence adjustment in the Coronary Drug Project: A call for better per-protocol effect estimates in randomized trials

Murray, E. J., & Hernán, M. A. (2016) · Clinical Trials · doi:10.1177/1740774516634335 · Cited by 57 · see citing works

The effects of yoga versus stretching and resistance training exercises on psychological distress for people with mild-to-moderate Parkinson’s disease: study protocol for a randomized controlled trial

Kwok, J. Y. Y., Kwan, J. C. Y., Auyeung, M., Mok, V. C. T., & Chan, H. Y. L. (2017) · Trials · doi:10.1186/s13063-017-2223-x · Cited by 56 · see citing works

Optimizing Outcomes of Treatment-Resistant Depression in Older Adults (OPTIMUM): Study Design and Treatment Characteristics of the First 396 Participants Randomized

Cristancho, P., Lenard, E., Lenze, E. J., Miller, J. P., Brown, P. J., Roose, S. P., Montes-Garcia, C., Blumberger, D. M., Mulsant, B. H., Lavretsky, H., et al. (2019) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2019.04.005 · Cited by 54 · see citing works

Dose-response relationship between weight loss and improvements in obstructive sleep apnea severity after a diet/lifestyle interventions: Secondary analyses of the “MIMOSA” randomized clinical trial

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