Cited by 389Physical Activity and HealthCardiovascular Health and Risk FactorsCoffee research and impacts

The DOI matches its Crossref record, with a small difference in title or year; 26 of the 26 references it cites were found in a registry or an index.

Relationship of Sedentary Behavior and Physical Activity to Incident Cardiovascular Disease

Open access

Chomistek, Andrea K., Manson, JoAnn E., Stefanick, Marcia L., Lu, Bing, Sands-Lincoln, Megan, Going, Scott B., Garcia, Lorena, Allison, Matthew A., Sims, Stacy T., LaMonte, Michael J., Johnson, Karen C., Eaton, Charles B.·2013·Journal of the American College of Cardiology

DOI 10.1016/j.jacc.2013.03.031PMC PMC3676694

Open this paper in CoChat — free account Open PDF

Abstract

Objectives The aim was to examine the independent and joint associations of sitting time and physical activity with risk of incident cardiovascular disease (CVD). Background Sedentary behavior is recognized as a distinct construct beyond lack of leisure-time physical activity, but limited data exists on the interrelationship between these two components of energy balance. Methods Participants in the prospective Women’s Health Initiative Observational Study (N = 71,018), aged 50–79 and free of CVD at baseline (1993–1998), provided information on sedentary behavior, defined as hours of sitting per day, and usual physical activity at baseline and during follow-up through September 2010. First CVD (coronary heart disease or stroke) events were centrally adjudicated. Results Sitting ≥ 10 hours/day compared to ≤ 5 hours/day was associated with increased CVD risk (HR=1.18, 95% CI 1.09, 1.29) in multivariable models including physical activity. Low physical activity was also associated with higher CVD risk (P, trend <0.001). When women were cross-classified by sitting time and physical activity (P, interaction = 0.94), CVD risk was highest in inactive women (≤1.7 MET-hrs/week) who also reported ≥10 hrs/day of sitting. Results were similar for CHD and stroke when examined separately. Associations between prolonged sitting and risk of CVD were stronger in overweight versus normal weight women and women aged 70 years and older compared to younger women. Conclusions Prolonged sitting time was associated with increased CVD risk, independent of leisure-time physical activity, in postmenopausal women without a history of CVD. A combination of low physical activity and prolonged sitting augments CVD risk.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.jacc.2013.03.031

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Compendium of physical activities: an update of activity codes and MET intensities
AINSWORTH, B. E., HASKELL, W. L., WHITT, M. C., IRWIN, M. L., SWARTZ, A. M., STRATH, S. J., O???BRIEN, W. L., BASSETT, D. R., SCHMITZ, K. H., EMPLAINCOURT, P. O., et al. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200009001-00009 · Cited by 8,497 · cited 1×
“Each type of activity was assigned a MET score on the basis of its energy cost (12), and physical activity-related energy expenditure (MET-h/week) was computed as the summed product of frequency, duration, and intensity.”
Flexible regression models with cubic splines
Durrleman, S., & Simon, R. M. (1989) · Statistics in Medicine · doi:10.1002/sim.4780080504 · Cited by 2,722 · cited 1×
“The possibility of nonlinear relations between sitting time, physical activity, and CVD were examined nonparametrically with restricted cubic splines (14).”
Too Much Sitting: The Population Health Science of Sedentary Behavior
Owen, N., Healy, G. N., Matthews, C. E., & Dunstan, D. W. (2010) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e3181e373a2 · Cited by 2,202 · cited 2×
“Sitting, a unique aspect of human behavior, might not simply represent the extreme low end of the physical activity continuum (7).”
Variations in the Prevalence of Obesity Among European Countries, and a Consideration of Possible Causes
Blundell, J. E., Baker, J. L., Boyland, E. J., Blaak, E. E., Charzewska, J., Henauw, S. D., Frühbeck, G., González‐Gross, M., Hebebrand, J., Holm, L., et al. (2017) · Obesity Facts · doi:10.1159/000455952 · Cited by 1,983
The Effects of Climate Change on Cardiac Health
De Blois, J., Kjellstrom, T., Agewall, S., Ezekowitz, J. A., Armstrong, P. W., & Atar, D. (2015) · Cardiology · doi:10.1159/000398787 · Cited by 1,697
Role of Low Energy Expenditure and Sitting in Obesity, Metabolic Syndrome, Type 2 Diabetes, and Cardiovascular Disease
Hamilton, M. T., Hamilton, D. G., & Zderic, T. W. (2007) · Diabetes · doi:10.2337/db07-0882 · Cited by 1,655
Sitting time and mortality from all causes, cardiovascular disease, and cancer
KATZMARZYK, P. T., CHURCH, T. S., CRAIG, C. L., & BOUCHARD, C. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181930355 · Cited by 1,611 · cited 2×
“Previous studies (16,18) have reported similar results, where the positive association between time spent sitting and mortality was stronger in overweight and obese versus normal weight individuals.”
Breaks in Sedentary Time
Healy, G. N., Dunstan, D. W., Salmon, J., Cerin, E., Shaw, J. E., Zimmet, P. Z., & Owen, N. (2008) · Diabetes Care · doi:10.2337/dc07-2046 · Cited by 1,465
Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003–06
Healy, G. N., Matthews, C. E., Dunstan, D. W., Winkler, E. A. H., & Owen, N. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehq451 · Cited by 1,368 · cited 1×
“In accelerometer studies, having a higher number of breaks in sedentary time was inversely associated with waist circumference, BMI, triglycerides, 2-h plasma glucose, and C-reactive protein, independent of total time spent sitting and physical activity (22,23).”
Walking Compared with Vigorous Exercise for the Prevention of Cardiovascular Events in Women
Manson, J. E., Greenland, P., LaCroix, A. Z., Stefanick, M. L., Mouton, C. P., Oberman, A., Perri, M. G., Sheps, D. S., Pettinger, M. B., & Siscovick, D. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021067 · Cited by 1,349 · cited 4×
“Methods P articipants in the prospective Women’s Health Initiative Observational Study (n ¼ 71,018), 50 to 79 years of age and free of CVD at baseline (1993 to 1998), provided information on sedentary behavior, defined as hours of sitting/day, and usual physical activity at baseline and during follow-up through Septem…”
InfluentialSelf-citation

Flagged first, then by citations

Show all 26 references

Sorted by citations

Items 201–300 of 387

Superwoman’s kryptonite: The superwoman schema and perceived barriers to weight management among U.S. Black women
Harris, C., Goldman, B., Gurkas, P., Butler, C., & Bookman, P. (2022) · Journal of Health Psychology · doi:10.1177/13591053211068974 · Cited by 11
“Overweight women who misperceive their weight do not meet the recommendations for physical activity compared to other ethnic groups, conferring greater risk for adverse health effects such as cardiovascular disease (Chomistek et al., 2013; Duncan et al., 2011).”
Background
Physical activity, sedentary behavior, and cardiovascular disease risk in Korea: a trajectory analysis
Han, J., Ju, Y. J., & Lee, S. Y. (2023) · Epidemiology and Health · doi:10.4178/epih.e2023028 · Cited by 10
“Many epidemiological investigations have confirmed that SB and PA are independently, directly, and/or indirectly associated with CVD in adults [1-8].”
Background
Age-related decline in cardiac autonomic function is not attenuated with increased physical activity
Njemanze, H., Warren, C., Eggett, C. J., MacGowan, G. A., Bates, M. G. D., Siervo, M., Ivkovic, S., Trenell, M. I., & Jakovljević, D. G. (2016) · Oncotarget · doi:10.18632/oncotarget.12403 · Cited by 13
“The most recent data from the Women’s Health Initiative study suggest that low active and sedentary women had 63% greater risk of developing cardiovascular disease than high active women [15].”
Practices of Adults in a Periurban Community of the Ho Municipality on Prevention of Hypertension
Konlan, K. D., Baku, E. A., Japiong, M., Konlan, K. D., Doat, A. R., Suuk, A. N., & Amoah, R. M. (2020) · International Journal of Hypertension · doi:10.1155/2020/2136213 · Cited by 10
Perceptions on activity behavior during the COVID-19 pandemic “second wave” among US adults: results of a short online survey
Sebastião, É., Steffens, M. T., Nakamura, P. M., & Papini, C. B. (2021) · Sport Sciences for Health · doi:10.1007/s11332-021-00813-z · Cited by 10
STRESS: PERSONAL MATTER OR FAMILY AFFAIR? INTRA- AND INTER-INDIVIDUAL RELATIONSHIPS BETWEEN STRESS, PHYSICAL ACTIVITY, SEDENTARY BEHAVIOR, AND NUTRITION
Reiner, M., Niermann, C. Y. N., Krapf, F., & Wöll, A. (2015) · International Journal of Child Youth and Family Studies · doi:10.18357/ijcyfs.61201513479 · Cited by 12
“It has been shown that time spent on sedentary behavior increases the risk of developing obesity, certain coronary heart diseases (Chomistek et al., 2013), and diabetes mellitus Type 2 (Proper, Singh, Van Mechelen, & Chinapaw, 2011).”
Background
Association of Physical Activity (Sport) and Quality of Life: A Literature Review
DEVITA, S., & Müller, A. (2020) · Geosport for Society · doi:10.30892/gss.1205-057 · Cited by 10
Atherosclerotic cardiovascular disease events among adults with high predicted risk without established risk factors
Kong, N., Sakhuja, S., Colantonio, L. D., Levitan, E. B., Lloyd‐Jones, D. M., Cushman, M., Muntner, P., & Polonsky, T. S. (2023) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2023.100612 · Cited by 9
Atherosclerotic Cardiovascular Disease in Cancer Survivors: Current Evidence, Risk Prediction, Prevention, and Management
Choi, A., Kim, S., Kim, S., Cho, I., Cha, M. J., & You, S. C. (2025) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2025.14.1.30 · Cited by 9
“27 Moreover, significant adverse effects of sedentary behavior on cancer incidence have been reported.”
The Development of Health Lifestyles in Families Experiencing Disability
Rigles, B. (2019) · Journal of Family Issues · doi:10.1177/0192513x19831410 · Cited by 9
Chronic Standing Desk Use and Arterial Stiffness
Greenlund, I. M., Suriano, P., Elmer, S. J., Carter, J. R., & Durocher, J. J. (2019) · Journal of Physical Activity and Health · doi:10.1123/jpah.2018-0668 · Cited by 9
Global cognitive function before, surrounding, and after ischemic stroke: the role of risk and protective factors varies with time among ischemic stroke survivors
Vaughan, L., Bushnell, C., Bell, C., & Espeland, M. A. (2015) · Aging Neuropsychology and Cognition · doi:10.1080/13825585.2015.1058323 · Cited by 9
“…of stroke and poststroke mortality has been shown to be increased in women with low physical activity and low physical function (Bell et al., 2013; Chomistek et al., 2013), this study adds to the stroke literature by additionally demonstrating that women with low physical function have…”
Result
A pilot study combining Go4Life® materials with an interactive voice response system to promote physical activity in older women
Saquib, J., King, A., Castro, C., Tinker, L., Sims, S., Shikany, J., Bea, J., LaCroix, A., Horn, L. V. V., & Stefanick, M. (2016) · Journal of Women & Aging · doi:10.1080/08952841.2015.1018065 · Cited by 9
“Physical activity was assessed at baseline and postintervention with a questionnaire used previously in the WHI cohort (Chomistek et al., 2013; Manson et al., 2002; Nguyen et al., 2012) that included the frequency of walks outside the home, average duration, and pace of each walk, as well as other…”
BackgroundMethodInfluentialSelf-citation
Preventive fraction of physical fitness on risk factors in cardiac patients: Retrospective epidemiological study
Caru, M., Kern, L., Bousquet, M., & Curnier, D. Y. (2018) · World Journal of Cardiology · doi:10.4330/wjc.v10.i4.26 · Cited by 9
Television Viewing Time and Stroke Risk: Australian Diabetes Obesity and Lifestyle Study (1999-2012)
Cumming, T. B., Holliday, E. G., Dunstan, D. W., & English, C. (2019) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2018.12.020 · Cited by 9
Something is definitely better than nothing: simple strategies to prevent vascular dysfunction
Trinity, J. D. (2017) · Clinical Science · doi:10.1042/cs20170130 · Cited by 9
Impact of scale of aggregation on associations of cardiovascular hospitalization and socio-economic disadvantage
Hanigan, I., Cochrane, T., & Davey, R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188161 · Cited by 9
Revisiting the MotionWatch8©: Calibrating Cut-Points for Measuring Physical Activity and Sedentary Behavior Among Adults With Stroke
Falck, R. S., Best, J. R., Li, M. C. R., Eng, J. J., & Liu-Ambrose, T. Y. L. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00203 · Cited by 10
“Although little is known about the consequences of high SB following a stroke, high SB is a risk factor for stroke independent of PA (Chomistek et al., 2013), which suggests that reducing SB among adults with stroke may help maintain the health of this population.”
BackgroundInfluential
Health behavior change following a diagnosis of ductal carcinoma in situ: An opportunity to improve health outcomes
Berkman, A. M., Trentham‐Dietz, A., Dittus, K. L., Hart, V., Vatovec, C. M., King, J. G., James, T. A., Lakoski, S. G., & Sprague, B. L. (2015) · Preventive Medicine · doi:10.1016/j.ypmed.2015.03.020 · Cited by 9
“Sedentary behavior and decreased physical activity have also been found to contribute to elevated risks of all-cause, CVD, and cancer mortality (Kim et al., 2013).”
Influential
Association Between Sedentary Time and Coronary Artery Calcium
Kulinski, J. P., Kozlitina, J., Berry, J. D., de Lemos, J. A., & Khera, A. (2016) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2016.01.013 · Cited by 9
“Habitual sedentary behavior has been associated with incident cardiovascular disease, regardless of physical activity (1).”
Background
Cardiovascular Health and Healthy Aging
Reynolds, I. J., Page, R. L., II, & Boxer, R. S. (2019) · Springer eBooks · doi:10.1007/978-3-030-06200-2_5 · Cited by 10
Lifestyle-related education and counseling resource utilization and cardiovascular biomarkers in midlife women with low physical activity
Badon, S. E., Nance, N., Fogelberg, R., Quesenberry, C. P., Hedderson, M. M., & Avalos, L. A. (2021) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2021.101401 · Cited by 8
Leisure time physical activity, sedentary behavior and risk of cardiovascular disease and mortality among US Veterans
Djoussé, L., Schubert, P. L., Ho, Y.-L. A., Whitbourne, S. B., Cho, K., & Gaziano, J. M. (2021) · Journal of Novel Physiotherapy and Physical Rehabilitation · doi:10.17352/2455-5487.000091 · Cited by 8
Sitting Behavior and Physical Activity of College Students
D’Abundo, M. L., Sidman, C. L., & Fiala, K. A. (2015) · International Journal of Adult Vocational Education and Technology · doi:10.4018/ijavet.2015070105 · Cited by 8
“In a prospective study of 50-79 year-old women, prolonged sitting time was associated with increased CVD risk, independent of leisure-time physical activity (Chomistek et al., 2013).”
Background
Cross-associations between physical activity and sedentary time on metabolic health: a comparative assessment using self-reported and objectively measured activity
Thakkar, N. A., Jamnik, V., & Ardern, C. I. (2018) · Journal of Public Health · doi:10.1093/pubmed/fdy060 · Cited by 10
Sitting leg vasculopathy: potential adaptations beyond the endothelium
Ferreira‐Santos, L., Martinez‐Lemus, L. A., & Padilla, J. (2024) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00489.2023 · Cited by 8
Association of sitting time with cardiovascular events among manual and non-manual workers: a prospective cohort study (PURE-China)
Lan, L., Lang, X., McKee, M., Tse, L. A., Rangarajan, S., Qiang, D., Liu, Z., Wang, B., Liu, Z., Yan, M., et al. (2025) · BMC Public Health · doi:10.1186/s12889-025-21948-5 · Cited by 8
“Covariates were determined in advance based on existing literature and proposed mechanisms underlying the associations between sitting time and clinical outcomes [7, 19, 26, 27].”
Television Watching as Sedentary Behavior and Atrial Fibrillation: The Atherosclerosis Risk in Communities Study
Kubota, Y., Alonso, Á., Shah, A. M., Chen, L. Y., & Folsom, A. R. (2018) · Journal of Physical Activity and Health · doi:10.1123/jpah.2018-0064 · Cited by 7
Living with a Smoker and Multiple Health-Risk Behaviors
Holahan, C. J., Holahan, C. K., Lim, S., & Powers, D. A. (2020) · Annals of Behavioral Medicine · doi:10.1093/abm/kaaa059 · Cited by 6
“Measures encompassed exercise and walking, including their frequency and duration [25].”
Background
Parent-child physical activity, sedentary behaviour, and obesity
Sigmund, E., & Sigmundová, D. (2017) · doi:10.5507/ftk.17.24451824 · Cited by 7
Epidemiology of Cardiovascular Disease
Reid, C. M., & Owen, A. J. (2015) · Springer eBooks · doi:10.1007/978-981-4560-53-5_5-1 · Cited by 7
Independent, Stratified, and Joint Associations of Sedentary Time and Physical Activity With Cardiovascular Disease: A Systematic Review
Alves, C. P. D. L., Leão, O. A. D. A., Delpino, F. M., Mielke, G. I., Ekelund, U., Costa, E. C., & Crochemore‐Silva, I. (2024) · Journal of Physical Activity and Health · doi:10.1123/jpah.2024-0019 · Cited by 6
Exploring the Impact of PA and Sedentary Behavior on Gout Risk in Hyperuricemia: Insights From Machine Learning and SHAP Analysis
Jiao, Y., Cheng, Z., Lan, Z., Kan, S., & Du, Y. (2025) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.70238 · Cited by 6
“Another study involving 82 695 US men found that sedentary time ≥ 5 h per day was associated with a higher risk of heart failure [23].”
Changes in urban walking before and during COVID-19 in a metropolitan city of South Korea
Kim, D. H., & Yoo, S. (2021) · Journal of Healthy Eating and Active Living · doi:10.51250/jheal.v1i4.27 · Cited by 6
The impact of the COVID-19 pandemic on physical activity habits at a residential university
Hudgins, B. L., Kurti, S. P., Edwards, E. S., & Hargens, T. A. (2021) · Journal of American College Health · doi:10.1080/07448481.2021.2016772 · Cited by 7
Associations Between Cancer Risk Perceptions, Self-Efficacy, and Health Behaviors by BMI Category and Race and Ethnicity
Ezeani, A., Boggan, B., Hopper, L. N., Herren, O. M., & Agurs‐Collins, T. (2023) · International Journal of Behavioral Medicine · doi:10.1007/s12529-023-10225-7 · Cited by 6
Structural covariation between cerebellum and neocortex intrinsic structural covariation links cerebellum subregions to the cerebral cortex
Wang, Z., Diedrichsen, J., Saltoun, K., Steele, C. J., Anteraper, S. A., Yeo, B. T. T., Schmahmann, J. D., & Bzdok, D. (2024) · Journal of Neurophysiology · doi:10.1152/jn.00164.2024 · Cited by 9
The effects of physical activity and sedentary time on the prevalence rate of metabolic syndrome and perceived stress in Korean adults
Kim, W. K., Chung, W.-C., & Oh, D.-J. (2019) · Journal of Exercise Rehabilitation · doi:10.12965/jer.1836552.276 · Cited by 6
“…known that lack of physical activity works as a death risk factor for adult diseases including metabolic syndrome (Normandin, 2017) and reduces life expectancy and increases the risk of cardiovascular disease and metabolic disease (Archer and Blair, 2011; Chomistek et al., 2013; Lee et al., 2012b).”
Background
A fizikai inaktivitás nemzetgazdasági terhei
Gabnai, Z., Müller, A., Bács, Z., & Bába, É. B. (2019) · Egészségfejlesztés · doi:10.24365/ef.v60i1.308 · Cited by 6
Effect of Physical Activity on Hospital Service Use and Expenditures of Patients with Coronary Heart Disease: Results from Dongfeng-Tongji Cohort Study in China
Wang, F., Zhang, L., Zhang, P., Cheng, Y., Ye, B., He, M., Guo, H., Zhang, X.-M., Yuan, J., Chen, W., et al. (2019) · Current Medical Science · doi:10.1007/s11596-019-2063-x · Cited by 6
Echocardiography evaluation of left ventricular diastolic function in elderly women with metabolic syndrome
Chung, J.-W., Seo, D.-I., Park, Y., & So, W.-Y. (2019) · Open Medicine · doi:10.1515/med-2019-0073 · Cited by 6
Sedentary women: sit less, live more!
Pines, A. (2015) · Climacteric · doi:10.3109/13697137.2015.1038512 · Cited by 6
Global trends and patterns in cardiovascular disease burden attributable to low physical activity: A systematic analysis for Global Burden of Disease Study from 1990 to 2021
Zhang, R., Fan, S., Zhu, C., Chen, S., Tian, F., Huang, P., & Chen, Y. (2025) · PLoS ONE · doi:10.1371/journal.pone.0323374 · Cited by 5
Exercise as elixir to combat cardiovascular ageing
Feng, Z., Yuan, X., Yi, W., Gao, F., Sun, Y., & Zhang, X. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102848 · Cited by 7
Does meeting physical activity recommendations ameliorate association between television viewing with cardiovascular disease risk? A cross-sectional, population-based analysis
Patterson, F., Mitchell, J. A., Dominick, G. M., Lozano, A. J., Huang, L., & Hanlon, A. L. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-036507 · Cited by 5
The pediatric oncology exercise field speeds up to address important issues regarding chemotherapy-related cardiotoxicity
Caru, M., & Curnier, D. Y. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.998337 · Cited by 5
“It has been well demonstrated that physical inactivity and sedentary behavior favor cardiovascular diseases (57).”
Background
Sedentary Behaviour and Cardiovascular Disease
Stamatakis, E., Rezende, L. F. M., & Rey-López, J. P. (2023) · Springer series on epidemiology and public health · doi:10.1007/978-3-031-41881-5_8 · Cited by 5
Preferência de exercícios de indivíduos acometidos pelo acidente vascular cerebral usuários da atenção básica de saúde
Bastos, V. S., Martins, J. C., & Faria, C. D. C. D. M. (2021) · Fisioterapia e Pesquisa · doi:10.1590/1809-2950/20008528032021 · Cited by 5
Interventions outside the workplace for reducing sedentary behaviour in adults under 60
Murtagh, E., MURPHY, M. H., Foster, C. E., Milton, K. E., Roberts, N. W., & O’Gorman, C. S. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012554 · Cited by 5
Reducing Sedentary Behavior: Active Steps for Overweight Women
Adams, M. M., & Gill, D. L. (2015) · Women in Sport and Physical Activity Journal · doi:10.1123/wspaj.2014-0030 · Cited by 5
Bioactive Food Components in the Prevention of Cardiovascular Diseases
Parihar, A., & Parihar, M. S. (2017) · Reference series in phytochemistry · doi:10.1007/978-3-319-54528-8_55-1 · Cited by 5
Dietary patterns and physical activity in young South Asians and white Europeans and their potential implications for cardiovascular risk
Richardson, S., Marshall, J. M., & Rendeiro, C. (2025) · Scientific Reports · doi:10.1038/s41598-025-97605-z · Cited by 5
Increasing physical activity in the vehicle with an interactive seating system in a male sample
Lampe, D., & Deml, B. (2022) · Ergonomics · doi:10.1080/00140139.2022.2098384 · Cited by 5
“The magnitude of the listed consequences can be reduced and even compensated through physical activity (Biswas et al. 2015; Chau et al. 2013; Chomistek et al. 2013; Ekelund et al. 2016; Petersen et al. 2014; Warren et al. 2010).”
Background
Quantifying the Effect of Monitor Wear Time and Monitor Type on the Estimate of Sedentary Time in People with COPD: Systematic Review and Meta-Analysis
Coll, F., Cavalheri, V., Gucciardi, D. F., Wulff, S., & Hill, K. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11071980 · Cited by 3
Objectively measured preoperative physical activity and sedentary behaviour among Finnish patients scheduled for elective cardiac procedures: baseline results from randomized controlled trial
Vasankari, S., Hartikainen, J. E. K., Vasankari, V., Anttila, V., Tokola, K., Vähä‐Ypyä, H., Husu, P., Sievänen, H. T., Vasankari, T. J., & Halonen, J. (2022) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-022-00522-1 · Cited by 4
Menopause: Questions and Answers for Improving Homeopathic Clinical Practice
Macías-Cortés, E. D. C. (2022) · Homeopathy · doi:10.1055/s-0042-1755362 · Cited by 4
Different conceptual constructs for modelling sedentary behaviour and physical activity: the impact on the correlates of behaviour
Anokye, N., & Stamatakis, E. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-921 · Cited by 6
Physical activity levels of allied health professionals working in a large Australian metropolitan health district – an observational study
Zafiropoulos, B., Alison, J. A., & Heard, R. C. (2019) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s189513 · Cited by 4
Comparison of Functional Capability, Flexibility, Strength and Quality of Life in Aged Women Engaged in Resistance Exercise, Weight-Bearing Training or Hydro-Gymnastics
Machado, O. A. S., Lima, W. P., de Souza, B. V., Gianolla, F., Killian, L. F., Machado, G. A. C., & Gorjão, R. (2019) · Journal of Sports Science · doi:10.17265/2332-7839/2019.04.002 · Cited by 4
“In this sense, the most aggravating factor is the sedentary lifestyle, because some researchers have noticed the prevalence of chronic diseases, like hypertension and cardiovascular diseases [5-7], diabetes [8-10], obesity [11], dyslipidemia [12, 13], hepatic steatosis/fatty non-alcoholic diseases [14], cancer [15-17]…”
Background
Sedentary Behaviour and Cardiovascular Disease
Stamatakis, E., Rezende, L. F. M., & Rey-López, J. P. (2017) · Springer series on epidemiology and public health · doi:10.1007/978-3-319-61552-3_9 · Cited by 6
Physical Wellness Among Gaming Adults: A Cross-Sectional StudyPreprint
Arnaez, J., Frey, G. C., Cothran, D. J., Lion, M., & Chomistek, A. K. (2017) · doi:10.2196/preprints.9571.a · Cited by 4
Self-citation
Correlates of physical activity, sedentary time, and cardiovascular disease risk factors in autistic adults without intellectual disabilities
Lee, D., KENNEDY, J. M., Cothran, D. J., Shih, P. C., Dickinson, S., Golzarri‐Arroyo, L., & Frey, G. C. (2025) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2025.104980 · Cited by 3
“It is well documented that lack of physical activity (PA) and excessive sedentary time (ST) are leading modifiable risk factors for cardiovascular disease (CVD) in the general population (Chomistek et al., 2013; Lavie et al., 2019).”
The impact of social activity on cardiovascular disease risk among middle-aged and older adults in China: a nationwide cohort study based on the CHARLS database
Wu, Y., Cheng, Q., Song, H., Gong, X., Wang, S., Xu, K., Qin, L., Cheng, J., & He, F. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1554130 · Cited by 3
“Studies by Du et al. have shown that moderate to high levels of physical activity significantly reduce the risk of developing CVDs (26).”
Influential
Changes in Urban Walking Before and During the COVID-19 Pandemic in a Metropolitan City of South Korea.
Kim, D. H., & Yoo, S. (2021) · PubMed Central · Cited by 3
Cardiovascular Disease Risk in Women: What Makes It Different from Men
Maas, A. H. E. M., & Merz, C. N. B. (2017) · Springer eBooks · doi:10.1007/978-3-319-54960-6_1 · Cited by 3
The studying of physical activity indices in students of medical university
Прохоров, Н. И., Shashina, E., Makarova, V. V., & Матвеев, А. А. (2020) · Hygiene and Sanitation · doi:10.47470/0016-9900-2020-99-8-816-821 · Cited by 3
Physiological and Lifestyle Factors Associated With Abnormal Blood Pressure in Adolescents Before and After a School-Based Wellness Program in Michigan: A Report From Project Healthy Schools
Bernardo, S., Krallman, R. H., Kline-Rogers, E. M., Montgomery, D., Brown, A. M., DuRussel‐Weston, J., Eagle, K. A., & Jackson, E. A. (2020) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2020.10.025 · Cited by 3
A lifestyle pattern characterised by high consumption of sweet and salty snacks, sugar sweetened beverages and sedentary time is associated with blood pressure in families at risk for type 2 diabetes mellitus in Europe. The Feel4Diabetes Study
Basdeki, E. D., Karatzi, K., Arnaoutis, G., Makrilakis, K., Liatis, S., Cardon, G., Craemer, M. D., Iotova, V., Tsochev, Κ., Tankova, T. I., et al. (2023) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.13145 · Cited by 3
Pre- Versus Postmeal Sedentary Duration—Impact on Postprandial Glucose in Older Adults With Overweight or Obesity
Chun, E., Gaynanova, I., Melanson, E. L., & Lyden, K. A. (2024) · Journal for the Measurement of Physical Behaviour · doi:10.1123/jmpb.2023-0032 · Cited by 3
The impact of uninterrupted sitting on central and peripheral cardiovascular function in pre-menopausal and post-menopausal women
Moinuddin, A., Stone, K. J., Turner, L. A., Paterson, C. A., Hall, N., Daykin, A. R., Lucas, S. J. E., Faulkner, J., & Fryer, S. M. (2024) · European Journal of Applied Physiology · doi:10.1007/s00421-024-05502-6 · Cited by 3
“…sedentary behaviour, specifically prolonged sitting (1.5–6 h), defined as activities consisting of < 1.5 metabolic equivalents in seated, reclined, or supine posture, is associated with heightened cardiovascular disease (CVD) risk and all-cause mortality(Biswas et al. 2015; Chomistek et al. 2013).”
Influential
Metabolic Factors Mediate the Causal Effect of Physical Activity and Sedentary Behavior on Stroke and Its Subtypes: Evidence from Mendelian Randomization Study
Wei, J., Zhao, J., Yang, K., Ma, S., Zhang, M., Sun, Y., He, C., Pan, X., & Zhu, X. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04881-x · Cited by 6
“A growing body of evidence has demonstrated that longer sedentary time increases the risk of cardiovascular disease, including strokes [6].”
Exploring the Association Between Physical Activity, Sedentary Behavior, and High-Sensitivity C-Reactive Protein Among Stroke Survivors
Pryzbek, M., Richardson, J. A., Thabane, L., & Tang, A. (2018) · Journal of Aging and Physical Activity · doi:10.1123/japa.2018-0080 · Cited by 4
Living with a smoker, health risk behaviors, and adiposity: an analysis with middle-aged and older women
Holahan, C. J., Holahan, C. K., Lim, S., & Powers, D. A. (2019) · Journal of Behavioral Medicine · doi:10.1007/s10865-019-00098-1 · Cited by 3
Cardiovascular Disease Prevention in Women
Saeed, A., & Gulati, M. (2020) · Contemporary cardiology · doi:10.1007/978-3-030-56279-3_19 · Cited by 3
Aktywność fizyczna i turystyczna wśród uczestników Uniwersytetów Trzeciego Wieku na przykładzie Krakowa
Dubińska, A. (2015) · Przedsiębiorczość - Edukacja · doi:10.24917/20833296.11.27 · Cited by 3
Associations between Area of Residence and Cardiovascular Risk
Costache, I. I., Miftode, E. G., Petriș, O. R., Popa, A. D., Iliescu, D., & Botnariu, G. (2015) · Revista de Cercetare si Interventie Sociala · Cited by 3
The Effect of a Physical Activity Coaching Intervention on Accelerometer-Measured Sedentary Behaviours in Insufficiently Physically Active Ambulatory Hospital Patients
Barrett, S., Begg, S. J., O’Halloran, P., & Kingsley, M. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18115543 · Cited by 3
“As MVPA and sedentary behaviours are both independent key factors for health [4,5], it is encouraging that the PA coaching Figure 3.”
BackgroundInfluential
Association of sedentary time with blood pressure in women of reproductive age
Spehar, S. M., Gibbs, B. B., Muldoon, M. F., & Catov, J. M. (2020) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2020.101219 · Cited by 5
“…< 1.5 metabolic equivalents while in a sitting or reclining position, with CVD and cardiovascular morbidity and mortality in the broader population, and in women specifically (Chomistek et al., 2013; Brocklebank et al., 2015; Biswas et al., 2015; Whitaker et al., 2019; Thorp et al., 2011).”
BackgroundInfluential
The impact of an 8-week green-exercise programme on systemic health, and on markers associated with cardiovascular disease risk
Thompson, J. E. S. (2014) · Cardiff Metropolitan Research Repository (Cardiff Metropolitan University) · doi:10.25401/cardiffmet.20319141 · Cited by 3
Intrinsic structural covariation links cerebellum subregions to the cerebral cortexPreprint
Wang, Z., Diedrichsen, J., Saltoun, K., Steele, C. J., Anteraper, S. A., Yeo, B. T. T., Schmahmann, J. D., & Bzdok, D. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.16.580701 · Cited by 3
“…(Dougherty et al., 2022; Takeuchi & Kawashima, 2023; Takeuchi et al., 2015) but positively correlated with risks of type-2 diabetes, cardiovascular diseases and increased BMI (Grøntved & Hu, 2011; Patterson et al., 2020), despite physical activity (Chomistek et al., 2013; Ekelund et al., 2016).”
Background
Physiological basis for recommending changes to the physical activity guidelines
Skinner, J. S., & Durstine, J. L. (2025) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2025.09.006 · Cited by 2
Joint association of sedentary behaviour and physical activity with cardiovascular disease: a systematic review and meta-analysis
Lunar, F. R., Du, Z., Amagasa, S., Kondo, N., & Inoue, K. (2026) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwag263 · Cited by 2
TIP FAKÜLTESİNDE ÇALIŞAN TIBBİ SEKRETERLERİN VE İDARİ PERSONELİN MESLEKİ DOYUMLARI, TÜKENMİŞLİKLERİ, DEPRESYON DÜZEYLERİ VE FİZİKSEL AKTİVİTE DÜZEYLERİ
Çetin, E. C., Özdengül, F., Yargıç, M. P., & Aydın, L. (2021) · Sağlık Bilimleri Dergisi · doi:10.34108/eujhs.657151 · Cited by 3
Objective and Subjective Physical Activity Levels in Austrian Middle School Students
Greier, C., Drenowatz, C. J., Riechelmann, H., & Greier, K. (2021) · Advances in Physical Education · doi:10.4236/ape.2021.114037 · Cited by 3
“…has been associated with increased morbidity and mortality (Koster et al., 2012; Patel et al., 2010; Schmid, Ricci, & Leitzmann, 2015; van der Ploeg et al., 2012) and sitting for more than 10 hours/day was associated with an increased risk for cardiovascular disease (Chomistek et al., 2013).”
Association between tea consumption and stroke in the American adult females: analyses of NHANES 2011–2018 data
Miao, Y., Ma, S., & Wu, X. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1452137 · Cited by 2
Bioactive Food Components in the Prevention of Cardiovascular Diseases
Parihar, A., & Parihar, M. S. (2019) · Reference series in phytochemistry · doi:10.1007/978-3-319-78030-6_55 · Cited by 2
Women and Heart Disease: Understanding Risk Factors for Coronary Artery Disease
Alsarah, A., Alsara, O., & Laird-Fick, H. S. (2015) · Women s Health - Open Journal · doi:10.17140/whoj-1-103 · Cited by 2
Sedentary Behavior: Considerations for the Nurse Practitioner
Halloway, S., & Buchholz, S. W. (2017) · The Journal for Nurse Practitioners · doi:10.1016/j.nurpra.2016.08.024 · Cited by 3
Comparison of coronary heart disease stratification using the Jakarta cardiovascular score between main office and site office workers
Dharma, S., Soemarko, D. S., & Setianto, B. Y. (2018) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1073/4/042018 · Cited by 2
Hygiène de vie et hypertension artérielle chez la femme : spécificités féminines du traitement non medicamenteux
Lantelme, P. (2019) · La Presse Médicale · doi:10.1016/j.lpm.2019.06.003 · Cited by 2
Twitter-Based Social Support Added to Fitbit Self-Monitoring for Decreasing Sedentary Behavior: Protocol for a Randomized Controlled Pilot Trial With Female Patients From a Women’s Heart Clinic
Oppezzo, M., Tremmel, J. A., Desai, M., Baiocchi, M., Ramo, D. E., Cullen, M. R., & Prochaska, J. J. (2020) · JMIR Research Protocols · doi:10.2196/20926 · Cited by 2
“Sedentary behavior is an independent risk factor for heart disease, particularly in women, [2,4,6] and is less studied than physical activity interventions [1,2,4,14].”
Exercise, Physical Activity, and Cardiovascular Disease
Bauman, A. E., Alharbi, M. S. N., Lowres, N., Gallagher, R., & Stamatakis, E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809657-4.99595-4 · Cited by 2
The Optimal Dose of Exercise
Eijsvogels, T. M. H., & Baggish, A. L. (2020) · Springer eBooks · doi:10.1007/978-3-030-35374-2_41 · Cited by 1
Dose–response association of total and leisure-time physical activity with the risk of different subtypes of stroke: a systematic-review and meta-analysis
Liu, Y., Ya, X., Zhou, L., Chen, T., Shen, F., Chen, Y., & Wang, X. (2025) · Journal of Public Health · doi:10.1093/pubmed/fdaf043 · Cited by 1
Cross-Sectional Association between Sedentary Behavior and Physical Inactivity with Cardiometabolic Risk Factors among Japanese: The NIPPON DATA2010
Ohashi, M., Miyagawa, N., Yanagita, M., Okuda, N., Fujiyoshi, A., Ohkubo, T., Kadota, A., Okami, Y., Kondo, K., Harada, A., et al. (2025) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.65190 · Cited by 1
Bidirectional reallocations of sitting time, physical activity, and sleep in relation to risk of all-cause mortality and cardiovascular disease: An analysis of the Prospective Urban Rural Epidemiology (PURE)-China cohort study
Huang, Y., Hao, J., Hu, B., Wang, Y., Tse, L. A., Liu, W., Cai, Q., Wang, B., Liu, Z., Bu, T., et al. (2026) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2026.101140 · Cited by 1
“4,10 (cid:2) 12 However, this may be partly explained by urban-rural differences as additional studies conducted in suburban or rural populations reported a linear association.”
Does physical inactivity increase personalised cardiovascular risk in males and females aged 40-80 years?
West, J. (2024) · PEARL (University of Plymouth) · doi:10.24382/x42z-mg11 · Cited by 1
Self-recalled Youth Physical Activity and Postmenopausal Cardiovascular Disease
Goodman, D., Park, H. L., Stefanick, M. L., Hingle, M. D., LaMonte, M. J., LeBlanc, E. L., Johnson, K., Desai, M., & Anton‐Culver, H. (2014) · Health Behavior and Policy Review · doi:10.14485/hbpr.1.6.5 · Cited by 1
Self-citation
Risk of Stroke in Patients With Spontaneous Pneumothorax
Cheng, C., Yeh, D. Y.-W., Lin, C., & Kao, C. (2016) · Medicine · doi:10.1097/md.0000000000003375 · Cited by 1
OBSOLETE: Exercise, Physical Activity and Cardiovascular Disease
Bauman, A. E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.99595-3 · Cited by 1

Authors: Chomistek, A. K., Manson, J. E., Stefanick, M. L., Lu, B., Sands-Lincoln, M., Going, S. B., Garcia, L., Allison, M. A., Sims, S. T., LaMonte, M. J., Johnson, K. C., & Eaton, C. B.
Affiliations: Harvard University (US)
Brigham and Women's Hospital (US)
Stanford University (US)
University of Arizona (US)
University of California San Diego (US)
University at Buffalo, State University of New York (US)
University of Tennessee Health Science Center (US)
Brown University (US)
Corresponding author: Chomistek, Andrea K.
ORCID: Chomistek, Andrea K.
Manson, JoAnn E.
Stefanick, Marcia L.
Going, Scott B.
Allison, Matthew A.
Sims, Stacy T.
LaMonte, Michael J.
Johnson, Karen C.
Eaton, Charles B.
Venue: Journal of the American College of Cardiology
Publisher: Elsevier BV
Published: 2013-06
Volume: 61
Issue: 23
Pages: 2346-2354
ISSN: 0735-1097 (ISSN-L)
DOI: 10.1016/j.jacc.2013.03.031
PMC: PMC3676694
OpenAlex: W1495777861
Semantic Scholar: 5c485803781b186b6e6f011fd743b707d53f91ac
Cited by: 389
References: 26
Citations by year: 2026: 13 · 2025: 18 · 2024: 24 · 2023: 28 · 2022: 27 · 2021: 32 · 2020: 33 · 2019: 44 · 2018: 35 · 2017: 30 · 2016: 36 · 2015: 39 · 2014: 24 · 2013: 5
FWCI: 24.07
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 375 d)
Locations: Journal of the American College of Cardiology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (HL035464)
National Institutes of Health, U.S. Department of Health and Human Services
National Cancer Institute (CA152904)
National Institute of Diabetes and Digestive and Kidney Diseases (DK007703-17)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Keywords: sedentary behavior, sitting time, physical activity, cardiovascular disease, coronary artery disease, stroke, postmenopausal women, energy balance, overweight, older women, Women's Health Initiative
MeSH terms: Age Factors, Aged, Cardiovascular Diseases, Female, Humans, Middle Aged, Motor Activity, Prognosis, Prospective Studies, Time Factors, United States, Cohort Studies, Body Mass Index, Incidence, Survival Rate, Multivariate Analysis, Proportional Hazards Models, Women's Health, Postmenopause, Risk Assessment, Overweight, Sedentary Behavior

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Relationship of Sedentary Behavior and Physical Activity to Incident Cardiovascular Disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks