The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Body Fat Distribution, Incident Cardiovascular Disease, Cancer, and All-Cause Mortality
Open accessAbstract
Objective To determine whether ectopic fat depots are prospectively associated with cardiovascular disease, cancer and all-cause mortality. Background The morbidity associated with excess body weight varies among individuals of similar body mass index. Ectopic fat depots may underlie this risk differential. However, prospective studies of directly measured fat are limited. Methods Participants from the Framingham Heart Study (n=3086, 49% women, mean age 50.2 years) underwent assessment of fat depots (visceral adipose tissue, pericardial adipose tissue, and periaortic adipose tissue) using multidetector computed tomography, and were followed longitudinally for a median of 5.0 years. Cox proportional hazards regression models were used to examine the association of each fat depot (per 1 standard deviation increment) with the risk of incident cardiovascular disease, cancer, and all-cause mortality after adjustment for standard risk factors, including body mass index. Results Overall, there were 90 cardiovascular events, 141 cancer events, and 71 deaths. After multivariable adjustment, visceral adipose tissue was associated with cardiovascular disease (HR 1.44, 95% CI 1.08–1.92, p=0.01) and cancer (HR 1.43, 95% CI 1.12–1.84, p=0.005). Addition of visceral adipose tissue to a multivariable model that included body mass index modestly improved cardiovascular risk prediction (net reclassification improvement of 16.3%). None of the fat depots were associated with all-cause mortality. Conclusion Visceral adiposity is associated with incident cardiovascular disease and cancer after adjustment for clinical risk factors and generalized adiposity. These findings support the growing appreciation of a pathogenic role of ectopic fat.
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Adipokines in inflammation and metabolic disease
Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625
Fox, C. S., Massaro, J. M., Hoffmann, U., Pou, K. M., Maurovich-Horvat, P., Liu, C.-Y., Vasan, R. S., Murabito, J. M., Meigs, J. B., Cupples, L. A., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.675355 · Cited by 2,882 · cited 3×
“Descriptions of the measurement of risk factors has been previously described (10).”
Self-citationThe Emerging Risk Factors Collaboration (2011) · The Lancet · doi:10.1016/s0140-6736(11)60105-0 · Cited by 1,216
Rosito, G. A., Massaro, J. M., Hoffmann, U., Ruberg, F. L., Mahabadi, A. A., Vasan, R. S., O’Donnell, C. J., & Fox, C. S. (2008) · Circulation · doi:10.1161/circulationaha.107.743062 · Cited by 1,017
Self-citationMahabadi, A. A., Massaro, J. M., Rosito, G. A., Levy, D., Murabito, J. M., Wolf, P. A., O'Donnell, C. J., Fox, C. S., & Hoffmann, U. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn573 · Cited by 651
Self-citationVisceral Fat Is an Independent Predictor of All‐cause Mortality in Men
Kuk, J. L., Katzmarzyk, P. T., Nichaman, M. Z., Church, T. S., Blair, S. N., & Ross, R. (2006) · Obesity · doi:10.1038/oby.2006.43 · Cited by 642
Greenstein, A. S., Khavandi, K., Withers, S. B., Sonoyama, K., Clancy, O., Jeziorska, M., Laing, I., Yates, A. P., Pemberton, P. W., Malik, R. A., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.821181 · Cited by 618
Ding, J., Hsu, F.-C., Harris, T. B., Liu, Y., Kritchevsky, S. B., Szklo, M., Ouyang, P., Espeland, M. A., Lohman, K. K., Criqui, M. H., et al. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27358 · Cited by 477
Cook, N. R., & Ridker, P. M. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-11-200906020-00007 · Cited by 458
Sex differences in obesity and the regulation of energy homeostasis
Lovejoy, J. C., Sainsbury, A., & the Stock Conference 2008 Working Group (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2008.00529.x · Cited by 421
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Obesity and cardiovascular disease: a scientific statement from the American Heart Association
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Di Angelantonio, E., Bhupathiraju, S. N., Wormser, D., Gao, P., Kaptoge, S., de Gonzalez, A. B., Cairns, B. J., Huxley, R., Jackson, C. L., Joshy, G., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30175-1 · Cited by 2,821
Obesity as a Major Risk Factor for Cancer
De Pergola, G., & Silvestris, F. (2013) · Journal of Obesity · doi:10.1155/2013/291546 · Cited by 959
Littlejohns, T. J., Holliday, J., Gibson, L. M., Garratt, S., Oesingmann, N., Alfaro-Almagro, F., Bell, J. D., Boultwood, C., Collins, R., Conroy, M. C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15948-9 · Cited by 812
Visceral Adiposity and the Risk of Metabolic Syndrome Across Body Mass Index
Shah, R. V., Murthy, V. L., Abbasi, S. A., Blankstein, R., Kwong, R. Y., Goldfine, A. B., Jerosch-Herold, M., Lima, J. A. C., Ding, J., & Allison, M. A. (2014) · JACC: Cardiovascular Imaging · doi:10.1016/j.jcmg.2014.07.017 · Cited by 427
Metadata
- Authors
- Britton, K. A., Massaro, J. M., Murabito, J. M., Kreger, B. E., Hoffmann, U., & Fox, C. S.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 62
- Issue
- 10
- Pages
- 921-925
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2086225923
- Cited by
- 688
- References
- 17
- FWCI
- 29.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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