The DOI matches its Crossref record; 159 of the 160 references it cites were found in a registry or an index.
Genetics and Causality of Triglyceride-Rich Lipoproteins in Atherosclerotic Cardiovascular Disease
Open accessAbstract
Triglycerides represent 1 component of a heterogeneous pool of triglyceride-rich lipoproteins (TGRLs). The reliance on triglycerides or TGRLs as cardiovascular disease (CVD) risk biomarkers prompted investigations into therapies that lower plasma triglycerides as a means to reduce CVD events. Genetic studies identified TGRL components and pathways involved in their synthesis and metabolism. We advocate that only a subset of genetic mechanisms regulating TGRLs contribute to the risk of CVD events. This "omic" approach recently resulted in new targets for reducing CVD events.
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“Fibrates or fibric acid derivatives exert their lipidmodifying effects by activating the peroxisome proliferator-activated receptor (PPAR)-a, a nuclear receptor that increases expression of LPL, apoAI, and other lipid-related genes”
From The Forgotten Lipids: Triglycerides, Remnant Cholesterol, and Atherosclerotic Cardiovascular Disease Risk (2019) · cites this paper as [13]
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“Specifically, TRLs have been implicated in pro-inflammatory signaling pathways, impairment of insulin sensitivity and upregulation of factors promoting thrombosis.22,23”
From Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor?: New Insights From the Framingham Offspring Study (2016) · cites this paper as [23]
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Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
Grundy, S. M., Becker, D. M., Clark, L. T., Cooper, R., Denke, M. A., Howard, J. L., Hunninghake, D. B., Illingworth, D. R., Luepker, R. V., McBride, P. E., et al. (2002) · Civil War Book Review · Cited by 12,198
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Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
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ESC/EAS Guidelines for the management of dyslipidaemias
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Biological, clinical and population relevance of 95 loci for blood lipids
Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Koseki, M., Pirruccello, J. P., Ripatti, S., Chasman, D. I., Willer, C. J., et al. (2010) · Nature · doi:10.1038/nature09270 · Cited by 3,487
Self-citationWiller (2013) · doi:10.1038/ng.2797 · Cited by 2,983
Self-citationGenome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
Saxena, R., Voight, B. F., Lyssenko, V., Burtt, N. P., de Bakker, P. I. W., Chen, H., Roix, J. J., Kathiresan, S., Hirschhorn, J. N., Daly, M. J., et al. (2007) · Science · doi:10.1126/science.1142358 · Cited by 2,843
Self-citationMajor lipids, apolipoproteins, and risk of vascular disease
The Emerging Risk Factors Collaboration* (2009) · JAMA · doi:10.1001/jama.2009.1619 · Cited by 2,731
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1 of the 160 references couldn’t be matched to a known paper.
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Nordestgaard, B. G. (2016) · Circulation Research · doi:10.1161/circresaha.115.306249 · Cited by 1,116
Dysfunctional HDL and atherosclerotic cardiovascular disease
Rosenson, R. S., Brewer, H. B., Ansell, B. J., Barter, P., Chapman, M. J., Heinecke, J. W., Kontush, A., Tall, A. R., & Webb, N. R. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.124 · Cited by 822
Self-citationSandesara, P. B., Virani, S. S., Fazio, S., & Shapiro, M. D. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00184 · Cited by 608
A Modern Approach to Dyslipidemia
Berberich, A. J., & Hegele, R. A. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab037 · Cited by 529
Hypertriglyceridaemia and risk of coronary artery disease
Reiner, Ž. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.31 · Cited by 390
Metadata
- Authors
- Rosenson, R. S., Davidson, M. H., Hirsh, B. J., Kathiresan, S., & Gaudet, D.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- University of Chicago (US)
- Mount Sinai Hospital (US)
- Harvard University (US)
- Université de Montréal (CA)
- Corresponding author
- Rosenson, Robert S.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 64
- Issue
- 23
- Pages
- 2525-2540
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2005157832
- Cited by
- 260
- References
- 160
- Citations by year
- 2026: 16 · 2025: 25 · 2024: 12 · 2023: 26 · 2022: 27 · 2021: 21 · 2020: 28 · 2019: 23 · 2018: 21 · 2017: 19 · 2016: 26 · 2015: 15
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Amgen
- Eli Lilly and Company
- AstraZeneca
- Sanofi
- Regeneron Pharmaceuticals
- Kowa Company
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- triglyceride-rich lipoproteins, atherosclerotic cardiovascular disease, triglycerides, genetic risk factors, causality, cardiovascular risk markers, triglyceride-lowering therapy, lipoprotein metabolism, omics, cardiovascular disease prevention
- MeSH terms
- Cardiovascular Diseases, Fasting, Humans, Inflammation, Intestinal Mucosa, Lipoproteins, Liver, Triglycerides, Genetic Variation, Hypertriglyceridemia, Fatty Acids, Omega-3, Sequence Analysis, DNA, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Postprandial Period, Atherosclerosis
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