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Genetics and Causality of Triglyceride-Rich Lipoproteins in Atherosclerotic Cardiovascular Disease
Open accessAbstract
Triglycerides represent 1 component of a heterogeneous pool of triglyceride-rich lipoproteins (TGRLs). The reliance on triglycerides or TGRLs as cardiovascular disease (CVD) risk biomarkers prompted investigations into therapies that lower plasma triglycerides as a means to reduce CVD events. Genetic studies identified TGRL components and pathways involved in their synthesis and metabolism. We advocate that only a subset of genetic mechanisms regulating TGRLs contribute to the risk of CVD events. This "omic" approach recently resulted in new targets for reducing CVD events.
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“Fibrates or fibric acid derivatives exert their lipidmodifying effects by activating the peroxisome proliferator-activated receptor (PPAR)-a, a nuclear receptor that increases expression of LPL, apoAI, and other lipid-related genes”
From The Forgotten Lipids: Triglycerides, Remnant Cholesterol, and Atherosclerotic Cardiovascular Disease Risk (2019) · cites this paper as [13]
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“Specifically, TRLs have been implicated in pro-inflammatory signaling pathways, impairment of insulin sensitivity and upregulation of factors promoting thrombosis.22,23”
From Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor?: New Insights From the Framingham Offspring Study (2016) · cites this paper as [23]
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Cites
Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
Grundy, S. M., Becker, D. M., Clark, L. T., Cooper, R., Denke, M. A., Howard, J. L., Hunninghake, D. B., Illingworth, D. R., Luepker, R. V., McBride, P. E., et al. (2002) · Civil War Book Review · Cited by 12,198
Stone, N. J., Robinson, J. G., Lichtenstein, A. H., Bairey Merz, C. N., Blum, C. B., Eckel, R. H., Goldberg, A. C., Gordon, D., Levy, D., Lloyd-Jones, D. M., et al. (2014) · Circulation · doi:10.1161/01.cir.0000437738.63853.7a · Cited by 7,081
Stone, N. J., Robinson, J. G., Lichtenstein, A. H., Bairey Merz, C. N., Blum, C. B., Eckel, R. H., Goldberg, A. C., Gordon, D., Levy, D., Lloyd-Jones, D. M., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.11.002 · Cited by 3,845
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844
ESC/EAS Guidelines for the management of dyslipidaemias
Reiner, Ž., Catapano, A. L., De Backer, G., Graham, I., Taskinen, M.-R., Wiklund, O., Agewall, S., Alegria, E., Chapman, M. J., Durrington, P., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr158 · Cited by 3,549
Biological, clinical and population relevance of 95 loci for blood lipids
Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Koseki, M., Pirruccello, J. P., Ripatti, S., Chasman, D. I., Willer, C. J., et al. (2010) · Nature · doi:10.1038/nature09270 · Cited by 3,487
Self-citationWiller (2013) · doi:10.1038/ng.2797 · Cited by 2,983
Self-citationGenome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
Saxena, R., Voight, B. F., Lyssenko, V., Burtt, N. P., de Bakker, P. I. W., Chen, H., Roix, J. J., Kathiresan, S., Hirschhorn, J. N., Daly, M. J., et al. (2007) · Science · doi:10.1126/science.1142358 · Cited by 2,843
Self-citationMajor lipids, apolipoproteins, and risk of vascular disease
The Emerging Risk Factors Collaboration* (2009) · JAMA · doi:10.1001/jama.2009.1619 · Cited by 2,731
Nordestgaard, B. G., Benn, M., Schnohr, P., & Tybjærg-Hansen, A. (2007) · JAMA · doi:10.1001/jama.298.3.299 · Cited by 2,058
Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association
Miller, M., Stone, N. J., Ballantyne, C., Bittner, V., Criqui, M. H., Ginsberg, H. N., Goldberg, A. C., Howard, W. J., Jacobson, M. S., Kris-Etherton, P. M., et al. (2011) · Circulation · doi:10.1161/cir.0b013e3182160726 · Cited by 1,871
Atherogenesis: a postprandial phenomenon.
Zilversmit, D. B. (1979) · Circulation · doi:10.1161/01.cir.60.3.473 · Cited by 1,701
Effects of extended-release niacin with laropiprant in high-risk patients
The HPS2-THRIVE Collaborative Group (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1300955 · Cited by 1,668
Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women
Bansal, S., Buring, J. E., Rifai, N., Mora, S., Sacks, F. M., & Ridker, P. M. (2007) · JAMA · doi:10.1001/jama.298.3.309 · Cited by 1,619
Newly identified loci that influence lipid concentrations and risk of coronary artery disease
Willer, C. J., Sanna, S., Jackson, A. U., Scuteri, A., Bonnycastle, L. L., Clarke, R., Heath, S. C., Timpson, N. J., Najjar, S. S., Stringham, H. M., et al. (2008) · Nature Genetics · doi:10.1038/ng.76 · Cited by 1,585
Sarwar, N., Danesh, J., Eiriksdottir, G., Sigurdsson, G., Wareham, N., Bingham, S., Boekholdt, S. M., Khaw, K.-T., & Gudnason, V. (2007) · Circulation · doi:10.1161/circulationaha.106.637793 · Cited by 1,408
Kathiresan, S., Melander, O., Guiducci, C., Surti, A., Burtt, N. P., Rieder, M. J., Cooper, G. M., Roos, C., Voight, B. F., Havulinna, A. S., et al. (2008) · Nature Genetics · doi:10.1038/ng.75 · Cited by 1,386
Self-citationCommon variants at 30 loci contribute to polygenic dyslipidemia
Kathiresan, S., Willer, C. J., Peloso, G. M., Demissie, S., Musunuru, K., Schadt, E. E., Kaplan, L., Bennett, D., Li, Y., Tanaka, T., et al. (2009) · Nature Genetics · doi:10.1038/ng.291 · Cited by 1,364
Self-citationChapman, M. J., Ginsberg, H. N., Amarenco, P., Andreotti, F., Borén, J., Catapano, A. L., Descamps, O. S., Fisher, E., Kovanen, P. T., Kuivenhoven, J. A., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr112 · Cited by 1,227
The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
Perry, R. J., Samuel, V. T., Petersen, K. F., & Shulman, G. I. (2014) · Nature · doi:10.1038/nature13478 · Cited by 1,170
Remnant Cholesterol as a Causal Risk Factor for Ischemic Heart Disease
Varbo, A., Benn, M., Tybjærg-Hansen, A., Jørgensen, A. B., Frikke-Schmidt, R., & Nordestgaard, B. G. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.08.1026 · Cited by 1,115
Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease
The TG and HDL Working Group of the Exome Sequencing Project, N. H. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1307095 · Cited by 1,071
An Apolipoprotein Influencing Triglycerides in Humans and Mice Revealed by Comparative Sequencing
Pennacchio, L. A., Olivier, M., Hubacek, J. A., Cohen, J. C., Cox, D. R., Fruchart, J.-C., Krauss, R. M., & Rubin, E. M. (2001) · Science · doi:10.1126/science.1064852 · Cited by 921
Loss-of-Function Mutations in APOC3 and Risk of Ischemic Vascular Disease
Jørgensen, A. B., Frikke-Schmidt, R., Nordestgaard, B. G., & Tybjærg-Hansen, A. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1308027 · Cited by 919
Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline
Berglund, L., Brunzell, J. D., Goldberg, A. C., Goldberg, I. J., Sacks, F., Murad, M. H., & Stalenhoef, A. F. H. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3213 · Cited by 887
Common variants associated with plasma triglycerides and risk for coronary artery disease
Do, R., Willer, C. J., Schmidt, E. M., Sengupta, S., Gao, C., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., et al. (2013) · Nature Genetics · doi:10.1038/ng.2795 · Cited by 862
Cloning of DGAT2, a Second Mammalian Diacylglycerol Acyltransferase, and Related Family Members
Cases, S., Stone, S. J., Zhou, P., Yen, E., Tow, B., Lardizabal, K. D., Voelker, T., & Farese, R. V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106219200 · Cited by 818
Boekholdt, S. M., Arsenault, B. J., Mora, S., Pedersen, T. R., LaRosa, J. C., Nestel, P. J., Simes, R. J., Durrington, P., Hitman, G. A., Welch, K. M. A., et al. (2012) · JAMA · doi:10.1001/jama.2012.366 · Cited by 795
Exome Sequencing, ANGPTL3 Mutations, and Familial Combined Hypolipidemia
Musunuru, K., Pirruccello, J. P., Do, R., Peloso, G. M., Guiducci, C., Sougnez, C., Garimella, K. V., Fisher, S., Abreu, J., Barry, A. J., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1002926 · Cited by 754
Self-citationTriglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies
(2010) · The Lancet · doi:10.1016/s0140-6736(10)60545-4 · Cited by 716
ESC/EAS Guidelines for the management of dyslipidaemias
Catapano, A. L., Reiner, Ž., De Backer, G., Graham, I., Taskinen, M.-R., Wiklund, O., Agewall, S., Alegria, E., Chapman, M. J., Durrington, P., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.06.028 · Cited by 706
PLASMA LIPID AND LIPOPROTEIN PATTERN IN GREENLANDIC WEST-COAST ESKIMOS
Bang, H. O., Dyerberg, J., & Nielsen, A. B. (1971) · The Lancet · doi:10.1016/s0140-6736(71)91658-8 · Cited by 690
Pollin, T. I., Damcott, C. M., Shen, H., Ott, S. H., Shelton, J., Horenstein, R. B., Post, W., McLenithan, J. C., Bielak, L. F., Peyser, P. A., et al. (2008) · Science · doi:10.1126/science.1161524 · Cited by 688
Hegele, R. A., Ginsberg, H. N., Chapman, M. J., Nordestgaard, B. G., Kuivenhoven, J. A., Averna, M., Borén, J., Bruckert, E., Catapano, A. L., Descamps, O. S., et al. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70191-8 · Cited by 635
PLASMA LIPID AND LIPOPROTEIN PATTERN IN GREENLANDIC WEST-COAST ESKIMOS
Bang, H. O., Dyerberg, J., & Nielsen, A. B. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1986.tb07607.x · Cited by 604
Langsted, A., Freiberg, J. J., & Nordestgaard, B. G. (2008) · Circulation · doi:10.1161/circulationaha.108.804146 · Cited by 588
Schaeffer, L., Gohlke, H., Müller, M., Heid, I. M., Palmer, L. J., Kompauer, I., Demmelmair, H., Illig, T., Koletzko, B., & Heinrich, J. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl117 · Cited by 561
Lipoprotein Management in Patients With Cardiometabolic Risk
Brunzell, J. D., Davidson, M. H., Furberg, C. D., Goldberg, R. B., Howard, B. V., Stein, J. H., & Witztum, J. L. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.02.034 · Cited by 526
Self-citationHoogeveen, R. C., Gaubatz, J. W., Sun, W., Dodge, R. C., Crosby, J. R., Jiang, J., Couper, D., Virani, S. S., Kathiresan, S., Boerwinkle, E., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303284 · Cited by 507
Self-citationJørgensen, A. B., Frikke-Schmidt, R., West, A. S., Grande, P., Nordestgaard, B. G., & Tybjærg-Hansen, A. (2013) · European Heart Journal · doi:10.1093/eurheartj/ehs431 · Cited by 501
Marx, N., Duez, H., Fruchart, J.-C., & Staels, B. (2004) · Circulation Research · doi:10.1161/01.res.0000127122.22685.0a · Cited by 501
Mora, S., Otvos, J. D., Rifai, N., Rosenson, R. S., Buring, J. E., & Ridker, P. M. (2009) · Circulation · doi:10.1161/circulationaha.108.816181 · Cited by 490
Self-citationSacks, F. M., Alaupovic, P., Moye, L. A., Cole, T. G., Sussex, B., Stampfer, M. J., Pfeffer, M. A., & Braunwald, E. (2000) · Circulation · doi:10.1161/01.cir.102.16.1886 · Cited by 490
Kersten, S., Mandard, S., Tan, N. S., Escher, P., Metzger, D., Chambon, P., Gonzalez, F. J., Desvergne, B., & Wahli, W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004029200 · Cited by 489
Fatty Acid Regulation of Hepatic Gene Transcription
Jump, D. Β., Botolin, D., Wang, Y., Xu, J., Christian, B., & Demeure, O. (2005) · Journal of Nutrition · doi:10.1093/jn/135.11.2503 · Cited by 477
Barter, P. J., Ballantyne, C. M., Carmena, R., Cabezas, M. C., Chapman, M. J., Couture, P., Graaf, J. D., Durrington, P. N., Færgeman, O., Frohlich, J., et al. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01616.x · Cited by 465
Self-citationPostprandial plasma lipoprotein changes in human subjects of different ages.
Cohn, J. S., McNamara, J. R., Cohn, S. D., Ordovás, J. M., & Schaefer, E. J. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38520-5 · Cited by 448
Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia
Johansen, C. T., Wang, J., Lanktree, M. B., Cao, H., McIntyre, A. D., Ban, M. R., Martins, R. A., Kennedy, B. A., Hassell, R. G., Visser, M. E., et al. (2010) · Nature Genetics · doi:10.1038/ng.628 · Cited by 437
Self-citationKöster, A., Chao, Y. B., Mosior, M., Ford, A., Gonzalez-DeWhitt, P. A., Hale, J. E., Li, D., Qiu, Y., Fraser, C. C., Yang, D. D., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0476 · Cited by 427
Ginsberg, H. N., Le, N. A., Goldberg, I. J., Gibson, J. C., Rubinstein, A., Wang-Iverson, P., Norum, R., & Brown, W. V. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112713 · Cited by 424 · cited 1×
“Various proteins regulate LPL including: apoC1 (25,26), apoC2 (27), apoC3 (26,28), apoA5 (29), angiopoietin-like protein 3 (ANGPTL3) (30), ANGPTL4 (31,32), and ANGPTL8 (33).”
Lemaître, R. N., Tanaka, T., Tang, W., Manichaikul, A. W., Foy, M., Kabagambe, E. K., Nettleton, J. A., King, I. B., Weng, L.-C. C., Bhattacharya, S., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002193 · Cited by 415
Atypical angiopoietin-like protein that regulates ANGPTL3
Quagliarini, F., Wang, Y., Kozlitina, J., Grishin, N. V., Hyde, R., Boerwinkle, E., Valenzuela, D. M., Murphy, A. J., Cohen, J. C., & Hobbs, H. H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217552109 · Cited by 409
Gaudet, D., Méthot, J., Déry, S., Brisson, D., Essiembre, C., Tremblay, G., Tremblay, K., de Wal, J., Twisk, J., van den Bulk, N., et al. (2013) · Gene Therapy · doi:10.1038/gt.2012.43 · Cited by 404
Self-citationComparison of statins in hypertriglyceridemia
Stein, E. A., Lane, M., & Laskarzewski, P. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00041-1 · Cited by 386
Mechanisms for the Hypotriglyceridemic Effect of Marine Omega-3 Fatty Acids
Davidson, M. H. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.12.024 · Cited by 383
Self-citationGraham, M. J., Lee, R. G., Bell, T. A., Fu, W., Mullick, A. E., Alexander, V. J., Singleton, W., Viney, N., Geary, R., Su, J., et al. (2013) · Circulation Research · doi:10.1161/circresaha.111.300367 · Cited by 377
Robinson, J. G., Wang, S., Smith, B. J., & Jacobson, T. A. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.10.024 · Cited by 368
Sukonina, V., Lookene, A., Olivecrona, T., & Olivecrona, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604026103 · Cited by 360
DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes
Harris, C. A., Haas, J. T., Streeper, R. S., Stone, S. J., Kumari, M., Yang, K., Han, X., Brownell, N. K., Gross, R. W., Zechner, R., et al. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m013003 · Cited by 357
Grundy, S. M. (2013) · Journal of clinical lipidology · doi:10.1016/j.jacl.2013.10.001 · Cited by 353
Rapp, J. H., Lespine, A., Hamilton, R. L., Colyvas, N., Chaumeton, A. H., Tweedie-Hardman, J., Kotite, L., Kunitake, S. T., Havel, R. J., & Kane, J. P. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.11.1767 · Cited by 340
Shimizugawa, T., Ono, M., Shimamura, M., Yoshida, K., Ando, Y., Koishi, R., Ueda, K., Inaba, T., Minekura, H., Kohama, T., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203215200 · Cited by 339
Grundy, S. M., Arai, H., Barter, P. J., Bersot, T. P., Betteridge, D. J., Carmena, R., Cuevas, A. M., Davidson, M. H., Genest, J. J., Kesäniemi, Y. A., et al. (2013) · Journal of clinical lipidology · doi:10.1016/j.jacl.2013.12.005 · Cited by 334
Self-citationMartinelli, N., Girelli, D., Malerba, G., Guarini, P., Illig, T., Trabetti, E., Sandri, M. F., Friso, S., Pizzolo, F., Schaeffer, L., et al. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.4.941 · Cited by 332
Contois, J. H., McConnell, J. P., Sethi, A. A., Csako, G., Devaraj, S., Hoefner, D. M., & Warnick, G. R. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.118356 · Cited by 326
Peloso, G. M., Auer, P. L., Bis, J. C., Voorman, A., Morrison, A. C., Stitziel, N. O., Brody, J. A., Khetarpal, S. A., Crosby, J. R., Fornage, M., et al. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.01.009 · Cited by 314
Self-citationWang, L., Gill, R., Pedersen, T. L., Higgins, L. J., Newman, J. W., & Rutledge, J. C. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m700505-jlr200 · Cited by 303
Wong, H., & Schotz, M. C. (2002) · Journal of Lipid Research · doi:10.1194/jlr.r200007-jlr200 · Cited by 298
Garber, A. J., Abrahamson, M. J., Barzilay, J. I., Blonde, L., Bloomgarden, Z. T., Bush, M. A., Dagogo-Jack, S. E., Davidson, M., EINHORN, D. F., Garvey, W. T., et al. (2013) · Endocrine Practice · doi:10.4158/ep13176.cs · Cited by 282
Self-citationGenetic determinants of plasma triglycerides
Johansen, C. T., Kathiresan, S., & Hegele, R. A. (2010) · Journal of Lipid Research · doi:10.1194/jlr.r009720 · Cited by 264
Self-citationDavidson, M. H., Ballantyne, C. M., Jacobson, T. A., Bittner, V. A., Braun, L. T., Brown, A. S., Brown, W. V., Cromwell, W. C., Goldberg, R. B., McKenney, J. M., et al. (2011) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2011.07.005 · Cited by 262
Self-citationYe, J., Li, J. Z., Liu, Y., Li, X., Yang, T., Ma, X., Li, Q., Yao, Z., & Li, P. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.013 · Cited by 248
Jackson, K. G., Poppitt, S. D., & Minihane, A. M. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.08.012 · Cited by 246
Kastelein, J. J. P., Maki, K. C., Susekov, A., Ezhov, M., Nordestgaard, B. G., Machielse, B. N., Kling, D., & Davidson, M. H. (2014) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2013.10.003 · Cited by 233
Self-citationChREBP: A Glucose-activated Transcription Factor Involved in the Development of Metabolic Syndrome
Iizuka, K., & Horikawa, Y. (2008) · Endocrine Journal · doi:10.1507/endocrj.k07e-110 · Cited by 232
Zheng, C., Khoo, C., Furtado, J., & Sacks, F. M. (2010) · Circulation · doi:10.1161/circulationaha.109.875807 · Cited by 223
Chylomicron clearance in normal and hyperlipidemic man
Grundy, S. M., & Mok, H. Y. I. (1976) · Metabolism · doi:10.1016/s0026-0495(76)80006-6 · Cited by 218
Civelek, M., Manduchi, E., Riley, R., Stoeckert, C. J., & Davies, P. F. (2009) · Circulation Research · doi:10.1161/circresaha.109.203711 · Cited by 208
Haidari, M., Leung, N., Mahbub, F., Uffelman, K., Kohen-Avramoglu, R., Lewis, G., & Adeli, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200544200 · Cited by 191
Gene therapy for lipoprotein lipase deficiency
Gaudet, D., Méthot, J., & Kastelein, J. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283555a7e · Cited by 178
Self-citationA largely random AAV integration profile after LPLD gene therapy
Kaeppel, C., Beattie, S. G., Fronza, R., van Logtenstein, R., Salmon, F., Schmidt, S., Wolf, S., Nowrouzi, A., Glimm, H., von Kalle, C., et al. (2013) · Nature Medicine · doi:10.1038/nm.3230 · Cited by 176
Self-citationLarsson, M., Vorrsjö, E., Talmud, P. J., Lõokene, A., & Olivecrona, G. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.495366 · Cited by 176
Sundaram, M., Zhong, S., Khalil, M. B., Links, P. H., Zhao, Y., Iqbal, J., Hussain, M. M., Parks, R. J., Wang, Y., & Yao, Z. (2009) · Journal of Lipid Research · doi:10.1194/m900346-jlr200 · Cited by 176
Complex links between dietary lipids, endogenous endotoxins and metabolic inflammation
Laugerette, F., Vors, C., Peretti, N., & Michalski, M. (2010) · Biochimie · doi:10.1016/j.biochi.2010.04.016 · Cited by 170
Kinnunen, P. K. J., Jackson, R. L., Smith, L. C., Gotto, A. M., & Sparrow, J. T. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.11.4848 · Cited by 167
Carpentier, A. C., Frisch, F., Labbé, S. M., Gagnon, R., de Wal, J., Greentree, S., Petry, H., Twisk, J., Brisson, D., & Gaudet, D. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3002 · Cited by 165
Self-citationLai, C.-Q., Demissie, S., Cupples, L. A., Zhu, Y., Adiconis, X., Parnell, L. D., Corella, D., & Ordovas, J. M. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400192-jlr200 · Cited by 163
Gower, R. M., Wu, H., Foster, G. A., Devaraj, S., Jialal, I., Ballantyne, C. M., Knowlton, A. A., & Simon, S. I. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.215434 · Cited by 160
Gusarova, V., Brodsky, J. L., & Fisher, E. A. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306898200 · Cited by 155
Changes in triglyceride levels and risk for coronary heart disease in young men.
Tirosh, A., Rudich, A., Shochat, T., Tekes-Manova, D., Israeli, E., Henkin, Y., Kochba, I., & Shai, I. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-6-200709180-00007 · Cited by 151
Rashid, S., Tavori, H., Brown, P. E., Linton, M. F., He, J., Giunzioni, I., & Fazio, S. (2014) · Circulation · doi:10.1161/circulationaha.113.006720 · Cited by 147
Zhu, J., Lee, B., Buhman, K. K., & Cheng, J. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800555-jlr200 · Cited by 145
Berbée, J. F. P., van der Hoogt, C. C., Sundararaman, D., Havekes, L. M., & Rensen, P. C. N. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400301-jlr200 · Cited by 140
Ferreira, V., Twisk, J., Kwikkers, K., Aronica, E., Brisson, D., Methot, J., Petry, H., & Gaudet, D. (2014) · Human Gene Therapy · doi:10.1089/hum.2013.169 · Cited by 137
Self-citationWebb, J. C., Patel, D. D., Jones, M. D., Knight, B. L., & Soutar, A. K. (1994) · Human Molecular Genetics · doi:10.1093/hmg/3.4.531 · Cited by 133
Grosskopf, I., Baroukh, N., Lee, S., Kamari, Y., Harats, D., Rubin, E. M., Pennacchio, L. A., & Cooper, A. D. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000186189.26141.12 · Cited by 128
Demignot, S., Beilstein, F., & Morel, É. (2013) · Biochimie · doi:10.1016/j.biochi.2013.07.009 · Cited by 125
Dashty, M., Motazacker, M. M., Levels, J. H. M., de Vries, M., Mahmoudi, M., Peppelenbosch, M. P., & Rezaee, F. (2014) · Thrombosis and Haemostasis · doi:10.1160/th13-02-0178 · Cited by 121
Severe Hypertriglyceridemia With Pancreatitis
Sacks, F. M., Stanesa, M., & Hegele, R. A. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.13309 · Cited by 119
Fenofibrate Effect on Triglyceride and Postprandial Response of Apolipoprotein A5 Variants
Lai, C., Arnett, D. K., Corella, D., Straka, R. J., Tsai, M. Y., Peacock, J. M., Adiconis, X., Parnell, L. D., Hixson, J. E., Province, M. A., et al. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.140103 · Cited by 119
Liu, J., Afroza, H., Rader, D. J., & Jin, W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.144279 · Cited by 118
Bouchoux, J., Beilstein, F., Pauquai, T., Guerrera, I. C., Château, D., Ly, N. Y., Alqub, M., Klein, C., Chambaz, J., Rousset, M., et al. (2011) · Biology of the Cell · doi:10.1042/bc20110024 · Cited by 118
Changes in Triglyceride Levels and Risk for Coronary Heart Disease in Young Men
(2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-6-200709180-00003 · Cited by 118
Rosenson, R. S., Wolff, D. A., Huskin, A. L., Helenowski, I. B., & Rademaker, A. W. (2007) · Diabetes Care · doi:10.2337/dc07-0015 · Cited by 117
Self-citationOka, K., Ishimura‐Oka, K., CHU, M., Sullivan, M., Krushkal, J., Li, W., & Chan, L. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.00975.x · Cited by 116
Deo, R. C., Reich, D., Tandon, A., Akylbekova, E. L., Patterson, N. J., Waliszewska, A., Kathiresan, S., Sarpong, D. F., Taylor, H. A., & Wilson, J. G. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000342 · Cited by 114
Self-citationRidker, P. M. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2007.097907 · Cited by 114
Postprandial lipoprotein metabolism and atherosclerosis
Karpe, F., & Hamsten, A. (1995) · Current Opinion in Lipidology · doi:10.1097/00041433-199506000-00003 · Cited by 112
IRF-1 and miRNA126 Modulate VCAM-1 Expression in Response to a High-Fat Meal
Sun, C., Alkhoury, K., Wang, Y. I., Foster, G. A., Radecke, C. E., Tam, K., Edwards, C. M., Facciotti, M. T., Armstrong, E. J., Knowlton, A. A., et al. (2012) · Circulation Research · doi:10.1161/circresaha.112.270314 · Cited by 102
Apolipoprotein CIII links dyslipidemia with atherosclerosis
Kawakami, A., & Yoshida, M. (2009) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.e607 · Cited by 98
Mamo, J. C. L., Proctor, S. D., & Smith, D. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00220-2 · Cited by 98
Recent advances in niacin and lipid metabolism
Kamanna, V. S., Ganji, S. H., & Kashyap, M. L. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283613a68 · Cited by 97
Direct Visualization of Lipid Deposition and Reverse Lipid Transport in a Perfused Artery
Rutledge, J., Mullick, A. E., Gardner, G., & Goldberg, I. J. (2000) · Circulation Research · doi:10.1161/01.res.86.7.768 · Cited by 91
Davidson, M. H. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000019 · Cited by 88
Self-citationAung, H. H., Lame, M. W., Gohil, K., An, C.-I., Wilson, D. W., & Rutledge, J. C. (2013) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.113.301375 · Cited by 86
Acylation of Acylglycerols by Acyl Coenzyme A:Diacylglycerol Acyltransferase 1 (DGAT1)
Cheng, D., Iqbal, J., Devenny, J. J., Chu, C.-H., Chen, L., Dong, J., Seethala, R., Keim, W. J., Azzara, A. V., Lawrence, R. M., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800494200 · Cited by 81
Safety Profile of Extended-Release Niacin in the AIM-HIGH Trial
Anderson, T. J., Boden, W. E., Desvigne-Nickens, P. M., Fleg, J. L., Kashyap, M. L., McBride, R., & Probstfield, J. L. (2014) · New England Journal of Medicine · doi:10.1056/nejmc1311039 · Cited by 81
Ganji, S. H., Kukes, G. D., Lambrecht, N. W. G., Kashyap, M. L., & Kamanna, V. S. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00181.2013 · Cited by 80
Gil‐Zamorano, J., Martín‐Hernández, R., Daimiel, L., Richardson, K., Giordano, E., Nicod, N. M., García-Carrasco, B., Soares, S. M. A., Iglesias‐Gutiérrez, E., Lasunción, M. A., et al. (2014) · Journal of Nutrition · doi:10.3945/jn.113.189050 · Cited by 77
Yan, F., Wang, Q., Xu, C., Cao, M., Zhou, X., Wang, T., Yu, C., Jing, F., Chen, W., Gao, L., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099245 · Cited by 76
Multhaupt, H. A. B., Gåfvels, M. E., Karikó, K., Jin, H., Arenas-Elliott, C. P., Goldman, B., Strauss, J. F., Angelin, B., Warhol, M. J., & McCrae, K. R. (1996) · Europe PMC (PubMed Central) · Cited by 74
Ables, G. P., Yang, K. J. Z., Vogel, S., Hernández‐Ono, A., Yu, S., Yuen, J. J., Birtles, S., Buckett, L. K., Turnbull, A. V., Goldberg, I. J., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m029041 · Cited by 73
Davidson, M. H., Maki, K. C., Bays, H., Carter, R., & Ballantyne, C. M. (2009) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2009.08.001 · Cited by 71
Self-citationElosúa, R., Ordovás, J. M., Cupples, L. A., Lai, C., Demissie, S., Fox, C. S., Polak, J. F., Wolf, P. A., D’Agostino, R. B., & O’Donnell, C. J. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m500446-jlr200 · Cited by 71
Abnormalities in apo B-containing lipoproteins in diabetes and atherosclerosis
TOMKIN, G. H., & Owens, D. (2001) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.179 · Cited by 71
Apolipoprotein C-III: Going Back to the Future for a Lipid Drug Target
Huff, M. W., & Hegele, R. A. (2013) · Circulation Research · doi:10.1161/circresaha.113.301464 · Cited by 70
Guérin, M., Egger, P., Soudant, C., Goff, W. L., van Tol, A., Dupuis, R., & Chapman, M. J. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200135-jlr200 · Cited by 69
Adiels, M., Matikainen, N., Westerbacka, J., Söderlund, S., Larsson, T. P., Olofsson, S., Borén, J., & Taskinen, M. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.02.001 · Cited by 68
Grundy, S. M., Arai, H., Barter, P., Bersot, T. P., Betteridge, D. J., Carmena, R., Cuevas, A., Davidson, M. H., Genest, J., Kesäniemi, Y. A., et al. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.11.031 · Cited by 68
Self-citationWang, Y. I., Bettaieb, A., Sun, C., DeVerse, J. S., Radecke, C. E., Mathew, S., Edwards, C. M., Haj, F. G., Passerini, A. G., & Simon, S. I. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078322 · Cited by 65
Folsom, A. R., Peacock, J. M., Demerath, E., & Boerwinkle, E. (2008) · Metabolism · doi:10.1016/j.metabol.2008.06.016 · Cited by 64
Wang, L., Sapuri-Butti, A. R., Aung, H. H., Parikh, A. N., & Rutledge, J. C. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01366.2007 · Cited by 64
Etiology and risk of lactescent plasma and severe hypertriglyceridemia
Tremblay, K., Méthot, J., Brisson, D., & Gaudet, D. (2010) · Journal of clinical lipidology · doi:10.1016/j.jacl.2010.11.004 · Cited by 63
Self-citationPPAR agonists reduce steatosis in oleic acid-overloaded HepaRG cells
Rogue, A., Anthérieu, S., Vluggens, A., Umbdenstock, T., Claude, N., de la Moureyre-Spire, C., Weaver, R. J., & Guillouzo, A. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.02.001 · Cited by 60
Update on genetics of postprandial lipemia
Pérez‐Martínez, P., Delgado‐Lista, J., Pérez‐Jiménez, F., & López‐Miranda, J. (2010) · Atherosclerosis Supplements · doi:10.1016/j.atherosclerosissup.2010.03.002 · Cited by 59
Romeo, S., Yin, W., Kozlitina, J., Pennacchio, L. A., Boerwinkle, E., Hobbs, H. H., & Cohen, J. C. (2008) · Journal of Clinical Investigation · doi:10.1172/jci37118 · Cited by 58
Gao, Y., Shen, W., Lu, B., Zhang, Q., Hu, Y., & Chen, Y. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m041988 · Cited by 56
Endothelial inflammation correlates with subject triglycerides and waist size after a high-fat meal
Wang, Y. I., Schulze, J., Raymond, N., Tomita, T. M., Tam, K., Simon, S. I., & Passerini, A. G. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01036.2010 · Cited by 56
ApoE in Atherosclerosis: A Protein With Multiple Hats
Curtiss, L. K. (2000) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.20.8.1852 · Cited by 55
Rosenson, R. S., Davidson, M. H., & Pourfarzib, R. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.03.038 · Cited by 51
Self-citationDocosahexaenoic acid suppresses the expression of FoxO and its target genes
Chen, Y.-J., Chen, C.-C., Li, T., Wang, P.-H., Liu, L.-R., Chang, F.-Y., Wang, Y.-C., Yu, Y., Lin, S., Mersmann, H. J., et al. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.11.003 · Cited by 48
Zheng, C., Murdoch, S. J., Brunzell, J. D., & Sacks, F. M. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000203512.01007.3d · Cited by 48
Mendivil, C. O., Rimm, E. B., Furtado, J., & Sacks, F. M. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000130 · Cited by 48
Lassel, T. S., Guérin, M., Auboiron, S., Chapman, M. J., & Guy-grand, B. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.1.65 · Cited by 46
Atheroprotective Effect of Human Apolipoprotein A5 in a Mouse Model of Mixed Dyslipidemia
Mansouri, R. M., Baugé, E., Gervois, P. P., Fruchart‐Najib, J., Fiévet, C., Staels, B., & Fruchart, J. (2008) · Circulation Research · doi:10.1161/circresaha.108.179861 · Cited by 40
PKCζ-mediated phosphorylation controls budding of the pre-chylomicron transport vesicle
Siddiqi, S. A., & Mansbach, C. M. (2008) · Journal of Cell Science · doi:10.1242/jcs.022780 · Cited by 35
Vine, D. F., Glimm, D. R., & Proctor, S. D. (2008) · Atherosclerosis Supplements · doi:10.1016/j.atherosclerosissup.2008.05.004 · Cited by 34
Nicotinic Acid Receptor GPR109A Is Down-Regulated in Human Macrophage-Derived Foam Cells
Chai, J. T., Digby, J. E., Ruparelia, N., Jefferson, A., Handa, A. I., & Choudhury, R. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062934 · Cited by 27
McPherson, R. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.11.009 · Cited by 26
Meyers, C. D., Serrano‐Wu, M. H., Amer, A., Chen, J., Rocheford, E. C., Commerford, R., Hubbard, B. K., Brousseau, M., Li, L., Meihui, P., et al. (2013) · Journal of clinical lipidology · doi:10.1016/j.jacl.2013.03.093 · Cited by 24
Introduction to the DISRUPT postprandial database: subjects, studies and methodologies
Jackson, K. G., Clarke, D. T., Murray, P., Lovegrove, J. A., O’Malley, B., Minihane, A. M., & Williams, C. M. (2009) · Genes & Nutrition · doi:10.1007/s12263-009-0149-y · Cited by 24
Management of non-high-density lipoprotein abnormalities
Rosenson, R. S. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.05.020 · Cited by 23
Self-citationLee, S. H., Lee, B., Won, H. K., Moon, J. H., Kim, K. J., Kang, E. S., Soo, B., & Lee, H. C. (2011) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2011.35.4.404 · Cited by 19
Niacin in Pharmacological Doses Alters MicroRNA Expression in Skeletal Muscle of Obese Zucker Rats
Couturier, A., Keller, J., Most, E., Ringseis, R., & Eder, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098313 · Cited by 16
Ouellette, C., Cormier, H., Rudkowska, I., Guénard, F., Lemieux, S., Couture, P., & Vohl, M. (2013) · Lifestyle Genomics · doi:10.1159/000357432 · Cited by 14
[Very low-density lipoprotein (VLDL) receptor].
Yamamoto, N. (1993) · PubMed · Cited by 13
Rosenson, R. S., Helenowski, I., & Tangney, C. (2010) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-010-6264-6 · Cited by 9
Self-citationGaudet, D., Alexander, V. J., Brisson, D., Tremblay, K., Flaim, J., Hughes, S. G., Singleton, W., & Geary, R. S. (2014) · Journal of clinical lipidology · doi:10.1016/j.jacl.2014.02.090 · Cited by 2
Self-citation
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Rosenson, R. S., Brewer, H. B., Ansell, B. J., Barter, P., Chapman, M. J., Heinecke, J. W., Kontush, A., Tall, A. R., & Webb, N. R. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.124 · Cited by 822
Self-citationSandesara, P. B., Virani, S. S., Fazio, S., & Shapiro, M. D. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00184 · Cited by 608
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Berberich, A. J., & Hegele, R. A. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab037 · Cited by 529
Hypertriglyceridaemia and risk of coronary artery disease
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Metadata
- Authors
- Rosenson, R. S., Davidson, M. H., Hirsh, B. J., Kathiresan, S., & Gaudet, D.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- University of Chicago (US)
- Mount Sinai Hospital (US)
- Harvard University (US)
- Université de Montréal (CA)
- Corresponding author
- Rosenson, Robert S.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 64
- Issue
- 23
- Pages
- 2525-2540
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2005157832
- Cited by
- 260
- References
- 160
- Citations by year
- 2026: 16 · 2025: 25 · 2024: 12 · 2023: 26 · 2022: 27 · 2021: 21 · 2020: 28 · 2019: 23 · 2018: 21 · 2017: 19 · 2016: 26 · 2015: 15
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Amgen
- Eli Lilly and Company
- AstraZeneca
- Sanofi
- Regeneron Pharmaceuticals
- Kowa Company
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- triglyceride-rich lipoproteins, atherosclerotic cardiovascular disease, triglycerides, genetic risk factors, causality, cardiovascular risk markers, triglyceride-lowering therapy, lipoprotein metabolism, omics, cardiovascular disease prevention
- MeSH terms
- Cardiovascular Diseases, Fasting, Humans, Inflammation, Intestinal Mucosa, Lipoproteins, Liver, Triglycerides, Genetic Variation, Hypertriglyceridemia, Fatty Acids, Omega-3, Sequence Analysis, DNA, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Postprandial Period, Atherosclerosis
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