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The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Arterial Stiffening With Exercise in Patients With Heart Failure and Preserved Ejection Fraction

Reddy, Yogesh N.V., Andersen, Mads J., Obokata, Masaru, Koepp, Katlyn E., Kane, Garvan C., Melenovsky, Vojtech, Olson, Thomas P., Borlaug, Barry A.·2017·Journal of the American College of Cardiology
DOI 10.1016/j.jacc.2017.05.029PMC PMC5520668
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Crossref · 10.1016/j.jacc.2017.05.029

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  • Pulse pressure is inversely correlated with arterial compliance.

    “Pulse pressure is inversely correlated with arterial compliance, which is frequently impaired in patients with HFpEF, where increases in aortic stiffness contribute to elevation in cardiac filling pressures, especially during exercise24.”

    From Effects of tirzepatide on circulatory overload and end-organ damage in heart failure with preserved ejection fraction and obesity: a secondary analysis of the SUMMIT trial (2025) · cites this paper as [24]

    The Methods (Arterial Waveform Analysis) define total arterial compliance as stroke volume index divided by central pulse pressure, supporting an inverse relationship when stroke volume is held constant. The Results (Arterial Reserve With Submaximal Exercise) report lower compliance in HFpEF and an association between lower compliance and higher filling pressures during exercise. The Discussion (Vascular Stiffening in HFpEF) explicitly says this study cannot prove causality, so the sentence's assertion that increased stiffness contributes to elevated filling pressures is stronger than the evidence establishes. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • Increases in aortic stiffness contribute to elevation in cardiac filling pressures, especially during exercise, in patients with HFpEF.

    “Pulse pressure is inversely correlated with arterial compliance, which is frequently impaired in patients with HFpEF, where increases in aortic stiffness contribute to elevation in cardiac filling pressures, especially during exercise24.”

    From Effects of tirzepatide on circulatory overload and end-organ damage in heart failure with preserved ejection fraction and obesity: a secondary analysis of the SUMMIT trial (2025) · cites this paper as [24]

    The Discussion section reports that arterial stiffening in HFpEF was associated with abnormal hemodynamics, including filling pressures measured during exercise, and argues that it likely plays an important role. It also explicitly says the study cannot prove causality, so the claim that stiffness contributes to elevated filling pressures is stronger than the evidence establishes. Page numbers were not provided in our copy. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

  • Arterial compliance is frequently impaired in patients with HFpEF.

    “Pulse pressure is inversely correlated with arterial compliance, which is frequently impaired in patients with HFpEF, where increases in aortic stiffness contribute to elevation in cardiac filling pressures, especially during exercise24.”

    From Effects of tirzepatide on circulatory overload and end-organ damage in heart failure with preserved ejection fraction and obesity: a secondary analysis of the SUMMIT trial (2025) · cites this paper as [24]

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Citations

Cites

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Research works printed but not linked: 31

  1. Shah, 2016, Phenotype-specific treatment of heart failure with preserved ejection fraction: a multiorgan roadmap, Circulation, 134, 73, 10.1161/CIRCULATIONAHA.116.021884 · DOI · Paper page
  2. Borlaug, 2011, Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment, Eur Heart J, 32, 670, 10.1093/eurheartj/ehq426 · DOI
  3. Hundley, 2001, Cardiac cycle-dependent changes in aortic area and distensibility are reduced in older patients with isolated diastolic heart failure and correlate with exercise intolerance, J Am Coll Cardiol, 38, 796, 10.1016/S0735-1097(01)01447-4 · DOI
  4. Melenovsky, 2007, Cardiovascular features of heart failure with preserved ejection fraction versus nonfailing hypertensive left ventricular hypertrophy in the urban Baltimore community: the role of atrial remodeling/dysfunction, J Am Coll Cardiol, 49, 198, 10.1016/j.jacc.2006.08.050 · DOI
  5. Desai, 2009, Central aortic stiffness is increased in patients with heart failure and preserved ejection fraction, J Card Fail, 15, 658, 10.1016/j.cardfail.2009.03.006 · DOI
  6. Tartiere-Kesri, 2012, Increased proximal arterial stiffness and cardiac response with moderate exercise in patients with heart failure and preserved ejection fraction, J Am Coll Cardiol, 59, 455, 10.1016/j.jacc.2011.10.873 · DOI
  7. Weber, 2013, Pulsatile hemodynamics in patients with exertional dyspnea: potentially of value in the diagnostic evaluation of suspected heart failure with preserved ejection fraction, J Am Coll Cardiol, 61, 1874, 10.1016/j.jacc.2013.02.013 · DOI
  8. Kitzman, 2013, Carotid arterial stiffness and its relationship to exercise intolerance in older patients with heart failure and preserved ejection fraction, Hypertension, 61, 112, 10.1161/HYPERTENSIONAHA.111.00163 · DOI
  9. Borlaug, 2015, Sodium nitrite improves exercise hemodynamics and ventricular performance in heart failure with preserved ejection fraction, J Am Coll Cardiol, 66, 1672, 10.1016/j.jacc.2015.07.067 · DOI
  10. Borlaug, 2016, Inhaled sodium nitrite improves rest and exercise hemodynamics in heart failure with preserved ejection fraction, Circ Res, 119, 880, 10.1161/CIRCRESAHA.116.309184 · DOI
  11. Borlaug, 2016, Abnormal right ventricular-pulmonary artery coupling with exercise in heart failure with preserved ejection fraction, Eur Heart J, 37, 3293, 10.1093/eurheartj/ehw241 · DOI
  12. Andersen, 2015, Differential hemodynamic effects of exercise and volume expansion in people with and without heart failure, Circ Heart Fail, 8, 41, 10.1161/CIRCHEARTFAILURE.114.001731 · DOI
  13. Andersen, 2015, Enhanced pulmonary vasodilator reserve and abnormal right ventricular: pulmonary artery coupling in heart failure with preserved ejection fraction, Circ Heart Fail, 8, 542, 10.1161/CIRCHEARTFAILURE.114.002114 · DOI
  14. Pauca, 2001, Prospective evaluation of a method for estimating ascending aortic pressure from the radial artery pressure waveform, Hypertension, 38, 932, 10.1161/hy1001.096106 · DOI · Paper page
  15. Sharman, 2006, Validation of a generalized transfer function to noninvasively derive central blood pressure during exercise, Hypertension, 47, 1203, 10.1161/01.HYP.0000223013.60612.72 · DOI
  16. Borlaug, 2014, A randomized pilot study of aortic waveform guided therapy in chronic heart failure, J Am Heart Assoc, 3, e000745, 10.1161/JAHA.113.000745 · DOI
  17. Kelly, 1992, Effective arterial elastance as index of arterial vascular load in humans, Circulation, 86, 513, 10.1161/01.CIR.86.2.513 · DOI
  18. Liu, 1986, Estimation of total arterial compliance: an improved method and evaluation of current methods, Am J Physiol, 251, H588
  19. Stergiopulos, 1995, Evaluation of methods for estimation of total arterial compliance, Am J Physiol, 268, H1540
  20. Chemla, 1998, Total arterial compliance estimated by stroke volume-to-aortic pulse pressure ratio in humans, Am J Physiol, 274, H500
  21. Wohlfahrt, 2017, Aortic waveform analysis to individualize treatment in heart failure, Circ Heart Fail, 10, 10.1161/CIRCHEARTFAILURE.116.003516 · DOI
  22. Gillebert, 2000, Load dependent diastolic dysfunction in heart failure, Heart Fail Rev, 5, 345, 10.1023/A:1026563313952 · DOI
  23. Borlaug, 2011, Ventricular-vascular interaction in heart failure, Cardiology clinics, 29, 447, 10.1016/j.ccl.2011.06.004 · DOI
  24. Brunner, 2015, Adiposity, obesity, and arterial aging: longitudinal study of aortic stiffness in the Whitehall II cohort, Hypertension, 66, 294, 10.1161/HYPERTENSIONAHA.115.05494 · DOI
  25. Wohlfahrt, 2014, Impact of general and central adiposity on ventricular-arterial aging in women and men, J Am Coll Cardiol HF, 2, 489
  26. Williams, 2006, Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study, Circulation, 113, 1213, 10.1161/CIRCULATIONAHA.105.595496 · DOI · Paper page
  27. Reil, 2013, Selective heart rate reduction with ivabradine unloads the left ventricle in heart failure patients, J Am Coll Cardiol, 62, 1977, 10.1016/j.jacc.2013.07.027 · DOI
  28. Mitchell, 2002, Omapatrilat reduces pulse pressure and proximal aortic stiffness in patients with systolic hypertension: results of the conduit hemodynamics of omapatrilat international research study, Circulation, 105, 2955, 10.1161/01.CIR.0000020500.77568.3C · DOI
  29. Omar, 2015, Paradoxical normoxia-dependent selective actions of inorganic nitrite in human muscular conduit arteries and related selective actions on central blood pressures, Circulation, 131, 381, 10.1161/CIRCULATIONAHA.114.009554 · DOI
  30. Zamani, 2015, Effect of inorganic nitrate on exercise capacity in heart failure with preserved ejection fraction, Circulation, 131, 371, 10.1161/CIRCULATIONAHA.114.012957 · DOI · Paper page
  31. Simon, 2016, Acute hemodynamic effects of inhaled sodium nitrite in pulmonary hypertension associated with heart failure with preserved ejection fraction, JCI Insight, 1, e89620, 10.1172/jci.insight.89620 · DOI

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Metadata

Authors
Reddy, Y. N. V., Andersen, M. J., Obokata, M., Koepp, K. E., Kane, G. C., Melenovsky, V., Olson, T. P., & Borlaug, B. A.
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2017-07
Volume
70
Issue
2
Pages
136-148
ISSN
0735-1097
DOI
10.1016/j.jacc.2017.05.029
PMC
PMC5520668
Cited by
262
References
6
Language
en
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