The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Mechanisms of Vascular Aging, A Geroscience Perspective
Open accessAbstract
Age-related pathological alterations of the vasculature have a critical role in morbidity and mortality of older adults. In epidemiological studies age is the single most important cardiovascular risk factor that dwarfs the impact of traditional risk factors. In order to develop novel therapeutic interventions for prevention of age-related vascular pathologies it is crucial to understand the cellular and molecular mechanisms of vascular aging. In this review, shared molecular mechanisms of aging are considered in terms of their contribution to the pathogenesis of macro- and microvascular diseases associated with old age. The role of cellular senescence in development of vascular aging phenotypes is highlighted and potential interventions to prevent senescence and to eliminate senescent cells for prevention of vascular pathologies are presented. The evidence supporting a role for inter-organ communication and circulating pro-geronic and anti-geronic factors in vascular aging is discussed.
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Cites
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BackgroundNaturally occurring p16Ink4a-positive cells shorten healthy lifespan
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“, free radical and peroxynitrite scavengers, Nrf2 activators(6)), exert anti-inflammatory effects mitigating the impact of the SASP factors(26), improve mitochondrial function(27), activate AMPK(28) and sirtuin pathways(9), inhibit mTOR(29) and/or restore cellular NAD+ levels(30,31).”
Background
Cited by
El Assar, M., Álvarez-Bustos, A., Sosa, P., Angulo, J., & Rodríguez-Mañas, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158713 · Cited by 371
Aging Biomarker Consortium, Zhang, L., Guo, J., Liu, Y., Sun, S., Liu, B., Yang, Q., Tao, J., Tian, X.-L., Pu, J., et al. (2023) · Life Medicine · doi:10.1093/lifemedi/lnad033 · Cited by 60
Aliberti, S. M., & Capunzo, M. (2025) · Nutrients · doi:10.3390/nu17040722 · Cited by 29
Metadata
- Authors
- Ungvari, Z., Tarantini, S., Sorond, F., Merkely, B., & Csiszar, A.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 75
- Issue
- 8
- Pages
- 931-941
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W3007173654
- Cited by
- 328
- References
- 16
- FWCI
- 16.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ungvari, Z., Tarantini, S., Sorond, F., Merkely, B., & Csiszar, A. (2020). Mechanisms of Vascular Aging, A Geroscience Perspective. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2019.11.061
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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