Cited by 412Frailty in Older AdultsNutrition and Health in AgingCardiac Health and Mental Health

The DOI matches its Crossref record, with a small difference in title or year; 110 of the 112 references it cites were found in a registry or an index.

Interventions for Frailty Among Older Adults With Cardiovascular Disease

Open access

Ijaz, Naila, Buta, Brian, Xue, Qian-Li, Mohess, Denise T., Bushan, Archana, Tran, Henry, Batchelor, Wayne, deFilippi, Christopher R., Walston, Jeremy D., Bandeen-Roche, Karen, Forman, Daniel E., Resar, Jon R., O’Connor, Christopher M., Gerstenblith, Gary, Damluji, Abdulla A.·2022·Journal of the American College of Cardiology

DOI 10.1016/j.jacc.2021.11.029PMC PMC8852369

Open this paper in CoChat — free account Open PDF

Abstract

With the aging of the world's population, a large proportion of patients seen in cardiovascular practice are older adults, but many patients also exhibit signs of physical frailty. Cardiovascular disease and frailty are interdependent and have the same physiological underpinning that predisposes to the progression of both disease processes. Frailty can be defined as a phenomenon of increased vulnerability to stressors due to decreased physiological reserves in older patients and thus leads to poor clinical outcomes after cardiovascular insults. There are various pathophysiologic mechanisms for the development of frailty: cognitive decline, physical inactivity, poor nutrition, and lack of social supports; these risk factors provide opportunity for various types of interventions that aim to prevent, improve, or reverse the development of frailty syndrome in the context of cardiovascular disease. There is no compelling study demonstrating a successful intervention to improve a global measure of frailty. Emerging data from patients admitted with heart failure indicate that interventions associated with positive outcomes on frailty and physical function are multidimensional and include tailored cardiac rehabilitation. Contemporary cardiovascular practice should actively identify patients with physical frailty who could benefit from frailty interventions and aim to deliver these therapies in a patient-centered model to optimize quality of life, particularly after cardiovascular interventions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.jacc.2021.11.029

Cites

110 of 110 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
Self-citation
Frailty in elderly people
Clegg, A., Young, J., Iliffe, S., Rikkert, M. O., & Rockwood, K. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62167-9 · Cited by 9,503
A global clinical measure of fitness and frailty in elderly people
Rockwood, K. (2005) · Canadian Medical Association Journal · doi:10.1503/cmaj.050051 · Cited by 8,968
Heart Disease and Stroke Statistics—2021 Update: A Report From the American Heart Association
Virani, S. S., Alonso, A., Aparicio, H. J., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Cheng, S., Delling, F. N., et al. (2021) · Circulation · doi:10.1161/cir.0000000000000950 · Cited by 5,784
Untangling the concepts of disability, frailty, and comorbidity: Implications for improved targeting and care
Fried, L. P., Ferrucci, L., Darer, J., Williamson, J. D., & Anderson, G. (2004) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/59.3.m255 · Cited by 4,032
A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial
Ngandu, T., Lehtisalo, J., Solomon, A., Levälahti, E., Ahtiluoto, S., Antikainen, R., Bäckman, L., Hänninen, T., Jula, A., Laatikainen, T., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60461-5 · Cited by 3,689
Prevalence of frailty in community-dwelling older persons: a systematic review
Collard, R. M., Boter, H., Schoevers, R. A., & Oude Voshaar, R. C. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2012.04054.x · Cited by 3,073
Exercise training and nutritional supplementation for physical frailty in very elderly people
Fiatarone, M. A., O'Neill, E. F., Ryan, N. D., Clements, K. M., Solares, G. R., Nelson, M. E., Roberts, S. B., Kehayias, J. J., Lipsitz, L. A., & Evans, W. J. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406233302501 · Cited by 2,857
A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans
Morley, J. E., Malmstrom, T. K., & Miller, D. K. (2012) · The journal of nutrition health & aging · doi:10.1007/s12603-012-0084-2 · Cited by 2,082
Validity and reliability of the Edmonton Frail Scale
Rolfson, D. B., Majumdar, S. R., Tsuyuki, R. T., Tahir, A., & Rockwood, K. (2006) · Age and Ageing · doi:10.1093/ageing/afl041 · Cited by 1,643 · cited 1×
“Similarly, the Edmonton scale includes assessments of cognition, social support, and nutrition in addition to function.(34) Some tools use a deficit accumulation approach to formulate an index of frailty, one of which is the CSHA (Canadian Study of Health and Aging) frailty index.”
Method

Show all 112 references

Research works printed but not linked: 1

1997, Proceedings from the conference. May 16-18 1996, Med Care, 35, JS1

Sorted by citations

Items 301–400 of 412

The impact of frailty on initiation, continuation and discontinuation of secondary prevention medications following myocardial infarction
Doody, H., Ayre, J., Livori, A., Ilomäki, J., Khalil, V., Bell, J. S., & Morton, J. I. (2024) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2024.105370
Remotely monitored physical activity from older people with cardiac devices associates with physical functioningPreprint
Taylor, J., Peek, N. B., Greenstein, A. S., Sammut‐Powell, C., Martin, G. P., & Ahmed, F. Z. (2024) · Research Square · doi:10.21203/rs.3.rs-3993496/v1
Establishment and validation of a risk prediction model for the occurrence of frailty in elderly patients with heart failure with preserved ejection fractionPreprint
Wang, S., Min, X., Chen, X., Pang, S., Zha, Z., Zhou, C., Guo, Y., & Wang, X. (2024) · Research Square · doi:10.21203/rs.3.rs-4146071/v1
Ageing and Mid-Life Adult Considerations
Deaton, C. (2024) · Springer eBooks · doi:10.1007/978-3-031-53705-9_23
Cross‐sectional and longitudinal associations among healthcare costs and deficit accumulation
Espeland, M. A., Harada, A. S. M., Ross, J., Bancks, M. P., Pajewski, N. M., Simpson, F. R., Walkup, M. P., Davis, I., Huckfeldt, P. J., & for the Action for Health in Diabetes Aging Study Group (2024) · Journal of the American Geriatrics Society · doi:10.1111/jgs.19053 · Cited by 1
The Feasibility, Safety and Middle Term Clinical Outcome Study of Chronic Total Occlusion Percutaneous Coronary Intervention among Elderly Aged <75 Years versus ≥75 Years in a High Intravascular Imaging Usage Centre
Kim, H. S., Imura, S., Ando, M., Tsukiji, M., Tarutani, Y., Nakanishi, Y., & Hosaka, F. (2024) · Journal of Asian Pacific Society of Cardiology · doi:10.15420/japsc.2023.65
Linear-inverse associations of serum Klotho protein with prevalence of frailty among adults in the United States
Yuan, M. (2024) · American Journal of Translational Research · doi:10.62347/ozhf3072
Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment
Heinz, E. R., Bernardo, R. C., Birk, S. E., Manson, W. C., MacLeod, D. B., Molinger, J., Vincent, A., & Bronshteyn, Y. S. (2024) · Journal of Visualized Experiments · doi:10.3791/66803
Causal association between frailty and chronic obstructive pulmonary disease: insights from bidirectional Mendelian randomization and mediation analysisPreprint
Cheng, Z., Wu, J., Xu, C., & Yan, X. (2024) · Research Square · doi:10.21203/rs.3.rs-4869762/v1
Older Adults with Cardiovascular Disease: Linking in Cognitive Impairments
Adachi, T. (2024) · Springer eBooks · doi:10.1007/978-3-031-32046-0_8-1
From Hemorrhagic Shock to Postoperative Complications: Anesthesia, Intensive Care, and Surgical Management of a Young Male With Pulmonary Aspergillosis
Vargatu-Dinica, L. B., Sava, M., Bereanu, A. S., Achim, D., Bancila, S. A., Seceleanu, C. R., & Vintilă, B. I. (2024) · Cureus · doi:10.7759/cureus.73017
The Role of Physical Activity and Exercise in the Prevention and Treatment of Depression
ÇAKMAK, S. (2024) · International Journal of Computational and Experimental Science and Engineering · doi:10.22399/ijcesen.757
A Fragilidade e relação com teste de caminhada de seis minutos.
Silveira, C. M., de Almeida, A. J. G., Mendes‐Rodrigues, C., & Campos, E. C. (2024) · Diversitas Journal · doi:10.48017/dj.v9i4.2788
Prognostic Value of Frailty in Patients With Takotsubo Cardiomyopathy
Diaz‐Arocutipa, C., & Hernández, A. V. (2025) · Clinical Cardiology · doi:10.1002/clc.70054
“By identifying patients with frailty early, clinicians can tailor interventions to mitigate risks associated with frailty [18], such as increased susceptibility to complications and prolonged recovery times [15, 19].”
Influential
Frailty and nutrition in older adults with ACS: advancing risk stratification and care—a commentary
Czapla, M., & Uchmanowicz, I. (2025) · European Journal of Cardiovascular Nursing · doi:10.1093/eurjcn/zvaf019
Antiarrhythmic Drugs in Elderly and Frail Patients
Proietti, M., & Popescu, R. (2024) · Springer eBooks · doi:10.1007/978-3-031-74046-6_13
Dual-task training and cognitive performance in individuals with coronary artery disease and/or heart failure: a systematic review
da Silva, T. C., de Souza, W. M. M., Deslandes, A. C., Guimarães, T. C. F., Kasal, D. A. B., Rodrigues, L. F., & Mediano, M. F. F. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1462385
Senile Asthenia Syndrome in Patients With Acute Decompensation of Heart Failure: Prevalence, Impact on Quality of Life, Management Tactics, Prognosis
Витальевна, С. Е., & Смирнова, Е. А. (2025) · Kardiologiia · doi:10.18087/cardio.2025.2.n2791
Exploration and practice of comprehensive nursing management model for elderly patients with cardiovascular disease and cognitive decline
Zhu, T., & Hua, J. (2025) · Asian Journal of Surgery · doi:10.1016/j.asjsur.2024.12.191
Apixaban and the improved psychologic profile in frailty and disability. Myth or reality?
Fumagalli, S., Pasquale, G. D., Molon, G., Agnelli, G., & Marchionni, N. (2025) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2025.03.012
A Simple One‐Item Nursing Falls Assessment Predicts Outcomes for Patients With Stage D Heart Failure Undergoing Surgical Advanced Therapies
Salvador, V. D., Perez, J. A., Hudec, P. W., Gorodeski, E. Z., & JosephO'Neill, T. (2025) · Clinical Transplantation · doi:10.1111/ctr.70146
Frailty in patients with atrial fibrillation: diagnosis, management, prevention and influence on prognosis
Станиславовна, К. Е., Dashaeva, M. I., & Панченко, Е. П. (2025) · Russian Cardiology Bulletin · doi:10.17116/cardiobulletin2025200115
Association of Frailty With Readmissions and Outcomes After Impella Mechanical Circulatory Support
Maffey, M. W., Kuchtaruk, A. A., Damluji, A. A., García, S., Elgendy, I. Y., Villablanca, P. A., Moroni, F., Denicolai, M., Mamas, M. A., & Bagur, R. (2025) · CJC Open · doi:10.1016/j.cjco.2025.04.011
“22,30 Furthermore, functional declining and deconditioning are often observed during admission and even more so in sicker patients.”
Self-citation
Frailty Burden and Efficacy of Initial Invasive Strategy in Chronic Coronary Disease: The ISCHEMIA Trials
Patel, L., Segar, M. W., Usman, M., Dhruve, R., Keshvani, N., Postalian, A., Mentias, A. G., Rubin, C. D., Patel, K. V., Kumbhani, D. J., et al. (2025) · Journal of the American Geriatrics Society · doi:10.1111/jgs.19508
Frailty Risk After a Cardiovascular Event Among Community-Dwelling Older People: Influence of Sociodemographic, Polypharmacy, and Pre-event Frailty
Phyo, A. Z. Z., Tonkin, A., Espinoza, S. E., Ekram, A. S., Woods, R. L., & Ryan, J. L. (2025) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2025.06.003
“Tailored strategies for frailty management 10,42,44,45 should be incorporated into CVD treatment and could include physical therapy, exercise programs, psychosocial and nutritional support, and regular follow-up to monitor frailty progression, particularly for CVD survivors who are of advanced age,…”
TAVR in older adults with cardiogenic shock: current practice and future direction
Kwak, M. J., Irizarry‐Caro, J. A., Martinez, P. R., Going, J., Lee, J. L., Giza, D. E., Amjad, N., Leech, A. L., Jantea, R., Flores, R. J., et al. (2025) · 老年心脏病学杂志：英文版 · doi:10.26599/1671-5411.2025.05.003
Frailty as a Predictor of In-Hospital Outcomes in Patients Undergoing Percutaneous Coronary Intervention for Chronic Total Occlusion
Vicent, L., Bodes, R. S., Martín‐Asenjo, R., & Diaz‐Arocutipa, C. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14134745
“For example, minimizing contrast volume, utilizing radial access when feasible, employing intravascular imaging to limit procedural time, or staging complex interventions may help reduce complications in this population [5,26].”
Síndromes cardiogeriátricos: potenciadores y determinantes del riesgo cardiovascular
Suárez, G., Palacio, M. S., Blanco, P., SCHYGIEL, P. O., & Flor, M. L. (2025) · REC CardioClinics · doi:10.1016/j.rccl.2025.06.003 · Cited by 2
"Youth Is a Disease that is Cured with Age"
Lerman, J. (2025) · Revista Argentina de Cardiología · doi:10.7775/rac.v93.i3.20895
Low ALT levels and a new diagnosis of congestive heart failure following COVID-19 infection
Shafrir, A., Dagan, G., Alcalai, R., & Leibowitz, D. W. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1470239
Research Progress on Frailty and Cardiovascular Risk Factors in Middle-Aged and Elderly People
石, 佳. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.1582361
Patterns of Frailty in Newly Diagnosed Older Patients With Nonvalvular Atrial Fibrillation Initiating Oral Anticoagulation
Nakamaru, R., Nishimura, S., Kumamaru, H., Yamamoto, H., Miyata, H., Nakatani, E., Miyachi, Y., & Kohsaka, S. (2025) · JCSM Communications · doi:10.1002/rco2.70009
“A significant clinical challenge is the difficulty of conducting practical frailty assessments due to its intricate nature [7, 8].”
The relationship between frailty, polypharmacy, and nutritional status in older adultsPreprint
Saeid, S., & Afshar, P. F. (2025) · Research Square · doi:10.21203/rs.3.rs-7339190/v1
Age and Health Status Benefits Following Initiation of Atrial Fibrillation‐Specific Treatments
Nakamaru, R., Ikemura, N., Kohsaka, S., Kimura, T., Katsumata, Y., Nishiyama, T., Ueda, I., Tanimoto, K., Negishi, K., Takatsuki, S., et al. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.041512
“Older adults are more prone than the younger population to a decline in physiological reserve 27,28 and comorbid conditions.”
Cardiac rehabilitation for outpatients aged over 80 years with cardiovascular diseases
Someya, R., Matsuzawa, Y., Shimizu, Y., Nakahashi, H., Konishi, M., Akiyama, E., Hanajima, Y., Kondo, H., Yoshii, T., Sato, R., et al. (2025) · International Journal of Cardiology Cardiovascular Risk and Prevention · doi:10.1016/j.ijcrp.2025.200516
“Furthermore, frailty encompasses cognitive, nutritional, and psychosocial factors, all of which require targeted interventions [6].”
Older Adults with Cardiovascular Disease: Linking in Cognitive Impairments
Adachi, T. (2025) · Springer eBooks · doi:10.1007/978-3-031-73363-5_8
From glucose to global burden: Three decades of atherosclerotic cardiovascular disease attributable to high fasting plasma glucose and projections to 2040
Yang, F., Long, Y., Xiang, B., Deng, Y. J., & Zhao, L. (2025) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2025.104421 · Cited by 1
Association between frailty status and the risk of cardiovascular diseases in Chinese adults: A prospective cohort study
Fan, X., Jiang, H., Su, J., Yu, H., Chen, L., Lü, Y., Hua, Y., Ren, H., Pei, P., Sun, D., et al. (2025) · Public Health · doi:10.1016/j.puhe.2025.105990
Sex Differences in Frailty-Associated Outcomes of Patients with Cardiogenic Shock
Diaz‐Arocutipa, C., Bodes, R. S., Manso, R. J., Martín‐Asenjo, R., Lopez-Bendezu, G., & Vicent, L. (2025) · Shock · doi:10.1097/shk.0000000000002650
Identifying Risk Factors for All-Cause Mortality in Older Adults: Rest-Activity Rhythm, Frailty, and Metabolic Syndrome
Kim, J., Kenyon, J. D., Sargent, L. J., Kirkman, D. L., & Kim, Y. (2025) · American Journal of Lifestyle Medicine · doi:10.1177/15598276251392883
Awareness of physicians about the management of elderly patients with arterial hypertension: results of an anonymous survey in the Russian Federation and the Kyrgyz Republic
Sagynbaeva, A. C., & Конради, А. О. (2025) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2025-2531
Analysis of Physical, Psychological, and Lifestyle Factors Affecting Falls in Older Adults: A Study Based on the Korea National Health and Nutrition Examination Survey
Jang, K. (2025) · Journal of Ageing and Longevity · doi:10.3390/jal5040053
Development and internal validation of an age less-dependent frailty score in the cardiovascular health study
Troy, A. L., Choy, B., Dong, H., Gardin, J. M., Hirsch, C. H., Koh, A. S.-M., Kong, W. K. F., Mukamal, K. J., Newman, A. B., Odden, M. C., et al. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1718015
“This score may yield insights into the processes underlying biologic aging and could be used in clinical practice to better identify individuals who are frailer than expected for their age or who may beneﬁt from early frailty-directed interventions (9).”
Influential
Associations of lifestyles and frailty status with survival among older adults in China: a nationwide, community-based, prospective cohort study
Ruan, H., Ban, C., Wei, Y., Liu, Y., Ma, H., Zhao, L., Wang, Z., Wang, K., Zheng, Y., Song, N., et al. (2025) · BMC Geriatrics · doi:10.1186/s12877-025-06878-6
“Frailty has been associated with a broad range of adverse health outcomes, such as disability [5], falls [6], depression [7], dementia [8], cardiovascular disease [9], and notably, mortality [2, 3, 10]; furthermore, frailty also correlates with elevated healthcare expenditures [1, 11].”
Additional file 1 of Association of frailty status with overall survival in elderly hypertensive patients: based on the Chinese Longitudinal Healthy Longevity Survey
Li, L., Liang, Y., Xin, D., Liu, L., Tan, Z., Wang, Z., Zhang, M., Ruan, H., Zhao, L., Wang, K., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25951893
Additional file 1 of Remotely monitored physical activity from older people with cardiac devices associates with physical functioning
Taylor, J., Peek, N. B., Greenstein, A. S., Sammut‐Powell, C., Martin, G. P., & Ahmed, F. Z. (2024) · Figshare · doi:10.6084/m9.figshare.26735442
Additional file 1 of Prevalence of physical frailty and impact on survival in patients with chronic kidney disease: a systematic review and meta-analysis
Zhang, F., Wang, H., Bai, Y., Zhang, Y., Huang, L., & Zhang, H. (2023) · Figshare · doi:10.6084/m9.figshare.24079673
Additional file 1 of Frailty efficacy as a predictor of clinical and cognitive complications in patients undergoing coronary artery bypass grafting: a prospective cohort study
Bakhtiari, M., Shaker, F., Shirmard, F. O., Jalali, A., Vakili‐Basir, A., Balabandian, M., Khamene, S. S., Khawajah, I. M., Shafiee, A., Badrkhahan, S. Z., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25237308
Chronic Heart Failure in Frail and Elderly Patients
Dorobanţu, M., & Ioniţă, O. (2025) · Springer eBooks · doi:10.1007/978-3-031-96562-3_24
Pain and functional disability in older adults with cardiovascular disease: A cross-national comparison of India, China, and Mexico
Cheng, H., Wu, H., Shao, L., Jiang, J., Xie, T., & Zhang, J. (2025) · Journal of Pain · doi:10.1016/j.jpain.2025.106182
Research Progress on the Association between Serum 25-Hydroxyvitamin D and Frailty in Elderly Patients with Coronary Heart Disease
田, 昕. (2026) · Advances in Clinical Medicine · doi:10.12677/acm.2026.161036
Relationship between nutrition status and muscle mass and its impact on 1-year mortality in patients with aortic stenosis undergoing transcatheter aortic valve implantation
Miyata, H., Matsumura, K., Hamamura, K., Yasuda, M., Hakozaki, S., Onishi, K., Yagi, E., Fujita, K., Kajihara, K., Amagai, T., et al. (2026) · International Journal of Cardiology Cardiovascular Risk and Prevention · doi:10.1016/j.ijcrp.2026.200573
“Nutritional-and exercise-based therapeutic interventions have been shown to improve nutritional status and muscle mass, and some investigations have reported beneficial effects on long-term clinical outcomes [21,27,28].”
Rethinking Frailty as a Dynamic and Reversible Risk Factor for Cardiovascular Disease
Qazi, S., & Orkaby, A. R. (2026) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2026.01.032
Impact of Preoperative Malnutrition and Sarcopenia on Clinical Outcomes After Transcatheter Aortic Valve Replacement
Nakamura, K., Taniguchi, T., Omori, A., Nishi, H., Bando, G., Idouji, M., Motoyoshi, T., Sano, M., Azumi, Y., Murai, R., et al. (2026) · Circulation Reports · doi:10.1253/circrep.cr-25-0281
Frailty trajectories and risk of incident advanced CKM syndrome: A national cohort analysis
Li, H., Li, Q., Sun, R., Ni, L., Wang, F., Cheng, J., Zhou, L., & Zhao, C. (2026) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2026.106159 · Cited by 2
Clinical Impact, Assessment and Management of Frailty in Patients with Peripheral Arterial Disease
Liew, A. (2026) · Springer eBooks · doi:10.1007/978-3-031-82232-2_26
Architect of Frailty Biology and Champion of Translational Geroscience
Abadir, P. M., Buta, B. J., & Bandeen‐Roche, K. (2026) · Aging Cell · doi:10.1111/acel.70406
Self-citation
Assessing Cardiovascular Risk in Older Adults Integrating Frailty and Competing Risks
Howick, J. F., Sanchez, C. V., Shapiro, B., & Gharacholou, S. M. (2026) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2025.12.002
Frailty and functional recovery after cardiac surgery: a randomized pilot trial of extended exercise-based rehabilitation
Tamulevičiūtė-Prascienė, E., Balnė, K., Kuznecova, I., Beigienė, A., Stonkuvienė, V., & Kubilius, R. (2026) · BMC Geriatrics · doi:10.1186/s12877-026-07192-5
Mechanism of the effectiveness of mindfulness on intrinsic capacity in elderly patients with cardiovascular diseases: a dual-pathway emotion regulation framework
Cui, Y., Lei, S., & Yang, F. (2026) · BMC Geriatrics · doi:10.1186/s12877-026-07226-y
“For instance, medication side effects may compromise the vitality domain, disease-related activity limitations can affect the locomotion domain, and the psychological burden of long-term survival with illness can impact the psychological domain [3].”
Exercise Never Gets Old
Brazile, T. L., & Sarma, S. (2026) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2025.12.006
Patient and Clinician Perspectives on a Multicomponent Frailty Intervention for Adults With Heart Failure: A Qualitative Study
McDonagh, J., Mulugeta, H., William, S., Davidson, P. M., & Ferguson, C. (2026) · Journal of Cardiac Failure - Intersections · doi:10.1016/j.yjcafi.2026.02.010
Frailty as a risk factor for hospitalization and mortality in older adults admitted to a chronic heart failure hospital program before and during the COVID-19 pandemic
Bastidas, J. C., Sánchez, E. G. M., Ramos, W., Huamán-Severino, M. L., Bastidas, J. L. C., Zeladita-Huamán, J. A., & Smith, L. (2026) · 老年心脏病学杂志：英文版 · doi:10.26599/1671-5411.2026.01.002
Managing Bleeding Risk in Older Adults
Alexandrino, F. B., Menon, V., Reed, G., Krishnaswamy, A., Kapadia, S., Nanna, M. G., & Damluji, A. A. (2026) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2025.12.007
Self-citation
Association of frailty index with chronic diseases: from China Health and Retirement Longitudinal Study and a two-sample Mendelian randomization
Yang, L., Zeng, T., & Yue, H. (2026) · European journal of medical research · doi:10.1186/s40001-026-03899-8
The role of sleep disorders in the motoric and cognitive trajectories of older physically frail sarcopenic and healthy active subjects: SOMNUS-DARE, a prospective cohort study
Salvi, M., Zucchini, I., Lauretani, F., Tanzi, B., Testa, C., Ughetti, G., Parrino, L., Mutti, C., Rausa, F., Pollara, I., et al. (2026) · BMC Geriatrics · doi:10.1186/s12877-026-07275-3 · Cited by 1
“Cardiovascular diseases (CVD) mediate the sleep– frailty nexus, through bidirectional sleep and cardiac-skeletal muscle interactions [17].”
CHANGES IN INDICATORS OF FRAILTY IN PATIENTS AFTER DIRECT MYOCARDIAL REVASCULARIZATION
Евгеньевна, К. К., Дмитриевич, Б. Е., & Барбараш, О. Л. (2026) · Complex Issues of Cardiovascular Diseases · doi:10.17802/2306-1278-2025-14-6s-31-39
Provider, researcher, and community perspectives on comorbidities affecting the health-related quality of life of people living with HIV in Spain
White, T. M., Prats‐Silvestre, C., van Selm, L., Iniesta, C., Fuster‐RuizdeApodaca, M. J., & Lazarus, J. V. (2026) · BMC Public Health · doi:10.1186/s12889-026-26971-8
“Physical limitations, such as reduced capacity for exercise and daily activities, along with the emotional burden of managing a chronic condition, may lead to depression, anxiety, and decreased mental well-being in some persons [62, 64].”
Multidimensional care in transthyretin cardiac amyloidosis: Integrating extracardiac organ involvement and comorbidity management
Magnano, R., Rossi, D., Saraullo, S., Pezzi, L., D’Alleva, A., Scollo, C., Marino, M. D., Genovesi, E., Vitulli, P., Fortuni, F., et al. (2026) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2026.103338
Care and Outcomes of New‐Onset Heart Failure Across Vulnerable Populations: Temporal Trends in Mortality and Treatment in a Danish Nationwide Cohort From 2003 to 2022
Ødum, S.-L. F., Friis, C., Garred, C. H., Nouhravesh, N., Zahir, D., Andersen, C. F., Jensen, J., Fosbøl, E. L., Køber, L., Christensen, D. M., et al. (2026) · Journal of the American Heart Association · doi:10.1161/jaha.125.044072
Consistent benefit of physiology-guided complete revascularization across the spectrum of frailty in older patients with myocardial infarction: a prespecified analysis of the FIRE trial
Passo, B. D., Tonet, E., Lanzilotti, V., Menozzi, M., Scarsini, R., Picchi, A., ANDO, G. O., Sarti, A., Farina, J., Cantone, A., et al. (2026) · Age and Ageing · doi:10.1093/ageing/afag078
Impact of oral frailty on postoperative delirium in older patients undergoing off-pump coronary artery bypass grafting: a prospective observational study
Wang, S., Huang, P., Zhang, F., Jiang, S., Di, L., Cui, S., Kang, R., & Huang, L. (2026) · BMC Anesthesiology · doi:10.1186/s12871-026-03811-1
“De Senectute” in the perioperative and critical care continuum—advancing personalized care for the geriatric patient at the intersection of frailty, aging, and multimorbidity
Ursoleo, J. D., & Bignami, E. G. (2026) · Journal of Anesthesia Analgesia and Critical Care · doi:10.1186/s44158-026-00390-y
Comparative study on the predictive value of PNI and GNRI for all-cause mortality rates of elderly patients in cardiac care unit and cardiovascular intensive care unit
Zhou, W., Yu, J., Zheng, M., & Shi, R. (2026) · European Journal of Clinical Nutrition · doi:10.1038/s41430-026-01741-2
“To validate the observed association between nutritional status at admission and CVD-related mortality, future research should focus on multicenter prospective studies.”
Working Together With Perspective on our Next “Win” in Frailty and Heart Failure
Denfeld, Q. E., & Vitale, C. (2026) · Journal of Cardiac Failure - Intersections · doi:10.1016/j.yjcafi.2026.04.002
Association Between Trajectories of Estimated Glucose Disposal Rate (eGDR) and Incident Cardiovascular Disease in a Chinese Population: A Longitudinal Cohort Study
Kong, Q., Zhou, J., Liu, X., & Huang, Y. (2026) · Endocrine · doi:10.1007/s12020-026-04604-9
Arterial hipertenziyanın ahıl və qoca insanların həyat keyfiyyətinə və ömür uzunluğuna təsiri, onun ambulator nəzarətinin optimallaşdırılması
Hacıyeva, Y., & Əhmədova, C. (2026) · İctimai sağlamlıq · doi:10.33864/3105-7020.2026.n1.23-33
Preventive Cardiology for the Clinically Complex Older Adult
Harper, G. M. (2026) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2026.03.001
Preferences of frail elderly patients with cardiovascular disease for web-based exercise telerehabilitation interventions in China: protocol for a discrete choice experiment study
Zou, H., Wu, L., Zheng, X., Dong, P., Yuan, W., Li, J., Zhang, S., & Chen, Y. (2026) · BMJ Open · doi:10.1136/bmjopen-2025-111370
Screening for physical frailty in older patients with cardiovascular disease and cognitive decline: one tool does not fit all
Instenes, I., Amofah, H. A., Frantzen, A. T., & Norekvål, T. M. (2026) · European Journal of Cardiovascular Nursing · doi:10.1093/eurjcn/zvag106
Association of Frailty and Delirium with Hospitalization Outcomes Among Older Adults With Rheumatic Diseases
Bansal, B., Jung, Y., Kwak, M. J., Kochar, B. D., Goyal, P., Damluji, A. A., & Singh, N. (2026) · ACR Open Rheumatology · doi:10.1002/acr2.90073
“4,5 9 – 11 Frailty, which is characterized by diminished physiologic reserves, and delirium, which is marked by acute disturbances in attention and cognition, are common complications during hospitalization for older adults and signi ﬁ cantly worsen patient outcomes.”
Self-citation
Life satisfaction mediates advanced maternal age at childbirth and frailty across cohorts
Zhao, Z., Tian, W., & Wang, X. (2026) · iScience · doi:10.1016/j.isci.2026.116023
The application value of frailty assessment tools in the perioperative period: A narrative review
Shen, H., Ju, M., Wu, X., Shi, S., Sun, J., & Tian, M. (2026) · Journal of Anesthesia and Translational Medicine · doi:10.1016/j.jatmed.2026.04.002
“58 These factors interact to promote PND. 59,60 Thus, the FFP may serve as an indicator for PND risk, based on the shared pathophysiological link between frailty and reduced brain functional reserve.”
Age at menopause, frailty, and risk of incident sarcopenia among middle-aged and older Chinese women: A longitudinal cohort study
Gong, X., Liu, S., Shen, L., Li, Y. X., Xie, W., Cai, Y., Chen, Q., Li, X., Liu, Z. H., Wang, C., et al. (2026) · Maturitas · doi:10.1016/j.maturitas.2026.109006
Frailty Syndrome and Depressive Symptoms in Patients with Ischemic Heart Disease
Евгеньевна, К. К., Tsygankova, D. P., Neeshpapa, A., Bazdyrev, E. D., Каретникова, В. Н., & Барбараш, О. Л. (2026) · Diagnostics · doi:10.3390/diagnostics16111707
Mapping interventions addressing frailty and associated outcomes in people with heart failure: a scoping review
Menoud, G., Mgbaman, F., Santos, G. C., Cavin-Trombert, A., Mabire, C., & Schäfer‐Keller, P. (2026) · BMJ Open · doi:10.1136/bmjopen-2025-111747 · Cited by 1
Physical Frailty, Self-Care Behaviors, and 6-Month Clinical Outcomes Among Adults With Heart Failure
Denfeld, Q. E., Hiatt, S. O., Dieckmann, N. F., Hansen, L., Rosenkranz, S. E., Camacho, S. A., Chien, C., Riegel, B. J., & Lee, C. S. (2026) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0000000000001342
Prognostic Value of Frailty in Aortic Surgery: A Systematic Review and Meta-Analysis Comparing Frailty Assessment Tools
Coutinho, M. L., Delgado, L. M., Torres, I. O., Rocha-Neves, J. P., Zerati, A. E., D’Oria, M., & Leao, P. P. (2026) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2026.06.034
Rapid progression of cardiovascular-kidney-metabolic syndrome drives accelerated frailty trajectories: A longitudinal cohort study
Chen, L., Zheng, W., & Liu, L. (2026) · Medicine · doi:10.1097/md.0000000000049742
“[33,34] Furthermore, rapid CKM progression may reflect, rather than directly demonstrate, biological processes such as a heightened inflammatory burden or mitochondrial dysfunction, which have been proposed as shared pathological pathways underlying both cardiovascular aging and physical frailty.”
Longitudinal Changes in Frailty and Major Adverse Cardiovascular Events in Patients With Coronary Heart Disease
Ding, Y., He, D., He, J., Wu, J., Shen, Z., Chen, S., Zhou, D., Yuan, C., Zhu, Y., & Huang, H. (2026) · Journal of the American Heart Association · doi:10.1161/jaha.125.050557
Six Weeks of Mini-Trampoline Training Improves Balance, Mobility, and Walking Capacity in Older Adults
Kendall, B., Dykstra, B. J., Anderson, Q. T., Breuer, R., van Bergen, S., & Hayes, E. (2026) · Journal of Aging and Physical Activity · doi:10.1123/japa.2025-0257
Performance status and outcomes in patients with cancer receiving thromboprophylaxis: a subanalysis of the AVERT trial
Potere, N., Xu, Y., Mallick, R., Wang, T., Hill, D., Lazo‐Langner, A., Tagalakis, V., Shivakumar, S., Nisio, M. D., Wells, P. S., et al. (2026) · Cardio-Oncology · doi:10.1186/s40959-026-00542-7
“Integrating ECOG-PS with dedicated frailty measures is recommended in onco-geriatric care and may refine prognostication and clinical decision-making in cancer-associated VTE [37, 39].”
Frailty transitions and the risk of multisystem burden of chronic disease: a prospective cohort study in China
Wu, J.-C., Weng, T., & Xu, Q. (2026) · Archives of Public Health · doi:10.1186/s13690-026-01970-8
“Given the potential reversibility of frailty, targeted interventions—nutritional [41], physical [42], pharmacological [43], or behavioral [43]—could meaningfully alter health trajectories.”
Association of the remnant cholesterol inflammatory index and frailty with cardiometabolic multimorbidity among Chinese middle-aged and elderly populations: a nationwide cohort study
Zhao, S., Wang, Z., & Chang, L. (2026) · BMC Cardiovascular Disorders · doi:10.1186/s12872-026-06356-w
“Emerging evidence suggests that higher FI and accelerated frailty progression are associated with increased CMM risk [17] and frailty is also more prevalent among individuals with cardiovascular disease, diabetes, and stroke [18–20].”
Multidimensional Frailty and Resilience in Relation to Quality of Life in Senior Patients with Cardiovascular Disease: An Exploratory Cross-Sectional Pilot Study
Albişteanu, S.-M., Nistoreanu-Neculau, B., Nistoreanu‐Neculau, A., Ștefăniu, R., Grigoraș, G., Lungu, I.-D., Constantinescu, D.-G., Turcu, A.-M., Ilie, A. C., & Pîslaru, A. I. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15156083
“This finding is consistent with recent evidence emphasizing that frailty and functional status are major determinants of cardiovascular prognosis in older adults, sometimes surpassing the predictive value of classical cardiological parameters [13].”
Cognitive Impairment and Frailty in Older Adults With Cardiovascular Disease: 2026 ACC Scientific Statement
Alexander, K. P., Damluji, A. A., Erqou, S., Ferrucci, L., Forman, D. E., Galasko, D., & Yaffe, K. S. (2026) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2026.07.009 · Cited by 4
Self-citation
Agreement Between Performance-Based and Adult Patient Self-Report Measures for Classifying Physical Frailty
Timurtaş, M. E., & Inceer, M. (2026) · Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi · doi:10.46413/boneyusbad.1767098
Frailty and nutritional status as prognostic factors in older adults with heart failure: a public health perspective
Li, J., Liu, M., & Wang, J. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1893715
Effectiveness of Multidomain Cardiac Rehabilitation After Myocardial Infarction by Patient Frailty: Prespecified Subgroup Analysis of the PIpELINe Trial
Passo, B. D., Tonet, E., Raisi, A., Zagnoni, S., Chiaranda, G., Pasanisi, G., Pavasini, R., Cimaglia, P., Piva, T., Casella, G., et al. (2026) · Circulation Population Health and Outcomes · doi:10.1161/circoutcomes.126.013410
Cardiac Rehabilitation and Frailty: A Rescue Rope for a Slippery Slope?
Thomas, R. J. (2026) · Circulation Population Health and Outcomes · doi:10.1161/circoutcomes.126.014093

Authors: Ijaz, N., Buta, B., Xue, Q.-L., Mohess, D. T., Bushan, A., Tran, H., Batchelor, W., deFilippi, C. R., Walston, J. D., Bandeen-Roche, K., Forman, D. E., Resar, J. R., O’Connor, C. M., Gerstenblith, G., & Damluji, A. A.
Affiliations: Inova Health System (US)
Johns Hopkins University (US)
University of Pittsburgh (US)
Corresponding author: Damluji, Abdulla A.
ORCID: Ijaz, Naila
Buta, Brian
Xue, Qian-Li
Batchelor, Wayne
deFilippi, Christopher R.
Walston, Jeremy D.
Forman, Daniel E.
Resar, Jon R.
O’Connor, Christopher M.
Gerstenblith, Gary
Damluji, Abdulla A.
Venue: Journal of the American College of Cardiology
Publisher: Elsevier BV
Published: 2022-02
Volume: 79
Issue: 5
Pages: 482-503
ISSN: 0735-1097 (ISSN-L)
DOI: 10.1016/j.jacc.2021.11.029
PMC: PMC8852369
OpenAlex: W4210642841
Cited by: 412
References: 112
Citations by year: 2026: 87 · 2025: 126 · 2024: 105 · 2023: 66 · 2022: 28
FWCI: 11.62
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Journal of the American College of Cardiology (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (P30AG021334)
National Heart, Lung, and Blood Institute (K23HL153771)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords: frailty, older adults, cardiovascular disease, frailty interventions, heart failure, cardiac rehabilitation, physical function, cognitive decline, physical inactivity, nutrition, social support, frailty prevention, quality of life
MeSH terms: Cardiac Rehabilitation, Frailty, Aged, Aging, Cardiovascular Diseases, Humans, Quality of Life, Risk Factors, Frail Elderly

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Interventions for Frailty Among Older Adults With Cardiovascular Disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks