The DOI matches its Crossref record, with a small difference in title or year; 110 of the 112 references it cites were found in a registry or an index.
Interventions for Frailty Among Older Adults With Cardiovascular Disease
Open accessAbstract
With the aging of the world's population, a large proportion of patients seen in cardiovascular practice are older adults, but many patients also exhibit signs of physical frailty. Cardiovascular disease and frailty are interdependent and have the same physiological underpinning that predisposes to the progression of both disease processes. Frailty can be defined as a phenomenon of increased vulnerability to stressors due to decreased physiological reserves in older patients and thus leads to poor clinical outcomes after cardiovascular insults. There are various pathophysiologic mechanisms for the development of frailty: cognitive decline, physical inactivity, poor nutrition, and lack of social supports; these risk factors provide opportunity for various types of interventions that aim to prevent, improve, or reverse the development of frailty syndrome in the context of cardiovascular disease. There is no compelling study demonstrating a successful intervention to improve a global measure of frailty. Emerging data from patients admitted with heart failure indicate that interventions associated with positive outcomes on frailty and physical function are multidimensional and include tailored cardiac rehabilitation. Contemporary cardiovascular practice should actively identify patients with physical frailty who could benefit from frailty interventions and aim to deliver these therapies in a patient-centered model to optimize quality of life, particularly after cardiovascular interventions.
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“Malnutrition, cachexia, sarcopenia, and frailty are phenotypically distinct but interconnected conditions with interrelated pathophysiological processes that lead to different magnitudes of wasting and susceptibility to adverse outcomes.81–83”
From Malnutrition and Cachexia in Inpatients With Acute Cardiac Conditions: A Scientific Statement From the American Heart Association (2026) · cites this paper as [83]
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Cites
Frailty in Older Adults: Evidence for a Phenotype
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Self-citationClegg, A., Young, J., Iliffe, S., Rikkert, M. O., & Rockwood, K. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62167-9 · Cited by 9,503
A global clinical measure of fitness and frailty in elderly people
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A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans
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“Similarly, the Edmonton scale includes assessments of cognition, social support, and nutrition in addition to function.(34) Some tools use a deficit accumulation approach to formulate an index of frailty, one of which is the CSHA (Canadian Study of Health and Aging) frailty index.”
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- 1997, Proceedings from the conference. May 16-18 1996, Med Care, 35, JS1
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Items 401–412 of 412
Wang, G., Li, X., Fan, L., Lin, L., Yu, Z., 方清, & Lu, W. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1877465
Enhancing Cardiovascular Care in Frailty: Priorities for Future Research
Nguyen, T. N. (2026) · European Cardiology Review · doi:10.15420/ecr.2026.43
Jiang, C., Li, Z., Ye, Y., Li, Z., Zhang, B., Feng, D., Gao, R., Xu, H., & Wu, Y. (2026) · JACC Advances · doi:10.1016/j.jacadv.2026.103193
Promoting Healthy Aging with Gerotherapeutic Medications
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Wu, J., Chen, L., Sun, S., Jia, Y., 侯婷婷, Chen, Y., Zhang, C., Li, J., & Zhao, Y. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1902925
“Pathophysiologically, hypertension and CVD share fundamental pathological bases, including chronic inflammation and metabolic dysregulation, which establishes a bidirectional vicious cycle (12).”
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Frailty in Patients With Pulmonary Hypertension
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Diretriz Brasileira de Cardiogeriatria – 2026
Helber, I., Zanon, J. C. D. C., Peixoto, J. M., Caixeta, A. M., Nussbacher, A., de Oliveira, D. C., de Freitas, E. V., Cintra, F. D., Garcia, J. S., Miranda, R. D., et al. (2026) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20260795
Carny, D., Folman, A., Fana, R. A., Barel, M. S., Roguin, A., & Kobo, O. M. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15208107
“In cardiovascular populations, frailty has been associated with higher mortality, more complications, longer hospital stays, and greater healthcare use [9–11].”
Yang, M., Deng, H., Lang, Q., Liao, C., Ma, Q., 高涵, Jiang, X., Zhu, Y., Ma, R., & Li, S. (2026) · Research Square · doi:10.21203/rs.3.rs-11027863/v1
KOMONSKI, A., Métais, A., & Rulleau, T. (2026) · Kinésithérapie la Revue · doi:10.1016/j.kine.2026.09.030
Aging in cardio-oncology: Pathophysiology, clinical implications and future directions
Madaudo, C., Cannata, A., Corrado, E., Lisi, D. D., Rossetto, L., Triolo, O. F., Cacciatore, G., Bovo, F., Fiore, F., Attanasio, U., et al. (2026) · Vascular Pharmacology · doi:10.1016/j.vph.2026.107716
Metadata
- Authors
- Ijaz, N., Buta, B., Xue, Q.-L., Mohess, D. T., Bushan, A., Tran, H., Batchelor, W., deFilippi, C. R., Walston, J. D., Bandeen-Roche, K., Forman, D. E., Resar, J. R., O’Connor, C. M., Gerstenblith, G., & Damluji, A. A.
- Affiliations
- Inova Health System (US)
- Johns Hopkins University (US)
- University of Pittsburgh (US)
- Corresponding author
- Damluji, Abdulla A.
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2022-02
- Volume
- 79
- Issue
- 5
- Pages
- 482-503
- ISSN
- 0735-1097 (ISSN-L)
- PMC
- PMC8852369
- OpenAlex
- W4210642841
- Cited by
- 412
- References
- 112
- Citations by year
- 2026: 87 · 2025: 126 · 2024: 105 · 2023: 66 · 2022: 28
- FWCI
- 11.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P30AG021334)
- National Heart, Lung, and Blood Institute (K23HL153771)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- frailty, older adults, cardiovascular disease, frailty interventions, heart failure, cardiac rehabilitation, physical function, cognitive decline, physical inactivity, nutrition, social support, frailty prevention, quality of life
- MeSH terms
- Cardiac Rehabilitation, Frailty, Aged, Aging, Cardiovascular Diseases, Humans, Quality of Life, Risk Factors, Frail Elderly
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