Validity and reliability of the Edmonton Frail Scale
Open accessAbstract
SIR—Age is broadly recognised to confer a risk for adverse health outcomes, but it is an insensitive and non-specific measure for use in individual decision-making. Frailty has been emerging to take its rightful place as a better measure for over a decade [1]. Despite general consensus that the concept of frailty is clinically useful, the lack of agreement on its definition and the challenge of its measurement by front-line health providers mean that frailty remains only ‘heir apparent’ to chronological age as a criterion to select older persons at risk [2]. Frailty is multidimensional, heterogeneous and unstable, thus distinguishing it from disability or ageing alone [3]. Rather, it is widely conceived of as a state of vulnerability. Frailty is measured in many ways, including ‘rules based’ instruments, summative impairment lists and algorithms derived from clinical judgement [4-6]. However much these tools might have advanced research in frailty, most are impractical for bedside screening by front-line providers because they require the multidimensional clinical data that constitute a comprehensive geriatric assessment (CGA) and/or require special training. Often, neither is available to the primary care providers who care for these patients. Furthermore, previously validated frailty assessments are time-consuming, making them impractical in more volume-driven settings, such as a primary care physician’s office. We therefore developed and tested a brief and user-friendly screening interview for frailty in seniors commonly encountered by geriatricians in both the inpatient and outpatient settings. Our objective was to assess the validity and reliability of the Edmonton Frail Scale (EFS) in a sample referred for CGA (Table 1). All patients aged 65+ years were approached for informed consent; exclusions were only for communication barriers (deafness, blindness or the need for translation), problems with manual dexterity or previous enrolment in our study. Patients were a referral population for CGA seen during July 2000 in acute care wards, rehabilitation units, day hospitals and outpatient clinics in Edmonton, Alberta, a major Canadian metropolitan centre (population one million). The Edmonton Frail Scale A lay research assistant who had no formal medical training collected demographic and medical data and then administered the EFS [7]. The EFS samples 10 domains; the maximum score is 17 and represents the highest level of frailty. Two domains are tested using performance-based items: the Clock test [8] for cognitive impairment and the ‘Timed Get Up and Go’ [9] for balance and mobility. The other domains are mood, functional independence, medication use, social support, nutrition, health attitudes, continence, burden of medical illness and quality of life (all standard historical items in geriatric assessment). All patients had a minimum of 1 h specialist CGA, which included a personal and informant history, a physical examination, a functional performance assessment, a mental status examination and a formulation. The CGA was completed independent of and blinded to the EFS scoring. Following each CGA, the specialist completed a questionnaire (developed by the study investigators, with its content validity tested by a panel of geriatricians) summarised as a Geriatrician’s Clinical Impression of Frailty (GCIF) [10]. The GCIF (Appendix: available online at http://ageing.oxfordjournals.org) included nine items for pre-morbid geriatric syndromes that threaten future independence and six items about acute atypical disease presentations. Finally, using each of the four different definitions of frailty, subjects were rated on a scale from 0 (not frail) to 5 (maximal frailty). These included definitions based on physical frailty (e.g. muscle wasting and weakness), physiological frailty (organ system-based vulnerability), frailty as disability (impairment in functional independence) and dynamic frailty (functional instability inclusive of social reserve). The GCIF thus has a score ranging from 0 (none) to 35 (maximal) frailty, which was correlated with the EFS score. In a randomly selected subset, the EFS was re-administered within 24 h by a geriatric assessment nurse blinded to the first score and to the CGA. For additional convergent construct validity, other subsets of participants were similarly requested to complete the Mini-Mental State Examination (MMSE) [11] and the Barthel Index [12]. To estimate the sample size for construct validity using a Pearson correlation, we reckoned a modest correlation of 0.30 and an expected correlation of 0.70, with α = 0.05 and β = 0.90 showing a need for 60 subjects [13]. This was doubled to allow for multiple testing. To test inter-rater reliability of the EFS using the kappa coefficient (κ) and assuming that excellent agreement was indicated by a value of ≥0.80, we calculated a requirement of 23 subjects [12]. The EFS score was also correlated with age, gender, number of medi
AI snapshot
Written from the paper’s full text.
TL;DR
The Edmonton Frail Scale (EFS) was tested in 158 older adults referred for comprehensive geriatric assessment and showed validity against geriatricians’ clinical impression, good inter-rater reliability, and acceptable internal consistency. It was brief, usable by non-specialists, and correlated with age, medication count, and functional dependence, though the authors call for cross-validation in other settings.
Key findings
- EFS scores were normally distributed (mean 7.6, SD 3.0, range 0–16) and correlated significantly with the Geriatrician’s Clinical Impression of Frailty (r = 0.64, P < 0.001), age (r = 0.27, P = 0.015), and medication count (r = 0.34, P < 0.001), but not sex (r = 0.05, P = 0.647).
- Inpatients scored higher than outpatients (9.9 ± 2.5 vs 6.2 ± 2.5; t = −8.9, P < 0.001), and those living with assistance scored higher than those living independently (8.1 SD 2.8 vs 7.0 SD 2.8; t = −2.29, P = 0.02).
- Construct validity: EFS correlated significantly with the Barthel Index (r = −0.58, P = 0.006, n = 21) but not with the MMSE (r = −0.05, P = 0.801, n = 30).
- Reliability: inter-rater reliability was k = 0.77 (P = 0.0001, n = 18); internal consistency was Cronbach’s alpha = 0.62; administration took <5 min and was acceptable to operators and participants.
Methods
- Referral sample for comprehensive geriatric assessment (CGA): patients aged 65+ seen in July 2000 in acute care wards, rehabilitation units, day hospitals, and outpatient clinics in Edmonton, Alberta; exclusions were communication barriers, manual dexterity problems, or previous enrolment. Of 364 eligible, 163 were excluded, 34 declined, leaving 158 participants (43% of eligible); mean age 80.4 years (SD 6.8), 53% women, 59% unmarried, mean medications 5.4 (SD 3.3).
- A lay research assistant administered the EFS, which samples 10 domains with a maximum score of 17. All patients had ≥1 h specialist CGA blinded to EFS scoring; the specialist completed a Geriatrician’s Clinical Impression of Frailty (GCIF) scored 0–35, correlated with EFS. Random subsets had EFS re-administered within 24 h by a blinded geriatric assessment nurse, or completed MMSE and Barthel Index.
- Analyses included Pearson correlations, t-tests by residence and consultation site, kappa for inter-rater reliability, and Cronbach’s alpha for internal reliability; sample size calculations targeted 60 subjects for construct validity and 23 for inter-rater reliability.
Limitations
- The authors state the GCIF is no “gold standard,” although it reflects blinded specialist judgement after CGA; they also caution that the sample was a select referral population, so findings may not generalise to an unscreened community population or to a narrower research population.
- The authors state that further studies are needed to test responsiveness of the EFS and to cross-validate it in other settings.
- Evident from the text: no systematic information was available on non-responders, and only 43% of eligible individuals participated; the inter-rater reliability sample was n = 18, below the 23 subjects calculated as required.
Model-written summary. Check it against the paper before relying on it.
Integrity signals
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Claims the paper makes
0 of 13 cited sources checked · 0 supported · 0 flagged
- Findingown data
In construct validation sub-samples, the correlation between the EFS and the Barthel Index was statistically significant (r=-0.58, P=0.006, n=21).
“In the construct validation sub-samples, the correlation with the Barthel Index was statistically significant (r = -0.58,P = 0.006, n = 21)”
Quote in the paperSubstantial claim - Findingown data
The internal consistency of the EFS using Cronbach's alpha was 0.62.
“The internal consistency of the EFS using Crohnbach's a was 0.62.”
Quote in the paperSubstantial claim - Findingown data
Inpatients had higher EFS scores than outpatients (9.9 ± 2.5 versus 6.2 ± 2.5; t=-8.9, P<0.001).
“Inpatients had higher scores than outpatients (9.9 ± 2.5 versus 6.2 ± 2.5; t = -8.9,P<0.001)”
Quote in the paperNot a substantial claim - Findingown data
The EFS showed good inter-rater reliability (k=0.77, P=0.0001, n=18).
“The EFS showed good inter-rater reliability (k = 0.77, P = 0.0001, n = 18).”
Quote in the paperSubstantial claim - Findingown data
In construct validation sub-samples, the correlation between the EFS and the MMSE was not statistically significant (r=-0.05, P=0.801, n=30).
“but the correlation with the MMSE was not (r = -0.05,P = 0.801, n = 30).”
Quote in the paperNot a substantial claim
- Findingnone given
The study population was a select population referred for comprehensive geriatric assessment (CGA).
“Ours was a select population referred for CGA.”
Quote in the paperSubstantial claim - Findingown data
Those who lived with assistance had higher EFS scores than those who lived independently (8.1 SD=2.8 versus 7.0 SD=2.8; t=-2.29, P=0.02).
“those who lived with assistance had higher scores than those who lived independently (8.1 SD = 2.8 versus 7.0 SD = 2.8; t = -2.29,P = 0.02).”
Quote in the paperSubstantial claim - Interpretationown data
In this community-based referral sample, the EFS was a valid measure of frailty compared to the clinical impression of geriatric specialists after their more comprehensive assessment.
“In this community-based referral sample, the EFS was a valid measure of frailty compared to the clinical impression of geriatric specialists after their more comprehensive assessment.”
Quote in the paperSubstantial claim- Rests on an assumption: The GCIF has good face validity.
- Rests on an assumption: The GCIF includes most current concepts of frailty.
- Interpretationown data
The EFS was validated in the hands of non-specialists who had no formal training in geriatric care.
“Of note, the EFS was validated in the hands of non-specialists who had no formal training in geriatric care.”
Quote in the paperSubstantial claim - Interpretationown data
The EFS had acceptable internal consistency.
“acceptable internal consistency.”
Quote in the paperSubstantial claim - Interpretationown data
The EFS had good construct validity.
“The EFS also had good construct validity”
Quote in the paperSubstantial claim- Rests on an assumption: The GCIF has good face validity.
- Rests on an assumption: The GCIF includes most current concepts of frailty.
- Interpretationown data
The EFS had good reliability.
“good reliability”
Quote in the paperSubstantial claim - Interpretationreasoning
The EFS has the potential as a practical and clinically meaningful measure of frailty in a variety of settings.
“Thus, the EFS has the potential as a practical and clinically meaningful measure of frailty in a variety of settings.”
Quote in the paperSubstantial claim
- Classified as probably not a substantial claim. 16
- The quote only partly states this claim. 4
- May combine two claims. 10
Probably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataThe EFS was reported to be acceptable to the operators and study participants.
“was reported to be acceptable to the operators and study participants.”
Quote in the paperNot a substantial claimThe quote only partly states this claim.
Findingown dataThe EFS correlated significantly with medication count (r=0.34, P<0.001).
“The EFS correlated significantly with the GCIF, age and medication count but not with sex (Table 2).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe GCIF was normally distributed with a mean score of 15.7, SD 6.95 and range 0-32.
“as was the GCIF (mean score of 15.7, SD = 6.95, range = 0-32)”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe EFS was normally distributed with a mean score of 7.6, SD 3.0 and range 0-16.
“The EFS was normally distributed (mean score 7.6, SD = 3.0, range = 0-16)”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataThe EFS required less than 5 minutes to administer.
“The EFS required <5 min to administer”
Quote in the paperNot a substantial claimThe quote only partly states this claim.
Findingown dataThe EFS correlated significantly with age (r=0.27, P=0.015).
“The EFS correlated significantly with the GCIF, age and medication count but not with sex (Table 2).”
Quote in the paperNot a substantial claimThe quote only partly states this claim.
Findingown dataThe EFS did not correlate significantly with sex (r=0.05, P=0.647).
“The EFS correlated significantly with the GCIF, age and medication count but not with sex (Table 2).”
Quote in the paperNot a substantial claimThe quote only partly states this claim.
Findingown dataThe EFS correlated significantly with the Geriatrician's Clinical Impression of Frailty (GCIF) (r=0.64, P<0.001).
“The EFS correlated significantly with the GCIF, age and medication count but not with sex (Table 2).”
Quote in the paperSubstantial claimMay combine two claims.
InterpretationreasoningIn summary, the EFS appears to be valid, reliable and feasible for routine use by non-geriatricians.
“In summary, the EFS appears to be valid, reliable and feasible for routine use by non-geriatricians.”
Quote in the paperSubstantial claim- Rests on an assumption: The GCIF has good face validity.
- Rests on an assumption: The GCIF includes most current concepts of frailty.
Classified as probably not a substantial claim.
PremisereasoningMost existing frailty tools are impractical for bedside screening by front-line providers because they require the multidimensional clinical data that constitute a comprehensive geriatric assessment (CGA) and/or require special training.
“However much these tools might have advanced research in frailty, most are impractical for bedside screening by front-line providers because they require the multidimensional clinical data that constitute a comprehensive geriatric assessment (CGA) and/or require special training.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim.
Study design and conductnone givenIn a randomly selected subset, the EFS was re-administered within 24 hours by a geriatric assessment nurse blinded to the first score and to the CGA.
“In a randomly selected subset, the EFS was re-administered within 24 h by a geriatric assessment nurse blinded to the first score and to the CGA.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim.
Study design and conductnone givenThe comprehensive geriatric assessment (CGA) was completed independent of and blinded to the EFS scoring.
“The CGA was completed independent of and blinded to the EFS scoring.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductcitationA lay research assistant with no formal medical training collected demographic and medical data and administered the EFS.
“A lay research assistant who had no formal medical training collected demographic and medical data and then administered the EFS [7].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [7] Rolfson DB , Majumdar SR, Taher A, Tsuyuki RT. Development and validation of a new instrument for frailty. Clin Invest Med2000; 23: 336.
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenThe health research ethics board of the University of Alberta approved the project.
“The health research ethics board of the University of Alberta approved the project.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
InterpretationcitationA unique characteristic of the EFS as a clinical frailty instrument is its inclusion of the domain of social support, suggesting an endorsement of the dynamic model of frailty.
“A unique characteristic of the EFS as a clinical frailty instrument is its inclusion of the domain of social support, suggesting an endorsement of the dynamic model of frailty [1].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [1] Rockwood K , Fox RA, Stolee P, Robertson D, Beattie BL. Frailty in elderly people: an evolving concept. Can Med Assoc J1994; 150: 489–95.
Not checked in the free run.
May combine two claims.
PremisecitationThe Canadian Study of Health and Aging (CSHA) Clinical Frailty Scale is short but was validated only after a comprehensive geriatric assessment (CGA) was carried out.
“Another new judgement-based measure, the Canadian Study of Health and Aging (CSHA) Clinical Frailty Scale [4], is short but was validated only after a CGA was carried out.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [4] Rockwood K , Xiaowei S, MacKnight C et al. A global clinical measure of fitness and frailty in elderly people. Can Med Assoc J2005; 173: 489–95. source
Not checked in the free run.
Probably not a substantial claim: may not pass S4 (based).
Premisenone givenPreviously validated frailty assessments are time-consuming, making them impractical in volume-driven settings such as a primary care physician's office.
“Furthermore, previously validated frailty assessments are time-consuming, making them impractical in more volumedriven settings, such as a primary care physician's office.”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationown dataThe EFS is a brief, valid and reliable tool that can be completed by people without special training in geriatric medicine.
“The EFS is a brief, valid and reliable tool that can be completed by people without special training in geriatric medicine.”
Quote in the paperSubstantial claim- Rests on an assumption: The GCIF has good face validity.
- Rests on an assumption: The GCIF includes most current concepts of frailty.
Classified as probably not a substantial claim.
PremisecitationFrailty remains only 'heir apparent' to chronological age as a criterion to select older persons at risk due to lack of agreement on its definition and the challenge of its measurement by front-line health providers.
“Despite general consensus that the concept of frailty is clinically useful, the lack of agreement on its definition and the challenge of its measurement by front-line health providers mean that frailty remains only 'heir apparent' to chronological age as a criterion to select older persons at risk [2].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [2] Kaethler Y , Molnar F, Mitchell S, Soucie P, Man-Son-Hing M. Defining the concept of frailty: a survey of multi-disciplinary health professionals. Geriatrics Today2003; 6: 26–31.
Not checked in the free run.
May combine two claims.
PremisecitationThe FI-CGA still requires a comprehensive geriatric assessment (CGA), which limits its potential for routine application.
“Similarly, the FI-CGA [19] still requires a CGA, which also limits its potential for routine application.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [19] Jones D , Song X, Mitnitski A, Rockwood K. Evaluation of a frailty index based on a comprehensive geriatric assessment in a population based study of elderly Canadians. Aging Clin Exp Res2005; 17: 465–71. source
Not checked in the free run.
May combine two claims.
PremisecitationBoth CGA-dependent tools predict death and institutionalisation in tightly graded patterns.
“and both predict death and institutionalisation in tightly graded patterns.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [20] Jones D , Song X, Rockwood K. Operationalizing a frailty index from a standardised comprehensive geriatric assessment. J Am Geriatr Soc2004; 52: 1929–33. source
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationFrailty is multidimensional, heterogeneous and unstable, distinguishing it from disability or ageing alone.
“Frailty is multidimensional, heterogeneous and unstable, thus distinguishing it from disability or ageing alone [3].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [3] Hogan DB , MacKnight C, Bergman H. Models, definitions and criteria of frailty. Aging Clin Exp Res2003; 15 (Suppl. 1): 1–29.
Not checked in the free run.
Classified as probably not a substantial claim.
Study design and conductcitationA sample size of 60 subjects was needed for construct validity using a Pearson correlation, based on a modest correlation of 0.30, an expected correlation of 0.70, alpha 0.05 and beta 0.90.
“To estimate the sample size for construct validity using a Pearson correlation, we reckoned a modest correlation of 0.30 and an expected correlation of 0.70, with a = 0.05 and b = 0.90 showing a need for 60 subjects [13].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [13] Kraemer HC , Thiemann S. How Many Subjects? Statistical Power Analysis in Research. Newbury Park: NJ: Sage, 1987, 33.
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationFrailty is measured in many ways, including rules-based instruments, summative impairment lists and algorithms derived from clinical judgement.
“Frailty is measured in many ways, including 'rules based' instruments, summative impairment lists and algorithms derived from clinical judgement [4][5][6].”
Quote in the paperNot a substantial claim0 of 3 sources checked- cites [4] Rockwood K , Xiaowei S, MacKnight C et al. A global clinical measure of fitness and frailty in elderly people. Can Med Assoc J2005; 173: 489–95. source
Not checked in the free run.
- cites [5] Stuck AE , Siu AL, Wieland GD, Adams J, Rubenstein LZ. Comprehensive geriatric assessment: a meta-analysis of controlled trials. Lancet1993; 342: 1032–6. source
Not checked in the free run.
- cites [6] Charlson ME , Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chron Dis1987; 40: 373–83. source
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
Interpretationnone givenThe GCIF is no 'gold standard' for frailty.
“Although the GCIF has a good face validity and includes most current concepts of frailty (physical, physiological, functional and dynamic), it is no 'gold standard'.”
Quote in the paperNot a substantial claim- Rests on an assumption: The GCIF has good face validity.
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationThe EFS is shorter than another recent clinical proposal that focused on change.
“The EFS is shorter than another recent clinical proposal [18] that focused on change”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [18] Studenski S , Hayes R, Leibowitz R et al. Clinical global impression of change in physical frailty: development of a measure based on clinical judgement. J Am Geriatr Soc2004; 52: 1560–6. source
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductcitationA sample size of 23 subjects was needed to test inter-rater reliability of the EFS using the kappa coefficient, assuming excellent agreement was indicated by a value of ≥0.80.
“To test inter-rater reliability of the EFS using the kappa coefficient (k) and assuming that excellent agreement was indicated by a value of ≥0.80, we calculated a requirement of 23 subjects [12].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [12] Mahoney F , Barthel D. Functional evaluation: the Barthel index. Md State Med J1965; 14: 61–5. source
Not checked in the free run.
The paper relies on this without support.
The need for a brief tool that can be used by nonspecialist geriatrician remains.
“What is known: Frailty is broadly used and measurable, but the need for a brief tool that can be used by nonspecialist geriatrician remains.”
The paper relies on this without support.
The GCIF has good face validity.
“Although the GCIF has a good face validity”
The paper relies on this without support.
The GCIF includes most current concepts of frailty.
“includes most current concepts of frailty (physical, physiological, functional and dynamic)”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
CHESS has been demonstrated to be a strong predictor of mortality.
“CHESS has been demonstrated to be a strong predictor of mortality”
From Frailty in elderly people (2013) · cites this paper as [109]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
July recruitment window conflicts with eight-week enrolment
MinorThe methods describe patients seen during July 2000, whereas the results describe an eight-week enrolment period. Eight weeks cannot fit within July alone.
“Patients were a referral population for CGA seen during July 2000 in acute care wards, rehabilitation units, day hospitals and outpatient clinics in Edmonton, Alberta, a major Canadian metropolitan centre (population one million).”
“During the 8-week period of enrolment, 364 individuals were considered to be eligible.”
Domain count conflicts with the domains listed
MinorThe text says the EFS samples 10 domains, but then describes two performance-based domains and lists nine other domains, for a total of 11.
“The EFS samples 10 domains;”
“Two domains are tested using performance-based items: the Clock test [8] for cognitive impairment and the 'Timed Get Up and Go' [9] for balance and mobility.The other domains are mood, functional independence, medication use, social support, nutrition, health attitudes, continence, burden of medical illness and quality of life”
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A global clinical measure of fitness and frailty in elderly people
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“Another new judgement-based measure, the Canadian Study of Health and Aging (CSHA) Clinical Frailty Scale [4], is short but was validated only after a CGA was carried out.”
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“Similarly, the FI-CGA [19] still requires a CGA, which also limits its potential for routine application.”
BackgroundSelf-citationStudenski, S., Hayes, R. P., Leibowitz, R. Q., Bode, R., Lavery, L., Walston, J., Duncan, P., & Perera, S. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52423.x · Cited by 252 · see citing works
Schalk, B. W. M., Visser, M., Deeg, D. J. H., & Bouter, L. M. (2004) · Age and Ageing · doi:10.1093/ageing/afh073 · Cited by 98 · see citing works
Treloar, A. J., & Macdonald, A. (1997) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(199706)12:6 · Cited by 45 · cited 1× · see citing works
“Two domains are tested using performance-based items: the Clock test [8] for cognitive impairment and the ‘Timed Get Up and Go’ [9] for balance and mobility.”
MethodDevelopment and validation of a new instrument for frailty
(2000) · Cited by 29 · see citing works
Self-citationMacWalter, R. S., Ersoy, Y., & Wolfson, D. R. (2001) · Gerontology · doi:10.1159/000052785 · Cited by 14 · see citing works
(1965) · PubMed
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- Kaethler Y , Molnar F, Mitchell S, Soucie P, Man-Son-Hing M. Defining the concept of frailty: a survey of multi-disciplinary health professionals. Geriatrics Today2003; 6: 26–31.
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Sorted by citations
Clegg, A., Young, J., Iliffe, S., Rikkert, M. O., & Rockwood, K. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62167-9 · Cited by 9,503 · see citing works
Self-citationManagement of frailty: opportunities, challenges, and future directions
Dent, E., Martin, F. C., Bergman, H., Woo, J., Romero‐Ortuño, R., & Walston, J. D. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31785-4 · Cited by 1,722 · see citing works
Frailty measurement in research and clinical practice: A review.
Dent, E., Kowal, P., & Hoogendijk, E. (2016) · European journal of internal medicine · doi:10.1016/j.ejim.2016.03.007 · Cited by 1,175 · see citing works
The Tilburg Frailty Indicator: Psychometric Properties
Gobbens, R. J. J., van Assen, M. A. L. M., Luijkx, K. G., Wijnen-Sponselee, M. T., & Schols, J. M. G. A. (2010) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2009.11.003 · Cited by 1,121 · see citing works
“The social domain of frailty (social frailty; range 0–3), includes living alone, social relations,(16,27) and social support.(9,20,25,27) Eleven items from the TFI have 2 response categories: ‘‘yes’’ and ‘‘no’’; 4 items have 3 response categories: ‘‘yes,’’ ‘‘sometimes,’’ and ‘‘no’’; these items were dichotomized (see…”
Physical Frailty: ICFSR International Clinical Practice Guidelines for Identification and Management
Dent, E., Morley, J. E., Cruz-Jentoft, A. J., Woodhouse, L. J., Rodríguez‐Mañas, L., Fried, L. P., Woo, J., Aprahamian, I., Sanford, A. M., Lundy, J., et al. (2019) · The journal of nutrition health & aging · doi:10.1007/s12603-019-1273-z · Cited by 1,084 · see citing works
“The EFS includes nine components: functional limitation, self-reported health, general health status, cognition, social support, mood, functional performance, polypharmacy and continence (75), and is most commonly used in the hospital setting (81).”
Kim, D. H., & Rockwood, K. J. (2024) · New England Journal of Medicine · doi:10.1056/nejmra2301292 · Cited by 892 · see citing works
Self-citationOutcome instruments to measure frailty: a systematic review
de Vries, N. M., Staal, J. B., van Ravensberg, C. D., Hobbelen, J. S. M., Olde Rikkert, M. G. M., & Nijhuis-van der Sanden, M. W. G. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.09.001 · Cited by 793 · see citing works
“For this reason a number of more or less well known frailty screening instrumentswere not included in this systematic review, for example the Edmunton Frail Scale (Rolfson, 2006).”
BackgroundValidity of the K ihon Checklist for assessing frailty status
Satake, S., Senda, K., Hong, Y., Miura, H., Endo, H., Sakurai, T., Kondo, I., & Toba, K. (2015) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.12543 · Cited by 698 · see citing works
The Identification of Frailty: A Systematic Literature Review
Sternberg, S. A., Schwartz, A. W., Karunananthan, S., Bergman, H., & Mark Clarfield, A. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03597.x · Cited by 703 · see citing works
Ezekowitz, J. A., O'Meara, E., McDonald, M. A., Abrams, H., Chan, M., Ducharme, A., Giannetti, N., Grzeslo, A., Hamilton, P. G., Heckman, G. A., et al. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.08.022 · Cited by 676 · see citing works
Theou, O., Brothers, T. D., Mitnitski, A., & Rockwood, K. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12420 · Cited by 665 · see citing works
Self-citationLee, D. H., Buth, K. J., Martin, B., Yip, A. M., & Hirsch, G. M. (2010) · Circulation · doi:10.1161/circulationaha.108.841437 · Cited by 677 · see citing works
Frailty in the older surgical patient: a review
Partridge, J. S. L., Harari, D., & Dhesi, J. K. (2012) · Age and Ageing · doi:10.1093/ageing/afr182 · Cited by 658 · see citing works
“The measurement tools that exist are either scoring systems based on various aspects of physical, cognitive or functional capability [28, 30, 38 – 40] or are ‘ surrogate single measures ’ of frailty based on assessment of functional status [41 – 43].”
The effectiveness of exercise interventions for the management of frailty: a systematic review
Theou, O., Stathokostas, L., Roland, K. P., Jakobi, J. M., Patterson, C., Vandervoort, A. A., & Jones, G. R. (2011) · Journal of Aging Research · doi:10.4061/2011/569194 · Cited by 652 · see citing works
“The most commonly used definitions of frailty are the frailty phenotype [5], the frailty index [6], the classification of frailty and vigorousness [7], and the Edmonton frail scale [8].”
BackgroundMethodApóstolo, J., Cooke, R. W. I., Campos, E. B., Santana, S., Marcucci, M., Cano, A., Vollenbroek-Hutten, M. M. R., Germini, F., D’Avanzo, B., Gwyther, H., et al. (2018) · The JBI Database of Systematic Reviews and Implementation Reports · doi:10.11124/jbisrir-2017-003382 · Cited by 621 · see citing works
The Asia-Pacific Clinical Practice Guidelines for the Management of Frailty
Dent, E., Lien, C. T. C., Lim, W. S., Wong, W. C., Wong, C. H., Ng, T. P., Woo, J., Dong, B., de la Vega, S., Poi, P. J. H., et al. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.04.018 · Cited by 633 · see citing works
Self-citationChou, C., Hwang, C., & Wu, Y. (2012) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2011.08.042 · Cited by 630 · see citing works
Tarazona‐Santabalbina, F. J., Gómez‐Cabrera, M. C., Pérez‐Ros, P., Martínez‐Arnau, F. M., Cabo, H., Tsaparas, K., Salvador‐Pascual, A., Rodríguez‐Mañas, L., & Viña, J. (2016) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.01.019 · Cited by 602 · see citing works
Frailty and sarcopenia: The potential role of an aged immune system
Wilson, D., Jackson, T., Sapey, E., & Lord, J. M. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.01.006 · Cited by 573 · see citing works
“This is reflected in recent diagnostic and screening tools, dmonton Frail Scale and PRISMA 7, including the assessment of everal domains of health (Rolfson et al., 2006; Raiche et al., 2008). owever, the relative ease of utilising the Frailty Phenotype means t is still used in research as a method…”
Frailty and cancer: Implications for oncology surgery, medical oncology, and radiation oncology
Ethun, C. G., Bilen, M. A., Jani, A. B., Maithel, S. K., Ogan, K., & Master, V. A. (2017) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21406 · Cited by 577 · see citing works
Redefining Geriatric Preoperative Assessment Using Frailty, Disability and Co-Morbidity
Robinson, T. N., Eiseman, B., Wallace, J. I., Church, S. D., McFann, K. K., Pfister, S. M., Sharp, T. J., & Moss, M. (2009) · Annals of Surgery · doi:10.1097/sla.0b013e3181b45598 · Cited by 543 · see citing works
“(3) Polypharmacy–The number of outpatient medications an individual took within 30 days of the operation was recorded as a surrogate to represent burden of comorbidities.(11,12)”
BackgroundMethodOtto, C. M., Kumbhani, D. J., Alexander, K. P., Calhoon, J., Desai, M. Y., Kaul, S., Lee, J. C., Ruiz, C. E., & Vassileva, C. M. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.12.006 · Cited by 512 · see citing works
Simple frailty score predicts postoperative complications across surgical specialties
Robinson, T. N., Wu, D. S., Pointer, L., Dunn, C. L., Cleveland, J. C., & Moss, M. (2013) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2013.03.012 · Cited by 513 · see citing works
Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults
Wilson, E. M. P., Goswami, J., Baqui, A. H., Doreski, P. A., Marc, G. P., Zaman, K., Monroy, J., Duncan, C. J. A., Ujiie, M., Rämet, M., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2307079 · Cited by 517 · see citing works
Burden of frailty in the elderly population: perspectives for a public health challenge
Buckinx, F., Rolland, Y., Reginster, J., Ricour, C., Pétermans, J., & Bruyère, O. (2015) · Archives of Public Health · doi:10.1186/s13690-015-0068-x · Cited by 466 · see citing works
“The maximum score is 17 and represents the highest level of frailty [28].”
Measures of frailty in population-based studies: an overview
Bouillon, K., Mika Kivimaki, B., Hamer, M., Sabia, S., Fransson, E. I., Singh‐Manoux, A., Galé, C. R., & Batty, G. D. (2013) · BMC Geriatrics · doi:10.1186/1471-2318-13-64 · Cited by 466 · see citing works
“In 69% of publications, a frailty scale developed by Fried and colleagues [47] was utilized; 12% used the Frailty Index developed by Mitnitski and colleagues [34]; 4% the Edmonton Frail Scale [52]; and ≤ 2% used the remaining instruments.”
BackgroundMethodResultInfluentialFrailty is associated with postoperative complications in older adults with medical problems
Dasgupta, M., Rolfson, D. B., Stolee, P., BORRIE, M. J., & Speechley, M. R. (2008) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2007.10.007 · Cited by 462 · see citing works
“It was tested on older adults undergoing comprehensive geriatric assessment at a different site (Edmonton, Canada), and found to be reliable and valid compared to a geriatrician’s clinical impression of frailty (Rolfson et al., 2006).”
BackgroundSelf-citationShall we operate? Preoperative assessment in elderly cancer patients (PACE) can help
participants, P. (2007) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2007.11.001 · Cited by 462 · see citing works
Towards an integral conceptual model of frailty
Gobbens, R. J. J., Luijkx, K. G., Wijnen-Sponselee, M. T., & Schols, J. M. G. A. (2010) · The journal of nutrition health & aging · doi:10.1007/s12603-010-0045-6 · Cited by 449 · see citing works
“Literature searches have shown that more and more researchers are becoming convinced of the multifactorial nature of the concept of frailty (2, 4, 9-13 ).”
Prognostic significance of potential frailty criteria
Rothman, M. D., Leo‐Summers, L., & Gill, T. M. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.02008.x · Cited by 428 · see citing works
“Other definitions of frailty that focus on overall deficit accumulation have also been shown to predict adverse outcomes in older persons.(5,31,32) Although routine assessment of large numbers of deficits in clinical practice may be difficult, it is likely that the availability of many self-reported patient characteri…”
BackgroundA Narrative Review on Sarcopenia in Type 2 Diabetes Mellitus: Prevalence and Associated Factors
Izzo, A. C., Massimino, E., Riccardi, G., & Pepa, G. D. (2021) · Nutrients · doi:10.3390/nu13010183 · Cited by 431 · see citing works
“The Edmonton Frail Scale (EFS) [29], its recent validated short version (EFS-SF) [30,31], the Fatigue, Resistance, Ambulation, Illnesses, and Loss of Weight (FRAIL) Score [32], the Geriatricians’ Clinical Impression of Frailty (GCIF) scale [33], and the Clinical-Functional Vulnerability Index-20 (IVCF-20) [34] are oth…”
Toward a conceptual definition of frail community dwelling older people
Gobbens, R. J. J., Luijkx, K. G., Wijnen-Sponselee, M. T., & Schols, J. M. G. A. (2010) · Nursing Outlook · doi:10.1016/j.outlook.2009.09.005 · Cited by 416 · see citing works
Interventions for Frailty Among Older Adults With Cardiovascular Disease
Ijaz, N., Buta, B., Xue, Q.-L., Mohess, D. T., Bushan, A., Tran, H., Batchelor, W., deFilippi, C. R., Walston, J. D., Bandeen-Roche, K., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.11.029 · Cited by 412 · see citing works
“Similarly, the Edmonton scale includes assessments of cognition, social support, and nutrition in addition to function.(34) Some tools use a deficit accumulation approach to formulate an index of frailty, one of which is the CSHA (Canadian Study of Health and Aging) frailty index.”
MethodClegg, A., Rogers, L., & Young, J. (2015) · Age and Ageing · doi:10.1093/ageing/afu157 · Cited by 380 · see citing works
“Sixteen articles were excluded: 10 did not apply a reference standard test [10–19], and 6 did not report DTA data [20–25].”
BackgroundWoo, J., Leung, J. C. S., & Morley, J. E. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2012.04074.x · Cited by 383 · see citing works
Gobbens, R. J. J., van Assen, M. A. L. M., Luijkx, K. G., Wijnen-Sponselee, M. T., & Schols, J. M. G. A. (2010) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2009.11.008 · Cited by 380 · see citing works
Robinson, T. N., Wallace, J. I., Wu, D. S., Wiktor, A. J., Pointer, L., Pfister, S., Sharp, T. J., Buckley, M. J., & Moss, M. (2011) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2011.01.056 · Cited by 387 · see citing works
Instruments for the detection of frailty syndrome in older adults: A systematic review
Faller, J. W., Pereira, D. D. N., de Souza, S., Nampo, F. K., Orlandi, F. D. S., & Matumoto, S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216166 · Cited by 353 · see citing works
Thompson, A., Fleischmann, K. E., Smilowitz, N. R., Fuentes, L. D. L., Mukherjee, D., Aggarwal, N. R., Ahmad, F. S., Allen, R. B., Altin, S. E., Auerbach, A. D., et al. (2024) · Circulation · doi:10.1161/cir.0000000000001285 · Cited by 420 · see citing works
The degree of frailty as a translational measure of health in aging
Howlett, S. E., Rutenberg, A. D., & Rockwood, K. J. (2021) · Nature Aging · doi:10.1038/s43587-021-00099-3 · Cited by 343 · see citing works
Self-citationFrailty and Subsequent Disability and Mortality among Patients with Critical Illness
Brummel, N. E., Bell, S. P., Girard, T. D., Pandharipande, P. P., Jackson, J. C., Morandi, A., Thompson, J. L., Chandrasekhar, R., Bernard, G. R., Dittus, R. S., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201605-0939oc · Cited by 332 · see citing works
“These in-depth assessments include evaluation with a multidimensional tool, such as the Edmonton Frailty Scale (49) or via a comprehensive geriatric assessment.”
MethodImportance of frailty in patients with cardiovascular disease
Singh, M., Stewart, R., & White, H. D. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu197 · Cited by 325 · see citing works
Sarcopenia and frailty in chronic respiratory disease
Bone, A. E., Hepgul, N., Kon, S. S. C., & Maddocks, M. M. (2016) · Chronic Respiratory Disease · doi:10.1177/1479972316679664 · Cited by 309 · see citing works
“Edmonton Scale (54) - Timed up and go test - Weight loss (yes/ no) General health - Help with ADLs, continence Draw clockface task Social support Sadness, depression >5 drugs prescribed”
MethodInfluentialFrailty for Perioperative Clinicians: A Narrative Review
McIsaac, D. I., Macdonald, D. B., & Aucoin, S. D. (2020) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000004602 · Cited by 300 · see citing works
Jadczak, A. D., Makwana, N. R., Luscombe‐Marsh, N. D., Visvanathan, R., & Schultz, T. (2018) · The JBI Database of Systematic Reviews and Implementation Reports · doi:10.11124/jbisrir-2017-003551 · Cited by 292 · see citing works
Gobbens, R. J. J., van Assen, M. A. L. M., Luijkx, K. G., & Schols, J. M. G. A. (2012) · The Gerontologist · doi:10.1093/geront/gnr135 · Cited by 289 · see citing works
“Several other multi-dimensional instruments are currently available for measuring frailty in older persons, such as the Edmonton Frail Scale (Rolfson, Majumdar, Tsuyuki, Tahir, & Rockwood, 2006), the Frailty Index (Jones et al., 2004), and the Groningen Frailty Indicator (Schuurmans, Steverink,…”
Agreement Between 35 Published Frailty Scores in the General Population
Aguayo, G., Donneau, A., Vaillant, M., Schritz, A., Franco, O. H., Stranges, S., Malisoux, L., Guillaume, M., & Witte, D. R. (2017) · American Journal of Epidemiology · doi:10.1093/aje/kwx061 · Cited by 265 · see citing works
“4 Rolfson, 2006 (35) Edmonton Frail Scale Canada MD CS Binary 9 9 12.”
BackgroundIbrahim, K., Cox, N. J., Stevenson, J. M., et al. (2021) · BMC Geriatrics · doi:10.1186/s12877-021-02208-8 · Cited by 268 · see citing works
“The Edmonton frailty tool consists of 9 domains including number of medications [46].”
MethodVitale, C., Jankowska, E. A., Hill, L., Piepoli, M. F., Doehner, W., Anker, S. D., Lainščak, M., Jaarsma, T., Ponikowski, P. P., Rosano, G. M. C., et al. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1611 · Cited by 264 · see citing works
Moving against frailty: does physical activity matter?
Landi, F., Abbatecola, A. M., Provinciali, M., Corsonello, A., Bustacchini, S., Manigrasso, L., Cherubini, A., Bernabei, R., & Lattanzio, F. (2010) · Biogerontology · doi:10.1007/s10522-010-9296-1 · Cited by 242 · see citing works
“Other definitions of frailty include components related to cognitive impairment, urinary incontinence, presence of multiple comorbidities (Rockwood et al. 2005; Rolfson et al. 2006).”
BackgroundFrailty in primary care: a review of its conceptualization and implications for practice
Lacas, A., & Rockwood, K. J. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-4 · Cited by 237 · see citing works
“Rolfson DB, Majumdar SR, Tsuyuki RT, Tahir A, Rockwood K: Validity and reliability of the Edmonton Frail Scale.”
MethodSelf-citationFrailty: an emerging concept for general practice
Lepeleire, J. D., Iliffe, S., Mann, E., & Degryse, J. (2009) · British Journal of General Practice · doi:10.3399/bjgp09x420653 · Cited by 235 · see citing works
“British Journal of General Practice, May 2009 e181 measure than chronological age.(6,23) For example, using clinical judgment alone, GPs are able to identify older people who would benefit from multidisciplinary interventions and those on the boundary of frailty who could benefit from exercise therapy.”
BackgroundResultInfluentialThe assessment of frailty in older people in acute care
Hilmer, S. N., Perera, V., Mitchell, S. J., Murnion, B. P., Dent, J., Bajorek, B. V., Matthews, S. T., & Rolfson, D. B. (2009) · Australian Journal on Ageing · doi:10.1111/j.1741-6612.2009.00367.x · Cited by 234 · see citing works
Self-citationWatt, J. A., Tricco, A. C., Talbot‐Hamon, C., Pham, B., Rios, P. D. L., Grudniewicz, A., Wong, C. L., Sinclair, D. E., & Straus, S. E. (2018) · BMC Medicine · doi:10.1186/s12916-017-0986-2 · Cited by 219 · see citing works
Álvarez-Nebreda, M. L., Bentov, N., Urman, R. D., Setia, S., Huang, J. C.-S., Pfeifer, K. J., Bennett, K. A., Ong, T. D., Richman, D. C., Gollapudi, D., et al. (2018) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2018.02.011 · Cited by 234 · see citing works
“Perioperative teams at institutions lacking a geriatrician to con fi rm a frailty diagnosis may use comprehensive screening tools like the Edmonton Frail Scale [14] (Table 3) to identify basic areas of intervention.”
George, E., Hall, D. E., Youk, A. O., Chen, R., Kashikar, A., Trickey, A. W., Varley, P. R., Shireman, P. K., Shinall, M. C., Massarweh, N. N., et al. (2020) · JAMA Surgery · doi:10.1001/jamasurg.2020.5152 · Cited by 225 · see citing works
Herr, M., Robine, J., Pinot, J., Arvieu, J., & Ankri, J. (2015) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.3772 · Cited by 216 · see citing works
Skeletal Muscle Health and Cognitive Function: A Narrative Review
Sui, S. X., Williams, L. J., Holloway‐Kew, K. L., Hyde, N. K., & Pasco, J. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010255 · Cited by 214 · see citing works
“For example, a cross-sectional study in Singapore examined participants attending an outpatient clinic where frailty was assessed using the Edmonton Frail Scale [28] and sarcopenia was assessed using the rapid five item (SARC-F) questionnaire [29].”
MethodSutton, J. L., Gould, R. L., Daley, S., Coulson, M., Ward, E. V., Butler, A. M., Nunn, S., & Howard, R. J. (2016) · BMC Geriatrics · doi:10.1186/s12877-016-0225-2 · Cited by 215 · see citing works
“Overall Internal Consistency was assessed in 7/38 tools [29, 41, 51, 54, 57, 58, 61, 79, 84, 85, 94]; Internal Consistency was determined via Cronbach α calculations for 6/7 tools, the scores of which ranged from 0.”
MethodInfluentialIdentifying Common Characteristics of Frailty Across Seven Scales
Theou, O., Brothers, T. D., Peña, F. G., Mitnitski, A., & Rockwood, K. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12773 · Cited by 209 · see citing works
Self-citationPerera, V., Bajorek, B. V., Matthews, S. T., & Hilmer, S. N. (2008) · Age and Ageing · doi:10.1093/ageing/afn293 · Cited by 203 · see citing works
“Recently, several objective tools have been developed to define frailty [9–11], facilitating studies of the physiologic”
BackgroundMethodInfluentialThompson, A., Fleischmann, K. E., Smilowitz, N. R., Fuentes, L. D. L., Mukherjee, D., Aggarwal, N. R., Ahmad, F. S., Allen, R. B., Altin, S. E., Auerbach, A. D., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.06.013 · Cited by 251 · see citing works
Fabrício-Wehbe, S. C. C., Schiaveto, F. V., Vendrusculo, T. R. P., Haas, V. J., Dantas, R. A. S., & Rodrigues, R. A. P. (2009) · Revista Latino-Americana de Enfermagem · doi:10.1590/s0104-11692009000600018 · Cited by 199 · see citing works
“Canadian participants in this group have studied a clinical proposal to detect frailty in elderly people, called the Edmonton Frail Scale (EFS)((3)).”
BackgroundMethodInfluentialPerna, S., Francis, M., Bologna, C., Moncaglieri, F., Riva, A., Morazzoni, P., Allegrini, P., Isu, A., Vigo, B., Guerriero, F., et al. (2017) · BMC Geriatrics · doi:10.1186/s12877-016-0382-3 · Cited by 191 · see citing works
“Edmonton Frail Scale (EFS): The EFS assesses nine domains of frailty (cognition, general health status, functional independence, social support, medication usage, nutrition, mood, continence, functional performance) [9, 11].”
BackgroundFrailty and cardiac rehabilitation: A call to action from the EAPC Cardiac Rehabilitation Section
Vigorito, C., Abreu, A., Ambrosetti, M., Belardinelli, R., Corrà, U., Cupples, M., Davos, C. H., Hoefer, S., Iliou, M., Schmid, J., et al. (2016) · European Journal of Preventive Cardiology · doi:10.1177/2047487316682579 · Cited by 188 · see citing works
“Many studies have evaluated frailty in elderly patients after an acute coronary syndrome (ACS) or percutaneous transluminal coronary angioplasty (PTCA) by using several instruments, such as the phenotypic model (PFI),(4) the CSHA clinical frailty scale,(22) or the EFS.(23) In this setting frailty ranged from 10% to 48…”
MethodInfluentialCardiovascular Disease and Frailty: What Are the Mechanistic Links?
Stewart, R. (2018) · Clinical Chemistry · doi:10.1373/clinchem.2018.287318 · Cited by 170 · see citing works
The Frailty Syndrome: A Comprehensive Review
Heuberger, R. (2011) · Journal of Nutrition in Gerontology and Geriatrics · doi:10.1080/21551197.2011.623931 · Cited by 187 · see citing works
Frailty and muscle metabolism dysregulation in the elderly
Evans, W. J., Paolisso, G., Abbatecola, A. M., Corsonello, A., Bustacchini, S., Strollo, F., & Lattanzio, F. (2010) · Biogerontology · doi:10.1007/s10522-010-9297-0 · Cited by 173 · see citing works
“Other operational definitions also include clinical parameters of depression, urinary incontinence and cognitive impairment (Rockwood et al. 2005; Rolfson et al. 2006 ).”
BackgroundFrailty and postoperative outcomes in patients undergoing surgery for degenerative spine disease
Flexman, A. M., Charest-Morin, R., Stobart, L., Street, J., & Ryerson, C. J. (2016) · The Spine Journal · doi:10.1016/j.spinee.2016.06.017 · Cited by 177 · see citing works
Frailty and its quantitative clinical evaluation
Moorhouse, P. A., & Rockwood, K. J. (2012) · The Journal of the Royal College of Physicians of Edinburgh · doi:10.4997/jrcpe.2012.412 · Cited by 168 · see citing works
Self-citationCohen, C. I., Benyaminov, R., Rahman, M., Ngu, D., & Reinhardt, M. (2022) · Medical Clinics of North America · doi:10.1016/j.mcna.2022.04.006 · Cited by 193 · see citing works
Clegg, A. P., & Young, J. B. (2011) · Clinical Medicine · doi:10.7861/clinmedicine.11-1-72 · Cited by 181 · see citing works
Doody, P., Lord, J. M., Greig, C. A., & Phillips, A. C. (2022) · Gerontology · doi:10.1159/000528561 · Cited by 198 · see citing works
Predictive value of geriatric assessment for patients older than 70 years, treated with chemotherapy
Aaldriks, A. A., Maartense, E., le Cessie, S., Giltay, E. J., Verlaan, H. A. C. M., van der Geest, L. G., Kloosterman-Boele, W. M., Peters-Dijkshoorn, M. T., Blansjaar, B. A., van Schaick, H. W., et al. (2010) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2010.05.009 · Cited by 175 · see citing works
“[35], the Edmonton Frailty scale [36] and the Groningen Frailty Indicator [37].”
MethodHewitt, J., Carter, B., McCarthy, K. L., Pearce, L. E., Law, J., Wilson, F., Tay, H. S., McCormack, C., Stechman, M., Moug, S. J., et al. (2019) · Age and Ageing · doi:10.1093/ageing/afy217 · Cited by 163 · see citing works
Jürschik, P., Nunin, C., Botigué, T., Escobar, M. A., Lavedán, A., & Viladrosa, M. (2012) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2012.07.002 · Cited by 174 · see citing works
Comprehensive Geriatric assessment and its clinical impact in oncology
Maas, H. A. A. M., Janssen-Heijnen, M. L. G., Rikkert, M. G. M. O., & Wymenga, A. N. M. (2007) · European Journal of Cancer · doi:10.1016/j.ejca.2007.08.002 · Cited by 172 · see citing works
Frailty markers comprise blood metabolites involved in antioxidation, cognition, and mobility
Kameda, M., Teruya, T., Yanagida, M., & Kondoh, H. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1920795117 · Cited by 169 · see citing works
“mobility (TUG test), and fundamental daily activity by questionnaire, in which a score ≥7 indicates frailty (range, 0 to 17) (16).”
BackgroundMethodSocial Frailty and Functional Disability: Findings From the Singapore Longitudinal Ageing Studies
Teo, N., Gao, Q., Nyunt, M. S. Z., et al. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.04.015 · Cited by 162 · see citing works
Caraux-Paz, P., Diamantis, S., de Wazières, B., & Gallien, S. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10245888 · Cited by 174 · see citing works
Drug Metabolism in Older People--A Key Consideration in Achieving Optimal Outcomes With Medicines
McLachlan, A. J., & Pont, L. G. (2012) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glr118 · Cited by 172 · see citing works
Prevalence of frailty and its association with mortality in general surgery
Hewitt, J., Moug, S. J., Middleton, M., Chakrabarti, M., Stechman, M. J., & McCarthy, K. (2014) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2014.05.022 · Cited by 171 · see citing works
Functional Impairment, Disability, and Frailty in Adults Aging with HIV-Infection
Erlandson, K. M., Schrack, J. A., Jankowski, C. M., Brown, T. T., & Campbell, T. (2014) · Current HIV/AIDS Reports · doi:10.1007/s11904-014-0215-y · Cited by 159 · see citing works
Identification of Frailty in Chronic Heart Failure
Sze, S., Pellicori, P., Zhang, J., Weston, J., & Clark, A. L. (2019) · JACC Heart Failure · doi:10.1016/j.jchf.2018.11.017 · Cited by 170 · see citing works
Edoxaban Versus Warfarin in Atrial Fibrillation Patients at Risk of Falling
Steffel, J., Giugliano, R. P., D, E. B. M., Murphy, S. A., Mercuri, M. F., Choi, Y., Aylward, P. E., White, H. D., Zamorano, J. L., Antman, E. M., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.06.034 · Cited by 166 · see citing works
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Armstrong, J. J., Stolee, P., Hirdes, J. P., & Poss, J. W. (2010) · Age and Ageing · doi:10.1093/ageing/afq121 · Cited by 163 · see citing works
“The second measure examined is the Edmonton Frail Scale (EFS), a brief multidimensional clinical measure designed for geriatricians in both inpatient and outpatient settings [14].”
MethodSmoking as a predictor of frailty: a systematic review
Kojima, G., Iliffe, S., & Walters, K. R. (2015) · BMC Geriatrics · doi:10.1186/s12877-015-0134-9 · Cited by 163 · see citing works
“There have been further alternative measurements of frailty proposed in the literature [7], including a range of newer brief measures designed to be used in clinical practice such as FRAIL scale [8] or Edmonton Frail Scale [9].”
MethodLee, H.-J., & Son, Y. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18073471 · Cited by 158 · see citing works
“Whereas the Edmonton Frail Scale is a multiple domain tool that assesses various dimensions of frailty, including cognitive state, degree of dependence, social support, a physiological dimension, and a psychological dimension [46].”
BackgroundFabrício, D. D. M., Chagas, M. H. N., & Diniz, B. S. (2020) · Translational research · doi:10.1016/j.trsl.2020.01.002 · Cited by 148 · see citing works
da Câmara, S. M. A., Alvarado, B., Guralnik, J. M., Guerra, R. O., & Maciel, Á. C. C. (2012) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2012.00920.x · Cited by 152 · see citing works
Dong, L., Liu, N., Tian, X., Qiao, X., Gobbens, R. J. J., Kane, R. L., & Wang, C. (2017) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2017.07.001 · Cited by 148 · see citing works
“Frailty must consider the complex interplay of manifold factors (MarkleReid & Browne, 2003; Rolfson et al., 2006).”
BackgroundFrailty in the elderly: prevalence and associated factors
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“be a robust instrument for the capacity to evaluate the elderly in a multidimensional way, since there are nine aspects covered (cognition, state of health, functional independence, social support, medication use, nutrition, mood, urinary continence and functional performance)(9-10).”
Aceto, P., Incalzi, R. A., Bettelli, G., Carron, M., Chiumiento, F., Corcione, A., Crucitti, A., Maggi, S., Montorsi, M., Pace, M. C., et al. (2020) · Aging Clinical and Experimental Research · doi:10.1007/s40520-020-01624-x · Cited by 153 · see citing works
Huang, C., Hwang, A., Liu, L.-K., Lee, W., Chen, L.-Y., Peng, L.-N., Lin, M.-H., & Chen, L.-K. (2015) · Rejuvenation Research · doi:10.1089/rej.2015.1710 · Cited by 137 · see citing works
The comprehensive frailty assessment instrument: Development, validity and reliability
Witte, N. D., Gobbens, R. J. J., Donder, L. D., Dury, S., Buffel, T., Schols, J. M. G. A., & Verté, D. (2013) · Geriatric Nursing · doi:10.1016/j.gerinurse.2013.03.002 · Cited by 139 · see citing works
Aging, frailty and complex networks
Mitnitski, A., Rutenberg, A. D., Farrell, S. R. M., & Rockwood, K. J. (2017) · Biogerontology · doi:10.1007/s10522-017-9684-x · Cited by 129 · see citing works
“Other scales include neuro-physiological characteristics (Rolfson et al. 2006) or psychometric measurements (Gobbens et al. 2010).”
BackgroundSelf-citationPeri‐operative optimisation of elderly and frail patients: a narrative review
Chan, S. P., Ip, K. Y., & Irwin, M. G. (2019) · Anaesthesia · doi:10.1111/anae.14512 · Cited by 132 · see citing works
“The ‘get-up-and-go’ test of the EFS has been shown to predict morbidity and mortality across surgical specialties [34].”
BackgroundHogan, D. B., Maxwell, C. J., Afilalo, J., Arora, R. C., Bagshaw, S. M., Basran, J., Bergman, H., Bronskill, S. E., Carter, C., Dixon, E., et al. (2017) · Canadian Geriatrics Journal · doi:10.5770/cgj.20.240 · Cited by 129 · see citing works
Self-citationFhon, J. R. S., Rodrigues, R. A. P., Neira, W. F., Huayta, V. M. R., Robazzi, M. L. D. C. C., Universidad de Ciencias y Humanidades, P., & Universidad Nacional Mayor de San Marcos, P. (2016) · Revista da Escola de Enfermagem da USP · doi:10.1590/s0080-623420160000700018 · Cited by 131 · see citing works
- Authors
- Rolfson, D. B., Majumdar, S. R., Tsuyuki, R. T., Tahir, A., & Rockwood, K.
- Affiliations
- University of Alberta (CA)
- 48 Patterson Drive SW, Calgary, Alberta, Canada T3H 2B7
- Dalhousie University (CA)
- Corresponding author
- Rolfson, Darryl B
- Venue
- Age and Ageing
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-06-06
- Volume
- 35
- Issue
- 5
- Pages
- 526-529
- ISSN
- 0002-0729 (ISSN-L)
- 1468-2834
- PMC
- PMC5955195
- OpenAlex
- W2103940618
- Cited by
- 1,643
- References
- 27
- Citations by year
- 2026: 141 · 2025: 171 · 2024: 167 · 2023: 154 · 2022: 138 · 2021: 155 · 2020: 157 · 2019: 111 · 2018: 90 · 2017: 76 · 2016: 62 · 2015: 48 · 2014: 33 · 2013: 31 · 2012: 34
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Age and Ageing (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- University of Alberta
- Fondation pour la Recherche Médicale
- Dalhousie University
- Alberta Heritage Foundation for Medical Research
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
- Keywords
- Edmonton Frail Scale, frailty assessment, frailty screening, comprehensive geriatric assessment, scale validity, test-retest reliability, inter-rater reliability, older adults, primary care
- MeSH terms
- Activities of Daily Living, Affect, Aged, Aged, 80 and over, Cognition, Postural Balance, Female, Humans, Male, Quality of Life, Geriatric Assessment, Nutrition Assessment, Frail Elderly
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