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Cited by 349

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Omalizumab treatment downregulates dendritic cell FcεRI expression

Prussin, Calman, Griffith, Daniel T, Boesel, Kevin M, Lin, Henry, Foster, Barbara, Casale, Thomas B·2003·Journal of Allergy and Clinical Immunology
DOI 10.1016/j.jaci.2003.10.003
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Abstract

Abstract Background Dendritic cells (DCs) are potent antigen-presenting cells that express FceRI, the high-affinity IgE receptor. Although the downregulation of basophil FceRI during anti-IgE therapy with omalizumab is well documented, its effect on FceRI expression by DCs has not been reported. Objective We hypothesized that IgE regulates surface FceRI expression by DCs in vivo and that, consequently, anti-IgE therapy decreases FceRI expression by DCs. Methods In a randomized, double-blind, placebo-controlled clinical trial 24 subjects (16 receiving omalizumab and 8 receiving placebo) with seasonal allergic rhinitis received the study drug on days 0 and 28. Serial blood samples drawn on days 0, 7, 14, 28, and 42 were analyzed for precursor DC1 (pDC1) and pDC2 surface expression of FceRIα by using flow cytometry. Results Omalizumab caused a significant decrease in surface FceRI expression at all time points examined in both the pDC1 and pDC2 subsets. No significant change was seen with placebo. The maximum decrease in FceRI expression in the omalizumab group was 52% and 83%, respectively, for the pDC1 and pDC2 subsets. The decrease in FceRI expression by both pDC subsets correlated with the decrease in serum-free IgE and was of a similar magnitude to that found in basophils. A 10-fold decrease in IgE corresponded to a 42% and 54% decrease in surface FceRI expression by the pDC1 and pDC2 subsets, respectively. Conclusion These results demonstrate that anti-IgE therapy causes a rapid decrease in DC surface FceRI expression and establish that IgE is an important regulator of FceRI expression by DCs.

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Metadata

Authors
Prussin, C., Griffith, D. T., Boesel, K. M., Lin, H., Foster, B., & Casale, T. B.
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2003-12
Volume
112
Issue
6
Pages
1147-1154
ISSN
0091-6749 (ISSN-L)
DOI
10.1016/j.jaci.2003.10.003
OpenAlex
W2009608314
Cited by
349
References
23
FWCI
6.72
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Omalizumab treatment downregulates dendritic cell FcεRI expression. https://app.cochat.ai/papers/10.1016/j.jaci.2003.10.003
The paper
Prussin, C., Griffith, D. T., Boesel, K. M., Lin, H., Foster, B., & Casale, T. B. (2003). Omalizumab treatment downregulates dendritic cell FcεRI expression. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2003.10.003

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.