Rhinosinusitis: Establishing definitions for clinical research and patient care
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CRS patients must have objective evidence of sinonasal inflammation on nasal endoscopy (polyps, edema, mucopurulent rhinorrhea) or CT scans of the sinuses.
“In addition, patients must have objective evidence of sinonasal inflammation on either nasal endoscopy (polyps, edema, mucopurulent rhinorrhea) or on CT scans of the sinuses.137,138,266,267”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [267]
The consensus research definitions (page not provided) require objective evidence of CRS, including endoscopic findings such as polyps, discolored mucus, or edema. But they require a positive sinus CT as well as examination—not either one alone. The patient-care definitions (page not provided) say CT is not essential for clinical diagnosis and can establish it independently of examination only rarely. (LLM, conf=0.87)
Experimental — accuracy not yet measuredCRS is an inflammatory condition of the sinonasal cavity persisting for more than 12 weeks with at least 2 symptoms of nasal obstruction and congestion, mucopurulent nasal drainage, facial pressure or pain, and anosmia or hyposmia.
“CRS is an inflammatory condition of the sinonasal cavity persisting for more than 12 weeks with at least 2 symptoms of nasal obstruction and congestion, mucopurulent nasal drainage (anterior or posterior), facial pressure or pain, and anosmia/hyposmia.1,137,138,266,267”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [267]
The consensus research definitions section describes CRS as inflammation lasting beyond 12 weeks and lists the same symptoms, with two or more making CRS strongly suspected. It does not treat those symptoms alone as an established diagnosis: objective documentation is required, and the paper notes that CRS can occasionally be diagnosed from incidental imaging findings without symptoms. No page number is available in our copy. (LLM, conf=0.84)
Experimental — accuracy not yet measuredCRS is divided into 2 main phenotypic groups: CRSwNP and CRSsNP.
“CRS is divided into 2 main phenotypic groups: CRSwNP and CRSsNP.”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [267]
ARS is defined as sudden onset of sinonasal symptoms with sinonasal inflammation lasting less than 4 weeks.
“ARS is defined as the sudden onset of sinonasal symptoms with associated sinonasal inflammation that lasts less than 4 weeks.1,137,138,266,267”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [267]
ARS symptoms include nasal congestion, nasal obstruction or nasal discharge, and facial pressure or pain, or anosmia or hyposmia.
“Symptoms include nasal congestion, nasal obstruction or nasal discharge, and facial pressure or pain, or anosmia/hyposmia.”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [267]
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“symptoms of airway hyperresponsiveness increase significantly over those of nonsensitized individuals in similar situations.(79) Virtually all studies of the pathophysiology of AFRS have been based on the premise that IgEmediated allergy to one or more fungi underlie the disease, with the predominant finding of eosino…”
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- Authors
- Meltzer, E. O., Hamilos, D. L., Hadley, J. A., Lanza, D. C., Marple, B. F., Nicklas, R. A., Bachert, C., Baraniuk, J., Baroody, F. M., Benninger, M. S., Brook, I., Chowdhury, B. A., Druce, H. M., Durham, S., Ferguson, B., Gwaltney, J. M., Kaliner, M., Kennedy, D. W., Lund, V., Naclerio, R., Pawankar, R., Piccirillo, J. F., Rohane, P., Simon, R., Slavin, R. G., Togias, A., Wald, E. R., & Zinreich, S. J.
- Affiliations
- Allergy and Asthma Medical Group and Research Center (US)
- Harvard University (US)
- University of Rochester (US)
- Florida Institute of Oceanography (US)
- The University of Texas Southwestern Medical Center (US)
- George Washington University (US)
- Ghent University (BE)
- Georgetown University (US)
- University of Chicago (US)
- Henry Ford Health (US)
- Walter Reed National Military Medical Center (US)
- Rutgers New Jersey Medical School (US)
- Imperial College London (GB)
- University of Pittsburgh (US)
- University of Virginia (US)
- University of Pennsylvania (US)
- University College London (GB)
- Nippon Medical School (JP)
- Washington University in St. Louis (US)
- Celgene (United States) (US)
- Scripps Clinic (US)
- Saint Louis University (US)
- Johns Hopkins University (US)
- Corresponding author
- Meltzer, Eli O.
- ORCID
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2004-12
- Volume
- 114
- Issue
- 6
- Pages
- 155-212
- ISSN
- 0091-6749 (ISSN-L)
- PMC
- PMC7119142
- OpenAlex
- W2129761445
- Cited by
- 854
- References
- 363
- Citations by year
- 2026: 13 · 2025: 23 · 2024: 12 · 2023: 20 · 2022: 33 · 2021: 22 · 2020: 45 · 2019: 39 · 2018: 46 · 2017: 39 · 2016: 54 · 2015: 51 · 2014: 55 · 2013: 55 · 2012: 59
- FWCI
- 36.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Funders
- National Institutes of Health
- Georgetown University
- Topics
- Health Sciences › Medicine › Otorhinolaryngology › Sinusitis and nasal conditions
- Health Sciences › Medicine › Surgery › Nasal Surgery and Airway Studies
- Health Sciences › Medicine › Infectious Diseases › Otolaryngology and Infectious Diseases
- Keywords
- sinusitis, clinical definition, consensus definition, acute bacterial rhinosinusitis, allergic fungal rhinosinusitis, clinical trial design, quality of life instruments, radiographic evaluation, diagnosis
- MeSH terms
- Clinical Trials as Topic, Patient Care, Humans, Rhinitis, Sinusitis, Guidelines as Topic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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