The Origins of Asthma and Chronic Obstructive Pulmonary Disease in Early Life
Open accessAbstract
Results from birth cohort and cross-sectional studies of young children with wheezing have uncovered strong associations between both lung function and immune responses in early life and the subsequent development of persistent wheezing and chronic airway obstruction up to mid-adulthood. It is now apparent that the pattern of bronchial hyperresponsiveness, deficits in lung function, and structural airway remodeling that are characteristic of asthma may be already established during the preschool years in most patients. Interactions between acute viral infections, especially those due to rhinovirus and respiratory syncytial virus, and exposure to perennial aeroallergens may induce persistent alterations in immune responses and airway function in susceptible subjects. Similarly, deficits in airway function present shortly after birth predict airflow limitation in early adult life, which in turn is a strong predisposing factor for chronic obstructive pulmonary disease. The fact that these alterations are more likely to occur during early life and even in utero than later during childhood suggests that there a developmental window of susceptibility during which exposures can disrupt normal growth trajectories. Novel strategies for primary prevention of chronic respiratory diseases will be based on the identification of the genetic and environmental factors that interactively cause these disruptions.
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How lungs develop before birth and during childhood shapes lung function across life.
“Because lung development in utero and in childhood contributes to life-long trajectories of lung function,”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [316]
Nicotine exposure before birth might raise later-life risk of asthma and COPD in middle-aged and older people.
“the effects of prenatal exposure to nicotine could have negative effects on respiratory health in middle-aged and older adults, including increased risk of asthma and chronic obstructive pulmonary disease (COPD).(315-317)”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [316]
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- Authors
- Martinez, F. D.
- Affiliations
- University of Arizona (US)
- Corresponding author
- Martinez, Fernando D.
- Venue
- Proceedings of the American Thoracic Society
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-05-01
- Volume
- 6
- Issue
- 3
- Pages
- 272-277
- ISSN
- 1546-3222 (ISSN-L)
- 1943-5665
- PMC
- PMC2677402
- OpenAlex
- W2122312585
- Cited by
- 242
- References
- 53
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 11 · 2023: 6 · 2022: 12 · 2021: 19 · 2020: 13 · 2019: 10 · 2018: 15 · 2017: 14 · 2016: 19 · 2015: 16 · 2014: 12 · 2013: 19 · 2012: 21
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the American Thoracic Society (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (U10HL064307, HL-056177, HL064307, R01HL080083, R01HL056177, HL080083)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Keywords
- asthma, chronic obstructive pulmonary disease, persistent wheezing, early life exposure, airway hyperresponsiveness, lung function, airway remodeling, respiratory viral infections, rhinovirus, respiratory syncytial virus, aeroallergens, immune response, primary prevention, preschool children
- MeSH terms
- Adult, Asthma, Child, Cross-Sectional Studies, Humans, Lung Diseases, Obstructive, Cohort Studies
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