Update on glucocorticoid action and resistance

Glucocorticoid Inhibition of Granulocyte Macrophage–Colony-Stimulating Factor from T cells Is Independent of Control by Nuclear Factor-κB and Conserved Lymphokine Element 0

Bergmann, M. W., Staples, K. J., Smith, S. J., Barnes, P. J., & Newton, R. C. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2003-0295oc · Cited by 45

Serum Total Antioxidant Status in Severe Exacerbation of Asthma: Correlation with the Severity of the Disease

Katsoulis, K., Kontakiotis, T., Leonardopoulos, I., Kotsovili, A., Legakis, I., & Patakas, D. (2003) · Journal of Asthma · doi:10.1081/jas-120023575 · Cited by 45

Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS Task Force on Difficult/Therapy-Resistant Asthma. European Respiratory Society

Chung, K. F., Godard, P., Adelroth, E., et al. (1999) · Data Archiving and Networked Services (DANS) · Cited by 45

Hormone-induced hyperphosphorylation of specific phosphorylated sites in the mouse glucocorticoid receptor

Bodwell, J. E., Hu, J.-M., Ortí, E., & Munck, A. U. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(94)00157-h · Cited by 42

Glucocorticoid resistance — what is known?

Norman, M., & Hearing, S. D. (2002) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(02)00232-1 · Cited by 41

Inhibition of tristetraprolin expression by dexamethasone in activated macrophages

Jalonen, U., Lahti, A., Korhonen, R., Kankaanranta, H., & Moilanen, E. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.11.027 · Cited by 41

Failure of montelukast to reduce sputum eosinophilia in high-dose corticosteroid-dependent asthma

Jayaram, L., Duong, M., Pizzichini, M. M. M., Pizzichini, E., Kamada, D., Efthimiadis, A., & Hargreave, F. E. (2005) · European Respiratory Journal · doi:10.1183/09031936.04.00008104 · Cited by 41

Bronchial inflammation in corticosteroid‐sensitive and corticosteroid‐resistant asthma at baseline and on oral corticosteroid treatment

Chakir, J., Hamid, Q. A., Bossé, M., et al. (2002) · Clinical & Experimental Allergy · doi:10.1046/j.0954-7894.2002.01323.x · Cited by 38

Fluticasone propionate in Crohn's disease.

de Kaski, M. C., Peters, A. M., Lavender, J. P., & Hodgson, H. J. F. (1991) · Gut · doi:10.1136/gut.32.6.657 · Cited by 35

Asthma Refractory to Glucocorticoids

Corrigan, C. J. (2002) · American Journal of Respiratory Medicine · doi:10.1007/bf03257162 · Cited by 30

Hypothalamic-Pituitary-Adrenal Axis in Corticosteroid-Resistant Bronchial Asthma

Lane, S. M., Atkinson, B., Swaminathan, R., & Lee, T. H. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.2.8564097 · Cited by 30

Species-specific differences in the glucocorticoid receptor transactivation function upon binding with betamethasone-esters

Tanigawa, K., Nagase, H., Ohmori, K., Tanaka, K., Miyake, H., Kiniwa, M., & Ikizawa, K. (2002) · International Immunopharmacology · doi:10.1016/s1567-5769(02)00036-x · Cited by 26

Allergen sensitization evaluation and allergen avoidance education in an inner-city adult cohort with persistent asthma

Busse, P. J., WANG, J. J., & Halm, E. A. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.03.031 · Cited by 25

Shuttling components of nuclear import machinery involved in nuclear translocation of steroid receptors exit nucleus via exportin-1/CRM-1* independent pathway

Kumar, S., Chaturvedi, N. K., Nishi, M., Kawata, M., & Tyagi, R. K. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2004.03.003 · Cited by 25

Kinase Targets and Inhibitors for the Treatment of Airway Inflammatory Diseases

Adcock, I. M., & Caramori, G. (2004) · BioDrugs · doi:10.2165/00063030-200418030-00003 · Cited by 21

Decreased glucocorticoid binding affinity to glucocorticoid receptor is important in the poor response to steroid therapy of older-aged patients with severe bronchial asthma.

Cho, Y.-J., Lee, K. E., & Lee, K. E. (2004) · PubMed · Cited by 21

Expression of c-fos, rather than c-jun or glucocorticoid-receptor mRNA, correlates with decreased glucocorticoid response of peripheral blood mononuclear cells in asthma

Takahashi, E., Onda, K., Hirano, T., Oka, K., Maruoka, N., Tsuyuguchi, M., Matsumura, Y., Niitsuma, T., & Hayashi, T. (2002) · International Immunopharmacology · doi:10.1016/s1567-5769(02)00083-8 · Cited by 20

Clinical outcomes of steroid-insensitive asthma

Wamboldt, F. S., Spahn, J. D., Klinnert, M. D., Wamboldt, M. Z., Gavin, L. A., Szefler, S. J., & Leung, D. Y. M. (1999) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)63513-2 · Cited by 19

Glucocorticoid Receptors: ATP and Cell Cycle Dependence, Phosphorylation, and Hormone Resistance

Bodwell, J. E., Hu, J.-M., Hu, L.-M., et al. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm/154.2_pt_2.s2 · Cited by 15

Dexamethasone inhibits phosphorylation of histone H3 at serine 10

Hasegawa, Y., Tomita, K., Watanabe, M., Yamasaki, A., Sano, H., Hitsuda, Y., & Shimizu, E. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.231 · Cited by 7

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

Chung, K. F., Wenzel, S. E., Brozek, J. L., Bush, A., Castro, M., Sterk, P. J., Adcock, I. M., Bateman, E. D., Bel, E. H., Bleecker, E. R., et al. (2014) · European Respiratory Journal · doi:10.1183/09031936.00202013 · Cited by 3,926

Integrating cell-signalling pathways with NF-κB and IKK function

Perkins, N. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2083 · Cited by 2,350

Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma

Bousquet, J., Mantzouranis, E., Cruz, A. A., Aït-Khaled, N., Baena-Cagnani, C. E., Bleecker, E. R., Brightling, C. E., Burney, P., Bush, A., Busse, W. W., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.07.019 · Cited by 741

Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction

Chung, K. F., & Adcock, I. M. (2008) · European Respiratory Journal · doi:10.1183/09031936.00018908 · Cited by 599

Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples

Baines, K. J., Simpson, J. L., Wood, L. G., Scott, R. J., & Gibson, P. G. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.10.024 · Cited by 298