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Quantitative and functional impairment of pulmonary CD4+CD25hi regulatory T cells in pediatric asthma

Hartl, Dominik, Koller, Barbara, Mehlhorn, Alexander T., Reinhardt, Dietrich, Nicolai, Thomas, Schendel, Dolores J., Griese, Matthias, Krauss-Etschmann, Susanne·2007·Journal of Allergy and Clinical Immunology
DOI 10.1016/j.jaci.2007.02.023
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Abstract

Background Asthma is characterized by a T(H)2 immune response. CD4(+)CD25(hi) regulatory T cells (Tregs) have been proposed to prevent allergic diseases through suppression of T(H)2 responses. Objective We sought to investigate the role of CD4(+)CD25(hi) T cells in children with asthma. Methods CD4(+)CD25(hi) Tregs and forkhead/winged-helix transcription factor FOXP3 mRNA levels were quantified in peripheral blood and bronchoalveolar lavage fluid (BALF) of 18 children with asthma, 10 children with chronic cough, and 13 control subjects without lung diseases. CD4(+)CD25(hi) T cells were isolated from peripheral blood and BALF of asthmatic patients and control subjects, and their capacity to suppress proliferation and cytokine/chemokine production of autologous responder T cells was analyzed. Results CD4(+)CD25(hi) T cells were decreased in BALF of asthmatic children compared with values in children with cough or control subjects. In children with asthma, inhaled corticosteroid treatment was associated with increased percentages of CD4(+)CD25(hi) T cells in peripheral blood and BALF. Isolated BALF and peripheral blood CD4(+)CD25(hi) T cells from nonasthmatic subjects suppressed proliferation and cytokine/chemokine production by CD4(+)CD25(-) responder T cells. BALF CD4(+)CD25(hi) T cells from asthmatic subjects failed to suppress proliferation and production of T(H)2-associated cytokines and chemokines by CD4(+)CD25(-) responder T cells, which was restored after use of inhaled…

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Metadata

Authors
Hartl, D., Koller, B., Mehlhorn, A. T., Reinhardt, D., Nicolai, T., Schendel, D. J., Griese, M., & Krauss-Etschmann, S.
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2007-05
Volume
119
Issue
5
Pages
1258-1266
ISSN
0091-6749
DOI
10.1016/j.jaci.2007.02.023
Cited by
354
References
0
Language
en
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