The development and function of regulatory T cells

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989 · see citing works

Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>

Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187 · see citing works

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745 · see citing works

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992 · see citing works

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

Park, J., Adoro, S., Guinter, T. I., Erman, B., Alag, A., Catálfamo, M., Kimura, M. Y., Cui, Y., Lucas, P. J., Gress, R. E., et al. (2010) · Nature Immunology · doi:10.1038/ni.1840 · Cited by 5,835 · see citing works

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., & Toda, M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.3.1151 · Cited by 5,608 · see citing works

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

Curiel, T. J., Coukos, G., Zou, L., Alvarez, X., Cheng, P., Mottram, P., Evdemon-Hogan, M., Conejo-Garcia, J. R., Zhang, L., Burow, M., et al. (2004) · Nature Medicine · doi:10.1038/nm1093 · Cited by 5,151 · see citing works

IL-17 and th17 cells

Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873 · see citing works

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

Chen, W., Jin, W., Hardegen, N. J., Lei, K.-J., Li, L., Marinos, N. J., McGrady, G., & Wahl, S. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030152 · Cited by 4,678 · see citing works

Interleukin-10-deficient mice develop chronic enterocolitis

Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248 · see citing works

The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

Zhang, L., Xu, J., Zhang, X., Zhang, Y., Wang, L., Huang, X., & Xu, Z. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479442 · Cited by 4,090 · see citing works

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

Groux, H., O’Garra, A., Bigler, M., Rouleau, M., Antonenko, S. V., de Vries, J. E., & Roncarolo, M. G. (1997) · Nature · doi:10.1038/39614 · Cited by 3,588 · see citing works

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M., Ferguson, P., Whitesell, L., Kelly, T., Saulsbury, F., Chance, P., & Ochs, H. (2001) · Nature Genetics · doi:10.1038/83713 · Cited by 3,576 · see citing works

How regulatory T cells work

Vignali, D. A. A., Collison, L. W., & Workman, C. J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2343 · Cited by 3,463 · see citing works

N aturally A rising CD4+R egulatory T C ells for I mmunologic S elf -T olerance and N egative C ontrol of I mmune R esponses

Sakaguchi, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141122 · Cited by 3,293 · see citing works

CTLA-4 Control over Foxp3 ⁺ Regulatory T Cell Function

Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T., & Sakaguchi, S. (2008) · Science · doi:10.1126/science.1160062 · Cited by 2,956 · see citing works

An essential role for Scurfin in CD4+CD25+ T regulatory cells

Khattri, R., Cox, T., Yasayko, S.-A., & Ramsdell, F. (2003) · Nature Immunology · doi:10.1038/ni909 · Cited by 2,860 · see citing works

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

Coombes, J. L., Siddiqui, K. R. R., Arancibia-Cárcamo, C. V., Hall, J. A., Sun, C., Belkaid, Y., & Powrie, F. M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070590 · Cited by 2,708 · see citing works

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

Sakaguchi, S. (2005) · Nature Immunology · doi:10.1038/ni1178 · Cited by 2,669 · see citing works

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

Liu, W., Putnam, A. L., Xu-yu, Z., Szot, G. L., Lee, M. R., Zhu, S., Gottlieb, P. A., Kapranov, P., Gingeras, T. R., de St. Groth, B. F., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060772 · Cited by 2,606 · see citing works

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

Anderson, M. S., Venanzi, E. S., Klein, L., Chen, Z., Berzins, S. P., Turley, S. J., von Boehmer, H., Bronson, R. T., Dierich, A., Benoist, C. O., et al. (2002) · Science · doi:10.1126/science.1075958 · Cited by 2,474 · see citing works

Intraepithelial CD8 + tumor-infiltrating lymphocytes and a high CD8 + /regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

Sato, E., Olson, S. H., Ahn, J., Bundy, B. N., Nishikawa, H., Qian, F., Jungbluth, A. A., Frosina, D., Gnjatic, S., Ambrosone, C. B., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509182102 · Cited by 2,375 · see citing works

Ido expression by dendritic cells: tolerance and tryptophan catabolism

Mellor, A. L., & Munn, D. H. (2004) · Nature Reviews Immunology · doi:10.1038/nri1457 · Cited by 2,341 · see citing works

The inhibitory cytokine IL-35 contributes to regulatory T-cell function

Collison, L., Workman, C., Kuo, T. T., Boyd, K., Wang, Y., Vignali, K. M., Cross, R., Sehy, D., Blumberg, R., & Vignali, D. (2007) · Nature · doi:10.1038/nature06306 · Cited by 2,152 · see citing works

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

Salomon, B. L., Lenschow, D. J., Rhee, L., Ashourian, N., Singh, B., Sharpe, A. H., & Bluestone, J. A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80195-8 · Cited by 2,058 · see citing works

Reciprocal T _H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

Mucida, D., Park, Y., Kim, G., Turovskaya, O., Scott, I., Kronenberg, M., & Cheroutre, H. (2007) · Science · doi:10.1126/science.1145697 · Cited by 1,982 · see citing works

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

Kulkarni, A. B., Huh, C. G., Becker, D., Geiser, A., Lyght, M., Flanders, K. C., Roberts, A. B., Sporn, M. B., Ward, J. M., & Karlsson, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.770 · Cited by 1,967 · see citing works

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

Sun, C., Hall, J. A., Blank, R. B., Bouladoux, N. J., Oukka, M., Mora, J. R., & Belkaid, Y. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070602 · Cited by 1,880 · see citing works

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

Viglietta, V., Baecher‐Allan, C., Weiner, H. L., & Hafler, D. A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031579 · Cited by 1,858 · see citing works

A function for interleukin 2 in Foxp3-expressing regulatory T cells

Fontenot, J. D., Rasmussen, J. P., Gavin, M. A., & Rudensky, A. Y. (2005) · Nature Immunology · doi:10.1038/ni1263 · Cited by 1,819 · see citing works

Regulatory T Cells

Sakaguchi, S. (2000) · Cell · doi:10.1016/s0092-8674(00)80856-9 · Cited by 1,812 · see citing works

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

Belkaid, Y., Piccirillo, C. A., Méndez, S., Shevach, E. M., & Sacks, D. L. (2002) · Nature · doi:10.1038/nature01152 · Cited by 1,726 · see citing works

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

Jordan, M. S., Boesteanu, A. C., Reed, A. J., Petrone, A. L., Holenbeck, A. E., Lerman, M. A., Naji, A., & Caton, A. J. (2001) · Nature Immunology · doi:10.1038/86302 · Cited by 1,661 · see citing works

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

Asseman, C., Mauze, S., Leach, M. W., Coffman, R. L., & Powrie, F. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.7.995 · Cited by 1,617 · see citing works

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

Rubtsov, Y. P., Rasmussen, J. P., Chi, E. Y., Fontenot, J., Castelli, L., Ye, X., Treuting, P., Siewe, L., Roers, A., Henderson, W. R., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.017 · Cited by 1,586 · see citing works

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

Takahashi, T., Kuniyasu, Y., Toda, M., Sakaguchi, N., Itoh, M., Iwata, M., Shimizu, J., & Sakaguchi, S. (1998) · International Immunology · doi:10.1093/intimm/10.12.1969 · Cited by 1,566 · see citing works

Retinoic acid imprints gut-homing specificity on T cells

Iwata, M., Hirakiyama, A., Eshima, Y., Kagechika, H., Kato, C., & Song, S.-Y. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.011 · Cited by 1,541 · see citing works

Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

Shimizu, J., Yamazaki, S., & Sakaguchi, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.10.5211 · Cited by 1,491 · see citing works

Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma

Liyanage, U. K., Moore, T. T., Joo, H., Tanaka, Y., Herrmann, V. M., Doherty, G. M., Drebin, J. A., Strasberg, S. M., Eberlein, T. J., Goedegebuure, P. S., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.5.2756 · Cited by 1,466 · see citing works

Modulation of tryptophan catabolism by regulatory T cells

Fallarino, F., Grohmann, U., Hwang, K. W., Orabona, C., Vacca, C., Bianchi, R., Belladonna, M. L., Fioretti, M. C., Alegre, M., & Puccetti, P. (2003) · Nature Immunology · doi:10.1038/ni1003 · Cited by 1,375 · see citing works

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.

Asano, M., Toda, M., Sakaguchi, N., & Sakaguchi, S. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.2.387 · Cited by 1,328 · see citing works

Natural versus adaptive regulatory T cells

Bluestone, J. A., & Abbas, A. K. (2003) · Nature reviews. Immunology · doi:10.1038/nri1032 · Cited by 1,319 · see citing works

Epigenetic Control of the foxp3 Locus in Regulatory T Cells

Floess, S., Freyer, J., Siewert, C., Baron, U., Olek, S., Polansky, J. K., Schlawe, K., Chang, H., Bopp, T., Schmitt, E., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050038 · Cited by 1,272 · see citing works

Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

Walker, M., Kasprowicz, D. J., Gersuk, V. H., Bénard, A., Landeghen, M. V., Buckner, J. H., & Ziegler, S. F. (2003) · Journal of Clinical Investigation · doi:10.1172/jci19441 · Cited by 1,242 · see citing works

Inducing and expanding regulatory T cell populations by foreign antigen

Kretschmer, K., Apostolou, I., Hawiger, D., Khazaie, K., Nussenzweig, M. C., & von Boehmer, H. (2005) · Nature Immunology · doi:10.1038/ni1265 · Cited by 1,240 · see citing works

Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific

Thornton, A. M., & Shevach, E. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.1.183 · Cited by 1,229 · see citing works

Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

Herold, K. C., Hagopian, W., Auger, J. A., Poumian-Ruiz, E., Taylor, L., Donaldson, D., Gitelman, S. E., Harlan, D. M., Xu, D., Zivin, R. A., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012864 · Cited by 1,222 · see citing works

In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes

Tang, Q., Henriksen, K., Bi, M., Finger, E. B., Szot, G. L., Ye, J., Masteller, E. L., McDevitt, H. O., Bonyhadi, M. L., & Bluestone, J. A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040139 · Cited by 1,219 · see citing works

Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans

Roncarolo, M. G., Gregori, S., Battaglia, M., Bacchetta, R., Fleischhauer, K., & Levings, M. K. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00420.x · Cited by 1,174 · see citing works

In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines

Barrat, F. J., Cua, D. J., Boonstra, A., Richards, D. F., Crain, C., Savelkoul, H. F. J., Malefyt, R. D. W., Coffman, R. L., Hawrylowicz, C. M., & O’Garra, A. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011629 · Cited by 1,161 · see citing works

Foxp3-dependent programme of regulatory T-cell differentiation

Gavin, M. A., Rasmussen, J. P., Fontenot, J. D., Vasta, V., Manganiello, V. C., Beavo, J. A., & Rudensky, A. Y. (2007) · Nature · doi:10.1038/nature05543 · Cited by 1,127 · see citing works

Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer.

Woo, E. Y., Chu, C., Goletz, T. J., Schlienger, K., Yeh, H., Coukos, G., Rubin, S. C., Kaiser, L. R., & June, C. H. (2001) · PubMed · Cited by 1,113 · see citing works

Pillars Article: Control of Regulatory T Cell Development by the Transcription Factor Foxp3 . Science 2003. 299: 1057–1061

Hori, S., Nomura, T., & Sakaguchi, S. (2017) · The Journal of Immunology · doi:10.1093/jimmunol/198.3.981 · Cited by 1,067 · see citing works

Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.

Onizuka, S., Tawara, I., Shimizu, J., Sakaguchi, S., Fujita, T., & Nakayama, E. (1999) · PubMed · Cited by 1,062 · see citing works

The infusion of ex vivo activated and expanded CD4+CD25+ immune regulatory cells inhibits graft-versus-host disease lethality

Taylor, P. A., Lees, C. J., & Blazar, B. R. (2002) · Blood · doi:10.1182/blood.v99.10.3493 · Cited by 1,039 · see citing works

Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance

Cao, X., Cai, S. F., Fehniger, T. A., Song, J., Collins, L. I., Piwnica-Worms, D. R., & Ley, T. J. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.014 · Cited by 1,038 · see citing works

Natural regulatory T cells in infectious disease

Belkaid, Y., & Rouse, B. T. (2005) · Nature Immunology · doi:10.1038/ni1181 · Cited by 1,036 · see citing works

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

Tang, Q., & Bluestone, J. A. (2008) · Nature Immunology · doi:10.1038/ni1572 · Cited by 1,026 · see citing works

Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17–producing T cell responses

Denning, T. L., Wang, Y., Patel, S. R., Williams, I. R., & Pulendran, B. (2007) · Nature Immunology · doi:10.1038/ni1511 · Cited by 995 · see citing works

Tumor-Infiltrating FOXP3 + T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer

Salama, P. R., Phillips, M. R., Grieu, F., Morris, M. J., Zeps, N., Joseph, D. J., Platell, C. F. E., & Iacopetta, B. J. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.7229 · Cited by 992 · see citing works

TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

Marie, J. C., Letterio, J. J., Gavin, M. A., & Rudensky, A. Y. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042276 · Cited by 986 · see citing works

Multiple sclerosis: a complicated picture of autoimmunity

McFarland, H. F., & Martin, R. (2007) · Nature Immunology · doi:10.1038/ni1507 · Cited by 985 · see citing works

Role of interleukin 10 in specific immunotherapy.

Akdiş, C. A., Blesken, T., Akdiş, M., Wüthrich, B., & Blaser, K. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2250 · Cited by 966 · see citing works

Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

Gorelik, L., & Flavell, R. A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80170-3 · Cited by 959 · see citing works

CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor–β–dependent manner

Ghiringhelli, F., Menard, C., Terme, M., Flament, C., Taı̈eb, J., Chaput, N., Puig, P. E., Novault, S., Escudier, B. J., Vivier, É., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051511 · Cited by 948 · see citing works

Cutting Edge: Contact-Mediated Suppression by CD4+CD25+ Regulatory Cells Involves a Granzyme B-Dependent, Perforin-Independent Mechanism

Gondek, D. C., Lu, L., Quezada, S. A., Sakaguchi, S., & Noelle, R. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.1783 · Cited by 943 · see citing works

Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells

Mottet, C., Uhlig, H. H., & Powrie, F. M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.8.3939 · Cited by 928 · see citing works

FOXP3: Of Mice and Men

Ziegler, S. F. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090547 · Cited by 921 · see citing works

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

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Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

Allan, S. E., Crome, S. Q., Crellin, N. K., Passerini, L., Steiner, T. S., Bacchetta, R., Roncarolo, M. G., & Levings, M. K. (2007) · International Immunology · doi:10.1093/intimm/dxm014 · Cited by 872 · see citing works

"Infectious" Transplantation Tolerance

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Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells

Weiner, H. L. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.1820117.x · Cited by 850 · see citing works

Origin of regulatory T cells with known specificity for antigen

Apostolou, I., Sarukhan, A., Klein, L., & von Boehmer, H. (2002) · Nature Immunology · doi:10.1038/ni816 · Cited by 847 · see citing works

All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation

Benson, M. J., Pino-Lagos, K., Rosemblatt, M., & Noelle, R. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070719 · Cited by 847 · see citing works

Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals <i>in vivo</i>

Chen, M.-L., Pittet, M. J., Gorelik, L., Flavell, R. A., Weissleder, R., von Boehmer, H., & Khazaie, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408197102 · Cited by 806 · see citing works

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation

Korn, T., Reddy, J., Gao, W., Bettelli, E., Awasthi, A., Petersen, T. R., Bäckström, B. T., Sobel, R. A., Wucherpfennig, K. W., Strom, T. B., et al. (2007) · Nature Medicine · doi:10.1038/nm1564 · Cited by 803 · see citing works

Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase

Sharma, M. D., Baban, B., Chandler, P., Hou, D., Singh, N., Yagita∥, H., Azuma, M., Blazar, B. R., Mellor, A. L., & Munn, D. H. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31911 · Cited by 791 · see citing works

Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity

Akbari, O., Freeman, G. J., Meyer, E. H., Greenfield, E. A., Chang, T. T., Sharpe, A. H., Berry, G. J., DeKruyff, R. H., & Umetsu, D. T. (2002) · Nature Medicine · doi:10.1038/nm745 · Cited by 791 · see citing works

Cutting Edge: CD4+CD25+ Regulatory T Cells Suppress Antigen-Specific Autoreactive Immune Responses and Central Nervous System Inflammation During Active Experimental Autoimmune Encephalomyelitis

Kohm, A. P., Carpentier, P. A., Anger, H. A., & Miller, S. D. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.9.4712 · Cited by 782 · see citing works

CD4 Regulatory T Cells Prevent Lethal Autoimmunity in IL-2Rβ-Deficient Mice

Malek, T. R., Yu, A., Vincek, V., Scibelli, P., & Kong, L. (2002) · Immunity · doi:10.1016/s1074-7613(02)00367-9 · Cited by 781 · see citing works

Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4 + CD25 + regulatory T cell proliferation

Ghiringhelli, F., Puig, P. E., Roux, S., Parcellier, A., Schmitt, E., Solary, É., Kroemer, G., Martin, F., Chauffert, B., & Zitvogel, L. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050463 · Cited by 776 · see citing works

Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

Watanabe, N., Wang, Y.-H., Lee, H. K., Ito, T., Wang, Y., Cao, W., & Liu, Y. (2005) · Nature · doi:10.1038/nature03886 · Cited by 772 · see citing works

B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma

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Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease

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Escape of malaria parasites from host immunity requires CD4+CD25+ regulatory T cells

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Vitamin A Metabolites Induce Gut-Homing FoxP3+ Regulatory T Cells

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CCR7-Dependent Cortex-to-Medulla Migration of Positively Selected Thymocytes Is Essential for Establishing Central Tolerance

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Cutting Edge: Regulatory T Cells Prevent Efficient Clearance of Mycobacterium tuberculosis

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