Cited by 130Asthma and respiratory diseasesChemokine receptors and signalingAllergic Rhinitis and Sensitization

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Contribution of CCR4 and CCR8 to antigen-specific TH2 cell trafficking in allergic pulmonary inflammation

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Mikhak, Zamaneh, Fukui, Mieko, Farsidjani, Alireza, Medoff, Benjamin D., Tager, Andrew M., Luster, Andrew D.·2009·Journal of Allergy and Clinical Immunology

DOI 10.1016/j.jaci.2008.09.049PMC PMC2782398

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Abstract

Background Recruitment of antigen-specific T(H)2 cells into the lung is critical for the development of allergic airway inflammation. Although CCR4 and CCR8 are preferentially expressed on T(H)2 cells and CCR4, CCR8, and CXCR3 ligands are increased in asthma, the specific relative contribution of these receptors to antigen-specific T(H)2 cell trafficking into the allergic lung is not known. Objective To determine the relative contribution of the chemokine receptors CCR4, CCR8, and CXCR3 to antigen-specific T(H)2 cell trafficking in a murine model of allergic pulmonary inflammation. Methods We used adoptive transfer experiments to compare the trafficking of wild-type antigen-specific T(H)2 cells with antigen-specific T(H)2 cells deficient in CCR4, CCR8, or CXCR3. Results CCR4-deficient antigen-specific T(H)2 cells failed to traffic efficiently into the lung and the airways. In contrast, CCR8-deficient antigen-specific T(H)2 cells accumulated in these sites. Trafficking of CXCR3-deficient antigen-specific T(H)2 cells and CCR4-deficient and CCR8-deficient antigen-specific T(H)1 cells were comparable to their wild-type counterparts. Approximately 60% of IL-4-producing antigen-specific T cells expressed CCR4. Disruption of CCR4-mediated antigen-specific T(H)2 cell trafficking decreased the levels of T(H)2-type cytokines in the airways and reduced airway eosinophilia and mucus production. Conclusions Our study demonstrates that CCR4 is required for the efficient entry of antigen-specific T(H)2 cells into the lung and the airways in a murine model of allergic pulmonary inflammation.

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Authors: Mikhak, Z., Fukui, M., Farsidjani, A., Medoff, B. D., Tager, A. M., & Luster, A. D.
Affiliations: Harvard University (US)
ORCID: Medoff, Benjamin D.
Tager, Andrew M.
Luster, Andrew D.
Venue: Journal of Allergy and Clinical Immunology
Publisher: Elsevier BV
Published: 2009-01
Volume: 123
Issue: 1
Pages: 67-73.e3
ISSN: 0091-6749 (ISSN-L)
DOI: 10.1016/j.jaci.2008.09.049
PMC: PMC2782398
OpenAlex: W2043133666
Cited by: 127
References: 38
Citations by year: 2026: 2 · 2025: 6 · 2024: 7 · 2023: 5 · 2022: 8 · 2021: 12 · 2020: 7 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 8 · 2014: 10 · 2013: 12 · 2012: 11
FWCI: 5.33
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Allergy and Clinical Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R01AI040618, K08AI067519, R37AI040618)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
Keywords: CCR4, CCR8, CXCR3, Th2 cells, allergic airway inflammation, asthma, chemokine receptors, IL-4, airway eosinophilia, mucus production, adoptive transfer
MeSH terms: Animals, Antigens, Cell Movement, Disease Models, Animal, Lung, Pneumonia, Respiratory Hypersensitivity, Mice, Knockout, Th1 Cells, Th2 Cells, Mice, Receptors, CXCR3, Receptors, CCR4, Receptors, CCR8

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Contribution of CCR4 and CCR8 to antigen-specific TH2 cell trafficking in allergic pulmonary inflammation

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