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Determinants of allergenicity
Open accessAbstract
The question "What makes an allergen an allergen?" has puzzled generations of researchers, and we still do not have a conclusive answer. Despite increasing knowledge about the molecular and functional characteristics of allergens that have been identified, we still do not fully understand why some proteins are clinically relevant allergens and most are not. Different approaches have been taken to identify the structural and functional features of allergens, aiming at developing methods to predict allergenicity and thus to identify allergens. However, none of these methods has allowed a reliable discrimination between allergenic and nonallergenic compounds on its own. This review sums up diverse determinants that contribute to the phenomenon of allergenicity and outlines that in addition to the structure and function of the allergen, factors derived from allergen carriers, the environment, and the susceptible individual are of importance.
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Cites
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Pöschl, U., & Shiraiwa, M. (2015) · Chemical Reviews · doi:10.1021/cr500487s · Cited by 657
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Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans
Bacher, P., Heinrich, F., Stervbo, U., Nienen, M., Vahldieck, M., Iwert, C., Vogt, K., Kollet, J., Babel, N., Sawitzki, B., et al. (2016) · Cell · doi:10.1016/j.cell.2016.09.050 · Cited by 319
Acute health effects of urban fine and ultrafine particles on children with atopic dermatitis.
Song, S., Lee, K., Lee, Y.-M., Lee, J.-H., Il Lee, S., Yu, S.-D., & Paek, D. (2011) · Environmental Research · doi:10.1016/j.envres.2010.10.010 · Cited by 162
Helminth Allergens, Parasite-Specific IgE, and Its Protective Role in Human Immunity
Fitzsimmons, C. M., Falcone, F. H., & Dunne, D. W. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00061 · Cited by 157
Metadata
- Authors
- Traidl-Hoffmann, C., Jakob, T., & Behrendt, H.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 123
- Issue
- 3
- Pages
- 558-566
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2041265431
- Cited by
- 194
- References
- 7
- FWCI
- 12.98
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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