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Cited by 72Allergic Rhinitis and SensitizationAsthma and respiratory diseasesT-cell and B-cell Immunology

Mechanisms of tolerance to inhalant allergens: the relevance of a modified Th2 response to allergens from domestic animals

Platts-Mills, Thomas A. E., Woodfolk, Judith A., Erwin, Elizabeth A., Aalberse, Rob·2004·Springer Seminars in Immunopathology
DOI 10.1007/s00281-003-0149-8
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Abstract

Subjects can be "non-allergic" because (1) they are not exposed, (2) they fail to make an immune response, or (3) they make an immune response that does not include IgE antibodies (Ab). The recent observation that children raised in a house with a cat are less likely to become allergic to cat allergen than those who only get indirect exposure provides a model to investigate the factors controlling allergic responses. Many of these highly exposed children have made an IgG and IgG4 Ab response to Fel d 1 without IgE Ab, i.e., a "modified Th2 response". In countries where cats are a major cause of asthma, the presence of a cat may decrease the risk of asthma. By contrast, in countries with high exposure to dust mites, cats can induce specific tolerance to Fel d 1 without influencing asthma or the IgE Ab response to dust mites. Using overlapping peptides to investigate T cell responses to Fel d 1 suggests that the structure of the molecule plays a special role in inducing the T cell responses that can "control" the immune response to cat allergens. This T cell response is characterized by high levels of IL-10 production, but this is not restricted to those who have made a modified Th2 response. The results suggest that there are major differences in the immune response to different allergens that profoundly affect their role in allergic disease. Dust mite and cockroach differ from cat (and rat) allergens not only in the quantity inhaled and the particles' sizes but also in the biochemistry of the molecule.

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  • Larger particles are more likely to deposit in the upper respiratory tract and ocular mucosa, commonly leading to symptoms of allergic rhinitis and conjunctivitis.

    “In contrast, larger particles are more likely to deposit in the upper respiratory tract and ocular mucosa, commonly leading to symptoms of allergic rhinitis and conjunctivitis [77].”

    From Advance in Managing Indoor Cat Allergen Proteins: Molecular Insights, Detection, and Control (2025) · cites this paper as [77]

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Authors
Platts-Mills, T. A. E., Woodfolk, J. A., Erwin, E. A., & Aalberse, R.
Affiliations
University of Virginia Health System (US)
ORCID
Venue
Springer Seminars in Immunopathology
Publisher
Springer Science and Business Media LLC
Published
2004-02-01
Volume
25
Issue
3-4
Pages
271-279
ISSN
0344-4325 (ISSN-L)
DOI
10.1007/s00281-003-0149-8
OpenAlex
W2000981638
Cited by
72
References
40
Citations by year
2025: 4 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 1 · 2016: 8 · 2015: 1 · 2014: 4 · 2013: 2 · 2012: 6
FWCI
3.03
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Springer Seminars in Immunopathology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
Fel d 1, cat allergen, IgG4 antibodies, IgE antibodies, house dust mite allergens, cockroach allergens, IL-10, T cell response, allergen structure, asthma risk
MeSH terms
Allergens, Animals, Animals, Domestic, Cats, Humans, Immune Tolerance, Th2 Cells, Inhalation Exposure, Pyroglyphidae

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