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Helminth Allergens, Parasite-Specific IgE, and Its Protective Role in Human Immunity

Fitzsimmons, Colin Matthew, Falcone, Franco Harald, Dunne, David William·2014·Frontiers in Immunology
DOI 10.3389/fimmu.2014.00061PMC PMC3924148
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Figure 1 (A) Homology modeling of the structure of the dominant SmTAL1 allergen in S. mansoni generated using protein homology/analogy recognition engine 2 (PHYRE2) (132), showing the two helix-loop-helix Ca2+-binding motifs within the EF-hand domain. (B) Transverse section of male S. mansoni worm stained for the surface protein SmCD59 (green) and under that in the tegument layer, the EF-hand protein SmTAL1 (red) (courtesy of Prof. Alan Wilson University of York). The walls of the gut also stain for SmTAL1. The location illustrates how this sub-surface allergen in inaccessible to host IgE, unless the tegument layer is damaged, but its physiological function and role in host protection remain to be elucidated.
Figure 1 (A) Homology modeling of the structure of the dominant SmTAL1 allergen in S. mansoni generated using protein homology/analogy recognition engine 2 (PHYRE2) (132), showing the two helix-loop-helix Ca2+-binding motifs within the EF-hand domain. (B) Transverse section of male S. mansoni worm stained for the surface protein SmCD59 (green) and under that in the tegument layer, the EF-hand protein SmTAL1 (red) (courtesy of Prof. Alan Wilson University of York). The walls of the gut also stain for SmTAL1. The location illustrates how this sub-surface allergen in inaccessible to host IgE, unless the tegument layer is damaged, but its physiological function and role in host protection remain to be elucidated.CC BY · PubMed Central

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Metadata

Authors
Fitzsimmons, C. M., Falcone, F. H., & Dunne, D. W.
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2014
Volume
5
ISSN
1664-3224
DOI
10.3389/fimmu.2014.00061
PMC
PMC3924148
Cited by
157
References
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CoChat. (2026). Citation check: Helminth Allergens, Parasite-Specific IgE, and Its Protective Role in Human Immunity. https://app.cochat.ai/papers/10.3389/fimmu.2014.00061
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Fitzsimmons, C. M., Falcone, F. H., & Dunne, D. W. (2014). Helminth Allergens, Parasite-Specific IgE, and Its Protective Role in Human Immunity. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2014.00061