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New Paradigms in Type 2 Immunity
Abstract
Insights into Type 2 Immunity: Different pathogens trigger characteristic immune responses. Although the immune responses against many bacteria, viruses, and fungi are relatively well understood, those against parasitic worms—termed type 2 responses—are much less so. Intriguingly, type 2 responses also mediate responses to allergens and allergic asthma. Pulendran and Artis (p. 431 ) review progress in understanding the signals that trigger type 2 immunity and the cellular responses that these responses initiate.
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“there is evidence that mast cells and IgE, as well as basophils (circulating granulocytes whose functions partially overlap with those of mast cells), can contribute to host defense as components of adaptive type 2 immune responses to helminths, ticks and certain other parasites.”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [4]
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Metadata
- Authors
- Pulendran, B., & Artis, D.
- Venue
- Science
- Published
- 2012-07-27
- Volume
- 337
- Issue
- 6093
- Pages
- 431-435
- ISSN
- 0036-8075
- 1095-9203
- PMC
- PMC4078898
- Cited by
- 401
- References
- 2
- Language
- en
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