Evolving concepts in how viruses impact asthma: A Work Group Report of the Microbes in Allergy Committee of the American Academy of Allergy, Asthma & Immunology
Open accessAbstract
Over the past decade, there have been substantial advances in our understanding about how viral infections regulate asthma. Important lessons have been learned from birth cohort studies examining viral infections and subsequent asthma and from understanding the relationships between host genetics and viral infections, the contributions of respiratory viral infections to patterns of immune development, the impact of environmental exposure on the severity of viral infections, and how the viral genome influences host immune responses to viral infections. Further, there has been major progress in our knowledge about how bacteria regulate host immune responses in asthma pathogenesis. In this article, we also examine the dynamics of bacterial colonization of the respiratory tract during viral upper respiratory tract infection, in addition to the relationship of the gut and respiratory microbiomes with respiratory viral infections. Finally, we focus on potential interventions that could decrease virus-induced wheezing and asthma. There are emerging therapeutic options to decrease the severity of wheezing exacerbations caused by respiratory viral infections. Primary prevention is a major goal, and a strategy toward this end is considered.
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Asthma features deficient antiviral immunity and exacerbations are elicited by respiratory viruses.
“Asthma features deficient antiviral immunity and exacerbations are elicited by respiratory viruses (Altman et al., 2020).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Altman et al., 2020
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The Early Development of Wheeze. Environmental Determinants and Genetic Susceptibility at 17q21
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Vitamin D and the development of allergic disease: how important is it?
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Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations
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Self-citationImmunostimulants for preventing respiratory tract infection in children
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Effects of rhinovirus species on viral replication and cytokine production
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Cadherin-related Family Member 3 Genetics and Rhinovirus C Respiratory Illnesses
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Self-citationEffects of dog ownership in early childhood on immune development and atopic diseases
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Rhinovirus-induced first wheezing episode predicts atopic but not nonatopic asthma at school age
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Self-citationA Mechanistic Role for Type III IFN-λ1 in Asthma Exacerbations Mediated by Human Rhinoviruses
Miller, E. K., Hernandez, J. Z., Wimmenauer, V., Shepherd, B. E., Hijano, D. R., Libster, R., Serra, M. E., Bhat, N., Batalle, J. P., Mohamed, Y. A., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201108-1462oc · Cited by 100 · see citing works
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Self-citationImproved Molecular Typing Assay for Rhinovirus Species A, B, and C
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Comparison of Viral Load in Individuals with and without Asthma during Infections with Rhinovirus
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Self-citationEarly-life respiratory infections and asthma development
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Self-citationThe Role of Probiotics in Preventing Allergic Disease
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Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice
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The Role of IL-15 Deficiency in the Pathogenesis of Virus-Induced Asthma Exacerbations
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Neonatal Rhinovirus Infection Induces Mucous Metaplasia and Airways Hyperresponsiveness
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Rhinovirus and serum IgE are associated with acute asthma exacerbation severity in children
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Vitamin D Supplementation and the Risk of Colds in Patients with Asthma
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Self-citationCat exposure in early life decreases asthma risk from the 17q21 high-risk variant
Stokholm, J., Chawes, B., Vissing, N. H., Bønnelykke, K., & Bisgaard, H. F. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.07.044 · Cited by 53 · see citing works
Carroll, K. N., Gebretsadik, T. S., Escobar, G. J., Wu, P., Li, S. X., Walsh, E. M., Mitchel, E. F., Sloan, C., Dupont, W. D., & Hartert, T. V. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.01.055 · Cited by 50 · see citing works
Genetic associations with viral respiratory illnesses and asthma control in children
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Omalizumab Is Associated with Reduced Acute Severity of Rhinovirus-triggered Asthma Exacerbation
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Community-acquired rhinovirus infection is associated with changes in the airway microbiome
Kloepfer, K. M., Sarsani, V., Poroyko, V. A., Lee, W. M., Pappas, T., Kang, T. J., Grindle, K. A., Bochkov, Y. A., Janga, S. C., Lemanske, R. F., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.01.038 · Cited by 36 · see citing works
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Self-citationCord Blood Cytokines and Acute Lower Respiratory Illnesses in the First Year of Life
Ly, N. P., Rifas‐Shiman, S. L., Litonjua, A. A., Tzianabos, A. O., Schaub, B., Ruiz‐Perez, B., Tantisira, K. G., Finn, P. W., Gillman, M. W., Weiss, S. T., et al. (2006) · PEDIATRICS · doi:10.1542/peds.2006-0524 · Cited by 34 · see citing works
Kennedy, J. L., Koziol‐White, C. J., Jeffus, S. K., Rettiganti, M. R., Fisher, P., Kurten, M., Eze, A., House, S. E., Sikes, J. D., Askew, E., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.11.041 · Cited by 33 · see citing works
Self-citationRhinovirus specific IgE can be detected in human sera
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Farm exposure in early childhood is associated with a lower risk of severe respiratory illnesses
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Patterns of immune development in urban preschoolers with recurrent wheeze and/or atopy
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Self-citationMetabolic control of type 2 immunity
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Host and Viral Determinants of Respiratory Syncytial Virus-induced Airway Mucus
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Self-citationAssociation of newborn screening metabolites with risk of wheezing in childhood
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Self-citation
Flagged first, then by citations
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Viral Infections, the Microbiome, and Probiotics
Harper, A., Vijayakumar, V., Ouwehand, A. C., ter Haar, J., Obis, D., Espadaler, J., Binda, S., Desiraju, S., & Day, R. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.596166 · Cited by 177 · see citing works
The environmental microbiome, allergic disease, and asthma
Kelly, M. S., Bunyavanich, S., Phipatanakul, W., & Lai, P. S. (2022) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2022.06.006 · Cited by 47 · see citing works
The intersect of genetics, environment, and microbiota in asthma-perspectives and challenges
Tang, H. H. F., Teo, S. M., Sly, P. D., Holt, P. G., & Inouye, M. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.08.026 · Cited by 43 · see citing works
- Authors
- Altman, M. C., Beigelman, A., Ciaccio, C., Gern, J. E., Heymann, P. W., Jackson, D. J., Kennedy, J. L., Kloepfer, K., Lemanske, R. F., McWilliams, L. M., Muehling, L., Nance, C., & Peebles, R. S.
- Affiliations
- University of Washington (US)
- Tel Aviv University (IL)
- University of Chicago (US)
- University of Wisconsin–Madison (US)
- University of Virginia Medical Center (US)
- University of Arkansas for Medical Sciences (US)
- Indiana University Indianapolis (US)
- Allergy Clinic of Tulsa (US)
- Baylor College of Medicine (US)
- Vanderbilt University Medical Center (US)
- Corresponding author
- Peebles, R. Stokes
- ORCID
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 145
- Issue
- 5
- Pages
- 1332-1344
- ISSN
- 0091-6749 (ISSN-L)
- PMC
- PMC7577409
- OpenAlex
- W2999404323
- Cited by
- 37
- References
- 132
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 8 · 2021: 7 · 2020: 6
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Purdue University Indianapolis (Indiana University) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01BX004299)
- National Institutes of Health (R21AI145397, R01AI145265, U19AI095227, R01AI124456, U01AI100799, T32AI007496, U19AI104317, UG3/UH3OD023282, UM1AI114271, K08AI1211345)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Keywords
- asthma, respiratory viral infections, wheezing, host genetics, immune system development, environmental exposure, viral genome, bacterial colonization, airway microbiome, gut microbiota, upper respiratory tract infection, asthma exacerbations, prevention, therapeutic interventions
- MeSH terms
- Gastrointestinal Microbiome, Animals, Asthma, Humans, Primary Prevention, Respiratory Sounds, Respiratory Tract Infections, Virus Diseases, Genome, Viral, Disease Progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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