Cited by 37Asthma and respiratory diseasesRespiratory viral infections researchOccupational exposure and asthma

Evolving concepts in how viruses impact asthma: A Work Group Report of the Microbes in Allergy Committee of the American Academy of Allergy, Asthma & Immunology

Open access
Altman, Matthew C., Beigelman, Avraham, Ciaccio, Christina, Gern, James E., Heymann, Peter W., Jackson, Daniel J., Kennedy, Joshua L., Kloepfer, Kirsten +5 more·2020·Journal of Allergy and Clinical Immunology

Abstract

Over the past decade, there have been substantial advances in our understanding about how viral infections regulate asthma. Important lessons have been learned from birth cohort studies examining viral infections and subsequent asthma and from understanding the relationships between host genetics and viral infections, the contributions of respiratory viral infections to patterns of immune development, the impact of environmental exposure on the severity of viral infections, and how the viral genome influences host immune responses to viral infections. Further, there has been major progress in our knowledge about how bacteria regulate host immune responses in asthma pathogenesis. In this article, we also examine the dynamics of bacterial colonization of the respiratory tract during viral upper respiratory tract infection, in addition to the relationship of the gut and respiratory microbiomes with respiratory viral infections. Finally, we focus on potential interventions that could decrease virus-induced wheezing and asthma. There are emerging therapeutic options to decrease the severity of wheezing exacerbations caused by respiratory viral infections. Primary prevention is a major goal, and a strategy toward this end is considered.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.jaci.2019.12.904

Cites

132 of 132 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Asthma features deficient antiviral immunity and exacerbations are elicited by respiratory viruses.

    “Asthma features deficient antiviral immunity and exacerbations are elicited by respiratory viruses (Altman et al., 2020).”

    From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Altman et al., 2020

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Altman, M. C., Beigelman, A., Ciaccio, C., Gern, J. E., Heymann, P. W., Jackson, D. J., Kennedy, J. L., Kloepfer, K., Lemanske, R. F., McWilliams, L. M., Muehling, L., Nance, C., & Peebles, R. S.
Affiliations
  • University of Washington (US)
  • Tel Aviv University (IL)
  • University of Chicago (US)
  • University of Wisconsin–Madison (US)
  • University of Virginia Medical Center (US)
  • University of Arkansas for Medical Sciences (US)
  • Indiana University Indianapolis (US)
  • Allergy Clinic of Tulsa (US)
  • Baylor College of Medicine (US)
  • Vanderbilt University Medical Center (US)
Corresponding author
Peebles, R. Stokes
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2020-05
Volume
145
Issue
5
Pages
1332-1344
ISSN
0091-6749 (ISSN-L)
OpenAlex
W2999404323
Cited by
37
References
132
Citations by year
2026: 2 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 8 · 2021: 7 · 2020: 6
FWCI
3.61
Type
journal article
Language
en
Open access
Locations
  • Journal of Allergy and Clinical Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • IUScholarWorks (Indiana University) (submittedVersion)
  • Purdue University Indianapolis (Indiana University) (submittedVersion)
Funders
  • U.S. Department of Veterans Affairs (I01BX004299)
  • National Institutes of Health (R21AI145397, R01AI145265, U19AI095227, R01AI124456, U01AI100799, T32AI007496, U19AI104317, UG3/UH3OD023282, UM1AI114271, K08AI1211345)
Topics
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
Keywords
asthma, respiratory viral infections, wheezing, host genetics, immune system development, environmental exposure, viral genome, bacterial colonization, airway microbiome, gut microbiota, upper respiratory tract infection, asthma exacerbations, prevention, therapeutic interventions
MeSH terms
Gastrointestinal Microbiome, Animals, Asthma, Humans, Primary Prevention, Respiratory Sounds, Respiratory Tract Infections, Virus Diseases, Genome, Viral, Disease Progression

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review