Update on risk factors for food allergy

Lack, Gideon

doi:10.1016/j.jaci.2012.02.036

Cited by 460Food Allergy and Anaphylaxis ResearchEosinophilic EsophagitisDrug-Induced Adverse Reactions

Update on risk factors for food allergy

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Lack, Gideon·2012·Journal of Allergy and Clinical Immunology

DOI 10.1016/j.jaci.2012.02.036

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Abstract

Despite efforts to prevent food allergy (FA) in children, IgE-mediated FAs are increasing in westernized countries. Previous preventive strategies, such as prolonged exclusive breast-feeding and delayed weaning onto solid foods, have recently been called into question. The present review considers possible risk factors and theories for the development of FA. An alternative hypothesis is proposed, suggesting that early cutaneous exposure to food protein through a disrupted skin barrier leads to allergic sensitization and that early oral exposure to food allergen induces tolerance. Novel interventional strategies to prevent the development of FA are also discussed.

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IgE responses against environmental allergens and self proteins correlate with cutaneous inflammation and overall AD severity.
“A significant part of the sensitization process leading to the generation of IgE responses against environmental allergens (including food allergens)100 as well as against self proteins101 correlates with cutaneous inflammation and overall severity102,103.”
From Atopic dermatitis: an expanding therapeutic pipeline for a complex disease (2022) · cites this paper as [100]

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Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis
Palmer, C. N. A., Irvine, A. D., Terron-Kwiatkowski, A., Zhao, Y., Liao, H., Lee, S. P., Goudie, D. R., Sandilands, A., Campbell, L. E., Smith, F. J. D., et al. (2006) · Nature Genetics · doi:10.1038/ng1767 · Cited by 2,978 · see citing works
Immunol. Cell Biol.
Fitzgerald, M., Hayward, I. P., Thomas, A. C., Campbell, J. H., & CAMPBELL, G. R. (1995) · Cited by 2,552 · see citing works
ALSPAC–The Avon Longitudinal Study of Parents and Children
Golding, Pembrey, Jones, & The Alspac Study Team (2001) · Paediatric and Perinatal Epidemiology · doi:10.1046/j.1365-3016.2001.00325.x · Cited by 1,549 · see citing works
The prevalence of food allergy: A meta-analysis
Rona, R. J., Keil, T. O. P., Summers, C. W., Gíslason, D., Zuidmeer, L., Södergren, E., SIGURDARDOTTIR, S. T., Lindner, T., Goldhahn, K., Dahlström, J., et al. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.05.026 · Cited by 1,355 · see citing works
Effects of Early Nutritional Interventions on the Development of Atopic Disease in Infants and Children: The Role of Maternal Dietary Restriction, Breastfeeding, Timing of Introduction of Complementary Foods, and Hydrolyzed Formulas
Greer, F. R., Sicherer, S. H., & Burks, A. W. (2007) · PEDIATRICS · doi:10.1542/peds.2007-3022 · Cited by 1,110 · see citing works
Cytokine modulation of atopic dermatitis filaggrin skin expression
Howell, M. D., Kim, B. E., Gao, P., Grant, A. V., Boguniewicz, M., DeBenedetto, A., Schneider, L., Beck, L. A., Barnes, K. C., & Leung, D. Y. M. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.04.031 · Cited by 1,084 · see citing works
The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction
Sudo, N., Sawamura, S., Tanaka, K., Aiba, Y., Kubo, C., & Koga, Y. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.4.1739 · Cited by 1,070 · see citing works
Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris
Smith, F. J. D., Irvine, A. D., Terron-Kwiatkowski, A., Sandilands, A., Campbell, L., Zhao, Y., Liao, H., Evans, A. T., Goudie, D. R., Lewis‐Jones, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1743 · Cited by 1,026 · see citing works
Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants
Osborne, N. J., Koplin, J. J., Martin, P. E., Gurrin, L. C., Lowe, A. J., Matheson, M. C., Ponsonby, A., Wake, M. A., Tang, M. L. K., Dharmage, S. C., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.01.039 · Cited by 1,014 · see citing works
US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up
Sicherer, S. H., Muñoz‐Furlong, A., Godbold, J., & Sampson, H. A. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.03.029 · Cited by 930 · see citing works
Factors Associated with the Development of Peanut Allergy in Childhood
Lack, G., Fox, D., Northstone, K., & Golding, J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa013536 · Cited by 908 · see citing works
Self-citation
Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy
Toit, G. D., Katz, Y., Sasieni, P. D., Mesher, D., Maleki, S. J., Fisher, H. R., Fox, A. T., Turcanu, V., Amir, T., Zadik-Mnuhin, G., et al. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.08.039 · Cited by 829 · see citing works
Self-citation
Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey
Sicherer, S. H., Muñoz‐Furlong, A., & Sampson, H. A. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(03)02026-8 · Cited by 745 · see citing works
Epidemiologic risks for food allergy
Lack, G. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.04.032 · Cited by 700 · see citing works
Self-citation
Food Allergy Among Children in the United States
Branum, A. M., & Lukacs, S. L. (2009) · PEDIATRICS · doi:10.1542/peds.2009-1210 · Cited by 698 · see citing works
Hypoallergenic Infant Formulas
(2000) · PEDIATRICS · doi:10.1542/peds.106.2.346 · Cited by 687 · see citing works
Long-term relation between breastfeeding and development of atopy and asthma in children and young adults: a longitudinal study
Sears, M. R., Greene, J. M., Willan, A. R., Taylor, D. R., Flannery, E. M., Cowan, J. O., Herbison, P., & Poulton, R. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11025-7 · Cited by 595 · see citing works
The Immunological Components of Human Milk and Their Effect on Immune Development in Infants ,
Field, C. J. (2005) · Journal of Nutrition · doi:10.1093/jn/135.1.1 · Cited by 555 · see citing works
The development and prediction of atopy in high-risk children: Follow-up at age seven years in a prospective randomized study of combined maternal and infant food allergen avoidance
Zeiger, R. S., & Heller, S. (1995) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(95)70074-9 · Cited by 539 · see citing works
National prevalence and risk factors for food allergy and relationship to asthma: Results from the National Health and Nutrition Examination Survey 2005-2006
Liu, A. H., Jaramillo, R., Sicherer, S. H., Wood, R. A., Bock, S. A., Burks, A. W., Massing, M. W., Cohn, R. D., & Zeldin, D. C. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.07.026 · Cited by 522 · see citing works
Caesarean delivery and risk of atopy and allergic disesase: meta‐analyses
Bager, P., Wohlfahrt, J., & Westergaard, T. (2008) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2008.02939.x · Cited by 503 · see citing works
Dietary fat and asthma: is there a connection?
Black, P., & Sharpe, S. (1997) · European Respiratory Journal · doi:10.1183/09031936.97.10010006 · Cited by 491 · see citing works
The prevalence of plant food allergies: A systematic review
Zuidmeer, L., Goldhahn, K., Rona, R. J., Gíslason, D., Madsen, C. B., Summers, C. W., Södergren, E., Dahlström, J., Lindner, T., SIGURDARDOTTIR, S. T., et al. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.02.019 · Cited by 481 · see citing works
Time trends in allergic disorders in the UK
Gupta, R., Sheikh, A., Strachan, D. P., & ANDERSON, H. R. (2006) · Thorax · doi:10.1136/thx.2004.038844 · Cited by 478 · see citing works
Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy
Brown, S., Asai, Y., Cordell, H. J., Campbell, L., Zhao, Y., Liao, H., Northstone, K., Henderson, J., Alizadehfar, R., Ben‐Shoshan, M., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.01.031 · Cited by 477 · see citing works
Self-citation
A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming
Fallon, P. G., Sasaki, T., Sandilands, A., Campbell, L., Saunders, S. P., Mangan, N. E., Callanan, J. J., Kawasaki, H., Shiohama, A., Kubo, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.358 · Cited by 474 · see citing works
Diet as a risk factor for atopy and asthma
Devereux, G. S., & Seaton, A. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.12.1139 · Cited by 465 · see citing works
Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy
Katz, Y., Rajuan, N., Goldberg, M. R., Eisenberg, E., Heyman, E., Cohen, A., & Leshno, M. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.04.020 · Cited by 425 · see citing works
Can early introduction of egg prevent egg allergy in infants? A population-based study
Koplin, J. J., Osborne, N. J., Wake, M. A., Martin, P. E., Gurrin, L. C., Robinson, M. N., Tey, D., Slaa, M., Thiele, L., Miles, L., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.07.028 · Cited by 387 · see citing works
Household peanut consumption as a risk factor for the development of peanut allergy
Fox, A. T., Sasieni, P. D., Toit, G. D., Syed, H., & Lack, G. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.12.014 · Cited by 359 · see citing works
Self-citation
Infant Vitamin D Supplementation and Allergic Conditions in Adulthood: Northern Finland Birth Cohort 1966
Hyppönen, E., Sovio, U., Wjst, M., Patel, S. P., Pekkanen, J., Hartikainen, A., & Järvelin, M. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1337.013 · Cited by 358 · see citing works
Peanut allergy in relation to heredity, maternal diet, and other atopic diseases: results of a questionnaire survey, skin prick testing, and food challenges
Hourihane, J. O., Dean, T., & Warner, J. O. (1996) · BMJ · doi:10.1136/bmj.313.7056.518 · Cited by 338 · see citing works
Peanut allergy: Clinical and immunologic differences among patients from 3 different geographic regions
Vereda, A., van Hage, M., Ahlstedt, S., Ibáñez, M. D., Cuesta‐Herranz, J., van Odijk, J., Wickman, M. C., & Sampson, H. A. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.09.010 · Cited by 312 · see citing works
Genetics of peanut allergy: A twin study
Sicherer, S. H., Furlong, T. J., MAES, H. H. M., Desnick, R. J., Sampson, H. A., & Gelb, B. D. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2000.108105 · Cited by 312 · see citing works
Probiotics in pregnant women to prevent allergic disease: a randomized, double-blind trial
Dotterud, C. K., Storrø, O., Johnsen, R., & Øien, T. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.09889.x · Cited by 296 · see citing works
Timing of Initial Exposure to Cereal Grains and the Risk of Wheat Allergy
Poole, J. A., Barriga, K., Leung, D. Y. M., Hoffman, M., Eisenbarth, G. S., Rewers, M., & Norris, J. M. (2006) · PEDIATRICS · doi:10.1542/peds.2005-1803 · Cited by 289 · see citing works
Original article: Prevalence and cumulative incidence of food hypersensitivity in the first 3 years of life
Venter, C., Pereira, B., Voigt, K., et al. (2008) · Allergy · doi:10.1111/j.1398-9995.2007.01570.x · Cited by 285 · see citing works
Fish consumption during the first year of life and development of allergic diseases during childhood
Kull, I., Bergström, A., Lilja, G., Pershagen, G., & Wickman, M. C. (2006) · Allergy · doi:10.1111/j.1398-9995.2006.01115.x · Cited by 267 · see citing works
Is delivery by cesarean section a risk factor for food allergy?
Eggesbø, M. Å., Botten, G., Stigum, H., Nafstad, P. H. J., & Magnus, P. M. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.1610 · Cited by 255 · see citing works
Filaggrin loss-of-function mutations are associated with early-onset eczema, eczema severity and transepidermal water loss at 3 months of age: Filaggrin mutations, TEWL and eczema at 3 months
Flohr, C., England, K., Radulovic, S., McLean, W. H. I., Campbell, L. E., Barker, J., Perkin, M., & Lack, G. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.10068.x · Cited by 251 · see citing works
Self-citation
Breastfeeding duration is a risk factor for atopic eczema
Bergmann, R. L., Diepgen, T. L., Kuß, O., Bergmann, K. E., Kujat, J., Dudenhausen, J. W., Wahn, U., & The MAS‐study group (2002) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2002.01274.x · Cited by 248 · see citing works
Breast milk immune complexes are potent inducers of oral tolerance in neonates and prevent asthma development
Mosconi, E., Rekima, A., Seitz‐Polski, B., Kanda, A., Fleury, S., Tissandié, E., Monteiro, R. C., Dombrowicz, D., Julia, V., Glaichenhaus, N., et al. (2010) · Mucosal Immunology · doi:10.1038/mi.2010.23 · Cited by 225 · see citing works
High dose oral tolerance in ovalbumin TCR-transgenic mice: systemic neutralization of IL-12 augments TGF-beta secretion and T cell apoptosis
Marth, T., Strober, W., & Kelsall, B. L. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.6.2348 · Cited by 221 · see citing works
Disruption of the stratum corneum allows potent epicutaneous immunization with protein antigens resulting in a dominant systemic Th2 response
Strid, J., Hourihane, J. O., Kimber, I., Callard, R. E., & Ströbel, S. (2004) · European Journal of Immunology · doi:10.1002/eji.200425196 · Cited by 221 · see citing works
Nickel allergy in adolescents in relation to orthodontic treatment and piercing of ears
Kerosuo, H., Kullaa, A. M., Kerosuo, E., et al. (1996) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/s0889-5406(96)70175-0 · Cited by 220 · see citing works
The impact of government advice to pregnant mothers regarding peanut avoidance on the prevalence of peanut allergy in United Kingdom children at school entry
Hourihane, J. O., Aiken, R., Briggs, R., et al. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.12.670 · Cited by 209 · see citing works
Association of obesity with IgE levels and allergy symptoms in children and adolescents: Results from the National Health and Nutrition Examination Survey 2005-2006
Visness, C. M., London, S. J., Daniels, J. L., Kaufman, J. S., Yeatts, K., Siega‐Riz, A. M., Liu, A. H., Calatroni, A., & Zeldin, D. C. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.12.1126 · Cited by 205 · see citing works
Prevention of allergic disease during childhood by allergen avoidance: The Isle of Wight prevention study
Arshad, S. H., Bateman, B., Sadeghnejad, A., Gant, C., & Matthews, S. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.12.621 · Cited by 188 · see citing works
Maternal consumption of peanut during pregnancy is associated with peanut sensitization in atopic infants
Sicherer, S. H., Wood, R. A., Stablein, D. M., Lindblad, R., Burks, A. W., Liu, A. H., Jones, S. M., Fleischer, D. M., Leung, D. Y. M., & Sampson, H. A. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.08.036 · Cited by 179 · see citing works
Perceived prevalence of peanut allergy in Great Britain and its association with other atopic conditions and with peanut allergy in other household members
Emmett, S., Angus, F., Fry, J., et al. (1999) · Allergy · doi:10.1034/j.1398-9995.1999.00768.x · Cited by 176 · see citing works
Nickel Sensitization in Adolescents and Association with Ear Piercing, Use of Dental Braces and Hand Eczema
Mortz, C. G., Lauritsen, J. L., Bindslev‐Jensen, C., et al. (2002) · Acta Dermato Venereologica · doi:10.1080/000155502320624096 · Cited by 170 · see citing works
Distribution of peanut allergen in the environment
Perry, T. T., Conover-Walker, M. K., Pomés, A., Chapman, M. D., & Wood, R. A. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.02.035 · Cited by 168 · see citing works
Early Infant Multivitamin Supplementation Is Associated With Increased Risk for Food Allergy and Asthma
Milner, J. D., Stein, D. M., McCarter, R., & Moon, R. Y. (2004) · PEDIATRICS · doi:10.1542/peds.114.1.27 · Cited by 165 · see citing works
Eczema Genetics: Current State of Knowledge and Future Goals
Brown, S., & McLean, W. H. I. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.413 · Cited by 162 · see citing works
Antigen-specific secretory IgA antibodies in the gut are decreased in a mouse model of food allergy
Frossard, C. P., Hauser, C., & Eigenmann, P. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.03.040 · Cited by 147 · see citing works
Omega 3 and 6 oils for primary prevention of allergic disease: systematic review and meta‐analysis
Anandan, C., Nurmatov, U. B., & Sheikh, A. (2009) · Allergy · doi:10.1111/j.1398-9995.2009.02042.x · Cited by 145 · see citing works
Maternal diet during pregnancy and allergic sensitization in the offspring by 5 yrs of age: a prospective cohort study
Nwaru, B. I., Ahonen, S., Kaila, M., et al. (2009) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2009.00949.x · Cited by 130 · see citing works
A novel model of sensitization and oral tolerance to peanut protein
Strid, J., Thomson, M., Hourihane, J. O., Kimber, I., & Ströbel, S. (2004) · Immunology · doi:10.1111/j.1365-2567.2004.01989.x · Cited by 124 · see citing works
Clinical spectrum of food allergy in children in Australia and South-East Asia: identification and targets for treatment
Hill, D. J., Hosking, C. S., & Heine, R. G. (1999) · Annals of Medicine · doi:10.3109/07853899908995890 · Cited by 114 · see citing works
Oat sensitization in children with atopic dermatitis: prevalence, risks and associated factors
Boussault, P., Léauté-Labrèze, C., Saubusse, É., Maurice-Tison, S., Perromat, M., Roul, S., Sarrat, A., Taı̈eb, A., & Boralévi, F. (2007) · Allergy · doi:10.1111/j.1398-9995.2007.01527.x · Cited by 113 · see citing works
Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children
Liu, X., Beaty, T. H., Deindl, P., Huang, S.-K., Lau, S., Sommerfeld, C., Fallin, M. D., Kao, W. H. L., Wahn, U., & Nickel, R. G. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.12.037 · Cited by 109 · see citing works
Pattern of food‐induced anaphylaxis in children of an Asian community
Dl, G., Lau, Y., Chew, F. T., et al. (1999) · Allergy · doi:10.1034/j.1398-9995.1999.00925.x · Cited by 102 · see citing works
Atopic Eczema and the Filaggrin Story
Brown, S., & Irvine, A. D. (2008) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/j.sder.2008.04.001 · Cited by 95 · see citing works
Gene polymorphisms, breast-feeding, and development of food sensitization in early childhood
Hong, X., Wang, G., Liu, X., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.05.007 · Cited by 90 · see citing works
Polymorphism in the STAT6 gene encodes risk for nut allergy
Amoli, M. M., Hand, S., Hajeer, A. H., Jones, K., Rolf, S., Sting, C., Davies, B. H., & Ollier, W. (2002) · Genes and Immunity · doi:10.1038/sj.gene.6363872 · Cited by 87 · see citing works
Mustard allergy in children
Rancé, F., Dutau, G., & Abbal, M. (2000) · Allergy · doi:10.1034/j.1398-9995.2000.00383.x · Cited by 81 · see citing works
T-cell reactivity for a peanut-derived epitope in the skin of a young infant with atopic dermatitis
van Reijsen, F. C., Felius, A., Wauters, E. A. K., Bruijnzeel-Koomen, C. A. F. M., & Koppelman, S. J. (1998) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(98)70410-5 · Cited by 76 · see citing works
Cutaneous lymphocyte antigen and α4β7 T ‐lymphocyte responses are associated with peanut allergy and tolerance in children
Chan, S., Turcanu, V., Stephens, A. C., Fox, A. T., Grieve, A. P., & Lack, G. (2012) · Allergy · doi:10.1111/j.1398-9995.2011.02765.x · Cited by 75 · see citing works
Self-citation
Atopic dermatitis: the role of Langerhans cells in disease pathogenesis
Dubrac, S., Schmuth, M., & Ebner, S. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.33 · Cited by 74 · see citing works
Antioxidants and allergic disease: a case of too little or too much?
Allan, K., Kelly, F., & Devereux, G. (2009) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2009.03413.x · Cited by 73 · see citing works
Race, Ancestry, and Development of Food-Allergen Sensitization in Early Childhood
Kumar, R., Tsai, H., Hong, X., Liu, X., Wang, G., Pearson, C., Ortiz, K., Fu, M., Pongracic, J. A., Bauchner, H., et al. (2011) · PEDIATRICS · doi:10.1542/peds.2011-0691 · Cited by 70 · see citing works
Increased Airways Responsiveness in Mice Depends on Local Challenge with Antigen
Saloga, J., Renz, H. E., Larsen, G. L., & Gelfand, E. W. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.149.1.8111600 · Cited by 69 · see citing works
Royal jelly consumption and hypersensitivity in the community
Leung, R. C.-Y., Ho, A. C.-H., Chan, J. C. N., CHOY, D., & LAI, C. K. W. (1997) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1997.tb00712.x · Cited by 63 · see citing works
IL‐10 gene polymorphism, but not TGF‐β1 gene polymorphisms, is associated with food allergy in a Japanese population
Campos‐Alberto, E., Shimojo, N., Suzuki, Y., Mashimo, Y., Arima, T., Matsuura, T., Inoue, Y., Yamaide, A., Tomiita, M., Fujii, K., et al. (2008) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2007.00709.x · Cited by 50 · see citing works
Association of single nucleotide polymorphisms in the IL-12 (IL-12A and B) and IL-12 receptor (IL-12Rβ1 and β2) genes and gene–gene interactions with atopic dermatitis in Koreans
Namkung, J., Lee, J.-E., Kim, E., et al. (2010) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2009.12.003 · Cited by 47 · see citing works
Clinical characteristics of childhood asthmatics in Johannesburg.
Green, R., & Luyt, D. K. (1997) · PubMed · Cited by 33 · see citing works
Another explanation for the low allergy rate in the rural Alpine foothills
Wjst, M. (2005) · Clinical and Molecular Allergy · doi:10.1186/1476-7961-3-7 · Cited by 31 · see citing works
Food Allergy—Lessons from Asia
Lee, B. W., Shek, L. P., Gerez, I., et al. (2008) · World Allergy Organization Journal · doi:10.1097/wox.0b013e31817b7431 · Cited by 31 · see citing works
Hypersensitivity to pancreatic extracts in parents of patients with cystic fibrosis
Twarog, F. J., Weinstein, S. F., Khaw, K. T., et al. (1977) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(77)90174-9 · Cited by 28 · see citing works
The Concept of Oral Tolerance Induction to Foods
Lack, G. (2007) · KARGER eBooks · doi:10.1159/000098513 · Cited by 23 · see citing works
Self-citation
Peanut allergy
Fox, D., & Lack, G. (1998) · The Lancet · doi:10.1016/s0140-6736(05)60863-x · Cited by 19 · see citing works
Self-citation
Association of genetic variants of CD14 with peanut allergy and elevated IgE levels in peanut allergic individuals
Dreskin, S. C., Ayars, A. G., Jin, Y., et al. (2010) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2010.11.008 · Cited by 18 · see citing works
Clinical characteristics of childhood asthma.
Mercer, M. J., & van Niekerk, C. H. (1991) · PubMed · Cited by 13 · see citing works
Regional Differences in EpiPen Prescriptions in the United States
Camargo, C. A., Clark, S., Kaplan, M., et al. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.12.554 · Cited by 11 · see citing works
Season of Birth is Associated with Risk of Food Allergy in Children
Vassallo, M. F., Banerji, A., Rudders, S. A., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.12.849 · Cited by 1 · see citing works
Filaggrin loss-of-function mutations are associated with early onset eczema, eczema severity, and transepidermal water loss at three months of age
Flohr, C., England, K., Radulović, S., et al. (2010) · Discovery Research Portal (University of Dundee) · doi:10.1038/jid.2010.238 · Cited by 1 · see citing works

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Research works printed but not linked: 2

Baker SS, Cochran WJ, Greer FR, Heyman MB, Jacobson MS, Jaksic T, et al. Hy- poallergenic infant formulas. Pediatrics 2000;106:346-9.
Fox DE, Lack G. Letter: peanut allergy. Lancet 1998;352:741.

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Atopic dermatitis: an expanding therapeutic pipeline for a complex disease
Bieber, T. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00266-6 · Cited by 623 · see citing works
Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy
Brough, H. A., Liu, A. H., Sicherer, S., Makinson, K., Douiri, A., Brown, S. J., Stephens, A. C., Irwin McLean, W. H., Turcanu, V., Wood, R. A., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.10.007 · Cited by 345 · see citing works
Self-citation
Epithelial barrier repair and prevention of allergy
Goleva, E., Berdyshev, E., & Leung, D. Y. M. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124608 · Cited by 251 · see citing works
Association between Stress and the HPA Axis in the Atopic Dermatitis
Lin, T.-K., Zhong, L., & Santiago, J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102131 · Cited by 127 · see citing works
“been shown that TEWL is correlated to both allergic and irritant contact dermatitis [6], and perturbed barrier function plays an essential role in the allergic sensitization to both protein antigens and staphylococcal superantigens in AD patients [7].”
Background
To what extent is allergen exposure a risk factor for the development of allergic disease?
Custovic, A. (2015) · Clinical & Experimental Allergy · doi:10.1111/cea.12450 · Cited by 79 · see citing works
Association of food allergy and atopic dermatitis exacerbations
Roerdink, E. M., Flokstra-de Blok, B. M. J., Blok, J. L., Schuttelaar, M.-L. A., Niggemann, B., Werfel, T., Van der Heide, S., Kukler, J., Kollen, B. J., & Dubois, A. E. (2016) · Annals of Allergy, Asthma & Immunology · doi:10.1016/j.anai.2016.01.022 · Cited by 47 · see citing works

Authors: Lack, G.
Affiliations: St Thomas' Hospital (GB)
Corresponding author: Lack, Gideon
ORCID: Lack, Gideon
Venue: Journal of Allergy and Clinical Immunology
Publisher: Elsevier BV
Published: 2012-05
Volume: 129
Issue: 5
Pages: 1187-1197
ISSN: 0091-6749 (ISSN-L)
DOI: 10.1016/j.jaci.2012.02.036
OpenAlex: W2082217757
Cited by: 460
References: 86
Citations by year: 2026: 15 · 2025: 15 · 2024: 20 · 2023: 37 · 2022: 29 · 2021: 31 · 2020: 41 · 2019: 28 · 2018: 36 · 2017: 37 · 2016: 41 · 2015: 49 · 2014: 39 · 2013: 31 · 2012: 10
FWCI: 5.66
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Allergy and Clinical Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Food Allergy Initiative
Danone
Anaphylaxis Campaign
Immune Tolerance Network
Action Medical Research
Guy's and St Thomas' Charity
National Institutes of Health
Medical Research Council (MC_G1001205)
Topics: Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
Health Sciences › Medicine › Surgery › Eosinophilic Esophagitis
Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
Keywords: food allergy, risk factors, IgE-mediated food allergy, food allergy prevention, exclusive breastfeeding, delayed weaning, skin barrier disruption, oral tolerance, allergen sensitization
MeSH terms: Allergens, Breast Feeding, Drug Administration Routes, Food Hypersensitivity, United Kingdom, Humans, Immune Tolerance, Immunization, Risk Factors, Models, Immunological

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