The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Bronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma
Open accessAbstract
Background Bronchial thermoplasty (BT) has previously been shown to improve asthma control out to 2 years in patients with severe persistent asthma. Objective To assess effectiveness and safety of BT in asthma patients 5 years post therapy. Methods BT-treated subjects from the Asthma Intervention Research 2 (AIR2) Trial (ClinicalTrials.gov NCT01350414) were evaluated annually for 5 years to assess long-term safety of BT and durability of treatment effect. Outcomes assessed post-BT included severe exacerbations, adverse events, healthcare utilization, spirometry data, and high resolution computed tomography (HRCT) scans. Results 162/190 BT-treated subjects (85.3%) from the AIR2 Trial completed 5 years of follow-up. The proportion of subjects experiencing severe exacerbations and Emergency Room visits, and the rates of events in each of years 1 to 5 remained low and were less than those observed in the 12 months prior to BT treatment (average 5 year reduction in proportions: 44% for exacerbations and 78% for ER visits). Respiratory adverse events and respiratory-related hospitalizations remained unchanged in Years 2 through 5 as compared to the first year after BT. Pre-BD FEV1 values remained stable between years 1 and 5 after BT, despite a 17% reduction in average daily inhaled corticosteroid dose. HRCT scans from baseline to 5 years after BT showed no structural abnormalities that could be attributed to BT. Conclusions These data demonstrate the 5-year durability of the benefits of BT with regard to both asthma control (based on maintained reduction in severe exacerbations and ER visits for respiratory symptoms) and safety. BT has become an important addition to our treatment armamentarium and should be considered for patients with severe persistent asthma who remain symptomatic despite taking ICS (inhaled corticosteroids) and LABA (long-acting-β2-agonists).
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Cites
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Self-citationCastro, M., Rubin, A. S., Laviolette, M., Fiterman, J., De Andrade Lima, M., Shah, P. L., Fiss, E., Olivenstein, R., Thomson, N. C., Niven, R. M., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200903-0354oc · Cited by 672
Self-citationAsthma Control during the Year after Bronchial Thermoplasty
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Self-citationSafety and Efficacy of Bronchial Thermoplasty in Symptomatic, Severe Asthma
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Self-citationQualitative Analysis of High-Resolution CT Scans in Severe Asthma
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Self-citationLong-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial
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Papi, A., Brightling, C., Pedersen, S. E., & Reddel, H. K. (2018) · The Lancet · doi:10.1016/s0140-6736(17)33311-1 · Cited by 1,759
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Asthma: pathogenesis and novel drugs for treatment
Olin, J. T., & Wechsler, M. E. (2014) · BMJ · doi:10.1136/bmj.g5517 · Cited by 256
Self-citationGuilbert, T. W., Bacharier, L. B., & Fitzpatrick, A. M. (2014) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2014.06.022 · Cited by 216
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Metadata
- Authors
- Wechsler, M. E., Laviolette, M., Rubin, A. S., Fiterman, J., Lapa e Silva, J. R., Shah, P. L., Fiss, E., Olivenstein, R., Thomson, N. C., Niven, R. M., Pavord, I. D., Simoff, M., Hales, J. B., McEvoy, C., Slebos, D.-J., Holmes, M., Phillips, M. J., Erzurum, S. C., Hanania, N. A., Sumino, K., Kraft, M., Cox, G., Sterman, D. H., Hogarth, K., Kline, J. N., Mansur, A. H., Louie, B. E., Leeds, W. M., Barbers, R. G., Austin, J. H. M., Shargill, N. S., Quiring, J., Armstrong, B., & Castro, M.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 132
- Issue
- 6
- Pages
- 1295-1302.e3
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2151256680
- Cited by
- 300
- References
- 14
- FWCI
- 19.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Wechsler, M. E., Laviolette, M., Rubin, A. S., Fiterman, J., Lapa e Silva, J. R., Shah, P. L., Fiss, E., Olivenstein, R., Thomson, N. C., Niven, R. M., Pavord, I. D., Simoff, M., Hales, J. B., McEvoy, C., Slebos, D.-J., Holmes, M., Phillips, M. J., Erzurum, S. C., Hanania, N. A., . . . Castro, M. (2013). Bronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2013.08.009
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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