The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
A Multivariate Analysis of Risk Factors for the Air-Trapping Asthmatic Phenotype as Measured by Quantitative CT Analysis
Open accessAbstract
Background Severe asthma subjects have increased physiologically measured air trapping. However, a similar study using CT measures of air trapping has not been performed. This study was designed to address two hypotheses: 1) air trapping, measured by multi-detector CT quantitative methodology, would be a predictor of a more severe asthma phenotype; and 2) historical, clinical, allergic, or inflammatory risk factors could be identified via multivariate analysis. Methods Multi-detector CT scanning of a subset of the Severe Asthma Research Program subjects was performed at functional residual capacity. Air trapping was defined as 9.66% or more of the lung tissue less than −850 HU. Subjects who were defined as air trappers were then compared to non-trappers on clinical and demographic factors using both univariate and multivariate statistical analysis. Results Air trappers were significantly more likely to have a history of asthma-related hospitalizations, ICU visits and/or mechanical ventilation. Duration of asthma (OR 1.42, 95% CI 1.08–1.87), history of pneumonia (OR 8.55, 95% CI 2.07–35.26), high levels of airway neutrophils (OR 8.67, 95% CI 2.05–36.57), air flow obstruction (FEV1/FVC) (OR 1.61, 95% CI 1.21–2.14) and atopy (OR 11.54, 95% CI 1.97–67.70), were identified as independent risk factors associated with the air trapping phenotype. Conclusions Quantitative CT determined air trapping in asthmatic subjects identifies a group of individuals with a high risk of severe disease. Several independent risk factors for the presence of this phenotype were identified, perhaps most interestingly history of pneumonia, neutrophilic inflammation, and atopy.
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Self-citationBronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma
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Metadata
- Authors
- Busacker, A., Newell, J. D., Keefe, T., Hoffman, E. A., Granroth, J. C., Castro, M., Fain, S., & Wenzel, S.
- Venue
- Chest
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 135
- Issue
- 1
- Pages
- 48-56
- ISSN
- 0012-3692 (ISSN-L)
- OpenAlex
- W2127666096
- Cited by
- 287
- References
- 33
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- green
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