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Cited by 110Asthma and respiratory diseasesAir Quality and Health ImpactsOccupational exposure and asthma

A mouse model links asthma susceptibility to prenatal exposure to diesel exhaust

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Manners, Sarah, Alam, Rafeul, Schwartz, David A., Gorska, Magdalena M.·2014·Journal of Allergy and Clinical Immunology
DOI 10.1016/j.jaci.2013.10.047PMC PMC4065237
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Abstract

Background Most asthma begins in the first years of life. This early onset cannot be attributed merely to genetic factors because the prevalence of asthma is increasing. Epidemiologic studies have indicated roles for prenatal and early childhood exposures, including exposure to diesel exhaust. However, little is known about the mechanisms. This is largely due to a paucity of animal models. Objective We aimed to develop a mouse model of asthma susceptibility through prenatal exposure to diesel exhaust. Methods Pregnant C57BL/6 female mice were given repeated intranasal applications of diesel exhaust particles (DEPs) or PBS. Offspring underwent suboptimal immunization and challenge with ovalbumin (OVA) or received PBS. Pups were examined for features of asthma; lung and liver tissues were analyzed for transcription of DEP-regulated genes. Results Offspring of mice exposed to DEPs were hypersensitive to OVA, as indicated by airway inflammation and hyperresponsiveness, increased serum OVA-specific IgE levels, and increased pulmonary and systemic TH2 and TH17 cytokine levels. These cytokines were primarily produced by natural killer (NK) cells. Antibody-mediated depletion of NK cells prevented airway inflammation. Asthma susceptibility was associated with increased transcription of genes known to be specifically regulated by the aryl hydrocarbon receptor and oxidative stress. Features of asthma were either marginal or absent in OVA-treated pups of PBS-exposed mice. Conclusion We created a mouse model that linked maternal exposure to DEPs with asthma susceptibility in offspring. Development of asthma was dependent on NK cells and associated with increased transcription from aryl hydrocarbon receptor- and oxidative stress-regulated genes.

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  1. [1]Moorman JE Akinbami LJ Bailey CM National Surveillance of Asthma: United States, 2001–2010 National Center for Health Statistics. Vital Health Stat 3 35 2012 Available at: http://www.cdc.gov/nchs/data/series/sr_03/sr03_035.pdf Accessed June 23, 2013 24252609
  2. [2]Litonjua AA Carey VJ Burge HA Weiss ST Gold DR Parental history and the risk for childhood asthma. Does mother confer more risk than father? Am J Respir Crit Care Med 1998 158 176 81 9655726
  3. [3]Sears MR Holdaway MD Flannery EM Herbison GP Silva PA Parental and neonatal risk factors for atopy, airway hyper-responsiveness, and asthma Arch Dis Child 1996 75 392 8 8957951 PMC1511782
  4. [4]Ruiz RG Kemeny DM Price JF Higher risk of infantile atopic dermatitis from maternal atopy than from paternal atopy Clin Exp Allergy 1992 22 762 6 1525695
  5. [5]Patel MM Quinn JW Jung KH Hoepner L Diaz D Perzanowski M Traffic density and stationary sources of air pollution associated with wheeze, asthma, and immunoglobulin E from birth to age 5 years among New York City children Environ Res 2011 111 1222 9 21855059 PMC3210909
  6. [6]Perzanowski MS Chew GL Divjan A Jung KH Ridder R Tang D Early-life cockroach allergen and polycyclic aromatic hydrocarbon exposures predict cockroach sensitization among inner-city children J Allergy Clin Immunol 2013 131 886 93 23391330 PMC3678290
  7. [7]Rosa MJ Jung KH Perzanowski MS Kelvin EA Darling KW Camann DE Prenatal exposure to polycyclic aromatic hydrocarbons, environmental tobacco smoke and asthma Respir Med 2011 105 869 76 21163637 PMC3081952
  8. [8]Jedrychowski WA Perera FP Maugeri U Mrozek-Budzyn D Mroz E Klimaszewska-Rembiasz M Intrauterine exposure to polycyclic aromatic hydrocarbons, fine particulate matter and early wheeze. Prospective birth cohort study in 4-year olds Pediatr Allergy Immunol 2010 21 e723 32 20444151 PMC3683604
  9. [9]Burke H Leonardi-Bee J Hashim A Pine-Abata H Chen Y Cook DG Prenatal and passive smoke exposure and incidence of asthma and wheeze: systematic review and meta-analysis Pediatrics 2012 129 735 44 22430451
  10. [10]Spanier AJ Kahn RS Kunselman AR Hornung R Xu Y Calafat AM Prenatal exposure to bisphenol A and child wheeze from birth to 3 years of age Environ Health Perspect 2012 120 916 20 22334053 PMC3385426
  11. [11]Ege MJ Bieli C Frei R van Strien RT Riedler J Ublagger E Parsifal Study team Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children J Allergy Clin Immunol 2006 117 817 23 16630939
  12. [12]Douwes J Cheng S Travier N Cohet C Niesink A McKenzie J Farm exposure in utero may protect against asthma, hay fever and eczema Eur Respir J 2008 32 603 11 18448493
  13. [13]Fedulov AV Leme A Yang Z Dahl M Lim R Mariani TJ Pulmonary exposure to particles during pregnancy causes increased neonatal asthma susceptibility Am J Respir Cell Mol Biol 2008 38 57 67 17656681 PMC2176127
  14. [14]Auten RL Gilmour MI Krantz QT Potts EN Mason SN Foster WM Maternal diesel inhalation increases airway hyperreactivity in ozone-exposed offspring Am J Respir Cell Mol Biol 2012 46 454 60 22052876 PMC3359947
  15. [15]Reiprich M Rudzok S Schütze N Simon JC Lehmann I Trump S Inhibition of endotoxin-induced perinatal asthma protection by pollutants in an experimental mouse model Allergy 2013 68 481 9 23409786
  16. [16]Kim J Natarajan S Vaickus LJ Bouchard JC Beal D Cruikshank WW Diesel exhaust particulates exacerbate asthma-like inflammation by increasing CXC chemokines Am J Pathol 2011 179 2730 9 21967814 PMC3260803
  17. [17]Arimoto T Kadiiska MB Sato K Corbett J Mason RP Synergistic production of lung free radicals by diesel exhaust particles and endotoxin Am J Respir Crit Care Med 2005 171 379 87 15477498
  18. [18]Mundandhara SD Becker S Madden MC Effects of diesel exhaust particles on human alveolar macrophage ability to secrete inflammatory mediators in response to lipopolysaccharide Toxicol In Vitro 2006 20 614 24 16360300
  19. [19]Gorska MM Liang Q Stafford SJ Goplen N Dharajiya N Guo L MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation J Exp Med 2007 204 1637 52 17576778 PMC2118652
  20. [20]Gorska MM Goplen N Liang Q Alam R Uncoordinated 119 preferentially induces Th2 differentiation and promotes the development of asthma J Immunol 2010 184 4488 96 20220094
  21. [21]Muranaka M Suzuki S Koizumi K Takafuji S Miyamoto T Ikemori R Adjuvant activity of diesel-exhaust particulates for the production of IgE antibody in mice J Allergy Clin Immunol 1986 77 616 23 2420853
  22. [22]Fujimaki H Nohara O Ichinose T Watanabe N Saito S IL-4 production in mediastinal lymph node cells in mice intratracheally instilled with diesel exhaust particulates and antigen Toxicology 1994 92 261 8 7524198
  23. [23]Fujimaki H Saneyoshi K Nohara O Shiraishi F Imai T Intranasal instillation of diesel exhaust particulates and antigen in mice modulated cytokine productions in cervical lymph node cells Int Arch Allergy Immunol 1995 108 268 73 7580292
  24. [24]Miyabara Y Takano H Ichinose T Lim HB Sagai M Diesel exhaust enhances allergic airway inflammation and hyperresponsiveness in mice Am J Respir Crit Care Med 1998 157 1138 44 9563731
  25. [25]Nel AE Diaz-Sanchez D Ng D Hiura T Saxon A Enhancement of allergic inflammation by the interaction between diesel exhaust particles and the immune system J Allergy Clin Immunol 1998 102 539 54 9802360
  26. [26]Salvi S Blomberg A Rudell B Kelly F Sandström T Holgate ST Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers Am J Respir Crit Care Med 1999 159 702 9 10051240
  27. [27]Diaz-Sanchez D Jyrala M Ng D Nel A Saxon A In vivo nasal challenge with diesel exhaust particles enhances expression of the CC chemokines rantes, MIP-1alpha, and MCP-3 in humans Clin Immunol 2000 97 140 5 11027454
  28. [28]Nightingale JA Maggs R Cullinan P Donnelly LE Rogers DF Kinnersley R Airway inflammation after controlled exposure to diesel exhaust particulates Am J Respir Crit Care Med 2000 162 161 6 10903236
  29. [29]Nordenhäll C Pourazar J Ledin MC Levin JO Sandström T Adelroth E Diesel exhaust enhances airway responsiveness in asthmatic subjects Eur Respir J 2001 17 909 15 11488325
  30. [30]Li N Harkema JR Lewandowski RP Wang M Bramble LA Gookin GR Ambient ultrafine particles provide a strong adjuvant effect in the secondary immune response: implication for traffic-related asthma flares Am J Physiol Lung Cell Mol Physiol 2010 299 L374 83 20562226 PMC2951067
  31. [31]Behndig AF Mudway IS Brown JL Stenfors N Helleday R Duggan ST Airway antioxidant and inflammatory responses to diesel exhaust exposure in healthy humans Eur Respir J 2006 27 359 65 16452593
  32. [32]Ristovski ZD Miljevic B Surawski NC Morawska L Fong KM Goh F Respiratory health effects of diesel particulate matter Respirology 2012 17 201 12 22126432
  33. [33]Caraballo JC Borcherding J Thorne PS Comellas AP Protein kinase C-ζ mediates lung injury induced by diesel exhaust particles Am J Respir Cell Mol Biol 2013 48 306 13 23221045 PMC3604088
  34. [34]Hwang YJ Jeung YS Seo MH Yoon JY Kim DY Park JW Asian dust and titanium dioxide particles-induced inflammation and oxidative DNA damage in C57BL/6 mice Inhal Toxicol 2010 22 1127 33 21070184
  35. [35]Nilsen A Hagemann R Eide I The adjuvant activity of diesel exhaust particles and carbon black on systemic IgE production to ovalbumin in mice after intranasal instillation Toxicology 1997 124 225 32 9482124
  36. [36]Billingham RE Brent L Medawar PB Actively acquired tolerance of foreign cells Nature 1953 172 603 6 13099277
  37. [37]Dixon FJ Mauer PH Immunologic unresponsiveness induced by protein antigens J Exp Med 1955 101 245 57 13233450 PMC2136466
  38. [38]Lommatzsch M Airway hyperresponsiveness: new insights into the pathogenesis Semin Respir Crit Care Med 2012 33 579 87 23047309
  39. [39]Sun JC Beilke JN Bezman NA Lanier LL Homeostatic proliferation generates long-lived natural killer cells that respond against viral infection J Exp Med 2011 208 357 68 21262959 PMC3039854
  40. [40]Geurtsvan Kessel CH Bergen IM Muskens F Boon L Hoogsteden HC Osterhaus AD Rimmelzwaan GF Lambrecht BN Both conventional and interferon killer dendritic cells have antigen-presenting capacity during influenza virus infection PLoS One 2009 4 9 e7187 19784375 PMC2747012
  41. [41]Joncker NT Shifrin N Delebecque F Raulet DH Mature natural killer cells reset their responsiveness when exposed to an altered MHC environment J Exp Med 2010 207 2065 72 20819928 PMC2947079
  42. [42]Ris C U.S. EPA health assessment for diesel engine exhaust: a review Inhal Toxicol 2007 19 Suppl 1 229 39 17886071
  43. [43]Diaz-Sanchez D The role of diesel exhaust particles and their associated polyaromatic hydrocarbons in the induction of allergic airway disease Allergy 1997 52 52 6 discussion 57–8 9208060
  44. [44]Srivastava VK Chauhan SS Srivastava PK Kumar V Misra UK Fetal translocation and metabolism of PAH obtained from coal fly ash given intratracheally to pregnant rats J Toxicol Environ Health 1986 18 459 69 3712502
  45. [45]Stevens EA Mezrich JD Bradfield CA The aryl hydrocarbon receptor: a perspective on potential roles in the immune system Immunology 2009 127 299 311 19538249 PMC2712099
  46. [47]Veldhoen M Hirota K Christensen J O’Garra A Stockinger B Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells J Exp Med 2009 206 43 9 19114668 PMC2626686
  47. [48]Qiu J Heller JJ Guo X Chen ZM Fish K Fu YX The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells Immunity 2012 36 92 104 22177117 PMC3268875
  48. [49]Hahn ME Allan LL Sherr DH Regulation of constitutive and inducible AHR signaling: complex interactions involving the AHR repressor Biochem Pharmacol 2009 77 485 97 18848529 PMC2701375
  49. [50]Schmidt JV Su GH Reddy JK Simon MC Bradfield CA Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development Proc Natl Acad Sci U S A 1996 93 6731 6 8692887 PMC39095
  50. [51]Xue W Warshawsky D Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: a review Toxicol Appl Pharmacol 2005 206 73 93 15963346
  51. [52]Li N Alam J Venkatesan MI Eiguren-Fernandez A Schmitz D Di Stefano E Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals J Immunol 2004 173 3467 81 15322212
  52. [53]Ryan PH LeMasters G Biagini J Bernstein D Grinshpun SA Shukla R Is it traffic type, volume, or distance? Wheezing in infants living near truck and bus traffic J Allergy Clin Immunol 2005 116 279 84 16083780
  53. [54]McConnell R Berhane K Yao L Jerrett M Lurmann F Gilliland F Traffic, susceptibility, and childhood asthma Environ Health Perspect 2006 114 766 72 16675435 PMC1459934
  54. [56]Jacquemin B Sunyer J Forsberg B Aguilera I Bouso L Briggs D Association between modelled traffic-related air pollution and asthma score in the ECRHS Eur Respir J 2009 34 834 42 19443533
  55. [57]Gent JF Koutrakis P Belanger K Triche E Holford TR Bracken MB Symptoms and medication use in children with asthma and traffic-related sources of fine particle pollution Environ Health Perspect 2009 117 1168 74 19654929 PMC2717146
  56. [58]McConnell R Islam T Shankardass K Jerrett M Lurmann F Gilliland F Childhood incident asthma and traffic-related air pollution at home and school Environ Health Perspect 2010 118 1021 6 20371422 PMC2920902
  57. [59]Diaz-Sanchez D Tsien A Fleming J Saxon A Combined diesel exhaust particulate and ragweed allergen challenge markedly enhances human in vivo nasal ragweed-specific IgE and skews cytokine production to a T helper cell 2-type pattern J Immunol 1997 158 2406 13 9036991
  58. [60]Sharkhuu T Doerfler DL Krantz QT Luebke RW Linak WP Gilmour MI Effects of prenatal diesel exhaust inhalation on pulmonary inflammation and development of specific immune responses Toxicol Lett 2010 196 12 20 20362647
  59. [61]Corson L Zhu H Quan C Grunig G Ballaney M Jin X Prenatal allergen and diesel exhaust exposure and their effects on allergy in adult offspring mice Allergy Asthma Clin Immunol 2010 6 7 20459836 PMC2875211
  60. [63]Wei H Zhang J Xiao W Feng J Sun R Tian Z Involvement of human natural killer cells in asthma pathogenesis: natural killer 2 cells in type 2 cytokine predominance J Allergy Clin Immunol 2005 115 841 7 15806008
  61. [64]Aktas E Akdis M Bilgic S Disch R Falk CS Blaser K Different natural killer (NK) receptor expression and immunoglobulin E (IgE) regulation by NK1 and NK2 cells Clin Exp Immunol 2005 140 301 9 15807855 PMC1809360
  62. [65]Horikawa M Hasegawa M Komura K Hayakawa I Yanaba K Matsushita T Abnormal natural killer cell function in systemic sclerosis: altered cytokine production and defective killing activity J Invest Dermatol 2005 125 731 7 16185273
  63. [66]Babu S Blauvelt CP Nutman TB Filarial parasites induce NK cell activation, type 1 and type 2 cytokine secretion, and subsequent apoptotic cell death J Immunol 2007 179 2445 56 17675506
  64. [67]Passos ST Silver JS O’Hara AC Sehy D Stumhofer JS Hunter CA IL-6 promotes NK cell production of IL-17 during toxoplasmosis J Immunol 2010 184 1776 83 20083665 PMC3757499
  65. [68]Feng M Li G Qian X Fan Y Huang X Zhang F IL-17A-producing NK cells were implicated in liver injury induced by ischemia and reperfusion Int Immunopharmacol 2012 13 135 40 22465963
  66. [69]Walker C Checkel J Cammisuli S Leibson PJ Gleich GJ IL-5 production by NK cells contributes to eosinophil infiltration in a mouse model of allergic inflammation J Immunol 1998 161 1962 9 9712067
  67. [70]Korsgren M Persson CG Sundler F Bjerke T Hansson T Chambers BJ Natural killer cells determine development of allergen-induced eosinophilic airway inflammation in mice J Exp Med 1999 189 553 62 9927517 PMC2192913
  68. [71]Ple C Barrier M Amniai L Marquillies P Bertout J Tsicopoulos A Natural killer cells accumulate in lung-draining lymph nodes and regulate airway eosinophilia in a murine model of asthma Scand J Immunol 2010 72 118 27 20618770
  69. [72]Wang W Hansbro PM Foster PS Yang M An alternate STAT6-independent pathway promotes eosinophil influx into blood during allergic airway inflammation PLoS One 2011 6 e17766 21423619 PMC3057993
  70. [73]Haworth O Cernadas M Levy BD NK cells are effectors for resolvin E1 in the timely resolution of allergic airway inflammation J Immunol 2011 186 6129 35 21515793 PMC3823382
  71. [74]Barnig C Cernadas M Dutile S Liu X Perrella MA Kazani S Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma Sci Transl Med 2013 5 174ra26 PMC3823369 23447017
  72. [75]Nakamura R Inoue K Fujitani Y Kiyono M Hirano S Takano H Effects of nanoparticle-rich diesel exhaust particles on IL-17 production in vitro J Immunotoxicol 2012 9 72 6 22299717
  73. [76]Hughes T Becknell B Freud AG McClory S Briercheck E Yu J Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue Immunity 2010 32 803 14 20620944 PMC3742307
  74. [77]Kiss EA Vonarbourg C Kopfmann S Hobeika E Finke D Esser C Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles Science 2011 334 1561 5 22033518
  75. [78]Rodríguez-Sosa M Elizondo G López-Durán RM Rivera I Gonzalez FJ Vega L Overproduction of IFN-gamma and IL-12 in AhR-null mice FEBS Lett 2005 579 6403 10 16289099
  76. [79]Zhou Y Tung HY Tsai YM Hsu SC Chang HW Kawasaki H Aryl hydrocarbon receptor controls murine mast cell homeostasis Blood 2013 121 3195 204 23462117 PMC3630832
  77. [80]Sibilano R Frossi B Calvaruso M Danelli L Betto E Dall’Agnese A The aryl hydrocarbon receptor modulates acute and late mast cell responses J Immunol 2012 189 120 7 22649193
  78. [81]Chang Y Sénéchal S de Nadai P Chenivesse C Gilet J Vorng H Diesel exhaust exposure favors TH2 cell recruitment in nonatopic subjects by differentially regulating chemokine production J Allergy Clin Immunol 2006 118 354 60 16890758
  79. [82]Negishi T Kato Y Ooneda O Mimura J Takada T Mochizuki H Effects of aryl hydrocarbon receptor signaling on the modulation of TH1/TH2 balance J Immunol 2005 175 7348 56 16301641
  80. [83]Kepley CL Lauer FT Oliver JM Burchiel SW Environmental polycyclic aromatic hydrocarbons, benzo(a) pyrene (BaP) and BaP-quinones, enhance IgE-mediatedhistamine release and IL-4 production in human basophils Clin Immunol 2003 107 10 9 12738245
  81. [84]Bömmel H Li-Weber M Serfling E Duschl A The environmental pollutant pyrene induces the production of IL-4 J Allergy Clin Immunol 2000 105 796 802 10756232
  82. [85]Veldhoen M Duarte JH The aryl hydrocarbon receptor: fine-tuning the immune-response Curr Opin Immunol 2010 22 747 52 20926270
  83. [86]Chen PH Chang H Chang JT Lin P Aryl hydrocarbon receptor in association with RelA modulates IL-6 expression in non-smoking lung cancer Oncogene 2012 31 2555 65 21996739
  84. [87]Zhu J Cao Y Li K Wang Z Zuo P Xiong W Increased expression of aryl hydrocarbon receptor and interleukin 22 in patients with allergic asthma Asian Pac J Allergy Immunol 2011 29 266 72 22053597
  85. [88]Suen JL Hsu SH Hung CH Chao YS Lee CL Lin CY A common environmental pollutant, 4-nonylphenol, promotes allergic lung inflammation in a murine model of asthma Allergy 2013 68 780 7 23621474
  86. [89]Tauchi M Hida A Negishi T Katsuoka F Noda S Mimura J Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesions Mol Cell Biol 2005 25 9360 8 16227587 PMC1265822
  87. [90]Mizutani N Nabe T Ohtani Y Han HY Fujii M Yoshino S Polycyclic aromatic hydrocarbons aggravate antigen-induced nasal blockage in experimental allergic rhinitis J Pharmacol Sci 2007 105 291 7 17986815
  88. [91]Kanoh T Suzuki T Ishimori M Ikeda S Ohasawa M Ohkuni H Adjuvant activities of pyrene, anthracene, fluoranthene and benzo(a)pyrene in production of anti-IgE antibody to Japanese cedar pollen allergen in mice J Clin Lab Immunol 1996 48 133 47 9819666
  89. [92]Suzuki T Kanoh T Kanbayashi M Todome Y Ohkuni H The adjuvant activity of pyrene in diesel exhaust on IgE antibody production in mice Arerugi 1993 42 963 8 7504446
  90. [93]Luebke RW Copeland CB Daniels M Lambert AL Gilmour MI Suppression of allergic immune responses to house dust mite (HDM) in rats exposed to 2,3,7,8-TCDD Toxicol Sci 2001 62 71 9 11399795
  91. [94]Schulz VJ Smit JJ Willemsen KJ Fiechter D Hassing I Bleumink R Activation of the aryl hydrocarbon receptor suppresses sensitization in a mouse peanut allergy model Toxicol Sci 2011 123 491 500 21804081
  92. [95]Bock KW Köhle C Ah receptor: dioxin-mediated toxic responses as hints to deregulated physiologic functions Biochem Pharmacol 2006 72 393 404 16545780

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Authors
Manners, S., Alam, R., Schwartz, D. A., & Gorska, M. M.
Affiliations
  • National Jewish Health (US)
  • University of Colorado Denver (US)
Corresponding author
Gorska, Magdalena M.
ORCID
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2014-07
Volume
134
Issue
1
Pages
63-72.e7
ISSN
0091-6749 (ISSN-L)
DOI
10.1016/j.jaci.2013.10.047
PMC
PMC4065237
OpenAlex
W2044740886
Cited by
110
References
3
Citations by year
2026: 4 · 2025: 3 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 16 · 2020: 10 · 2019: 17 · 2018: 9 · 2017: 4 · 2016: 6 · 2015: 15 · 2014: 8
FWCI
6.73
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Allergy and Clinical Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Asthma and Allergy Foundation of America
  • National Institutes of Health (UL1TR001082, KL2TR001080, KL2TR000156, TR000156)
  • National Heart, Lung, and Blood Institute (R01HL122995)
  • National Institute of Allergy and Infectious Diseases (R01AI091614, R01AI102943)
  • National Institute of Environmental Health Sciences (P01ES018181)
  • National Center for Advancing Translational Sciences (CTSI KL2 TR000156)
Topics
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
Keywords
asthma susceptibility, diesel exhaust particles, prenatal exposure, maternal exposure, mouse model, ovalbumin-induced asthma, airway hyperresponsiveness, airway inflammation, IgE, Th2 cytokines, Th17 cytokines, natural killer cells, aryl hydrocarbon receptor, oxidative stress, gene transcription, early childhood exposure
MeSH terms
Air Pollutants, Animals, Asthma, Vehicle Emissions, Disease Models, Animal, Disease Susceptibility, Female, Gene Expression Regulation, Humans, Immunoglobulin E, Killer Cells, Natural, Mice, Inbred C57BL, Ovalbumin, Pregnancy, Prenatal Exposure Delayed Effects, Transcription, Genetic, Bronchial Hyperreactivity, Receptors, Aryl Hydrocarbon, Maternal Exposure, Interleukin-17, Gene Expression Profiling, Mice

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