Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases

Akdis, Mübeccel; Aab, Alar; Altunbulakli, Can; Azkur, Kursat; Costa, Rita A.; Crameri, Reto; Duan, Su; Eiwegger, Thomas; Eljaszewicz, Andrzej; Ferstl, Ruth; Frei, Remo; Garbani, Mattia; Globinska, Anna; Hess, Lena; Huitema, Carly; Kubo, Terufumi; Komlosi, Zsolt; Konieczna, Patricia; Kovacs, Nora; Kucuksezer, Umut C.; Meyer, Norbert; Morita, Hideaki; Olzhausen, Judith; O'Mahony, Liam; Pezer, Marija; Prati, Moira; Rebane, Ana; Rhyner, Claudio; Rinaldi, Arturo; Sokolowska, Milena; Stanic, Barbara; Sugita, Kazunari; Treis, Angela; van de Veen, Willem; Wanke, Kerstin; Wawrzyniak, Marcin; Wawrzyniak, Paulina; Wirz, Oliver F.; Zakzuk, Josefina Sierra; Akdis, Cezmi A.

doi:10.1016/j.jaci.2016.06.033

Cited by 913Cytokine Signaling Pathways and InteractionsAsthma and respiratory diseasesIL-33, ST2, and ILC Pathways

Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases

Open access

Akdis, Mübeccel, Aab, Alar, Altunbulakli, Can, Azkur, Kursat, Costa, Rita A., Crameri, Reto, Duan, Su, Eiwegger, Thomas +32 more·2016·Journal of Allergy and Clinical Immunology

DOI 10.1016/j.jaci.2016.06.033

Open this paper in CoChat — free account Open PDF

Abstract

There have been extensive developments on cellular and molecular mechanisms of immune regulation in allergy, asthma, autoimmune diseases, tumor development, organ transplantation, and chronic infections during the last few years. Better understanding the functions, reciprocal regulation, and counterbalance of subsets of immune and inflammatory cells that interact through interleukins, interferons, TNF-α, and TGF-β offer opportunities for immune interventions and novel treatment modalities in the era of development of biological immune response modifiers particularly targeting these molecules or their receptors. More than 60 cytokines have been designated as interleukins since the initial discoveries of monocyte and lymphocyte interleukins (called IL-1 and IL-2, respectively). Studies of transgenic or gene-deficient mice with altered expression of these cytokines or their receptors and analyses of mutations and polymorphisms in human genes that encode these products have provided essential information about their functions. Here we review recent developments on IL-1 to IL-38, TNF-α, TGF-β, and interferons. We highlight recent advances during the last few years in this area and extensively discuss their cellular sources, targets, receptors, signaling pathways, and roles in immune regulation in patients with allergy and asthma and other inflammatory diseases.

Integrity signals

Registry

Crossref · 10.1016/j.jaci.2016.06.033

Cites

220 of 220 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742 · see citing works
An endotoxin-induced serum factor that causes necrosis of tumors
Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532 · see citing works
IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines
Schmitz, J., Owyang, A. M., Oldham, E. R., Song, Y., Murphy, E., McClanahan, T. K., Zurawski, G., Moshrefi, M., Qin, J., Li, X., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.09.015 · Cited by 3,701 · see citing works
Inflammasomes: mechanism of action, role in disease, and therapeutics
Guo, H., Callaway, J. B., & Ting, J. P.-Y. (2015) · Nature Medicine · doi:10.1038/nm.3893 · Cited by 3,340 · see citing works
Development of T H 1 CD4 + T Cells Through IL-12 Produced by Listeria -Induced Macrophages
Hsieh, C.-S., Macatonia, S. E., Tripp, C. S., Wolf, S. F., O'Garra, A., & Murphy, K. M. (1993) · Science · doi:10.1126/science.8097338 · Cited by 3,134 · see citing works
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
Coll, R. C., Robertson, A. A. B., Chae, J. J., Higgins, S. C., Muñoz-Planillo, R., Inserra, M. C., Vetter, I., Dungan, L. S., Monks, B. G., Stutz, A., et al. (2015) · Nature Medicine · doi:10.1038/nm.3806 · Cited by 2,849 · see citing works
Cloning of a new cytokine that induces IFN-γ production by T cells
Okamura, H., Tsutsui, H., Komatsu, T., Yutsudo, M., Hakura, A., Tanimoto, T., Torigoe, K., Okura, T., Nukada, Y., Hattori, K., et al. (1995) · Nature · doi:10.1038/378088a0 · Cited by 2,602 · see citing works
Selective in Vitro Growth of T Lymphocytes from Normal Human Bone Marrows
Morgan, D. A., Ruscetti, F. W., & Gallo, R. C. (1976) · Science · doi:10.1126/science.181845 · Cited by 2,509 · see citing works
The inhibitory cytokine IL-35 contributes to regulatory T-cell function
Collison, L., Workman, C., Kuo, T. T., Boyd, K., Wang, Y., Vignali, K. M., Cross, R., Sehy, D., Blumberg, R., & Vignali, D. (2007) · Nature · doi:10.1038/nature06306 · Cited by 2,152 · see citing works
Development, cytokine profile and function of human interleukin 17-producing helper T cells
Wilson, N. J., Boniface, K., Chan, J. R., McKenzie, B. S., Blumenschein, W. M., Mattson, J. D., Basham, B., Smith, K., Chen, T., Morel, F., et al. (2007) · Nature Immunology · doi:10.1038/ni1497 · Cited by 2,035 · see citing works
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Zheng, Y., Danilenko, D., Valdez, P., Kasman, I., Eastham-Anderson, J., Wu, J., & Ouyang, W. (2007) · Nature · doi:10.1038/nature05505 · Cited by 2,034 · see citing works
Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.
Kobayashi, M., Fitz, L. J., Ryan, M., Hewick, R. M., Clark, S., Chan, S. H., Loudon, R. P., Sherman, F., PERUSSIA, B., & Trinchieri, G. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.170.3.827 · Cited by 1,953 · see citing works
The interleukin-1 family: back to the future
Garlanda, C., Dinarello, C. A., & Mantovani, A. (2013) · Immunity · doi:10.1016/j.immuni.2013.11.010 · Cited by 1,945 · cited 1× · see citing works
“IL-1Ra lacks the IL-1 receptor accessory protein interacting domain, so that its binding to IL-1 type I receptor inhibits IL-1 signaling.(53) Therapies under development for some inflammatory disorders involve neutralization of IL-1 activity through administration of IL-1Ra and anti–IL-1 neutralizing mAbs.”
Background
Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome
Habashi, J. P., Judge, D. P., Holm, T. M., Cohn, R. D., Loeys, B. L., Cooper, T. K., Myers, L., Klein, E. C., Liu, G., Calvi, C., et al. (2006) · Science · doi:10.1126/science.1124287 · Cited by 1,794 · see citing works
The immunology of asthma
Lambrecht, B. N., & Hammad, H. (2015) · Nature Immunology · doi:10.1038/ni.3049 · Cited by 1,673 · see citing works
IL-28, IL-29 and their class II cytokine receptor IL-28R
Sheppard, P. O., Kindsvogel, W., Xu, W., Henderson, K., Schlutsmeyer, S., Whitmore, T. E., Kuestner, R. E., Garrigues, U., Birks, C., Roraback, J., et al. (2002) · Nature Immunology · doi:10.1038/ni873 · Cited by 1,563 · see citing works
IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4+ T Cells
Pflanz, S., Timans, J. C., Cheung, J., Rosales, R., Kanzler, H., Gilbert, J., Hibbert, L., Churakova, T., Travis, M. A., Vaisberg, E., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00324-2 · Cited by 1,462 · see citing works
Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor
Grabstein, K. H., Eisenman, J. R., Shanebeck, K. D., Rauch, C. T., Srinivasan, S., Fung, V., Beers, C., Richardson, J. S., Schoenborn, M. A., Ahdieh, M., et al. (1994) · Science · doi:10.1126/science.8178155 · Cited by 1,422 · see citing works
A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R
Parham, C. L., Chirica, M., Timans, J., Vaisberg, E., Travis, M. A., Cheung, J., Pflanz, S., Zhang, R. V., Singh, K. P., Vega, F., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5699 · Cited by 1,297 · see citing works
Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset
Veldhoen, M., Uyttenhove, C., van Snick, J., Helmby, H., Westendorf, A., Buer, J., Martin, B., Wilhelm, C., & Stockinger, B. (2008) · Nature Immunology · doi:10.1038/ni.1659 · Cited by 1,213 · see citing works
IL-25 Induces IL-4, IL-5, and IL-13 and Th2-Associated Pathologies In Vivo
Fort, M. M., Cheung, J., Yen, D., Li, J., Zurawski, S. M., Lo, S., Menon, S., Clifford, T., Hunte, B., Lesley, R., et al. (2001) · Immunity · doi:10.1016/s1074-7613(01)00243-6 · Cited by 1,203 · see citing works
TGF-β signaling in fibrosis
Biernacka, A., Dobaczewski, M. P., & Frangogiannis, N. G. (2011) · Growth Factors · doi:10.3109/08977194.2011.595714 · Cited by 1,175 · see citing works
Identification of a T cell-derived b cell growth factor distinct from interleukin 2.
Howard, M., Farrar, J., Hilfiker, M. L., Johnson, B., Takatsu, K., Hamaoka, T., & Paul, W. E. (1982) · The Journal of Experimental Medicine · doi:10.1084/jem.155.3.914 · Cited by 1,099 · see citing works
Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist
Eisenberg, S. P., Evans, R. J., Arend, W. P., Verderber, E. L., Brewer, M. T., Hannum, C. H., & Thompson, R. C. (1990) · Nature · doi:10.1038/343341a0 · Cited by 1,088 · see citing works
Structure and Functional Expression of a Human Interleukin-8 Receptor
Holmes, W. E., Lee, J., Kuang, W.-J., Rice, G. C., & Wood, W. I. (1991) · Science · doi:10.1126/science.1840701 · Cited by 1,088 · see citing works
Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology
Buonocore, S. M., Ahern, P. P., Uhlig, H. H., Ivanov, I. I., Littman, D. R., Maloy, K. J., & Powrie, F. M. (2010) · Nature · doi:10.1038/nature08949 · Cited by 1,066 · see citing works
Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling
Eyerich, S., Eyerich, K., Pennino, D., Carbone, T., Nasorri, F., Pallotta, S., Cianfarani, F., Odorisio, T., Traidl-Hoffmann, C., Behrendt, H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci40202 · Cited by 1,052 · see citing works
IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
Sugimoto, K., Ogawa, A., Mizoguchi, E., Shimomura, Y., Andoh, A., Bhan, A. K., Blumberg, R. S., Xavier, R. J., & Mizoguchi, A. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33194 · Cited by 1,016 · see citing works
Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice
Dillon, S. R., Sprecher, C. A., Hammond, A. J., Bilsborough, J., Rosenfeld-Franklin, M., Presnell, S., Haugen, H. S., Maurer, M. F., Harder, B., Johnston, J. V., et al. (2004) · Nature Immunology · doi:10.1038/ni1084 · Cited by 1,014 · see citing works
Latent TGF-β structure and activation
Shi, M., Zhu, J., Wang, R., Chen, X., Mi, L., Walz, T., & Springer, T. A. (2011) · Nature · doi:10.1038/nature10152 · Cited by 1,013 · see citing works
IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia
Wang, Y., Szretter, K. J., Vermi, W., Gilfillan, S., Rossini, C., Cella, M., Barrow, A. D., Diamond, M. S., & Colonna, M. (2012) · Nature Immunology · doi:10.1038/ni.2360 · Cited by 1,011 · see citing works
The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch
Wilson, S. R., Thé, L., Batia, L. M., Beattie, K., Katibah, G. E., McClain, S. P., Pellegrino, M., Estandian, D., & Bautista, D. M. (2013) · Cell · doi:10.1016/j.cell.2013.08.057 · Cited by 989 · see citing works
A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus
Prokunina‐Olsson, L., Muchmore, B., Tang, W., Pfeiffer, R. M., Park, H., Dickensheets, H. L., Hergott, D., Porter-Gill, P. A., Mumy, A., Kohaar, I., et al. (2013) · Nature Genetics · doi:10.1038/ng.2521 · Cited by 929 · see citing works
IL-37 is a fundamental inhibitor of innate immunity
Nold, M. F., Nold‐Petry, C. A., Zepp, J. A., Palmer, B. E., Bufler, P., & Dinarello, C. A. (2010) · Nature Immunology · doi:10.1038/ni.1944 · Cited by 850 · see citing works
Barrier Epithelial Cells and the Control of Type 2 Immunity
Hammad, H., & Lambrecht, B. N. (2015) · Immunity · doi:10.1016/j.immuni.2015.07.007 · Cited by 847 · see citing works
The 3 major types of innate and adaptive cell-mediated effector immunity
Annunziato, F., Romagnani, C., & Romagnani, S. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.11.001 · Cited by 818 · see citing works
Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17–producing T cells
Batten, M., Li, J., Yi, S., Kljavin, N. M., Danilenko, D. M., Lucas, S., Lee, J., de Sauvage, F. J., & Ghilardi, N. (2006) · Nature Immunology · doi:10.1038/ni1375 · Cited by 815 · see citing works
A sensory neuron–expressed IL-31 receptor mediates T helper cell–dependent itch: Involvement of TRPV1 and TRPA1
Cevikbas, F., Wang, X., Akiyama, T., Kempkes, C., Savinko, T., Antal, A. S., Kukova, G., Buhl, T., Ikoma, A., Buddenkotte, J., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.10.048 · Cited by 806 · see citing works
Effects of an Anti-TSLP Antibody on Allergen-Induced Asthmatic Responses
Gauvreau, G. M., O’Byrne, P. M., Boulet, L., Wang, Y., Cockcroft, D. W., Bigler, J., FitzGerald, J. M., Boedigheimer, M. J., Davis, B. E., Dias, C. S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1402895 · Cited by 790 · see citing works
Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases
Akdiş, M., Bürgler, S., Crameri, R., Eiwegger, T., Fujita, H., Alcaide, E. G., Klunker, S., Meyer, N., O’Mahony, L., Palomares, Ó., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.11.050 · Cited by 780 · see citing works
Self-citation
Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2).
Hirano, T., Taga, T., Nakano, N., Yasukawa, K., Kashiwamura, S., Shimizu, K., Nakajima, K., Pyun, K., & Kishimoto, T. (1985) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.82.16.5490 · Cited by 691 · see citing works
Anti-inflammatory and pro-inflammatory roles of TGF-β, IL-10, and IL-22 in immunity and autoimmunity
Sanjabi, S., Zenewicz, L. A., Kamanaka, M., & Flavell, R. A. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.04.008 · Cited by 662 · see citing works
The airway epithelium: soldier in the fight against respiratory viruses
Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655 · see citing works
IgG4 production is confined to human IL-10–producing regulatory B cells that suppress antigen-specific immune responses
van de Veen, W., Stanić, B., Yaman, G., Wawrzyniak, M., Söllner, S., Akdis, D. G., Rückert, B., Akdiş, C. A., & Akdis, M. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.01.014 · Cited by 652 · see citing works
Self-citation
TH2, allergy and group 2 innate lymphoid cells
Licona-Limón, P., Kim, L. K., Palm, N. W., & Flavell, R. A. (2013) · Nature Immunology · doi:10.1038/ni.2617 · Cited by 647 · see citing works
T Follicular Helper (TFH) Cells in Normal and Dysregulated Immune Responses
King, C., Tangye, S. G., & Mackay, C. R. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090344 · Cited by 632 · see citing works
Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells
Schuijs, M. J., Willart, M. A., Vergote, K., Gras, D., Deswarte, K., Ege, M. J., Madeira, F. B., Beyaert, R., van Loo, G., Bracher, F., et al. (2015) · Science · doi:10.1126/science.aac6623 · Cited by 576 · see citing works
Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites
Lantz, C. S., Boesiger, J., Song, C. H., Mach, N., Kobayashi, T., Mulligan, R. C., Nawa, Y., Dranoff, G., & Galli, S. J. (1998) · Nature · doi:10.1038/32190 · Cited by 573 · see citing works
Mechanisms of allergen-specific immunotherapy: Multiple suppressor factors at work in immune tolerance to allergens
Akdiş, M., & Akdiş, C. A. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.12.1088 · Cited by 567 · see citing works
IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding
Hymowitz, S. G., Filvaroff, E. H., Yin, J., Lee, J., Cai, L., Risser, P., Maruoka, M., Mao, W., Foster, J., Kelley, R. F., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.19.5332 · Cited by 548 · see citing works
Interleukin 20
Blumberg, H., Conklin, D., Xu, W., Grossmann, A., Brender, T., Carollo, S., Eagan, M., Foster, D., Haldeman, B. A., Hammond, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00187-8 · Cited by 542 · see citing works
Endotypes and phenotypes of chronic rhinosinusitis: A PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology
Akdis, C. A., Bachert, C., Cingi, C., Dykewicz, M. S., Hellings, P. W., Naclerio, R. M., Schleimer, R. P., & Ledford, D. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.02.036 · Cited by 538 · see citing works
Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System
LaPorte, S. L., Juo, Z. S., Václavíková, J., Colf, L. A., Qi, X., Heller, N. M., Keegan, A. D., & García, K. C. (2008) · Cell · doi:10.1016/j.cell.2007.12.030 · Cited by 519 · see citing works
Viral infection and Toll‐like receptor agonists induce a differential expression of type I and λ interferons in human plasmacytoid and monocyte‐derived dendritic cells
Coccia, E. M., Severa, M., Giacomini, E., Monneron, D., Remoli, M. E., Julkunen, I., Cella, M., Lande, R., & Uzé, G. (2004) · European Journal of Immunology · doi:10.1002/eji.200324610 · Cited by 489 · see citing works
Defective epithelial barrier in chronic rhinosinusitis: The regulation of tight junctions by IFN-γ and IL-4
Soyka, M. B., Wawrzyniak, P., Eiwegger, T., Holzmann, D., Treis, A., Wanke, K., Kast, J. I., & Akdis, C. A. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.05.052 · Cited by 486 · see citing works
Self-citation
Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression.
Jiang, H., Lin, J. J., Su, Z.-Z., Goldstein, N. I., & Fisher, P. B. (1995) · PubMed · Cited by 486 · see citing works
Welcome to the neighborhood: epithelial cell‐derived cytokines license innate and adaptive immune responses at mucosal sites
Saenz, S. A., Taylor, B. C., & Artis, D. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00713.x · Cited by 484 · see citing works
In vivo switch to IL-10–secreting T regulatory cells in high dose allergen exposure
Meiler, F., Zumkehr, J., Klunker, S., Rückert, B., Akdiş, C. A., & Akdis, M. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080193 · Cited by 468 · see citing works
Self-citation
Epithelial barrier function: At the front line of asthma immunology and allergic airway inflammation
Georas, S. N., & Rezaee, F. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.05.049 · Cited by 467 · see citing works
IL-27 regulates IL-12 responsiveness of naïve CD4 + T cells through Stat1-dependent and -independent mechanisms
Lucas, S., Ghilardi, N., Li, J., & de Sauvage, F. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536517100 · Cited by 460 · see citing works
Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia
Smith, S. G., Chen, R., Kjarsgaard, M., Huang, C., Oliveria, J. P., O’Byrne, P. M., Gauvreau, G. M., Boulet, L., Lemière, C., Martin, J. G., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.05.037 · Cited by 458 · see citing works
The interleukin (IL)-1 cytokine family – Balance between agonists and antagonists in inflammatory diseases
Palomo, J., Dietrich, D., Martin, P., Palmer, G., & Gabay, C. (2015) · Cytokine · doi:10.1016/j.cyto.2015.06.017 · Cited by 447 · see citing works
IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction
Nold‐Petry, C. A., Lo, C. Y.-W., Rudloff, I., Elgass, K., Li, S., Gantier, M. P., Lotz-Havla, A. S., Gersting, S. W., Cho, S., Lao, J. C., et al. (2015) · Nature Immunology · doi:10.1038/ni.3103 · Cited by 442 · see citing works
Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy
Vickery, B. P., Scurlock, A. M., Kulis, M. D., Steele, P. H., Kamilaris, J. S., Berglund, J. P., Burk, C. M., Hiegel, A. M., Carlisle, S. K., Christie, L., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.11.007 · Cited by 435 · see citing works
Lambda Interferon Inhibits Hepatitis B and C Virus Replication
Robek, M. D., Boyd, B. S., & Chisari, F. V. (2005) · Journal of Virology · doi:10.1128/jvi.79.6.3851-3854.2005 · Cited by 432 · see citing works
Cloning of the Murine Thymic Stromal Lymphopoietin (Tslp) Receptor
Park, L., Martin, U., Garka, K. E., Gliniak, B., Santo, J. P. D., Müller, W., Largaespada, D. A., Copeland, N. G., Jenkins, N. A., Farr, A. G., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.5.659 · Cited by 417 · see citing works
The IL-20 subfamily of cytokines — from host defence to tissue homeostasis
Rutz, S., Wang, X., & Ouyang, W. (2014) · Nature reviews. Immunology · doi:10.1038/nri3766 · Cited by 416 · see citing works
Structural Biology of Shared Cytokine Receptors
Wang, X., Lupardus, P. J., LaPorte, S. L., & García, K. C. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090616 · Cited by 407 · see citing works
The dynamic roles of TGF‐β in cancer
Meulmeester, E., & ten Dijke, P. (2010) · The Journal of Pathology · doi:10.1002/path.2785 · Cited by 391 · see citing works
Differentiation plasticity regulated by TGF-β family proteins in development and disease
Derynck, R., & Akhurst, R. J. (2007) · Nature Cell Biology · doi:10.1038/ncb434 · Cited by 383 · see citing works
Beyond TGFβ: roles of other TGFβ superfamily members in cancer
Wakefield, L. M., & Hill, C. S. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3500 · Cited by 373 · see citing works
Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family
Li, H., Chen, J., Huang, A. J. Y., Stinson, J., Heldens, S., Foster, J., Dowd, P., Gurney, A. L., & Wood, W. I. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.773 · Cited by 354 · see citing works
Asthma phenotypes and the use of biologic medications in asthma and allergic disease: The next steps toward personalized care
Fajt, M. L., & Wenzel, S. E. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.12.1871 · Cited by 352 · see citing works
IL-1 family nomenclature
Dinarello, C. A., Arend, W. P., Sims, J. E., Smith, D. E., Blumberg, H., O'Neill, L. A. J., Goldbach‐Mansky, R. T., Pizarro, T. T., Hoffman, H. M., Bufler, P., et al. (2010) · Nature Immunology · doi:10.1038/ni1110-973 · Cited by 351 · see citing works
Cutting Edge: IL-17F, a Novel Cytokine Selectively Expressed in Activated T Cells and Monocytes, Regulates Angiogenesis and Endothelial Cell Cytokine Production
Starnes, T., Robertson, M. J., Sledge, G. W., Kelich, S. L., Nakshatri, H., Broxmeyer, H. E., & Hromas, R. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.8.4137 · Cited by 349 · see citing works
Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-β
Palomares, Ó., Martín‐Fontecha, M., Lauener, R. P., Traidl‐Hoffmann, C., Cavkaytar, Ö., Akdis, M., & Akdiş, C. A. (2014) · Genes and Immunity · doi:10.1038/gene.2014.45 · Cited by 348 · see citing works
Self-citation
Human soluble IL-6 receptor: its detection and enhanced release by HIV infection
Honda, M., Yamamoto, S., Cheng, M., Yasukawa, K., Suzuki, H., Saito, T. R., Osugi, Y., Tokunaga, T., & Kishimoto, T. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.7.2175 · Cited by 331 · see citing works
Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis
Starnes, T., Broxmeyer, H. E., Robertson, M. J., & Hromas, R. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.2.642 · Cited by 331 · see citing works
IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39
Mascanfroni, I. D., Yeste, A., Vieira, S. M., Burns, E. J., Patel, B., Sloma, I., Wu, Y., Mayo, L., Ben‐Hamo, R., Efroni, S., et al. (2013) · Nature Immunology · doi:10.1038/ni.2695 · Cited by 328 · see citing works
Epstein–Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin
Devergne, O., Birkenbach, M. P., & Kieff, E. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.22.12041 · Cited by 327 · see citing works
Basophils and allergic inflammation
Siracusa, M. C., Kim, B., Spergel, J. M., & Artis, D. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.07.046 · Cited by 320 · see citing works
Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33
Christianson, C. A., Goplen, N., Zafar, I., Irvin, C., Good, J. T., Rollins, D. R., Gorentla, B. K., Liu, W., Gorska, M. M., Chu, H., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.11.037 · Cited by 304 · see citing works
Transcriptional regulation of innate lymphoid cell fate
Serafini, N., Vosshenrich, C. A. J., & Santo, J. P. D. (2015) · Nature reviews. Immunology · doi:10.1038/nri3855 · Cited by 292 · see citing works
Cloning, expression and initial characterisation of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10)
Gallagher, G. E., Dickensheets, H. L., Eskdale, J., Ls, I., Mirochnitchenko, O., Peat, J. E., Vazquez, N., Pestka, S., Donnelly, R. P., & Kotenko, S. V. (2000) · Genes and Immunity · doi:10.1038/sj.gene.6363714 · Cited by 288 · see citing works
Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection
Hernández, P. P., Mahlakõiv, T., Yang, I., Schwierzeck, V., Nguyen, N., Guendel, F., Gronke, K., Ryffel, B., Hölscher, C., Dumoutier, L., et al. (2015) · Nature Immunology · doi:10.1038/ni.3180 · Cited by 286 · see citing works
An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers
Morita, H., Arae, K., Unno, H., Miyauchi, K., Toyama, S., Nambu, A., Oboki, K., Ohno, T., Motomura, K., Matsuda, A., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.021 · Cited by 274 · see citing works
Self-citation
Human leukocytic pyrogen: purification and development of a radioimmunoassay.
Dinarello, C. A., Renfer, L., & Wolff, S. M. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.10.4624 · Cited by 272 · see citing works
RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications
Suárez‐Fariñas, M., Ungar, B., da Rosa, J. C., Ewald, D. A., Rozenblit, M., Gonzalez, J., Xu, H., Zheng, X., Peng, X., Estrada, Y. D., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.03.003 · Cited by 270 · see citing works
Interleukin 24 (MDA-7/MOB-5) Signals through Two Heterodimeric Receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2
Wang, M., Tan, Z., Zhang, R., Kotenko, S. V., & Liang, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106043200 · Cited by 269 · see citing works
Clinical outcome in IL-10– and IL-10 receptor–deficient patients with or without hematopoietic stem cell transplantation
Engelhardt, K. R., Shah, N., Faizura-Yeop, I., Uygun, D. F. K., Frede, N., Muise, A. M., Shteyer, E., Filiz, S., Chee, R., Elawad, M., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.09.025 · Cited by 268 · see citing works
TH17 cells in the big picture of immunology
Schmidt‐Weber, C. B., Akdiş, M., & Akdiş, C. A. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.06.039 · Cited by 266 · see citing works
Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing
Suárez‐Fariñas, M., Ungar, B., Noda, S., Shroff, A., Mansouri, Y., Fuentes‐Duculan, J., Czernik, A., Zheng, X., Estrada, Y. D., Xu, H., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.06.032 · Cited by 265 · see citing works
Targeting the interleukin pathway in the treatment of asthma
Chung, K. F. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00157-9 · Cited by 263 · see citing works
Modulation of lymphocyte migration by human lymphokines. I. Identification and characterization of chemoattractant activity for lymphocytes from mitogen-stimulated mononuclear cells.
Cruikshank, W. (1982) · The Journal of Immunology · doi:10.4049/jimmunol.128.6.2563 · Cited by 257 · see citing works
Recent advances in epithelium-derived cytokines (IL-33, IL-25, and thymic stromal lymphopoietin) and allergic inflammation
Divekar, R. D., & Kita, H. (2014) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000133 · Cited by 257 · see citing works
A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity
Bufler, P., Azam, T., Gamboni-Robertson, F., Reznikov, L. L., Kumar, S., Dinarello, C. A., & Kim, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212519099 · Cited by 252 · see citing works
T cell growth and differentiation induced by interleukin-HP1/IL-6, the murine hybridoma/plasmacytoma growth factor.
Uyttenhove, C., Coulie, P. G., & Snick, J. V. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.4.1417 · Cited by 251 · see citing works
Autocrine Transforming Growth Factor-β1 Promotes In Vivo Th17 Cell Differentiation
Gutcher, I., Donkor, M. K., Ma, Q., Rudensky, A. Y., Flavell, R. A., & Li, M. O. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.005 · Cited by 244 · see citing works
Pharmacogenetics: Implications of race and ethnicity on defining genetic profiles for personalized medicine
Ortega, V. E., & Meyers, D. A. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.10.040 · Cited by 237 · see citing works
TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26
Meller, S., Domizio, J. D., Voo, K. S., Hawerkamp, H. C., Chamilos, G., Ganguly, D., Conrad, C., Gregorio, J. D., Roy, D. L., Roger, T., et al. (2015) · Nature Immunology · doi:10.1038/ni.3211 · Cited by 231 · see citing works
Mechanisms of immune tolerance to allergens: role of IL-10 and Tregs
Akdiş, C. A., & Akdiş, M. (2014) · Journal of Clinical Investigation · doi:10.1172/jci78891 · Cited by 228 · see citing works
Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms
Hinks, T., Zhou, X., Staples, K. J., Dimitrov, B. D., Manta, A., Petrossian, T. C., Lum, P. Y., Smith, C. G., Ward, J., Howarth, P. H., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.01.014 · Cited by 228 · see citing works
Differentiation plasticity regulated by TGF-|[beta]| family proteins in development and disease
Derynck, R., & Akhurst, R. J. (2007) · Nature · doi:10.1038/ncb0907-1000 · Cited by 227 · see citing works
Severe atopic dermatitis is characterized by selective expansion of circulating TH2/TC2 and TH22/TC22, but not TH17/TC17, cells within the skin-homing T-cell population
Czarnowicki, T., Gonzalez, J., Shemer, A., Malajian, D., Xu, H., Zheng, X., Khattri, S., Gilleaudeau, P., Sullivan-Whalen, M. M., Suárez‐Fariñas, M., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.01.020 · Cited by 221 · see citing works
Interferon induction and function at the mucosal surface
Durbin, R. K., Kotenko, S. V., & Durbin, J. E. (2013) · Immunological Reviews · doi:10.1111/imr.12101 · Cited by 221 · see citing works
Interferon-λ–treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells
Mennechet, F. J. D., & Uzé, G. (2006) · Blood · doi:10.1182/blood-2005-10-4129 · Cited by 220 · see citing works
Identification of novel immune and barrier genes in atopic dermatitis by means of laser capture microdissection
Esaki, H., Ewald, D. A., Ungar, B., Rozenblit, M., Zheng, X., Xu, H., Estrada, Y. D., Peng, X., Mitsui, H., Litman, T., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.10.037 · Cited by 218 · see citing works
Crosstalk between TGF-β signaling and the microRNA machinery
Butz, H., Rácz, K., Hunyady, L., & Patócs, A. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.04.003 · Cited by 215 · see citing works
Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures
Gold, M. J., Antignano, F., Halim, T. Y. F., Hirota, J. A., Blanchet, M., Zaph, C., Takei, F., & McNagny, K. M. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.02.033 · Cited by 215 · see citing works
Induction of a Novel Cellular Homolog of Interleukin-10, AK155, by Transformation of T Lymphocytes with Herpesvirus Saimiri
Knappe, A., Hör, S., Wittmann, S., & Fickenscher, H. (2000) · Journal of Virology · doi:10.1128/jvi.74.8.3881-3887.2000 · Cited by 214 · see citing works
Intratumoral Injection of INGN 241, a Nonreplicating Adenovector Expressing the Melanoma-Differentiation Associated Gene-7 (mda-7/IL24): Biologic Outcome in Advanced Cancer Patients
Tong, A. W., Nemunaitis, J. J., Su, D., Zhang, Y., Cunningham, C. C., Senzer, N. N., Netto, G. J., Rich, D., Mhashilkar, A., Parker, K., et al. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.09.021 · Cited by 200 · see citing works
Therapeutic manipulation of immune tolerance in allergic disease
Akdiş, M., & Akdiş, C. A. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2653 · Cited by 195 · see citing works
Directing traffic: IL ‐17 and IL ‐22 coordinate pulmonary immune defense
McAleer, J. P., & Kolls, J. K. (2014) · Immunological Reviews · doi:10.1111/imr.12183 · Cited by 195 · see citing works
IL-32, a novel cytokine with a possible role in disease
Dinarello, C. A., & Kim, S.-H. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.058511 · Cited by 193 · see citing works
Deficient antiviral immune responses in childhood: Distinct roles of atopy and asthma
Baraldo, S., Contoli, M., Bazzan, E., Turato, G., Padovani, A., Marku, B., Calabrese, F., Caramori, G., Ballarin, A., Snijders, D., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.08.005 · Cited by 191 · see citing works
TH17 and TH22 cells: A confusion of antimicrobial response with tissue inflammation versus protection
Akdiş, M., Palomares, Ó., van de Veen, W., van Splunter, M. E., & Akdiş, C. A. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.05.003 · Cited by 191 · see citing works
Association of IL33–IL-1 receptor–like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood
Savenije, O. E. M., John, J. M., Granell, R., Kerkhof, M., Dijk, F. N., de Jongste, J. C., Smit, H. A., Brunekreef, B., Postma, D. S., Steen, K. V., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.12.1080 · Cited by 185 · see citing works
Regulation of Cellular Processes by Interleukin‐16 in Homeostasis and Cancer
Richmond, J. M., Tuzova, M. N., & Cruikshank, W. W. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24441 · Cited by 183 · see citing works
Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion
Nanzer, A. M., Chambers, E. S., Ryanna, K., Richards, D. F., Black, C., Timms, P. M., Martineau, A. R., Griffiths, C., Corrigan, C. J., & Hawrylowicz, C. M. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.03.037 · Cited by 181 · see citing works
Distinct endotypes of steroid-resistant asthma characterized by IL-17Ahigh and IFN-γhigh immunophenotypes: Potential benefits of calcitriol
Chambers, E. S., Nanzer, A. M., Pfeffer, P., Richards, D. F., Timms, P. M., Martineau, A. R., Griffiths, C., Corrigan, C. J., & Hawrylowicz, C. M. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.01.026 · Cited by 181 · see citing works
Human mast cells are major IL-22 producers in patients with psoriasis and atopic dermatitis
Mashiko, S., Bouguermouh, S., Rubio, M., Baba, N., Bissonnette, R., & Sarfati, M. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.01.033 · Cited by 180 · see citing works
TH9 cells are required for tissue mast cell accumulation during allergic inflammation
Sehra, S., Yao, W., Nguyen, E., Glosson, N. L., Akhtar, N., Zhou, B., & Kaplan, M. H. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.01.021 · Cited by 175 · see citing works
Healthy immune response to allergens: T regulatory cells and more
Akdis, M. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.06.003 · Cited by 174 · see citing works
Self-citation
Human IL-31 is induced by IL-4 and promotes TH2-driven inflammation
Stott, B., Lavender, P., Lehmann, S., Pennino, D., Durham, S., & Schmidt‐Weber, C. B. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.03.050 · Cited by 173 · see citing works
Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages
Sokołowska, M., Chen, L., Liu, Y., Martínez‐Antón, A., Qi, H., Logun, C., Alsaaty, S., Park, Y. H., Kastner, D. L., Chae, J. J., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401343 · Cited by 169 · see citing works
Interleukin-25 and Interleukin-13 Production by Alveolar Macrophages in Response to Particles
Kang, C.-M., Jang, A., Ahn, M., Shin, J.-A., Kim, J., Choi, Y.-S., Rhim, T., & Park, C. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2005-0003oc · Cited by 163 · see citing works
Mechanisms of IFN-γ–induced apoptosis of human skin keratinocytes in patients with atopic dermatitis
Rebane, A., Zimmermann, M., Aab, A., Baurecht, H., Koreck, A., Karelson, M., Abram, K., Metsalu, T., Pihlap, M., Meyer, N., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.02.020 · Cited by 162 · see citing works
Self-citation
Viral infection of the lung: Host response and sequelae
Yoo, J., Kim, T. S., Hufford, M. M., & Braciale, T. J. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.06.006 · Cited by 161 · see citing works
Therapeutic approaches to asthma–chronic obstructive pulmonary disease overlap syndromes
Barnes, P. J. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.05.052 · Cited by 161 · see citing works
IL-25 as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis
Shin, H., Kim, D., Park, M., Eun, K. M., Lee, M., So, D., Kong, I. G., Mo, J., Yang, M., Jin, H. R., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.01.003 · Cited by 158 · see citing works
Identification of novel immune phenotypes for allergic and nonallergic childhood asthma
Raedler, D., Ballenberger, N., Klucker, E., Böck, A., Otto, R., da Costa, O. P., Holst, O., Illig, T., Buch, T., von Mutius, E., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.07.046 · Cited by 154 · see citing works
IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis
Meyer, N., Zimmermann, M., Bürgler, S., Bassin, C., Woehrl, S., Moritz, K. B., Rhyner, C., Indermitte, P., Schmid‐Grendelmeier, P., Akdiş, M., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.01.016 · Cited by 151 · see citing works
Self-citation
Type 2 innate lymphoid cells in induced sputum from children with severe asthma
Nagakumar, P., Denney, L., Fleming, L., Bush, A., Lloyd, C. M., & Saglani, S. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.06.038 · Cited by 149 · see citing works
IL-10–overexpressing B cells regulate innate and adaptive immune responses
Stanić, B., van de Veen, W., Wirz, O. F., Rückert, B., Morita, H., Söllner, S., Akdiş, C. A., & Akdis, M. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.07.041 · Cited by 148 · see citing works
Self-citation
Pathogen-Specific Treg Cells Expand Early during Mycobacterium tuberculosis Infection but Are Later Eliminated in Response to Interleukin-12
Shafiani, S., Dinh, C., Ertelt, J. M., Moguche, A. O., Siddiqui, I., Smigiel, K. S., Sharma, P., Campbell, D., Way, S. S., & Urdahl, K. B. (2013) · Immunity · doi:10.1016/j.immuni.2013.06.003 · Cited by 148 · see citing works
Grass tablet sublingual immunotherapy downregulates the TH2 cytokine response followed by regulatory T-cell generation
Suárez-Fueyo, A., Ramos, T., Galán, A., Jimeno, L., Wurtzen, P. A., Marin, A., de Frutos, C., Blanco, C., Carrera, A. C., Barber, D., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.09.043 · Cited by 147 · see citing works
Expression of IL-17 Homologs and Their Receptors in the Synovial Cells of Rheumatoid Arthritis Patients
Hwang, S., & Kim, H. (2005) · Molecules and Cells · doi:10.1016/s1016-8478(23)13153-0 · Cited by 145 · see citing works
IL-2 is a critical regulator of group 2 innate lymphoid cell function during pulmonary inflammation
Roediger, B., Kyle, R. L., Tay, S. S., Mitchell, A. J., Bolton, H. A., Guy, T. V., Tan, S., Forbes‐Blom, E., Tong, P. L., Köller, Y., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.03.043 · Cited by 144 · see citing works
The T-cell Lymphokine Interleukin-26 Targets Epithelial Cells through the Interleukin-20 Receptor 1 and Interleukin-10 Receptor 2 Chains
Hör, S., Pirzer, H., Dumoutier, L., Bauer, F., Wittmann, S., Sticht, H., Renauld, J., Malefyt, R. D. W., & Fickenscher, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405000200 · Cited by 144 · see citing works
Regulation of T cells and cytokines by the interleukin‐10 (IL‐10)‐family cytokines IL‐19, IL‐20, IL‐22, IL‐24 andIL‐26
Oral, H. B., Kotenko, S. V., Yılmaz, M., Mani, O., Zumkehr, J., Blaser, K., Akdiş, C. A., & Akdiş, M. (2005) · European Journal of Immunology · doi:10.1002/eji.200425523 · Cited by 141 · see citing works
Randomized trial to evaluate azithromycin's effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial virus bronchiolitis
Beigelman, A., Isaacson-Schmid, M., Sajol, G., Baty, J., Rodriguez, O. M., Leege, E., Lyons, K., Schweiger, T. L., Zheng, J., Schechtman, K. B., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.10.001 · Cited by 140 · see citing works
Molecular targets on mast cells and basophils for novel therapies
Harvima, I. T., Levi‐Schaffer, F., Dráber, P., Friedman, S., Polakovičová, I., Gibbs, B. F., Blank, U., Nilsson, G. P., & Maurer, M. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.03.007 · Cited by 138 · see citing works
IL-33 impacts on the skin barrier by downregulating the expression of filaggrin
Seltmann, J., Roesner, L. M., von Hesler, F.-W., Wittmann, M., & Werfel, T. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.01.048 · Cited by 134 · see citing works
Signaling via the IL-20 receptor inhibits cutaneous production of IL-1β and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus
Myles, I. A., Fontecilla, N. M., Valdez, P. A., Vithayathil, P. J., Naik, S., Belkaid, Y., Ouyang, W., & Datta, S. K. (2013) · Nature Immunology · doi:10.1038/ni.2637 · Cited by 133 · see citing works
Molecular cloning, sequence, expression, and processing of the interleukin 16 precursor
Baier, M., Bannert, N., Werner, A., Lang, K., & Kurth, R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5273 · Cited by 133 · see citing works
Mapping the crossroads of immune activation and cellular stress response pathways
Cláudio, N., Dalet, A., Gatti, E., & Pierre, P. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.80 · Cited by 130 · see citing works
Cytokines of the γc family control CD4+ T cell differentiation and function
Yamane, H., & Paul, W. E. (2012) · Nature Immunology · doi:10.1038/ni.2431 · Cited by 128 · see citing works
Human mast cell activation with virus-associated stimuli leads to the selective chemotaxis of natural killer cells by a CXCL8-dependent mechanism
Burke, S. M., Issekutz, T. B., Karkada, M., Lee, P. W. K., Shmulevitz, M., & Marshall, J. S. (2008) · Blood · doi:10.1182/blood-2007-10-118547 · Cited by 127 · see citing works
TNF-like weak inducer of apoptosis (TWEAK) and TNF-α cooperate in the induction of keratinocyte apoptosis
Zimmermann, M., Koreck, A., Meyer, N., Basinski, T. M., Meiler, F., Bürgler, S., Woehrl, S., Moritz, K. B., Eiwegger, T., Schmid‐Grendelmeier, P., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.11.005 · Cited by 126 · see citing works
Self-citation
Differentiation and functional analysis of human TH17 cells
Bürgler, S., Ouaked, N., Bassin, C., Basinski, T. M., Mantel, P., Siegmund, K., Meyer, N., Akdiş, C. A., & Schmidt‐Weber, C. B. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.12.017 · Cited by 123 · see citing works
Self-citation
Group 2 innate lymphocytes (ILC2) are enriched in active eosinophilic esophagitis
Doherty, T. A., Baum, R. E., Newbury, R., Yang, T., Dohil, R., Aquino, M., Doshi, A., Walford, H. H., Kurten, R. C., Broide, D. H., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.05.048 · Cited by 120 · see citing works
Advances in allergen immunotherapy: Aiming for complete tolerance to allergens
Akdis, C. A., & Akdis, M. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa7390 · Cited by 118 · see citing works
Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood
Hunninghake, G. M., Soto-Quirós, M. E., Ávila, L., Lasky-Su, J. A., Murphy, A., DeMeo, D. L., Ly, N. P., Liang, C., Sylvia, J. S., Klanderman, B. J., et al. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.04.032 · Cited by 117 · see citing works
Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity
Yang, M., Hogan, S. P., Mahalingam, S., Pope, S. M., Zimmermann, N., Fulkerson, P. C., Dent, L. A., Young, I. G., MATTHAEI, K. I., Rothenberg, M. E., et al. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.08.010 · Cited by 117 · see citing works
IL-7 coordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection
Boudil, A., Matei, I. R., Shih, H., Bogdanoski, G., Yuan, J. S., Chang, S. G., Montpellier, B., Kowalski, P. E., Voisin, V., Bashir, S., et al. (2015) · Nature Immunology · doi:10.1038/ni.3122 · Cited by 115 · see citing works
Dysfunction of TGF-β1 signaling in Alzheimer’s disease: perspectives for neuroprotection
Caraci, F., Spampinato, S. F., Sortino, M. A., Bosco, P., Battaglia, G., Bruno, V., Drago, F., Nicoletti, F., & Copani, A. (2011) · Cell and Tissue Research · doi:10.1007/s00441-011-1230-6 · Cited by 115 · see citing works
Inflammatory IL-15 is required for optimal memory T cell responses
Richer, M. J., Pewe, L. L., Hancox, L. S., Hartwig, S. M., Varga, S. M., & Harty, J. T. (2015) · Journal of Clinical Investigation · doi:10.1172/jci81261 · Cited by 111 · see citing works
A mouse model links asthma susceptibility to prenatal exposure to diesel exhaust
Manners, S., Alam, R., Schwartz, D. A., & Gorska, M. M. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.10.047 · Cited by 110 · see citing works
Increased activation-induced cell death of high IFN-γ–producing TH1 cells as a mechanism of TH2 predominance in atopic diseases
Akkoç, T., de Koning, P. J. A., Rückert, B., Barlan, I. B., Akdiş, M., & Akdiş, C. A. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.12.1171 · Cited by 110 · see citing works
Chemokines provide the sustained inflammatory bridge between innate and acquired immunity
Coelho, A. L., Hogaboam, C. M., & Kunkel, S. L. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.03.004 · Cited by 109 · see citing works
IL-1 receptor antagonist reduces endotoxin-induced airway inflammation in healthy volunteers
Hernandez, M. L., Mills, K. H., Almond, M. A., Todoric, K., Aleman, M. M., Zhang, H., Zhou, H., & Peden, D. B. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.07.039 · Cited by 106 · see citing works
Development of Autoimmunity in IL-14α-Transgenic Mice
Shen, L., Zhang, C., Wang, T., Brooks, S. R., Ford, R. J., Lin-Lee, Y.-C., Kasianowicz, A., Kumar, V., Martin, L., Liang, P., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.5676 · Cited by 102 · see citing works
Liquid-crystalline ordering of antimicrobial peptide–DNA complexes controls TLR9 activation
Schmidt, N. W., Jin, F., Lande, R., Curk, T., Xian, W., Lee, C. K., Frasca, L., Frenkel, D., Dobnikar, J., Gilliet, M. F., et al. (2015) · Nature Materials · doi:10.1038/nmat4298 · Cited by 99 · see citing works
Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation
Ullah, M. A., Revez, J. A., Loh, Z., Simpson, J., Zhang, V., Bain, L., Varelias, A., Rose‐John, S., Blumenthal, A., Smyth, M. J., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.02.032 · Cited by 99 · see citing works
Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of innate interferons
Gielen, V., Sykes, A., Zhu, J., Chan, B., Macintyre, J., Regamey, N., Kieninger, E., Gupta, A. K., Shoemark, A., Bossley, C. J., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.11.039 · Cited by 96 · see citing works
IL-9 is a key component of memory TH cell peanut-specific responses from children with peanut allergy
Brough, H. A., Cousins, D. J., Munteanu, A., Wong, Y. F., Sudra, A., Makinson, K., Stephens, A. C., Arno, M. J., Ciortuz, L., Lack, G., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.06.032 · Cited by 96 · see citing works
T cells in asthma: Influences of genetics, environment, and T-cell plasticity
Lloyd, C. M., & Saglani, S. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.02.016 · Cited by 95 · see citing works
Thymic stromal lymphopoietin activation of basophils in patients with allergic asthma is IL-3 dependent
Salter, B., Oliveria, J. P., Nusca, G. M., Smith, S. G., Watson, R. M., Comeau, M., Sehmi, R., & Gauvreau, G. M. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.03.039 · Cited by 94 · see citing works
IL-22 suppresses IFN-γ–mediated lung inflammation in asthmatic patients
Pennino, D., Bhavsar, P. K., Effner, R., Avitabile, S., Venn, P., Quaranta, M., Marzaioli, V., Cifuentes, L., Durham, S. R., Cavani, A., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.09.036 · Cited by 93 · see citing works
New and future strategies to improve asthma control in children
Anderson, W. C., & Szefler, S. J. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.07.007 · Cited by 91 · see citing works
Role of IL-17A and neutrophils in fibrosis in experimental hypersensitivity pneumonitis
Hasan, S. A., Eksteen, B., Reid, D., Paine, H. V., Alansary, A., Johannson, K., Gwozd, C., Goring, K.-A. R., Vo, T., Proud, D., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.01.015 · Cited by 88 · see citing works
Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11
Chérel, M., Sorel, M., Lebeau, B., Dubois, S. P., Moreau, J., Bataille, R., Minvielle, S., & Jacques, Y. (1995) · Blood · doi:10.1182/blood.v86.7.2534.2534 · Cited by 88 · see citing works
Long-term assessment of esophageal remodeling in patients with pediatric eosinophilic esophagitis treated with topical corticosteroids
Rajan, J. P., Newbury, R., Anilkumar, A. A., Dohil, R., Broide, D. H., & Aceves, S. S. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.05.045 · Cited by 86 · see citing works
The Complex Type 2 Endotype in Allergy and Asthma: From Laboratory to Bedside
Agache, I., Sugita, K., Morita, H., Akdis, M., & Akdis, C. A. (2015) · Current Allergy and Asthma Reports · doi:10.1007/s11882-015-0529-x · Cited by 86 · see citing works
Self-citation
IL-9 Regulates Allergen-Specific Th1 Responses in Allergic Contact Dermatitis
Liu, J., Harberts, E. M., Tammaro, A., Girardi, N. G., Filler, R. B., Fishelevich, R., Temann, U.-A., Licona-Limón, P., Girardi, M., Flavell, R. A., et al. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.61 · Cited by 84 · see citing works
T cell–derived microvesicles induce mast cell production of IL-24: Relevance to inflammatory skin diseases
Shefler, I., Pasmanik‐Chor, M., Kidron, D., Mekori, Y. A., & Hershko, A. Y. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.04.035 · Cited by 84 · see citing works
IL‐27 stimulates human NK‐cell effector functions and primes NK cells for IL‐18 responsiveness
Ziblat, A., Domaica, C. I., Spallanzani, R. G., Iraolagoitia, X. L. R., Rossi, L. E., Avila, D. E., Torres, N. I., Fuertes, M. B., & Zwirner, N. W. (2014) · European Journal of Immunology · doi:10.1002/eji.201444699 · Cited by 79 · see citing works
Regulation of the foxp3 Gene by the Th1 Cytokines: The Role of IL-27-Induced STAT1
Ouaked, N., Mantel, P., Bassin, C., Bürgler, S., Siegmund, K., Akdiş, C. A., & Schmidt‐Weber, C. B. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.2.1041 · Cited by 78 · see citing works
B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells.
Jin, G., Hamaguchi, Y., Matsushita, T., Hasegawa, M., Huu, D. L., Ishiura, N., Naka, K., Hirao, A., Takehara, K., & Fujimoto, M. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.01.044 · Cited by 77 · see citing works
Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11
Chérel, M., Sorel, M., Lebeau, B., et al. (1995) · Blood · doi:10.1182/blood.v86.7.2534.bloodjournal8672534 · Cited by 77 · see citing works
Thymic Stromal Lymphopoietin-Mediated Extramedullary Hematopoiesis Promotes Allergic Inflammation
Siracusa, M. C., Saenz, S. A., Wojno, E. D. T., Kim, B., Osborne, L. C., Ziegler, C. G. K., Benitez, A., Ruymann, K., Färber, D. L., Abou‐Sleiman, P. M., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.09.016 · Cited by 76 · see citing works
TGF-β1–induced phospholamban expression alters esophageal smooth muscle cell contraction in patients with eosinophilic esophagitis
Beppu, L. Y., Anilkumar, A. A., Newbury, R., Dohil, R., Broide, D. H., & Aceves, S. S. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.04.004 · Cited by 74 · see citing works
Inhibition of angiogenesis by IL-32: Possible role in asthma
Meyer, N., Christoph, J. B., Makrinioti, H., Indermitte, P., Rhyner, C., Soyka, M., Eiwegger, T., Chałubiński, M., Wanke, K., Fujita, H., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.12.1002 · Cited by 73 · see citing works
Self-citation
Patients with cystic fibrosis have inducible IL-17+IL-22+ memory cells in lung draining lymph nodes
Chan, Y. R., Chen, K., Duncan, S. R., Lathrop, K. L., Latoche, J. D., Logar, A. J., Pociask, D. A., Wahlberg, B. J., Ray, P., Ray, A., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.05.036 · Cited by 73 · see citing works
The role of interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with solid tumors, lymphoma, acute myeloid leukemia and bone marrow failure syndromes
Bhatia, M., Davenport, V. D., & Cairo, M. S. (2006) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190600909115 · Cited by 68 · see citing works
Serum IL-31 levels are increased in a subset of patients with mastocytosis and correlate with disease severity in adult patients
Hartmann, K., Wagner, N., Rabenhorst, A., Pflanz, L., Leja, S., Förster, A., Gehring, M., Kapp, A., & Raap, U. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.11.008 · Cited by 67 · see citing works
The paradoxical TGF-β vasculopathies
Akhurst, R. J. (2012) · Nature Genetics · doi:10.1038/ng.2366 · Cited by 66 · see citing works
Distinct subunit pairing criteria within the heterodimeric IL-12 cytokine family
Jones, L. L., Chaturvedi, V., Uyttenhove, C., Snick, J. V., & Vignali, D. A. A. (2012) · Molecular Immunology · doi:10.1016/j.molimm.2012.03.025 · Cited by 62 · see citing works
Editorial: CSF1R, CSF-1, and IL-34, a “ménage à trois” conserved across vertebrates
Droin, N. M., & Solary, É. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.1209780 · Cited by 59 · see citing works
The future of biologics: Applications for food allergy
Bauer, R. N., Manohar, M., Singh, A. M., Jay, D. C., & Nadeau, K. C. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.12.1908 · Cited by 58 · see citing works
Thymic stromal lymphopoietin receptor blockade reduces allergic inflammation in a cynomolgus monkey model of asthma
Cheng, D. T., Ma, C. X., Niewoehner, J., Dahl, M. E., Tsai, A., Zhang, J., Gonsiorek, W., Apparsundaram, S., Pashine, A., Ravindran, P., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.05.011 · Cited by 58 · see citing works
The antitumor potential of Interleukin-27 in prostate cancer
Carlo, E. D., Sorrentino, C., Zorzoli, A., Meo, S. D., Tupone, M. G., Ognio, E., Mincione, G., & Airoldi, I. (2013) · Oncotarget · doi:10.18632/oncotarget.1425 · Cited by 56 · see citing works
The cloning and biological characterization of recombinant human interleukin 11
Paul, S. R., & Schendel, P. F. (1992) · The International Journal Of Cell Cloning · doi:10.1002/stem.5530100303 · Cited by 50 · see citing works
A genome-wide survey of CD4+ lymphocyte regulatory genetic variants identifies novel asthma genes
Sharma, S., Zhou, X., Thibault, D. M., Himes, B. E., Liu, A., Szefler, S. J., Strunk, R. C., Castro, M., Hansel, N. N., Diette, G. B., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.04.011 · Cited by 50 · see citing works
Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicated by eczema herpeticum
Gao, L., Bin, L., Rafaels, N. M., Huang, L., Potee, J., Ruczinski, I., Beaty, T. H., Paller, A. S., Schneider, L. C., Gallo, R. L., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.06.047 · Cited by 47 · see citing works
Characterization of a high TNF-α phenotype in children with moderate-to-severe asthma
Brown, S. D., Brown, L. A. S., Stephenson, S. T., Dodds, J. C., Douglas, S., Qu, H., & Fitzpatrick, A. M. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.08.054 · Cited by 46 · see citing works
Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand, thymic stromal lymphopoietin, and IL-33
Mehta, A. K., Duan, W., Doerner, A. M., Traves, S. L., Broide, D. H., Proud, D., Zuraw, B. L., & Croft, M. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.05.007 · Cited by 45 · see citing works
Dectin-1 activation unlocks IL12A expression and reveals the TH1 potency of neonatal dendritic cells
Lemoine, S., Jaron, B., Tabka, S., Ettreiki, C., Dériaud, E., Zhivaki, D., Ray, C. L., Launay, O., Majlessi, L., Tissières, P., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.02.030 · Cited by 44 · see citing works
Thyroid dysfunction: an autoimmune aspect.
Khan, F. A., Al‐Jameil, N., Khan, M. F., Al-Rashid, M., & Tabassum, H. (2015) · Europe PMC (PubMed Central) · Cited by 43 · see citing works
IL-27 and type 2 immunity in asthmatic patients: Association with severity, CXCL9, and signal transducer and activator of transcription signaling
Xie, M., Mustovich, A. T., Jiang, Y., Trudeau, J. B., Ray, A., Ray, P., Hu, H., Holguín, F., Freeman, B. Α., & Wenzel, S. E. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.08.023 · Cited by 43 · see citing works

Flagged first, then by citations

2 of the 222 references couldn’t be matched to a known paper.

Sorted by citations

The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479 · see citing works
Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?
Akdiş, C. A. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00538-7 · Cited by 1,016 · see citing works
The Tumor Microenvironment in the Response to Immune Checkpoint Blockade Therapies
Petitprez, F., Meylan, M., de Reyniès, A., Sautès‐Fridman, C., & Fridman, W. H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00784 · Cited by 602 · see citing works
Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics
Depuydt, M. A. C., Prange, K. H. M., Slenders, L., Örd, T., Elbersen, D., Boltjes, A., de Jager, S. C. A., Asselbergs, F. W., de Borst, G. J., Aavik, E., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.316770 · Cited by 590 · see citing works
Type 2 immunity in the skin and lungs
Akdiş, C. A., Arkwright, P. D., Brüggen, M., Busse, W. W., Gadina, M., Guttman‐Yassky, E., Kabashima, K., Mitamura, Y., Vian, L., Wu, J., et al. (2020) · Allergy · doi:10.1111/all.14318 · Cited by 559 · see citing works
International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
Wise, S. K., Lin, S. Y., Toskala, E., Orlandi, R. R., Akdis, C. A., Alt, J. A., Azar, A., Baroody, F. M., Bachert, C., Canonica, G. W., et al. (2018) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22073 · Cited by 557 · see citing works
International consensus statement on allergy and rhinology: Allergic rhinitis – 2023
Wise, S. K., Damask, C. C., Roland, L. T., Ebert, C. S., Levy, J. M., Lin, S. Y., Luong, A., Rodriguez, K., Sedaghat, A. R., Toskala, E. M., et al. (2023) · International Forum of Allergy & Rhinology · doi:10.1002/alr.23090 · Cited by 554 · see citing works
Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease
Sözener, Z. Ç., Öztürk, B. Ö., Çerçi, P., Türk, M., Akın, B. G., Akdiş, M., Altıner, S., Yücel, Ü. Ö., Öğülür, İ., Mitamura, Y., et al. (2022) · Allergy · doi:10.1111/all.15240 · Cited by 442 · see citing works
Neuromodulation by the immune system: a focus on cytokines
Salvador, A. F., de Lima, K. A., & Kipnis, J. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00508-z · Cited by 389 · see citing works
Atopic dermatitis (eczema) guidelines: 2023 American Academy of Allergy, Asthma and Immunology/American College of Allergy, Asthma and Immunology Joint Task Force on Practice Parameters GRADE– and Institute of Medicine–based recommendations
Chu, D. K., Schneider, L. C., Asiniwasis, R. N., Boguniewicz, M., Benedetto, A. D., Ellison, K., Frazier, W. T., Greenhawt, M., Huynh, J., Kim, E., et al. (2023) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2023.11.009 · Cited by 430 · see citing works
Circulating Cytokines Predict Immune-Related Toxicity in Melanoma Patients Receiving Anti-PD-1–Based Immunotherapy
Lim, S. Y., Lee, J. H., Gide, T. N., Menzies, A. M., Guminski, A., Carlino, M. S., Breen, E. J., Yang, J. Y. H., Ghazanfar, S., Kefford, R. F., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-2795 · Cited by 381 · see citing works
Type 2 immunity in allergic diseases
Öğülür, İ., Mitamura, Y., Yazıcı, D., Pat, Y., Ardıçlı, S., Li, M., D’Avino, P., Beha, C., Babayev, H., Zhao, B., et al. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01261-2 · Cited by 413 · see citing works
Allergen Immunotherapy in Children User’s Guide
Lozano, M. A., Akdiş, C. A., Akdiş, M., Alviani, C., Angier, E., Arasi, S., Arzt‐Gradwohl, L., Barber, D., Bazire, R., Cavkaytar, Ö., et al. (2020) · Pediatric Allergy and Immunology · doi:10.1111/pai.13189 · Cited by 381 · see citing works
Dictionary of immune responses to cytokines at single-cell resolution
Cui, A., Huang, T., Li, S., Ma, A., Pérez, J. L., Sander, C., Keskin, D. B., Wu, C. J., Fraenkel, E., & Hacohen, N. (2023) · Nature · doi:10.1038/s41586-023-06816-9 · Cited by 364 · see citing works
Markers of Inflammation
Germolec, D. R., Shipkowski, K. A., Frawley, R. P., & Evans, E. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8549-4_5 · Cited by 358 · see citing works
Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells
Palomares, Ó., Akdis, M., Martín‐Fontecha, M., & Akdiş, C. A. (2017) · Immunological Reviews · doi:10.1111/imr.12555 · Cited by 336 · see citing works
Self-citation
Food allergy across the globe
Sampath, V., Abrams, E. M., Adlou, B., Akdiş, C. A., Akdiş, M., Brough, H. A., Chan, S., Chatchatee, P., Chinthrajah, R. S., Cocco, R. R., et al. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.10.018 · Cited by 320 · see citing works
Selected cytokine pathways in rheumatoid arthritis
Noack, M., & Miossec, P. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0619-z · Cited by 307 · see citing works
Nomenclature of allergic diseases and hypersensitivity reactions: Adapted to modern needs: An EAACI position paper
Jutel, M., Agache, I. O., Zemelka‐Wiącek, M., Akdiş, M., Chivato, T., Giacco, S. D., Gajdanowicz, P., Eguíluz‐Gracia, I., Klimek, L., Lauerma, A., et al. (2023) · Allergy · doi:10.1111/all.15889 · Cited by 297 · see citing works
Self-citation
Pathological mechanisms and therapeutic outlooks for arthrofibrosis
Usher, K. M., Zhu, S., Mavropalias, G., Carrino, J. A., Zhao, J., & Xu, J. (2019) · Bone Research · doi:10.1038/s41413-019-0047-x · Cited by 291 · see citing works
Immunopathogenesis of Behcet's Disease
Tong, B., Liu, X., Xiao, J., & Su, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00665 · Cited by 283 · see citing works
Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients
Sugita, K., Steer, C. A., Martínez-González, I., Altunbulakli, C., Morita, H., Castro-Giner, F., Kubo, T., Wawrzyniak, P., Rückert, B., Sudo, K., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.02.038 · Cited by 277 · see citing works
Self-citation
Cellular and molecular mechanisms of allergic asthma
Komlósi, Z. I., van de Veen, W., Kovács, N., Szűcs, G., Sokołowska, M., O’Mahony, L., Akdiş, M., & Akdiş, C. A. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.100995 · Cited by 260 · see citing works
Self-citation
IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases
Wooff, Y., Man, S. M., Aggio‐Bruce, R., Natoli, R., & Fernando, N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01618 · Cited by 244 · see citing works
Systematic review and meta-analysis of the association between peripheral inflammatory cytokines and generalised anxiety disorder
Costello, H., Gould, R. L., Abrol, E., & Howard, R. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-027925 · Cited by 248 · see citing works
“Both IL-1α and IL-8 have proinflammatory functions as chemoattractants for leukocytes and haematopoiesis, and have been targeted for treatments in a number of autoimmune conditions.(32) However, there was no association between GAD and IL-5, which is thought to predominantly mediate myeloid cell activation and is a ta…”
BackgroundResultInfluential
Nutrition and the Immune System: A Complicated Tango
Venter, C., Eyerich, S., Sarin, T., & Klatt, K. C. (2020) · Nutrients · doi:10.3390/nu12030818 · Cited by 247 · see citing works
Alteration patterns of peripheral concentrations of cytokines and associated inflammatory proteins in acute and chronic stages of schizophrenia: a systematic review and network meta-analysis
Halstead, S., Siskind, D. J., Amft, M., Wagner, E. M., Yakimov, V., Liu, Z. S.-J., Walder, K. R., & Warren, N. (2023) · The Lancet Psychiatry · doi:10.1016/s2215-0366(23)00025-1 · Cited by 245 · see citing works
Animal models of asthma: utility and limitations
Aun, M. V., Bonamichi-Santos, R., Arantes-Costa, F. M., Kalil, J. E., & Junior, P. F. G.-B. (2017) · Journal of Asthma and Allergy · doi:10.2147/jaa.s121092 · Cited by 238 · see citing works
“90,91 In recent years, biological actions of some novel mediators, such as interleukins IL-25 and IL-33 and thymic stromal lymphopoietin, major airway epithelial-derived cytokines, have been described.”
Role of interleukins in the pathogenesis of pulmonary fibrosis
She, Y. X., Yu, Q. Y., & Tang, X. X. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00437-9 · Cited by 226 · see citing works
Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients
Michalovich, D., Rodríguez‐Pérez, N., Smolińska, S., Pirożyński, M., Mayhew, D. N., Uddin, S., Horn, S. V., Sokołowska, M., Altunbulakli, C., Eljaszewicz, A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13751-9 · Cited by 216 · see citing works
Self-citation
Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation‑mediating treatment options (Review)
Varra, F., Varras, M. N., Varra, V., & Theodosis‐Nobelos, P. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13219 · Cited by 194 · see citing works
“…β , a pro‑inflammatory cytokine, which becomes biologically active by cleavage, requiring the protease caspase‑1 (182), which is activated through the NLRP3 inflammasome complex (183). obesity appears to be directly related to the deregulation of il‑1 β expression and the increase in its levels.”
Background
Mechanisms of allergen-specific immunotherapy and allergen tolerance
Küçüksezer, U. C., Özdemir, C., Cevhertas, L., Öğülür, İ., Akdis, M., & Akdiş, C. A. (2020) · Allergology International · doi:10.1016/j.alit.2020.08.002 · Cited by 184 · see citing works
Self-citation
Biological roles and potential applications of immune cell‐derived extracellular vesicles
Wen, C., Seeger, R. C., Fabbri, M., Wang, L. W., Wayne, A. S., & Jong, A. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1400370 · Cited by 176 · see citing works
“cross-talk amongst immune cells is through interleukins, chemokines, interferons and other signalling molecules [51,52].”
Background
Regulatory B cells, A to Z
Jansen, K., Cevhertas, L., Ma, S.-Y., Satitsuksanoa, P., Akdiş, M., & van de Veen, W. (2021) · Allergy. European Journal of Allergy and Clinical Immunology · doi:10.1111/all.14763 · Cited by 149 · see citing works
Ozone exposure induces respiratory barrier biphasic injury and inflammation controlled by IL-33
Michaudel, C., Mackowiak, C., Maillet, I., Fauconnier, L., Akdiş, C. A., Sokołowska, M., Dreher, A., Tan, H. T., Quesniaux, V. F. J., Ryffel, B., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.11.044 · Cited by 172 · see citing works
The Diversification of Cell Death and Immunity: Memento Mori
Legrand, A. J., Konstantinou, M., Goode, E., & Meier, P. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.09.006 · Cited by 175 · see citing works
IL-31: A new key player in dermatology and beyond
Bağci, I. S., & Ruzicka, T. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.10.045 · Cited by 160 · see citing works
Type 2 chronic inflammatory diseases: targets, therapies and unmet needs
Kolkhir, P., Akdiş, C. A., Akdiş, M., Bachert, C., Bieber, T. R. M., Canonica, G. W., Guttman‐Yassky, E., Metz, M., Mullol, J., Palomares, Ó., et al. (2023) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00750-1 · Cited by 170 · see citing works
Varicocele-Mediated Male Infertility: From the Perspective of Testicular Immunity and Inflammation
Fang, Y., Su, Y., Xu, J. M., Hu, Z., Zhao, K., Liu, C., & Zhang, H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.729539 · Cited by 161 · see citing works
Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations
Mandarano, A. H., Maya, J., Giloteaux, L., Peterson, D. L., Maynard, M., Gottschalk, C. G., & Hanson, M. R. (2019) · Journal of Clinical Investigation · doi:10.1172/jci132185 · Cited by 143 · see citing works
“Surprisingly, we observed no significant increase in mitochondrial mass following activation, which has previously been demonstrated (57, 58). which was positively correlated with ME/CFS CD8 + T cell glycolysis, is a T cell growth factor but has complex effects (63).”
Influential
A comprehensive pathway map of IL-18-mediated signalling
Balaya, R. D. A., Agarwal, N., Prasad, T. S. K., Kandasamy, R. K., Subbannayya, Y., & Pinto, S. M. (2019) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-019-00544-4 · Cited by 142 · see citing works
TGF-β as A Master Regulator of Aging-Associated Tissue Fibrosis
Ren, L.-L., Miao, H., Wang, Y.-N., Liu, F., Li, P., & Zhao, Y.-Y. (2023) · Aging and disease · doi:10.14336/ad.2023.0222 · Cited by 139 · see citing works
Health effects of particulate matter air pollution in underground railway systems – a critical review of the evidence
Loxham, M., & Nieuwenhuijsen, M. J. (2019) · Particle and Fibre Toxicology · doi:10.1186/s12989-019-0296-2 · Cited by 135 · see citing works
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
Mohan, K., Ueda, G., Kim, A. R., Jude, K. M., Fallas, J. A., Guo, Y., Hafer, M., Miao, Y., Saxton, R. A., Piehler, J., et al. (2019) · Science · doi:10.1126/science.aav7532 · Cited by 135 · see citing works
Impact of diurnal intermittent fasting during Ramadan on inflammatory and oxidative stress markers in healthy people: Systematic review and meta-analysis
Faris, M. E., Jahrami, H., Obaideen, A. A., & Madkour, M. I. (2018) · Journal of Nutrition & Intermediary Metabolism · doi:10.1016/j.jnim.2018.11.005 · Cited by 132 · see citing works
Innate and adaptive immune responses to fungi in the airway
Bartemes, K. R., & Kita, H. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.06.015 · Cited by 124 · see citing works
The Interleukin-1 (IL-1) Superfamily Cytokines and Their Single Nucleotide Polymorphisms (SNPs)
Behzadi, P., Aga, S. S., Nissar, S., Banday, M. Z., Gajdács, M., García‐Perdomo, H. A., Akhtar, K., Pinheiro, M., Magnusson, P., Sarshar, M., et al. (2022) · Journal of Immunology Research · doi:10.1155/2022/2054431 · Cited by 129 · see citing works
“Decoy receptors are conserved evolutionary structures which restrict the chemokines, cytokines, and growth factors activities [45 – 48, 68, 128, 129, 134].”
Influential
Cancer-associated fibroblast-derived CXCL11 modulates hepatocellular carcinoma cell migration and tumor metastasis through the circUBAP2/miR-4756/IFIT1/3 axis
Liu, G., Sun, J., Yang, Z., Zhou, C., Zhou, P., Guan, R., Sun, B., Wang, Z.-T., Zhou, J., Fan, J., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03545-7 · Cited by 124 · see citing works
IL-36 in chronic inflammation and fibrosis — bridging the gap?
Elias, M., Zhao, S., Le, H. T., Wang, J., Neurath, M. F., Neufert, C., Fiocchi, C., & Rieder, F. (2021) · Journal of Clinical Investigation · doi:10.1172/jci144336 · Cited by 118 · see citing works
Effects of inflammation on the kynurenine pathway in schizophrenia—a systematic review
Pedraz-Petrozzi, B., Elyamany, O., Rummel, C., & Mulert, C. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1721-z · Cited by 119 · see citing works
Acute Respiratory Barrier Disruption by Ozone Exposure in Mice
Sokołowska, M., Quesniaux, V. F. J., Akdiş, C. A., Chung, K. F., Ryffel, B., & Togbe, D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02169 · Cited by 117 · see citing works
Chronic urticaria: unmet needs, emerging drugs, and new perspectives on personalised treatment
Zuberbier, T., Ensina, L. F., Giménez‐Arnau, A. M., Grattan, C., Kocatürk, E., Kulthanan, K., Kolkhir, P., & Maurer, M. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00852-3 · Cited by 114 · see citing works
“23 Th2 cell-derived cytokines (eg, IL-4, IL-5, IL-13, IL-31) and IgE against autoallergens produced by B cells (eg, IgE-anti-thyroperoxidase and IgE-anti-IL-24) activate a broad range of receptors, including IL-4Rα, IL-5Rα, IL-31RA, and FcεRI, on mast cells and other target cells.”
The Dynamic Inflammatory Tissue Microenvironment: Signality and Disease Therapy by Biomaterials
Mata, R., Yao, Y., Cao, W., Ding, J., Zhou, T., Zhai, Z., & Gao, C.-Y. (2021) · Research · doi:10.34133/2021/4189516 · Cited by 112 · see citing works
“A recent study has indicated critical roles of CXCL8 and CXCR1 or CXCR2 in fostering neutrophil stimulation and induction to the inflammation site [24].”
Background
Injectable polymeric nanoparticle hydrogel system for long-term anti-inflammatory effect to treat osteoarthritis
Seo, B., Kwon, Y., Kim, J., Hong, K. H., Kim, S. E., Song, H., Kim, Y., & Song, S. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.05.028 · Cited by 113 · see citing works
Il-10 producing T and B cells in allergy
Boonpiyathad, T., Satitsuksanoa, P., Akdiş, M., & Akdiş, C. A. (2019) · Seminars in Immunology · doi:10.1016/j.smim.2019.101326 · Cited by 109 · see citing works
Regulation of the germinal center and humoral immunity by interleukin-21
Tangye, S. G., & Ma, C. S. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20191638 · Cited by 104 · see citing works
Tight junctions in the development of asthma, chronic rhinosinusitis, atopic dermatitis, eosinophilic esophagitis, and inflammatory bowel diseases
Sugita, K., & Kabashima, K. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.5mr0120-230r · Cited by 101 · see citing works
Self-citation
The Role of Cytokines in the Pathogenesis of Schizophrenia
Dawidowski, B., Górniak, A., Podwalski, P., Lebiecka, Z., Misiak, B., & Samochowiec, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10173849 · Cited by 102 · see citing works
“Nuclear factor-κB (NF-κB), which mediates the increase in the secretion by microglia of such cytokines as IL-1β and IL-18 and is activated by IL-1β, TNF-α, PAMP, adrenal cortex hormones and adrenaline, may play an important role in the potential pathological feedback loop associated with disturbances in the cytokine n…”
BackgroundInfluential
The micro(nano)plastics perspective: exploring cancer development and therapy
Deng, X., Gui, Y., & Zhao, L. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02230-z · Cited by 99 · see citing works
Immunological Outcomes of Allergen-Specific Immunotherapy in Food Allergy
Schoos, A. M., Bullens, D. M. A., Chawes, B., Costa, J. S., Vlieger, L. D., DunnGalvin, A., Epstein, M. M., Garssen, J., Hilger, C., Knipping, K., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.568598 · Cited by 99 · see citing works
“IL-4 and IL13 are structurally and functionally related cytokines that play a central role in allergic inflammation through induction of IgE class switch recombination, smooth muscle cell contraction, goblet cell hyperplasia and mucus production (26).”
Background
Interleukin-1 in obesity-related low-grade inflammation: From molecular mechanisms to therapeutic strategies
Ghanbari, M., Maragheh, S. M., Aghazadeh, A., Mehrjuyan, S. R., Hussen, B. M., Shadbad, M. A., Dastmalchi, N., & Safaralizadeh, R. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107765 · Cited by 99 · see citing works
Biological function of eosinophil extracellular traps in patients with severe eosinophilic asthma
Choi, Y., Pham, D. L., Lee, D., Lee, S. H., Kim, S., & Park, H. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0136-8 · Cited by 95 · see citing works
Phenotypes, Functions, and Clinical Relevance of Regulatory B Cells in Cancer
Shang, J., Zha, H., & Sun, Y. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.582657 · Cited by 93 · see citing works
miR-146b Probably Assists miRNA-146a in the Suppression of Keratinocyte Proliferation and Inflammatory Responses in Psoriasis
Vaher, H., Runnel, T., Aab, A., Baurecht, H., Rodríguez, E., Magilnick, N., Urgard, E., Šahmatova, L., Prans, E., Maslovskaja, J., et al. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.05.012 · Cited by 91 · see citing works
“The miR-146b signal was weaker than that of miR-146a and was detected in both the epidermis and the dermis of the lesional skin of patients with psoriasis (Figure 1d). miR-146a was induced by IL-1b, tumor necrosis factor-a (TNF-a), and IL-17A in human proliferating keratinocytes, in 3D reconstituted epidermis, and in…”
BackgroundSelf-citation
Computationally predicted SARS-COV-2 encoded microRNAs target NFKB, JAK/STAT and TGFB signaling pathways
Aydemir, M. N., Aydemir, H. B., Korkmaz, E. M., Budak, M., Çekin, N., & Pınarbaşı, E. (2020) · Gene Reports · doi:10.1016/j.genrep.2020.101012 · Cited by 89 · see citing works
Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis
Kuzumi, A., Yoshizaki, A., Matsuda, K. M., Kotani, H., Norimatsu, Y., Fukayama, M., Ebata, S., Fukasawa, T., Yoshizaki‐Ogawa, A., Asano, Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26099-w · Cited by 90 · see citing works
Suitability of 3D human brain spheroid models to distinguish toxic effects of gold and poly-lactic acid nanoparticles to assess biocompatibility for brain drug delivery
Leite, P. E. C., Pereira, M. R., Harris, G., Pamies, D., dos Santos, L. M. G., Granjeiro, J. M., Hogberg, H. T., Hartung, T., & Smirnova, L. (2019) · Particle and Fibre Toxicology · doi:10.1186/s12989-019-0307-3 · Cited by 92 · see citing works
An overview of the tumor microenvironment, from cells to complex networks (Review)
Farc, O., & Cristea, V. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.9528 · Cited by 86 · see citing works
“However, they are an important source of IL4, which is Th2 polarizing and protumoral (23).”
Background
Novel insights into host-pathogen interactions of large yellow croakers (Larimichthys crocea) and pathogenic bacterium Pseudomonas plecoglossicida using time-resolved dual RNA-seq of infected spleens
Tang, Y., Xin, G., Zhao, L., Huang, L., Qin, Y., Su, Y., Zheng, W., Wu, B., Lin, N., & Yan, Q. (2020) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2020.035 · Cited by 83 · see citing works
Sulforaphane Normalizes Intestinal Flora and Enhances Gut Barrier in Mice with BBN‐Induced Bladder Cancer
He, C., Huang, L., Peng, L., Liu, X., Li, B., & Shan, Y. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800427 · Cited by 81 · see citing works
Interleukin 1 gene polymorphism and susceptibility to disease
Khazim, K., Azulay, E. E., Kristal, B., & Cohen, I. (2017) · Immunological Reviews · doi:10.1111/imr.12620 · Cited by 83 · see citing works
Peripheral human CD4+CD8+ T lymphocytes exhibit a memory phenotype and enhanced responses to IL-2, IL-7 and IL-15
Clénet, M., Gagnon, F., Moratalla, A. C., Viel, É. C., & Arbour, N. (2017) · Scientific Reports · doi:10.1038/s41598-017-11926-2 · Cited by 80 · see citing works
Role of Regulatory Cells in Oral Tolerance
Wawrzyniak, M., O’Mahony, L., & Akdiş, M. (2017) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2017.9.2.107 · Cited by 77 · see citing works
“Clinical tolerance induced by immunotherapy is associated with changes in basophils, IgG4, allergen-specific Th2 cells, and allergen-specific cells with regulatory markers.(76,77) A more complete understanding of mechanisms underlying the induction of oral tolerance with immunotherapy or natural tolerance to food alle…”
BackgroundSelf-citation
A Current Perspective of Allergic Asthma: From Mechanisms to Management
Papadopoulos, N. G., Miligkos, M., & Xepapadaki, P. V. (2021) · Handbook of experimental pharmacology · doi:10.1007/164_2021_483 · Cited by 83 · see citing works
IL-26, a Cytokine With Roles in Extracellular DNA-Induced Inflammation and Microbial Defense
Larochette, V., Miot, C., Poli, C., Beaumont, É., Roingeard, P., Fickenscher, H., Jeannin, P., & Delneste, Y. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00204 · Cited by 76 · see citing works
The Complex Interplay between Lipids, Immune System and Interleukins in Cardio-Metabolic Diseases
Bernardi, S., Marcuzzi, A., Piscianz, E., Tommasini, A., & Fabris, B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19124058 · Cited by 71 · see citing works
Risk factors for immune-related adverse events: what have we learned and what lies ahead?
Liu, X., Shi, Y., Zhang, D., Zhou, Q., Liu, J., Chen, M., Xu, Y., Zhao, J., Zhong, W., & Wang, M. (2021) · Biomarker Research · doi:10.1186/s40364-021-00314-8 · Cited by 73 · see citing works
The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design
Saxton, R. A., Henneberg, L. T., Calafiore, M., Su, L., Jude, K. M., Hanash, A. M., & García, K. C. (2021) · Immunity · doi:10.1016/j.immuni.2021.03.008 · Cited by 72 · see citing works
Laundry detergents and surfactants‐induced eosinophilic airway inflammation by increasing IL ‐33 expression and activating ILC2s
Saito, K., Orimo, K., Kubo, T., Tamari, M., Yamada, A., Motomura, K., Sugiyama, H., Matsuoka, R., Nagano, N., Hayashi, Y., et al. (2023) · Allergy · doi:10.1111/all.15762 · Cited by 72 · see citing works
Self-citation
Structural elucidation and immune-enhancing activity of an arabinogalactan from flowers of Carthamus tinctorius L.
Yao, Y., Yao, J., Du, Z., Wang, P., & Ding, K. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.08.098 · Cited by 73 · see citing works
Extracellular Membrane Vesicles from Lactobacilli Dampen IFN-γ Responses in a Monocyte-Dependent Manner
Forsberg, M. M., Björkander, S., Pang, Y., Lundqvist, L., Ndi, M., Ott, M., Escribá, I. B., Jaeger, M.-C., Roos, S., & Sverremark‐Ekström, E. (2019) · Scientific Reports · doi:10.1038/s41598-019-53576-6 · Cited by 70 · see citing works
Human dendritic cells activated with MV130 induce Th1, Th17 and IL‐10 responses via RIPK2 and MyD88 signalling pathways
Cirauqui, C., Benito‐Villalvilla, C., Sánchez‐Ramón, S., Sirvent, S., Diez-Rivero, C. M., Conejero, L., Brandi, P., Hernández‐Cillero, L., Ochoa, J., Pérez‐Villamil, B., et al. (2017) · European Journal of Immunology · doi:10.1002/eji.201747024 · Cited by 69 · see citing works
Novel Biologicals for the Treatment of Allergic Diseases and Asthma
Tan, H.-T. T., Sugita, K., & Akdis, C. A. (2016) · Current Allergy and Asthma Reports · doi:10.1007/s11882-016-0650-5 · Cited by 68 · see citing works
Self-citation
The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19
Makaremi, S., Asgarzadeh, A., Kianfar, H., Mohammadnia, A., Asghariazar, V., & Safarzadeh, E. (2022) · Inflammation Research · doi:10.1007/s00011-022-01596-w · Cited by 68 · see citing works
Cytokines in oncolytic virotherapy
Pol, J. G., Workenhe, S. T., Konda, P., Gujar, S. A., & Kroemer, G. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.10.007 · Cited by 68 · see citing works
Posthemorrhagic hydrocephalus associates with elevated inflammation and CSF hypersecretion via activation of choroidal transporters
Lolansen, S. D., Rostgaard, N., Barbuskaite, D., Capion, T., Olsen, M. H., Nørager, N. H., Vilhardt, F., Andreassen, S. N., Toft‐Bertelsen, T. L., Ye, F., et al. (2022) · Fluids and Barriers of the CNS · doi:10.1186/s12987-022-00360-w · Cited by 67 · see citing works
“The majority of the upregulated inflammatory markers were chemokines (CCL3, CCL4, CCL20, MCP-1, and MCP-3) or interleukins (IL6, IL-8, and IL-10), which promote and regulate immune responses in a pleiotropic manner, depending on their target [59, 60].”
Background
N-acetylcysteine regulates dental follicle stem cell osteogenesis and alveolar bone repair via ROS scavenging
Meng, Z., Liu, J., Feng, Z., Guo, S., Wang, M., Wang, Z., Li, Z., Li, H., & Sui, L. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03161-y · Cited by 67 · see citing works
STAT6 gain-of-function variant exacerbates multiple allergic symptoms
Takeuchi, I., Yanagi, K., Takada, S., Uchiyama, T., Igarashi, A., Motomura, K., Hayashi, Y., Nagano, N., Matsuoka, R., Sugiyama, H., et al. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.12.802 · Cited by 67 · see citing works
Self-citation
A Narrative Review of Cytokine Networks: Pathophysiological and Therapeutic Implications for Inflammatory Bowel Disease Pathogenesis
Vébr, M., Pomahačová, R., Sýkora, J., & Schwarz, J. (2023) · Biomedicines · doi:10.3390/biomedicines11123229 · Cited by 71 · see citing works
Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory Skin Diseases
Ahmad, F., Alam, M. A., Ansari, A. W., Jochebeth, A., Leo, R., Al-Abdulla, M. N., Al‐Khawaga, S., AlHammadi, A., Al-Malki, A., Naama, K. A., et al. (2024) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2023.11.004 · Cited by 67 · see citing works
The Evolution, Immunopathogenesis and Biomarkers of Type 2 Inflammation in Common Allergic Disorders
Gao, Y., Wang, Z., Öğülür, İ., Li, S., Yazıcı, D., Li, X., Pat, Y., Zheng, Y., Babayev, H., Zeyneloglu, C., et al. (2025) · Allergy · doi:10.1111/all.16620 · Cited by 72 · see citing works
Novel mechanisms in immune tolerance to allergens during natural allergen exposure and allergen-specific immunotherapy
van de Veen, W., Wirz, O. F., Głobińska, A., & Akdiş, M. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.08.012 · Cited by 67 · see citing works
Self-citation
Reactivation of latent tuberculosis with TNF inhibitors: critical role of the beta 2 chain of the IL-12 receptor
Robert, M., & Miossec, P. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00694-9 · Cited by 66 · see citing works
Salvia miltiorrhiza polysaccharide and its related metabolite 5-methoxyindole-3-carboxaldehyde ameliorate experimental colitis by regulating Nrf2/Keap1 signaling pathway
Fu, Y., Peng, X., Zhang, C., Jiang, Q.-X., Li, C., Paulsen, B. S., Rise, F., Huang, C., Feng, B., Li, L., et al. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.120626 · Cited by 66 · see citing works
Systemic Anti-Inflammatory Effects of Intravenous Lidocaine in Surgical Patients: A Systematic Review and Meta-Analysis
Castro, I., Carvalho, P., Vale, N., Monjardino, T., & Mourão, J. I. D. B. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12113772 · Cited by 66 · see citing works
“Likewise, TGF-β balances pro-inflammatory and anti-inflammatory effects by decreasing the cellular growth of almost all immune cell precursors and acts in the regulation of the differentiation of several T-helper cell subsets [58].”
Background
Human Mesenchymal Stem Cell–Educated Macrophages Are a Distinct High IL-6–Producing Subset that Confer Protection in Graft-versus-Host-Disease and Radiation Injury Models
Bouchlaka, M. N., Moffitt, A. B., Kim, J., Kink, J. A., Bloom, D. D., Love, C., Davé, S. S., Hematti, P., & Capitini, C. M. (2017) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2017.02.018 · Cited by 66 · see citing works
Immunotherapy for Colorectal Cancer: Mechanisms and Predictive Biomarkers
Carlsen, L., Huntington, K. E., & El‐Deiry, W. S. (2022) · Cancers · doi:10.3390/cancers14041028 · Cited by 66 · see citing works
“There are currently 38 recognized interleukins with some containing multiple family members such as IL-1α and IL-1β for an overall total of more than 60 [145].”
Background
An Oral Nanomedicine Elicits In Situ Vaccination Effect against Colorectal Cancer
Zu, M., Ma, Y., Zhang, J., Sun, J., Shahbazi, M., Pan, G., Reis, R. L., Kundu, S. C., Liu, J., & Xiao, B. (2024) · ACS Nano · doi:10.1021/acsnano.3c11436 · Cited by 64 · see citing works
The use of biologics for immune modulation in allergic disease
van de Veen, W., & Akdiş, M. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124607 · Cited by 63 · see citing works
“Key processes driving allergic sensitization include activation and maturation of dendritic cells (DCs) upon contact with allergens, epithelial alarmins, and infectious agents, followed by clonal expansion of allergen-specific Th2 cells that are polarized toward producing type 2 cytokines, including IL-4, IL-5, IL-9,…”
BackgroundInfluential
Biological functions and therapeutic opportunities of soluble cytokine receptors
Lokau, J., & Garbers, C. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.04.003 · Cited by 63 · see citing works

Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases
Akdiş, M., Bürgler, S., Crameri, R., Eiwegger, T., Fujita, H., Alcaide, E. G., Klunker, S., Meyer, N., O’Mahony, L., Palomares, Ó., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.11.050 · Cited by 780 · see citing works
Self-citation
Chapter 22. Cytokine Modulation as a Medicinal Chemistry Target
Cooper, K., & Masamune, H. (1992) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(08)60420-0 · Cited by 13 · see citing works
Cytokines, allergy, and asthma
Ngoc, L. P., Gold, D. R., Tzianabos, A. O., Weiss, S. T., & Celedon, J. C. (2005) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/01.all.0000162309.97480.45 · Cited by 357 · see citing works
Interleukins (ILs), a fascinating family of cytokines. Part I: ILs from IL-1 to IL-19.
Fietta, P., Costa, E., & Delsante, G. (2014) · PubMed · Cited by 19 · see citing works
Type I interferons and their therapeutic role in Th2-regulated inflammatory disorders
Tilg, H., & Kaser, A. (2004) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.4.4.469 · Cited by 20 · see citing works

Authors: Akdis, M., Aab, A., Altunbulakli, C., Azkur, K., Costa, R. A., Crameri, R., Duan, S., Eiwegger, T., Eljaszewicz, A., Ferstl, R., Frei, R., Garbani, M., Globinska, A., Hess, L., Huitema, C., Kubo, T., Komlosi, Z., Konieczna, P., Kovacs, N., Kucuksezer, U. C., Meyer, N., Morita, H., Olzhausen, J., O'Mahony, L., Pezer, M., Prati, M., Rebane, A., Rhyner, C., Rinaldi, A., Sokolowska, M., Stanic, B., Sugita, K., Treis, A., van de Veen, W., Wanke, K., Wawrzyniak, M., Wawrzyniak, P., Wirz, O. F., Zakzuk, J. S., & Akdis, C. A.
Affiliations: University of Zurich (CH)
ORCID: Aab, Alar
Altunbulakli, Can
Costa, Rita A.
Eiwegger, Thomas
Eljaszewicz, Andrzej
Frei, Remo
Huitema, Carly
Kubo, Terufumi
Morita, Hideaki
Pezer, Marija
Rebane, Ana
Rhyner, Claudio
Rinaldi, Arturo
Sugita, Kazunari
Wawrzyniak, Marcin
Wawrzyniak, Paulina
Wirz, Oliver F.
Zakzuk, Josefina Sierra
Venue: Journal of Allergy and Clinical Immunology
Publisher: Elsevier BV
Published: 2016-10
Volume: 138
Issue: 4
Pages: 984-1010
ISSN: 0091-6749 (ISSN-L)
DOI: 10.1016/j.jaci.2016.06.033
OpenAlex: W2517700447
Cited by: 912
References: 222
Citations by year: 2026: 57 · 2025: 117 · 2024: 102 · 2023: 108 · 2022: 119 · 2021: 128 · 2020: 97 · 2019: 75 · 2018: 64 · 2017: 39 · 2016: 4
FWCI: 6.10
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 369 d)
Locations: Journal of Allergy and Clinical Immunology (acceptedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich)
Funders: Swiss National Science Foundation (310030_156823, 320030-159870)
Christine Kühne-Center for Allergy Research and Education (CK-CARE)
PREDICTA
European Commission's Seventh Framework programme (260895, 261357)
GlaxoSmithKline
European Academy of Allergy and Clinical Immunology
Global Allergy and Asthma European Network (GA2LEN)
International Society for Applied Biological Sciences
Commission for Technology and Innovation
Novartis
MeDALL
Christine Kühne-Center for Allergy Research and Education
Topics: Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: interleukins, interferon, TGF-beta, TNF-α, cytokine receptors, cytokine signaling pathways, immune regulation, allergy, asthma, autoimmune disease, chronic infection, organ transplantation, carcinogenesis, gene-deficient mice, cytokine gene polymorphisms
MeSH terms: Animals, Humans, Immune System Diseases, Interferons, Interleukins, Tumor Necrosis Factor-alpha, Transforming Growth Factor beta, T-Lymphocytes, Regulatory

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases

Abstract

Integrity signals

Claims the paper makes

Self-check

Cites

Cited by

Related

Record

About these checks