Allergen challenge in allergic rhinitis rapidly induces increased peripheral blood type 2 innate lymphoid cells that express CD84
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Allergen challenge in AR subjects induces an increased number of peripheral serum ILC2s; however, a similar increase in the nasal mucosa has not yet been demonstrated.
“Allergen challenge in AR subjects induces an increased number of peripheral serum ILC2s332,333; however, a similar increase in the nasal mucosa is yet to be demonstrated.”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [332]
The paper’s results (section labeled Abstract; page not provided) report that the percentage of peripheral blood ILC2s increased four hours after nasal cat-allergen challenge in subjects with allergic rhinitis. The discussion says an increase in nasal-mucosa ILC2s remains to be investigated. It measured blood cells, not serum ILC2s, and reports a percentage rather than an absolute cell count. (LLM, conf=0.88)
Experimental — accuracy not yet measuredSimilarities between AR and asthma extend to innate immunity, including epithelial barrier function and innate lymphoid cells.
“Similarities are not only found in the acquired immune response, but also in the role of innate immunity like epithelial barrier function334 and innate lymphoid cells.332”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [332]
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- Authors
- Doherty, T. A., Scott, D., Walford, H. H., Khorram, N., Lund, S., Baum, R., Chang, J., Rosenthal, P., Beppu, A., Miller, M., & Broide, D. H.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Doherty, Taylor A.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 133
- Issue
- 4
- Pages
- 1203-1205.e7
- ISSN
- 0091-6749 (ISSN-L)
- PMC
- PMC3972276
- OpenAlex
- W2012492379
- Cited by
- 119
- References
- 11
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 14 · 2023: 6 · 2022: 6 · 2021: 12 · 2020: 10 · 2019: 8 · 2018: 17 · 2017: 15 · 2016: 10 · 2015: 6 · 2014: 6
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000100)
- National Institute of Allergy and Infectious Diseases (K08AI080938)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Keywords
- ILC2, allergic rhinitis, allergen challenge, CD84, peripheral blood, natural helper cells, Th2 cytokines, airway hyperresponsiveness, allergic diseases
- MeSH terms
- Signaling Lymphocytic Activation Molecule Family, Allergens, Humans, Lymphocytes, Rhinitis, Allergic, Perennial, Antigens, CD, Rhinitis, Allergic
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