Seasonal increases in peripheral innate lymphoid type 2 cells are inhibited by subcutaneous grass pollen immunotherapy
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Allergen challenge in AR subjects induces an increased number of peripheral serum ILC2s; however, a similar increase in the nasal mucosa has not yet been demonstrated.
“Allergen challenge in AR subjects induces an increased number of peripheral serum ILC2s332,333; however, a similar increase in the nasal mucosa is yet to be demonstrated.”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [333]
In the paper’s main text (page unavailable), the authors report increased peripheral-blood ILC2s during natural grass-pollen exposure in seasonal allergic rhinitis and note a prior finding after experimental nasal allergen challenge. The cited paper did not itself conduct an allergen challenge, and it measured cells in blood, not serum. The nasal-mucosa clause follows the citations and is not attributed to this source here. (LLM, conf=0.83)
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Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*
Bousquet, J., Khaltaev, N., Cruz, A. A., Denburg, J., Fokkens, W. J., Togias, A., Zuberbier, T., Baena‐Cagnani, C. E., Canonica, G. W., Van Weel, C., et al. (2008) · Allergy · doi:10.1111/j.1398-9995.2007.01620.x · Cited by 4,729 · see citing works
Self-citationInnate lymphoid cells — a proposal for uniform nomenclature
Spits, H., Artis, D., Colonna, M., Diefenbach, A., Disanto, J. D., Eberl, G., Koyasu, S., Locksley, R., McKenzie, A., Mebius, R., et al. (2013) · Nature reviews. Immunology · doi:10.1038/nri3365 · Cited by 2,380 · see citing works
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
Neill, D. R., Wong, S. H., Bellosi, A., Flynn, R. J., Daly, M. G., Langford, T. K. A., Bucks, C. M., Kane, C. M., Fallon, P. G., Pannell, R., et al. (2010) · Nature · doi:10.1038/nature08900 · Cited by 2,079 · see citing works
A role for IL-25 and IL-33–driven type-2 innate lymphoid cells in atopic dermatitis
Salimi, M., Barlow, J. L., Saunders, S. P., Xue, L., Gutowska‐Owsiak, D., Wang, X., Huang, L.-C., Johnson, D., Scanlon, S. T., McKenzie, A. N. J., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130351 · Cited by 980 · see citing works
Type 2 Innate Lymphoid Cells Drive CD4+ Th2 Cell Responses
Mirchandani, A. S., Besnard, A., Yip, E., Scott, C. L., Bain, C. C., Cerovic, V., Salmond, R. J., & Liew, F. Y. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1300974 · Cited by 302 · see citing works
Shaw, J. L., Fakhri, S., Citardi, M. J., Porter, P. C., Corry, D. B., Kheradmand, F., Liu, Y., & Luong, A. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201212-2227oc · Cited by 278 · see citing works
Mechanisms of immunotherapy to aeroallergens
Shamji, M. H., & Durham, S. R. (2011) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2011.03804.x · Cited by 157 · see citing works
Self-citationProstaglandin D2 regulates human type 2 innate lymphoid cell chemotaxis
Chang, J. E., Doherty, T. A., Baum, R. E., & Broide, D. H. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.09.020 · Cited by 126 · see citing works
Doherty, T. A., Scott, D., Walford, H. H., Khorram, N., Lund, S., Baum, R., Chang, J., Rosenthal, P., Beppu, A., Miller, M., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.12.1086 · Cited by 119 · see citing works
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International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
Wise, S. K., Lin, S. Y., Toskala, E., Orlandi, R. R., Akdis, C. A., Alt, J. A., Azar, A., Baroody, F. M., Bachert, C., Canonica, G. W., et al. (2018) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22073 · Cited by 557 · see citing works
International consensus statement on allergy and rhinology: Allergic rhinitis – 2023
Wise, S. K., Damask, C. C., Roland, L. T., Ebert, C. S., Levy, J. M., Lin, S. Y., Luong, A., Rodriguez, K., Sedaghat, A. R., Toskala, E. M., et al. (2023) · International Forum of Allergy & Rhinology · doi:10.1002/alr.23090 · Cited by 554 · see citing works
Mechanisms of allergen immunotherapy for inhaled allergens and predictive biomarkers
Shamji, M. H., & Durham, S. R. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.10.010 · Cited by 448 · see citing works
“After grass pollen subcutaneous immunotherapy, there was a marked inhibition of seasonal increases in lineage-negative CRTH2(1)CD127(1) ILC2s that correlated with the severity of self-reported symptoms during the pollen season.(26) These results were highly significant when compared with seasonal increases in ILC2 num…”
ResultSelf-citationAllergen immunotherapy: past, present and future
Durham, S. R., & Shamji, M. H. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00786-1 · Cited by 426 · see citing works
Self-citationEifan, A. O., & Durham, S. R. (2016) · Clinical & Experimental Allergy · doi:10.1111/cea.12780 · Cited by 379 · see citing works
Self-citationInnate lymphoid cells: major players in inflammatory diseases
Ebbo, M., Crinier, A., Vely, F., & Vivier, É. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.86 · Cited by 371 · see citing works
Allergen Immunotherapy in Children User’s Guide
Lozano, M. A., Akdiş, C. A., Akdiş, M., Alviani, C., Angier, E., Arasi, S., Arzt‐Gradwohl, L., Barber, D., Bazire, R., Cavkaytar, Ö., et al. (2020) · Pediatric Allergy and Immunology · doi:10.1111/pai.13189 · Cited by 382 · see citing works
“revealed to inhibit seasonal increases in peripheral ILC2s.(51) Induction of IL-10 ILCregs from ILC2s by retinoic acid was recently demonstrated in human nasal tissues as well as lung tissues of house dust mite-induced mouse model of type 2 lung inflammation.”
BackgroundResultSelf-citationChinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis
Cheng, L., Chen, J., Fu, Q., He, S., Li, H., Liu, Z., Tan, G., Tao, Z., Wang, D., Wen, W., et al. (2018) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2018.10.4.300 · Cited by 367 · see citing works
Mechanisms of allergen-specific immunotherapy and immune tolerance to allergens
Akdiş, C. A., & Akdiş, M. (2015) · World Allergy Organization Journal · doi:10.1186/s40413-015-0063-2 · Cited by 361 · see citing works
“Seasonal increases in peripheral innate lymphoid type 2 cells are inhibited by subcutaneous grass pollen immunotherapy [129].”
BackgroundMolecular and cellular mechanisms of food allergy and food tolerance
Chinthrajah, R. S., Hernandez, J. D., Boyd, S. D., Galli, S. J., & Nadeau, K. C. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.02.004 · Cited by 310 · see citing works
Advances and highlights in allergic rhinitis
Zhang, Y., Lan, F., & Zhang, L. (2021) · Allergy · doi:10.1111/all.15044 · Cited by 288 · see citing works
Innate Lymphoid Cells in Mucosal Immunity
Panda, S. K., & Colonna, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00861 · Cited by 276 · see citing works
“Furthermore, subcutaneous allergen therapy resulted in fewer circulating ILC2s in patients with allergic rhinitis (98).”
IL ‐33: biological properties, functions, and roles in airway disease
Drake, L. Y., & Kita, H. (2017) · Immunological Reviews · doi:10.1111/imr.12552 · Cited by 251 · see citing works
Golebski, K., Layhadi, J. A., Şahiner, Ü. M., Steveling, E. H., Lenormand, M. M., Li, R. C. Y., Bal, S. M., Heesters, B. A., Vilà-Nadal, G., Hunewald, O. E., et al. (2021) · Immunity · doi:10.1016/j.immuni.2020.12.013 · Cited by 250 · see citing works
Self-citationJutel, M., Agache, I. O., Bonini, S., Burks, A. W., Calderón, M. A., Canonica, G. W., Cox, L., Demoly, P. M., Frew, A. J., O’Hehir, R. E., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.12.1300 · Cited by 242 · see citing works
“AIT has been shown to regulate ILCs, and seasonal increases in peripheral ILC2 numbers are inhibited by subcutaneous grass pollen immunotherapy.(37) Circulating ILC2 responses are increased in asthmatic patients but not in those with allergic rhinitis.”
BackgroundGroup 2 Innate Lymphoid Cells in Airway Diseases
Kato, A. (2019) · CHEST Journal · doi:10.1016/j.chest.2019.04.101 · Cited by 199 · see citing works
“However, patients with seasonal allergic rhinitis who received allergenspecific immunotherapy did not show seasonal elevation of blood ILC2s.(46) These results indicate that ILC2s are elevated locally and systemically in patients with allergic rhinitis and that the accumulation of ILC2s is controlled at least in part…”
BackgroundMechanisms of Allergen Immunotherapy in Allergic Rhinitis
Drazdauskaitė, G., Layhadi, J. A., & Shamji, M. H. (2020) · Current Allergy and Asthma Reports · doi:10.1007/s11882-020-00977-7 · Cited by 197 · see citing works
Self-citationMechanisms of allergen-specific immunotherapy and allergen tolerance
Küçüksezer, U. C., Özdemir, C., Cevhertas, L., Öğülür, İ., Akdis, M., & Akdiş, C. A. (2020) · Allergology International · doi:10.1016/j.alit.2020.08.002 · Cited by 184 · see citing works
Diverse immune mechanisms of allergen immunotherapy for allergic rhinitis with and without asthma
Shamji, M. H., Sharif, H., Layhadi, J. A., Zhu, R., Kishore, U., & Renz, H. E. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.01.016 · Cited by 174 · see citing works
Self-citationGroup 2 innate lymphoid cells are elevated and activated in chronic rhinosinusitis with nasal polyps
Poposki, J. A., Klingler, A. I., Tan, B. K., Soroosh, P., Banie, H., Lewis, G. M., Hulse, K. E., Stevens, W. W., Peters, A. T., Grammer, L. C., et al. (2017) · Immunity Inflammation and Disease · doi:10.1002/iid3.161 · Cited by 133 · see citing works
“However, a recent study showed that peripheral blood ILC2 were increased during pollen season in patients with allergic rhinitis [14].”
BackgroundMechanisms of allergen-specific immunotherapy
Głobińska, A., Boonpiyathad, T., Satitsuksanoa, P., Kleuskens, M. T. A., van de Veen, W., Sokołowska, M., & Akdiş, M. (2018) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2018.06.026 · Cited by 133 · see citing works
Advances in allergen immunotherapy: Aiming for complete tolerance to allergens
Akdis, C. A., & Akdis, M. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa7390 · Cited by 118 · see citing works
Eljaszewicz, A., Ruchti, F., Radzikowska, U., Głobińska, A., Boonpiyathad, T., Gschwend, A., Morita, H., Helbling, A., Arasi, S., Kahlert, H., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.08.042 · Cited by 117 · see citing works
“0001 Total IgE level (kU/L), median (range) 106 (28-274) 26 (10-73) .”
BackgroundRoles of innate lymphoid cells (ILCs) in allergic diseases: The 10-year anniversary for ILC2s
Bartemes, K. R., & Kita, H. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.03.015 · Cited by 115 · see citing works
Role of IL-35 in sublingual allergen immunotherapy
Shamji, M. H., Layhadi, J. A., Achkova, D. Y., Kouser, L., Perera-web, A., Couto-Francisco, N. C., Parkin, R. V., Matsuoka, T., Scadding, G. W., Ashton‐Rickardt, P. G., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.06.041 · Cited by 111 · see citing works
Self-citationWatts, A. M., Cripps, A. W., West, N. P., & Cox, A. J. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00294 · Cited by 110 · see citing works
Yu, Q., Guo, Y., Li, X., Li, C., Tan, W., Fan, X., Qin, Z., Chen, D., Wen, W., Zheng, S. G., et al. (2018) · Allergy · doi:10.1111/all.13438 · Cited by 98 · see citing works
Role of innate lymphoid cells in allergic diseases
Pasha, M. A., Patel, G., Hopp, R. J., & Yang, Q. (2019) · Allergy and Asthma Proceedings · doi:10.2500/aap.2019.40.4217 · Cited by 98 · see citing works
Emerging roles of innate lymphoid cells in inflammatory diseases: Clinical implications
Krohn, I. K., Shikhagaie, M., Golebski, K., Bernink, J. H., Breynaert, C. M., Creyns, B., Diamant, Z., Fokkens, W. J., Gevaert, P., Hellings, P. W., et al. (2017) · Allergy · doi:10.1111/all.13340 · Cited by 96 · see citing works
“• Peripheral blood ILC2 numbers correlated with clinical symptoms in patients with seasonal AR.(25) • Group 2 ILCs in mucosal biopsies from patients with CRS correlated with tissue and blood eosinophilia and the presence of nasal polyps(28) and negatively correlated with the number of previous sinus surgeries.”
BackgroundInfluentialSelf-citationNovel approaches and perspectives in allergen immunotherapy
Hoffmann, H. J., Valovirta, E. J., Pfaar, O., Moingeon, P. E., Schmid, J. M., Skaarup, S. H., Cardell, L., Simonsen, K., Larché, M., Durham, S. R., et al. (2017) · Allergy · doi:10.1111/all.13135 · Cited by 95 · see citing works
“Recent studies have shown suppression of basophil activation (47, 48) and a decrease in circulating ILC2s (49).”
BackgroundSelf-citationImmunological Responses and Biomarkers for Allergen-Specific Immunotherapy Against Inhaled Allergens
Shamji, M. H., Layhadi, J. A., Sharif, H., Penagos, M., & Durham, S. R. (2021) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2021.03.029 · Cited by 95 · see citing works
Self-citationThe Role of Type 2 Innate Lymphoid Cells in Allergic Diseases
Zheng, H., Zhang, Y., Pan, J., Liu, N., Qin, Y., Qiu, L., Liu, M., & Wang, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.586078 · Cited by 97 · see citing works
“The possible mechanism underlying this difference is that HDM is more immunogenic than plant-derived allergens, and its sensitization mechanism is presumably different from that of plant-based allergens, such as wormwood pollen (118).”
BackgroundEastman, J. J., Cavagnero, K. J., DeConde, A. S., Kim, A. S., Karta, M. R., Broide, D. H., Zuraw, B. L., White, A. A., Christiansen, S. C., & Doherty, T. A. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.11.023 · Cited by 93 · see citing works
Şahiner, Ü. M., & Durham, S. R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01959 · Cited by 88 · see citing works
“AIT supressed seasonal increases in ILC2s in patients treated with immunotherapy compared to untreated controls (103).”
BackgroundSelf-citationApplications and mechanisms of immunotherapy in allergic rhinitis and asthma
Kappen, J. H., Durham, S. R., Veen, H. I. ’., & Shamji, M. H. (2016) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753465816669662 · Cited by 87 · see citing works
Self-citationOne hundred and ten years of Allergen Immunotherapy: A journey from empiric observation to evidence
Pfaar, O., Bousquet, J., Durham, S. R., Kleine‐Tebbe, J., Larché, M., Roberts, G. C., Shamji, M. H., & van Wijk, R. G. (2021) · Allergy · doi:10.1111/all.15023 · Cited by 86 · see citing works
Self-citationNew insights into the function, development, and plasticity of type 2 innate lymphoid cells
Krabbendam, L., Bal, S. M., Spits, H., & Golebski, K. (2018) · Immunological Reviews · doi:10.1111/imr.12708 · Cited by 83 · see citing works
Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease
Karta, M. R., Broide, D. H., & Doherty, T. A. (2016) · Current Allergy and Asthma Reports · doi:10.1007/s11882-015-0581-6 · Cited by 77 · see citing works
Hot topics in allergen immunotherapy, 2023: Current status and future perspective
Zemelka‐Wiącek, M., Agache, I. O., Akdiş, C. A., Akdiş, M., Casale, T. B., Dramburg, S., Jahnz‐Różyk, K., Kosowska, A., Matricardi, P. M., Pfaar, O., et al. (2023) · Allergy · doi:10.1111/all.15945 · Cited by 73 · see citing works
“46 Recently discovered IL-10”
Self-citationIncreased innate type 2 immune response in house dust mite-allergic patients with allergic rhinitis
Zhong, H., Fan, X., Yu, Q., Qin, Z.-L., Chen, D., Xu, R., Chen, D., Lin, Z., Wen, W., & Fu, Q. (2017) · Clinical Immunology · doi:10.1016/j.clim.2017.09.008 · Cited by 73 · see citing works
Karta, M. R., Rosenthal, P., Beppu, A., Vuong, C. Y., Miller, M., Das, S., Kurten, R. C., Doherty, T. A., & Broide, D. H. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.03.010 · Cited by 72 · see citing works
“In addition, ILC2 numbers in patients with grass pollen allergy increase in the blood during the grass pollen season.(33) These studies demonstrate that exposure to inhaled allergens in allergic subjects can significantly increase peripheral blood ILC2 numbers.”
Allergen Immunotherapy in Asthma
Nakagome, K., & Nagata, M. (2021) · Pathogens · doi:10.3390/pathogens10111406 · Cited by 73 · see citing works
“Moreover, AIT reportedly decreases the number of type-2 innate lymphoid cells as sources of Th2 cytokines in blood [44], although this remains controversial [45].”
BackgroundHelper-like Innate Lymphoid Cells in Humans and Mice
Guia, S., & Narni-Mancinelli, É. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.03.002 · Cited by 70 · see citing works
“Not defined Grass pollen, subcutaneous immunotherapy Seasonal allergic rhinitis Decreases number of circulating ILC2s [85]”
BackgroundGroup 2 Innate Lymphoid Cells: Team Players in Regulating Asthma
Rodríguez‐Rodríguez, N., Gogoi, M., & McKenzie, A. N. J. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-110119-091711 · Cited by 69 · see citing works
van de Veen, W., Wirz, O. F., Głobińska, A., & Akdiş, M. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.08.012 · Cited by 67 · see citing works
Innate and Adaptive Immunity: ILC2 and Th2 Cells in Upper and Lower Airway Allergic Diseases
Scadding, G. K., & Scadding, G. W. (2021) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2021.02.013 · Cited by 65 · see citing works
Self-citationCirculating innate lymphoid cells are differentially regulated in allergic and nonallergic subjects
Lombardi, V., Beuraud, C., Neukirch, C., Moussu, H., Morizur, L., Horiot, S., Luce, S., Wambre, E. R., Linsley, P. S., Chollet‐Martin, S., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.12.1325 · Cited by 65 · see citing works
Effects of myeloid and plasmacytoid dendritic cells on ILC2s in patients with allergic rhinitis
Peng, Y., Qin, Z.-L., Fang, S., Xu, Z., Zhang, H., Chen, D., Liu, Z., Bellanti, J. A., Zheng, S. G., & Fu, Q. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.11.029 · Cited by 63 · see citing works
Airway innate lymphoid cells in the induction and regulation of allergy
Doherty, T. A., & Broide, D. H. (2018) · Allergology International · doi:10.1016/j.alit.2018.11.001 · Cited by 62 · see citing works
Creticos, P. S., Günaydın, F. E., Nolte, H., Damask, C., & Durham, S. R. (2024) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2024.04.034 · Cited by 61 · see citing works
Self-citationAllergen-Dependent Differences in ILC2s Frequencies in Patients With Allergic Rhinitis
Fan, D., Wang, X., Wang, M., Wang, Y., Zhang, L., Li, Y., Fan, E., Cao, F., Crombruggen, K. V., & Zhang, L. (2016) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2016.8.3.216 · Cited by 60 · see citing works
At the Bench: Understanding group 2 innate lymphoid cells in disease
Doherty, T. A. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.5bt0814-374r · Cited by 58 · see citing works
“immunotherapy [109].”
Tojima, I., Kouzaki, H., Shimizu, S., Ogawa, T., Arikata, M., Kita, H., & Shimizu, T. (2016) · Clinical Immunology · doi:10.1016/j.clim.2016.07.010 · Cited by 58 · see citing works
“Peripheral blood ILC2s were increased during the pollen season in patients with grass pollen allergic rhinitis, and this increase was inhibited by subcutaneous grass pollen immunotherapy [22].”
BackgroundTojima, I., Matsumoto, K., Kikuoka, H., Hara, S., Yamamoto, S., Shimizu, S., Kouzaki, H., & Shimizu, T. (2019) · Allergy · doi:10.1111/all.13974 · Cited by 57 · see citing works
Basic science for the clinician: Mechanisms of sublingual and subcutaneous immunotherapy
Lawrence, M. G., Steinke, J. W., & Borish, L. (2016) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2016.06.027 · Cited by 54 · see citing works
The role of basophils as innate immune regulatory cells in allergy and immunotherapy
Chirumbolo, S., Bjørklund, G., Sboarina, A., & Vella, A. (2017) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2017.1417711 · Cited by 55 · see citing works
Tolerance mechanisms in allergen immunotherapy
Sözener, Z. Ç., Mungan, D., Cevhertas, L., Öğülür, İ., Akdiş, M., & Akdiş, C. A. (2020) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000693 · Cited by 52 · see citing works
“Marked inhibition of seasonal increases in ILC2s was seen after grass pollen SCIT when compared to untreated controls [81].”
BackgroundMechanisms of Subcutaneous and Sublingual Aeroallergen Immunotherapy
Komlósi, Z. I., Kovács, N., Sokołowska, M., van de Veen, W., Akdiş, M., & Akdiş, C. A. (2019) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2019.09.009 · Cited by 50 · see citing works
“21,88 The characteristic changes in the level of IgE and IgG4 during SCIT is mirrored by the local concentrations of those immunoglobulins in nasal secretions45 and saliva.89 The results of some recent studies confirm that the IgG4-mediated inhibition of CD23-dependent IgE-FAB,90 rather than the serum concentration of…”
BackgroundInfluentialGroup 2 Innate Lymphoid Cells in Human Respiratory Disorders
van der Ploeg, E. K., Mascaro, A. C., Huylebroeck, D., Hendriks, R. W., & Stadhouders, R. (2019) · Journal of Innate Immunity · doi:10.1159/000496212 · Cited by 49 · see citing works
Mechanisms of allergen-specific immunotherapy for allergic rhinitis and food allergies
Lam, H. Y., Tergaonkar, V., & Ahn, K. S. (2020) · Bioscience Reports · doi:10.1042/bsr20200256 · Cited by 49 · see citing works
Hesse, L., Elberink, J. N. G. O., van Oosterhout, A. J. M., & Nawijn, M. C. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108115 · Cited by 47 · see citing works
Boonpiyathad, T., Tantilipikorn, P., Ruxrungtham, K., Pradubpongsa, P., Mitthamsiri, W., Piedvache, A., Thantiworasit, P., Sirivichayakul, S., Jacquet, A., Suratannon, N., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.10.029 · Cited by 45 · see citing works
Group 2 innate lymphoid cells: new players in human allergic diseases.
Doherty, T. A., & Broide, D. H. (2015) · PubMed · Cited by 44 · see citing works
An Update on Lymphocyte Subtypes in Asthma and Airway Disease
Moldaver, D. M., Larché, M., & Rudulier, C. D. (2016) · CHEST Journal · doi:10.1016/j.chest.2016.10.038 · Cited by 44 · see citing works
The Use of Biomarkers to Predict Aero-Allergen and Food Immunotherapy Responses
Sindher, S., Long, A. J., Acharya, S., Sampath, V., & Nadeau, K. C. (2018) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-018-8678-z · Cited by 45 · see citing works
“Grass pollen SCIT blunted the seasonal increases of CD117ILC2s, as well as IL-13ILC2s [106].”
InfluentialThe future outlook on allergen immunotherapy in children: 2018 and beyond
Arasi, S., Corsello, G., Villani, A., & Pajno, G. B. (2018) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/s13052-018-0519-4 · Cited by 42 · see citing works
Mitthamsiri, W., Pradubpongsa, P., Sangasapaviliya, A., & Boonpiyathad, T. (2018) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2018.10.6.662 · Cited by 42 · see citing works
Allergic Rhinitis: What Do We Know About Allergen-Specific Immunotherapy?
Boonpiyathad, T., Lao‐Araya, M., Chiewchalermsri, C., Sangkanjanavanich, S., & Morita, H. (2021) · Frontiers in Allergy · doi:10.3389/falgy.2021.747323 · Cited by 41 · see citing works
“Indeed, the frequency of ILC2s in peripheral blood of seasonal AR patients was increased during the season compared to healthy individuals (39, 40).”
BackgroundSelf-citationMechanisms and Predictive Biomarkers of Allergen Immunotherapy in the Clinic
Layhadi, J. A., Lalioti, A., Palmer, E. N., van Zelm, M. C., Wambre, E. R., & Shamji, M. H. (2023) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2023.11.027 · Cited by 39 · see citing works
Self-citationKouser, L., Kappen, J. H., Walton, R. P., & Shamji, M. H. (2017) · Current Treatment Options in Allergy · doi:10.1007/s40521-017-0117-5 · Cited by 39 · see citing works
Self-citationRecent developments and highlights in immune monitoring of allergen immunotherapy
van Zelm, M. C., McKenzie, C. I., Varese, N. P., Rolland, J. M., & O’Hehir, R. E. (2019) · Allergy · doi:10.1111/all.14078 · Cited by 39 · see citing works
Therapeutic manipulation of innate lymphoid cells
Cobb, L., & Verneris, M. R. (2021) · JCI Insight · doi:10.1172/jci.insight.146006 · Cited by 32 · see citing works
“Interestingly, seasonal increases in ILC2s are suppressed by allergen immunotherapy (26).”
BackgroundRole of Group 2 Innate Lymphocytes in Aspirin-exacerbated Respiratory Disease Pathogenesis
White, A. A., & Doherty, T. A. (2018) · American Journal of Rhinology and Allergy · doi:10.2500/ajra.2018.32.4498 · Cited by 37 · see citing works
Innate lymphoid cells: The missing part of a puzzle in food allergy
Şahiner, Ü. M., Layhadi, J. A., Golebski, K., Komlósi, Z. I., Peng, Y., Şekerel, B. E., Durham, S. R., Brough, H. A., Morita, H., Akdiş, M., et al. (2021) · Allergy · doi:10.1111/all.14776 · Cited by 37 · see citing works
“15, 23 The putative role of ILC2s have been defined in several diseases including allergic asthma 24, 25 , allergic rhinitis 26 , atopic dermatitis (AD) 27 and eosinophilic esophagitis.”
BackgroundSelf-citationMechanisms of Aeroallergen Immunotherapy
Özdemir, C., Küçüksezer, U. C., Akdiş, M., & Akdiş, C. A. (2015) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2015.08.003 · Cited by 35 · see citing works
“Type 2 ILCs have been found to have possible roles in asthma and upper respiratory inflammation and AIT to grass pollen has been shown to inhibit seasonal increases of peripheral population of type 2 ILCs.6,30”
Zhang, J., He, X.-C., Zhou, M., Liu, Q.-D., Xu, W.-Z., Yan, Y.-J., & Ruan, Y. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155012 · Cited by 34 · see citing works
Innate lymphoid cells and allergic disease
Stier, M. T., & Peebles, R. S. (2017) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2017.08.290 · Cited by 34 · see citing works
Yu, Q., Tan, W., Fan, X., Guo, Y., Qin, Z.-L., Li, C., Chen, D., Lin, Z. B., Wen, W., & Fu, Q. (2018) · International Archives of Allergy and Immunology · doi:10.1159/000488050 · Cited by 34 · see citing works
Mucosal IgE immune responses in respiratory diseases
Eguíluz‐Gracia, I., Layhadi, J. A., Rondón, C., & Shamji, M. H. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.05.009 · Cited by 33 · see citing works
Self-citationOrimo, K., Tamari, M., Saito, H., Matsumoto, K., Nakae, S., & Morita, H. (2021) · Allergy · doi:10.1111/all.14863 · Cited by 34 · see citing works
The Role of Sphingolipids in Allergic Disorders
Díaz‐Perales, A., Escribese, M. M., Garrido‐Arandia, M., Obeso, D., Izquierdo, E., Tomé‐Amat, J., & Barber, D. (2021) · Frontiers in Allergy · doi:10.3389/falgy.2021.675557 · Cited by 31 · see citing works
“Allergic patients tend to present higher levels of this cell type in their circulation, which supports this hypothesis, and it is in accordance with previous reports of peripheral ILC2s growing in number after intranasal challenge and during the pollinic season in patients with a cat and Phleum pratense allergy, respe…”
ResultCavagnero, K. J., & Doherty, T. A. (2017) · Journal of Cytokine Biology · doi:10.4172/2576-3881.1000116 · Cited by 30 · see citing works
“TSLP expression is increased in nasal polyps from CRS and AERD patients, AR patient nasal tissue, and in asthmatic airway epithelial cells (with levels positively correlating with disease severity) [14,27-29].”
InfluentialArshad, S. H., Lack, G., Durham, S. R., Penagos, M., Larenas‐Linnemann, D. E., & Halken, S. (2023) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2023.10.013 · Cited by 30 · see citing works
Self-citationJordakieva, G., & Jensen‐Jarolim, E. (2018) · World Allergy Organization Journal · doi:10.1186/s40413-018-0197-0 · Cited by 29 · see citing works
“Similarly, another study described higher circulating ILC2 levels in AR during pollen season, compared to AR subjects after AIT and non-atopic individuals [47, 51].”
ResultSuppression of Immunotherapy on Group 2 Innate Lymphoid Cells in Allergic Rhinitis
Fan, D., Wang, X., Wang, C., Wang, Y., Cao, F., & Zhang, L. (2016) · Chinese Medical Journal · doi:10.4103/0366-6999.194642 · Cited by 27 · see citing works
“This suggested that ILC2s may have parallel functions to Th2 cells and mast cells in promoting the development of AR. Lao‑Araya et al.[9] have demonstrated that the proportion of ILC2s was elevated in AR patients sensitized to Phleum pratense, and SCIT for 8–36 months can induce a reduction of ILC2s in AR patients.”
BackgroundResultInfluentialGroup 2 innate lymphoid cells in human asthma
Iwata, A., Toda, Y., Furuya, H., & Nakajima, H. (2022) · Allergology International · doi:10.1016/j.alit.2022.12.001 · Cited by 27 · see citing works
Biomarkers for Allergen Immunotherapy
Moingeon, P. E. (2015) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2015.08.004 · Cited by 26 · see citing works
Increased expression of type 2 innate lymphoid cells in pediatric patients with allergic rhinitis
Sun, R., Yang, Y., Huo, Q., Gu, Z., Wei, P., & Tang, X. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.8235 · Cited by 26 · see citing works
“Subsequently, Lao et al (15) identified that ILC2s levels were elevated in patients with grass pollen-sensitized AR during the pollen season compared with the control group, and that the ILC2 levels were decreased following subcutaneous immunotherapy.”
BackgroundMechanisms and biomarkers of successful allergen-specific immunotherapy
López, J.-F., Imam, M. B., Satitsuksanoa, P., Lems, S., Yang, M., Hwang, Y.-K., Losol, P., Choi, J., Kim, S., Chang, Y., et al. (2022) · Asia Pacific Allergy · doi:10.5415/apallergy.2022.12.e45 · Cited by 26 · see citing works
“And they also found that SCIT for 8–36 months can induce a reduction of ILC2 cells, correlation with less seasonal symptoms compared to the subcutaneous AIT [136].”
ResultPelaia, C., Vatrella, A., Lombardo, N., Terracciano, R., Navalesi, P., Savino, R., & Pelaia, G. (2017) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2018.1402003 · Cited by 22 · see citing works
“proliferation of Th2 cells and ILC2, thus inhibiting the production of Th2 cytokines (IL-4, IL-5, IL-9, IL-13), and consequently decreasing the activation of eosinophils, basophils, mast cells, and IgE-secreting B lymphocytes [64,67,68].”
BackgroundBatard, T., Canonica, G. W., Pfaar, O., Shamji, M. H., O’Hehir, R. E., van Zelm, M. C., & Mascarell, L. (2023) · Molecular Immunology · doi:10.1016/j.molimm.2023.02.004 · Cited by 22 · see citing works
Self-citationInnate lymphocyte cells in asthma phenotypes
Özyiğit, L. P., Morita, H., & Akdiş, M. (2015) · Clinical and Translational Allergy · doi:10.1186/s13601-015-0068-5 · Cited by 22 · see citing works
“In contrast, the percentage of peripheral ILC2s in allergic rhinitis patients who were treated with SCIT and in control patients did not increase during pollen season [68].”
Innate immune cells for immunotherapy of autoimmune and cancer disorders
Schäfer, C., Ascui, G., Ribeiro, C. H., López, M. N., Prados‐Rosales, R., González, P. A., Bueno, S. M., Riedel, C. A., Baena, A., Kalergis, A. M., et al. (2017) · International Reviews of Immunology · doi:10.1080/08830185.2017.1365145 · Cited by 21 · see citing works
“Grass-polen subcutaneous immunotherapy (SCIT) was reported to inhibit seasonal increase of IL-13+ ILC2s in allergic individuals, probably by induction of IL-10+ Tregs [105].”
BackgroundBiomarkers of immunotherapy response in patients with allergic rhinitis
Licari, A., Castagnoli, R., Brambilla, I., Tosca, M. A., Filippo, M. D., Marseglia, G. L., & Ciprandi, G. (2018) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2018.1504679 · Cited by 21 · see citing works
“specific IgE synthesis, and promoting B-cell production of IgA and IgG4 antibody [19,21,23].”
BackgroundMorikawa, T., Fukuoka, A., Matsushita, K., Yasuda, K., Iwasaki, N., Akasaki, S., Fujieda, S., & Yoshimoto, T. (2017) · International Immunology · doi:10.1093/intimm/dxx030 · Cited by 20 · see citing works
Influence of Innate Immunity on Immune Tolerance
Küçüksezer, U. C., Özdemir, C., Akdiş, M., & Akdiş, C. A. (2020) · Acta Medica Academica · doi:10.5644/ama2006-124.295 · Cited by 20 · see citing works
“Peripheral ILC2s which could contribute to induction of Th2 cells from naïve T cells were revealed to be diminished as a result of subcutaneous allergen immunotherapy in patients with severe seasonal allergic rhinitis (105).”
BackgroundInnate Lymphoid Cells in the Airways: Their Functions and Regulators
Orimo, K., Saito, H., Matsumoto, K., & Morita, H. (2020) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2020.12.3.381 · Cited by 21 · see citing works
Allergen immunotherapy in asthma
Nakagome, K., & Nagata, M. (2024) · Allergology International · doi:10.1016/j.alit.2024.05.005 · Cited by 19 · see citing works
Immune monitoring for precision medicine in allergy and asthma
Boyd, S. D., Hoh, R. A., Nadeau, K. C., & Galli, S. J. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.08.007 · Cited by 19 · see citing works
van Rijt, L. S., Logiantara, A., Canbaz, D., & van Ree, R. (2018) · Clinical & Experimental Allergy · doi:10.1111/cea.13254 · Cited by 19 · see citing works
“An important chemoattractant for eosinophils is eotaxin‐2, which is under the control of Th2 cytokine IL‐13.35 Both the concentration of eotaxin‐2 and IL‐13 were significantly decreased in the BALF after BP SCIT.”
BackgroundInfluential
- Authors
- Lao-Araya, M., Steveling, E., Scadding, G. W., Durham, S. R., & Shamji, M. H.
- Affiliations
- Asthma UK (GB)
- Corresponding author
- Shamji, Mohamed H.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 134
- Issue
- 5
- Pages
- 1193-1195.e4
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2030393991
- Cited by
- 200
- References
- 9
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 14 · 2023: 17 · 2022: 17 · 2021: 29 · 2020: 21 · 2019: 18 · 2018: 22 · 2017: 24 · 2016: 14 · 2015: 9 · 2014: 1
- FWCI
- 12.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- edoc (University of Basel) (submittedVersion)
- Funders
- Wellcome Trust (097881/Z/11/Z)
- Immune Tolerance Network (N01 AI15416)
- Asthma and Lung UK
- Imperial College London
- Chiang Mai University
- National Institutes of Health (n01ai15416-28-0-11, N01-AI-15416)
- Medical Research Council
- Faculty of Medicine, Chiang Mai University
- National Institute of Allergy and Infectious Diseases (N01 AI 15416)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- innate lymphoid cells type 2, subcutaneous immunotherapy, grass pollen allergy, allergic rhinitis, seasonal variation, Th2 immune response, IL-4, IL-5, IL-13, nasal mucosa inflammation
- MeSH terms
- Allergens, Desensitization, Immunologic, Female, Rhinitis, Allergic, Seasonal, Humans, Lymphocytes, Male, Pollen, Seasons, Cytokines, Phleum
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