The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
De novo oligoclonal expansions of circulating plasmablasts in active and relapsing IgG4-related disease
Open accessAbstract
Background IgG4-related disease (IgG4-RD) is a poorly understood, multi-organ, chronic inflammatory disease characterized by tumefactive lesions, storiform fibrosis, obliterative phlebitis and the accumulation of IgG4-expressing plasma cells at disease sites. Objective The role of B cells and IgG4 antibodies in IgG4-RD pathogenesis is not well defined. We evaluated patients with IgG4-RD for activated B cells in disease lesions as well as peripheral blood and investigated their role in disease pathogenesis. Methods B cell populations were analyzed from the peripheral blood of 84 patients with active IgG4-RD using flow cytometry. The repertoire of B cell populations was analyzed in a subset of patients by Next-generation Sequencing. Fourteen of these patients, were longitudinally followed for 9-15 months after Rituximab therapy. Results CD19+CD27+CD20-CD38hi plasmablasts, which are largely IgG4+, are elevated in patients with active IgG4-RD. These expanded plasmablasts are oligoclonal, exhibit extensive somatic hypermutation and their numbers decline following rituximab-mediated B-cell depletion therapy; this loss correlates with disease remission. A subset of patients relapse after rituximab therapy, and circulating plasmablasts that re-emerge in these subjects are clonally distinct and exhibit enhanced somatic hypermutation. Cloning and expression of Ig heavy and light chain genes from expanded plasmablasts at the peak of disease reveals that disease-associated IgG4 antibodies are self-reactive. Conclusions Clonally expanded CD19+CD27+CD20-CD38hi plasmablasts are a hallmark of active IgG4-RD. Enhanced somatic mutation in activated B cells and plasmablasts and emergence of distinct plasmablast clones upon relapse indicate that the disease pathogenesis is linked to de novo recruitment of naïve B cells into T-dependent responses by CD4+ T cells, likely driving a self-reactive disease process.
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Differential Diagnosis of Glomerular Disease: A Systematic and Inclusive Approach
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High Serum IgG4 Concentrations in Patients with Sclerosing Pancreatitis
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CS1, a Potential New Therapeutic Antibody Target for the Treatment of Multiple Myeloma
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IgG4‐Related Disease: Clinical and Laboratory Features in One Hundred Twenty‐Five Patients
Wallace, Z. S., Deshpande, V., Mattoo, H., Mahajan, V. S., Kulikova, M., Pillai, S., & Stone, J. H. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39205 · Cited by 666
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Mattoo, H., Mahajan, V. S., Maehara, T., Deshpande, V., Della-Torre, E., Wallace, Z. S., Kulikova, M., Drijvers, J. M., Daccache, J., Carruthers, M. N., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.12.1330 · Cited by 406
Self-citationEuropean Guideline on IgG4-related digestive disease - UEG and SGF evidence-based recommendations
Löhr, J., Beuers, U., Vujasinovic, M., Alvaro, D., Frøkjær, J. B., Buttgereit, F., Capurso, G., Culver, E. L., de‐Madaria, E., Della‐Torre, E., et al. (2020) · United European Gastroenterology Journal · doi:10.1177/2050640620934911 · Cited by 252
Self-citationIshiguro, N., Moriyama, M., Furusho, K., Furukawa, S., Shibata, T., Murakami, Y., Chinju, A., Haque, A. S. M. R., Gion, Y., Ohta, M., et al. (2020) · Arthritis & Rheumatology · doi:10.1002/art.41052 · Cited by 86
The Role of B Cells and B Cell Therapies in Immune-Mediated Liver Diseases
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Metadata
- Authors
- Mattoo, H., Mahajan, V. S., Della-Torre, E., Sekigami, Y., Carruthers, M., Wallace, Z. S., Deshpande, V., Stone, J. H., & Pillai, S.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 134
- Issue
- 3
- Pages
- 679-687
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2082783569
- Cited by
- 386
- References
- 33
- FWCI
- 30.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mattoo, H., Mahajan, V. S., Della-Torre, E., Sekigami, Y., Carruthers, M., Wallace, Z. S., Deshpande, V., Stone, J. H., & Pillai, S. (2014). De novo oligoclonal expansions of circulating plasmablasts in active and relapsing IgG4-related disease. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2014.03.034
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