The Role of B Cells and B Cell Therapies in Immune-Mediated Liver Diseases

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Replicated association of 17q12‐21 with susceptibility of primary biliary cirrhosis in a Japanese cohort

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Loss of tolerance to gut immunity protein, glycoprotein 2 (GP2) is associated with progressive disease course in primary sclerosing cholangitis

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Characterization of the B cell response of patients with anti‐liver cytosol autoantibodies in type 2 autoimmune hepatitis

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Human B cells promote T-cell plasticity to optimize antibody response by inducing coexpression of TH1/TFH signatures

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Significance of serological markers in the disease course of ulcerative colitis in a prospective clinical cohort of patients

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A systematic review of patient-reported outcomes in primary biliary cholangitis and primary sclerosing cholangitis

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Divergent chemokine receptor expression and the consequence for human IgG4 B cell responses

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Gut and Liver B Cells of Common Clonal Origin in Primary Sclerosing Cholangitis–Inflammatory Bowel Disease

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Single-cell mass cytometry on peripheral blood identifies immune cell subsets associated with primary biliary cholangitis

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CD19+CD24hiCD38hi B Cell Dysfunction in Primary Biliary Cholangitis

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Integrated GWAS and mRNA Microarray Analysis Identified IFNG and CD40L as the Central Upstream Regulators in Primary Biliary Cholangitis

Ueno, K., Aiba, Y., Hitomi, Y., Shimoda, S., Nakamura, H., Gervais, O., Kawai, Y., Kawashima, M., Nishida, N., Kohn, S.-S., et al. (2020) · Hepatology Communications · doi:10.1002/hep4.1497 · Cited by 21 · see citing works

Blockade of BAFF Reshapes the Hepatic B Cell Receptor Repertoire and Attenuates Autoantibody Production in Cholestatic Liver Disease

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Clonal Characteristics of Circulating B Lymphocyte Repertoire in Primary Biliary Cholangitis

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Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitisPreprint

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Deviations in Peripheral Blood Cell Populations are Associated with the Stage of Primary Biliary Cholangitis and Presence of Itching

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Comparable profiles of serum histamine and IgG4 levels in allergic beekeepers

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Phenotypic changes of lymphocyte in a patient with IgG4-related disease after corticosteroid therapy

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Peripheral B Lymphocyte Repertoire to Mitochondrial Antigen in Primary Biliary Cirrhosis - Positive Correlation Between the Disease Activity and the Frequency of Circulating B Lymphocytes Specific for Pyruvate Dehydroge Nase Complex

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FRI0588 Interim results of a phase 2 study of XMAB®5871, a reversible B cell inhibitor, in IGG4-related disease

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Comparative efficacy and safety of current therapies for early rheumatoid arthritis: a systematic literature review and network meta-analysis.

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Profiling of the pattern of the human TRB/IGH–CDR3 repertoire in primary biliary cholangitis patients

Han, F., Fang, M.-X., Zhao, D., Dong, Y.-C., Yuan, G., Gao, J.-E., & Guo, C. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106393 · Cited by 3 · see citing works

FRI0224 Rituximab selectively reduces igg4 levels in rheumatoid arthritis patients

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Integrated analysis of GWAS and mRNA microarray identified IFN-? and CD40I as the central upstream-regulators in primary biliary cholangitis

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Primary biliary cholangitis.

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Immunosuppressive drugs modes of action

Meneghini, M., Bestard, O., & Grinyo, J. M. (2021) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2021.101757 · Cited by 74 · see citing works

Challenges and opportunities in achieving effective regulatory T cell therapy in autoimmune liver disease

Richardson, N., Wootton, G. E., Bozward, A. G., & Oo, Y. H. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00940-w · Cited by 58 · see citing works

The Role of B Cells in Adult and Paediatric Liver Injury

Patel, A. M., Liu, Y. S., Davies, S. P., Brown, R. M., Kelly, D. A., Scheel‐Toellner, D., Reynolds, G. M., & Stamataki, Z. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.729143 · Cited by 41 · see citing works

Immunological mechanisms in steatotic liver diseases: An overview and clinical perspectives

Yan, M., Man, S., Ma, L., Guo, L., Huang, L., & Gao, W. (2024) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2024.0315 · Cited by 37 · see citing works

Inhibition of Bruton Tyrosine Kinase Reduces Neuroimmune Cascade and Promotes Recovery after Spinal Cord Injury

Yu, C. G., Bondada, V., Iqbal, H., Moore, K. L., Gensel, J. C., Bondada, S., & Geddes, J. W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010355 · Cited by 29 · see citing works

Ongoing involvers and promising therapeutic targets of hepatic fibrosis: The hepatic immune microenvironment

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Immunobiology of the biliary tract system

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Repurposing of rituximab biosimilars to treat B cell mediated autoimmune diseases

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The immunological function of CXCR2 in the liver during sepsis

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The liver-resident immune cell repertoire - A boon or a bane during machine perfusion?

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Role of B Cell-Activating Factor in Fibrosis Progression in a Murine Model of Non-Alcoholic Steatohepatitis

Kanemitsu‐Okada, K., Abe, M., Nakamura, Y., Miyake, T., Watanabe, T., Yoshida, O., Koizumi, Y., Hirooka, M., Tokumoto, Y., Matsuura, B., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032509 · Cited by 14 · see citing works

Insights gained into the injury mechanism of drug and herb induced liver injury in the hepatic microenvironment

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Dynamic crosstalk between HSCs and liver microenvironment: multicellular interactions in the regulation of liver fibrosis

Wang, L., Huang, Y., Chen, J., Gao, J., Chen, S., Zhao, M., Lin, J., Zhou, S., Shen, Y., & Cheng, Y. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1635763 · Cited by 14 · see citing works

Inverse Vaccination for Autoimmune Diseases: Insights into the Role of B Lymphocytes

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Immunomodulatory Roles of IL-15 in Immune Cells and its Potential for Cancer Immunotherapy

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B cell immune profiles in dysbiotic vermiform appendixes of pancreatic cancer patients

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Systemic lupus erythematosus and autoimmune hepatitis overlap disease in a hospitalized systemic lupus erythematosus cohort

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The impact of T cells on immune-related liver diseases: an overview

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Biliary fibrosis is an important but neglected pathological feature in hepatobiliary disorders: from molecular mechanisms to clinical implications

Zhao, J., Yue, P., Mi, N., Li, M., Fu, W., Zhang, X., Gao, L., Bai, M., Tian, L., Jiang, N., et al. (2024) · Medical Review · doi:10.1515/mr-2024-0029 · Cited by 7 · see citing works

Rituximab in Pemphigus Vulgaris: A Review of Monoclonal Antibody Therapy in Dermatology

Khandelwal, K., Jajoo, V., Bajpai, K., Madke, B., Prasad, R., Wanjari, M. B., Munjewar, P. K., & Taksande, A. B. (2023) · Cureus · doi:10.7759/cureus.40734 · Cited by 6 · see citing works

Autoimmune hepatitis: Towards a personalized treatment

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Bacterial components‐driven intrahepatic CXCR5 hi B cells are important population for MASH progression through inducing inflammation

Kim, N., Kim, M., Yang, Y. M., Jeong, W., Lee, H. W., Kim, W., Kang, S. G., & Han, Y. (2025) · The FASEB Journal · doi:10.1096/fj.202401256r · Cited by 6 · see citing works

‘Can we cure IgG4-related diseases?’

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Immune traits in combination with inflammatory proteins revealing the pathogenesis of autoimmune liver diseases: A Mendelian randomization study

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Recent progress on the treatment of type 1 autoimmune pancreatitis and IgG4-related disease

Okazaki, K., Ikeura, T., & Uchida, K. (2022) · Modern Rheumatology · doi:10.1093/mr/roac054 · Cited by 4 · see citing works

Autoimmune hepatitis and primary biliary cholangitis overlap disease in a systemic lupus erythematosus patient receiving long-term B-cell depletion therapy

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The Differential Complement, Fc and Chemokine Receptor Expression of B Cells in IgG4-Related Pancreatobiliary Disease and Primary Sclerosing Cholangitis and Its Relevance for Targeting B Cell Pathways in Disease

Cargill, T. N., Barnes, E. J., Rispens, T., & Culver, E. L. (2024) · Biomedicines · doi:10.3390/biomedicines12122839 · Cited by 3 · see citing works

Gut Microbiota: Implications in Pathogenesis and Potential Therapeutic Target in Primary Biliary Cholangitis

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Isomaltooligosaccharide, galactomannan, and Lacticaseibacillus rhanmosus synergistically regulate intestinal immunity through the “gut-metabolism-immune axis”

Chen, C., Zhang, Q., Li, S., Su, Y., Zhang, Y. S., Jiang, Y., Guo, L., & Yang, X. (2026) · Food Research International · doi:10.1016/j.foodres.2026.118478 · Cited by 3 · see citing works

Prospective study of patients with immune checkpoint inhibitor-induced hepatitis; characterization of liver injury, outcome of therapy, and management of steroid-unresponsive and steroid-dependent hepatitis

Holmstroem, R. B., Teisner, A., Sweep, M. W. D., Noringriis, I. M., Khan, S., Aagaard, N. K., Karlström, J., Jurlander, R. S., Sohlin, J. E., Monberg, T. J., et al. (2026) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2025-013861 · Cited by 2 · see citing works

Harnessing reverse vaccinology for the design and validation of mRNA vaccine targeting the glycoprotein of human metapneumovirus (HMPV)

Oladipo, E. K., Ogunniran, J. A., Akinpelu, O. S., Akpan, B. I., Hamzah, H., Ogunmodede, S. P., Oluwasanya, G. J., Adaramola, E. O., Popoola, P. O., Adedokun, P. T., et al. (2026) · Discover Immunity. · doi:10.1007/s44368-026-00027-w · Cited by 1 · see citing works

The tumoral immunity state in purulent cholangitis

Maloshtan, O. V., Smachylo, R. M., Nekliudov, A. A., Kordon, T. I., Кlyosova, М. О., Bychenko, К. О., & Kozlov, D. S. (2023) · The Ukrainian Journal of Clinical Surgery · doi:10.26779/2786-832x.2023.1.17 · Cited by 1 · see citing works

Upadacitinib for refractory primary biliary cholangitis

Kolev, M., Möller, B., Berzigotti, A., & Semmo, N. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.03.004 · Cited by 1 · see citing works

Target Therapy in Systemic Lupus Erythematosus: A Narrative Literature Review

Delfin, M., Raveinal, & Elvira, D. (2023) · Bioscientia Medicina Journal of Biomedicine and Translational Research · doi:10.37275/bsm.v7i10.876

Frequency of seronegative cases in autoimmune hepatitis and their association with the systemic immune inflammation index

Bilgiç, N. M. (2024) · Journal of Health Sciences and Medicine · doi:10.32322/jhsm.1446058

STATE OF CELLULAR IMMUNITY IN PURULENT CHOLANGITIS

Maloshtan, O. V., Smachylo, R. M., Nekliudov, A. A., Kordon, T. I., Klosova, M. O., Kozlov, D. S., Omelchenko, M. F., & Chernyayev, М. S. (2024) · Kharkiv Surgical School · doi:10.37699/2308-7005.1.2024.08

Inflammatory Bowel Disease in patients with Primary Sclerosing Cholangitis: a distinct form of colitisPreprint

Bangma, A., Pibiri, P., Sun, S., de Jong, S., Bigaeva, E., Björk, J. R., Karmi, N., Verstappen, G. M. P. J., Kroese, F. G. M., Kats-Ugurlu, G., et al. (2024) · medRxiv · doi:10.1101/2024.07.23.24310848

STATE OF CELLULAR IMMUNITY IN PURULENT CHOLANGITIS

Maloshtan, O. V., Smachylo, R. M., Nekliudov, A. A., Kordon, T. I., Klosova, M. O., Kozlov, D. S., Chernyayev, М. S., Omelchenko, M. F., & Brovkin, V. A. (2024) · Kharkiv Surgical School · doi:10.37699/2308-7005.4.2024.06

Holothuria arenicola Extract-Loaded Polycaprolactone Nanoca psules Attenuate Bile Duct Ligation-Induced Acute Liver Injury

Mansour, E. M., Shemis, M. A., Fahmy, S. R., Amer, M. A., & Mohamed, A. S. (2025) · Current Nanomedicine · doi:10.2174/0124681873401484250924125945

Microbiome-immune interactions in autoimmune liver diseases

Kiseleva, Y. V., Maslennikov, R. V., Poluektova, E. A., Zolnikova, O., Sigidaev, A. S., Zharikov, Y. O., Shirokova, E. N., & Ivashkin, V. (2026) · World Journal of Gastroenterology · doi:10.3748/wjg.v32.i12.115853

Tumor necrosis factor receptor superfamily member 13B mutation-associated chronic cholangitis with cirrhosis: A case report and review of literature

Zhou, Y., Cheng, Q., Liang, M.-X., Li, S.-Q., Su, Y.-Z., Cai, Y.-M., Pan, Z.-Q., Xie, Y.-X., Chen, Y., & He, Y.-H. (2026) · World Journal of Hepatology · doi:10.4254/wjh.v18.i4.117993

Beyond the Graft: Optimizing Post-Transplant Care in Primary Sclerosing Cholangitis

Becchetti, C., Viganò, R., Aprile, F., Scaravaglio, M., Vitale, G., Perricone, G., Mazzarelli, C., Vangeli, M., Belli, L. S., Carbone, M., et al. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15093480

The diversity of STING in regulating immune cell function and its role in liver diseases: from bench to bedside

Lin, J., Liu, Y., Chen, Y., & Zhang, X. (2026) · Cell & Bioscience · doi:10.1186/s13578-026-01622-y

B cells in the progression from metabolic dysfunction-associated steatotic liver disease to hepatocellular carcinoma: immune regulation, microenvironmental crosstalk, and therapeutic implications

Bai, H., Fan, G., Deng, B., Liu, Y., Zhang, P., Cao, X., & Li, Y. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.117306

Beyond inflammation: exploring CAR-based cell therapy for fibrostenosing Crohn’s disease

Sun, Y., Chen, Q., Zhong, C., Chen, Y., Zhao, R., He, X., Mao, X., Li, J., Xing, Z., & Wu, F. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1967353

The Contribution of B Cells in Autoimmune Liver Diseases

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The Role of B Cells in Adult and Paediatric Liver Injury

Patel, A. M., Liu, Y. S., Davies, S. P., Brown, R. M., Kelly, D. A., Scheel‐Toellner, D., Reynolds, G. M., & Stamataki, Z. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.729143 · Cited by 41 · see citing works

PWE-130 Phenotype And Localisation Of Liver Infiltrating B Cell Subsets In Autoimmune And Inflammatory Liver Diseases

Geh, D., Jeffery, H. C., Adams, D., & Oo, Y. (2014) · Gut · doi:10.1136/gutjnl-2014-307263.390

B cells and autoimmune liver diseases

Moritoki, Y., Lian, Z., Ohsugi, Y., Ueno, Y., & Gershwin, M. E. (2006) · Autoimmunity Reviews · doi:10.1016/j.autrev.2006.02.006 · Cited by 48 · see citing works

原发性胆汁性肝硬化中B细胞免疫的研究进展

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