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Stress and asthma: Novel insights on genetic, epigenetic, and immunologic mechanisms
Open accessAbstract
In the United States the economically disadvantaged and some ethnic minorities are often exposed to chronic psychosocial stressors and disproportionately affected by asthma. Current evidence suggests a causal association between chronic psychosocial stress and asthma or asthma morbidity. Recent findings suggest potential mechanisms underlying this association, including changes in the methylation and expression of genes that regulate behavioral, autonomic, neuroendocrine, and immunologic responses to stress. There is also evidence suggesting the existence of susceptibility genes that predispose chronically stressed youth to both post-traumatic stress disorder and asthma. In this review we critically examine published evidence and suggest future directions for research in this field.
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“experimental studies have yielded novel insight into the potential pathways underlying the connection between these conditions and chronic pain, such as stress-related changes in epigenetic processes, gene expression, and immune responses [89].”
From The Risk Factors of Chronic Pain in Victims of Violence: A Scoping Review (2023) · cites this paper as [89]
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Metadata
- Authors
- Rosenberg, S. L., Miller, G. E., Brehm, J. M., & Celedón, J. C.
- Affiliations
- University of Pittsburgh (US)
- Northwestern University (US)
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 134
- Issue
- 5
- Pages
- 1009-1015
- ISSN
- 0091-6749 (ISSN-L)
- PMC
- PMC4252392
- OpenAlex
- W1987089225
- Cited by
- 183
- References
- 70
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 7 · 2023: 19 · 2022: 16 · 2021: 22 · 2020: 14 · 2019: 22 · 2018: 22 · 2017: 14 · 2016: 15 · 2015: 11
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (HD052892)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Keywords
- psychosocial stress, asthma, epigenetics, DNA methylation, genetic susceptibility, post-traumatic stress disorder, neuroendocrine stress response, autonomic nervous system, immune mechanisms, socioeconomic disparities, ethnic minorities, youth
- MeSH terms
- Asthma, Female, Humans, Male, Stress Disorders, Post-Traumatic, Stress, Psychological, United States, Genetic Predisposition to Disease, Epigenesis, Genetic
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