Chronic caregiver stress and IgE expression, allergen-induced proliferation, and cytokine profiles in a birth cohort predisposed to atopy
Open accessAbstract
Background Psychologic stress modifies immune function and cytokine production.Objective We examined relationships between caregiver stress on the following markers of early childhood immune response: (1) IgE expression (n=215); (2) mitogen-induced and allergen-specific (Dermatophagoides farinae [Der f 1] and cockroach [Bla g 2]) proliferative response (n=114); and (3) subsequent cytokine expression (INF-gamma, TNF-alpha, IL-10, and IL-13) in a prospective birth cohort predisposed to atopy.Methods Caregiver stress was measured at 2-month intervals for the first 2 years of life and yearly thereafter by using the Perceived Stress Scale. A subsequent blood sample obtained from the children (median age, 2.1 years; range, 18-32 months) was analyzed for total serum IgE level and allergen-induced proliferation quantified as the stimulation index (SI; mean thymidine incorporation of the stimulated sample divided by that of the unstimulated sample). The relationship between stress and the proliferative response (SI >3 vs SI < or =3), and total IgE level (< or =100 IU/mL vs >100 IU/mL) was examined by using logistic regression. The relationship between cytokine levels and stress was analyzed by using linear regression.Results In adjusted analyses higher caregiver stress in the first 6 months after birth was associated with a Der f 1 SI of greater than 3 (odds ratio [OR], 1.5; 95% CI, 1.0-2.3) and nominally associated with a Bla g 2 SI of greater than 3 (OR, 1.13; 95% CI, 0.7-1.8). Higher stress between ages 6 and 18 months was associated with a high total IgE level (OR, 2.03; 95% CI, 1.1-3.6). Higher stress was significantly associated with increased production of TNF-alpha, with a suggested trend between higher stress and reduced INF-gamma production.Conclusion Increased stress in early childhood was associated with an atopic immune profile in these children predisposed to atopy-asthma.
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2-year-old children whose parents reported higher cumulative stress during the child's life exhibited heightened TNF-α responses to an allergen.
“For instance, 2-year-old children whose parents reported higher cumulative stress during the child’s life exhibited heightened TNF-α responses to an allergen (Wright et al., 2004).”
From Developmental psychoneuroendocrine and psychoneuroimmune pathways from childhood adversity to disease (2017) · cites this paper as Wright et al., 2004
Cites
Coefficient Alpha and the Internal Structure of Tests
Cronbach, L. J. (1951) · Psychometrika · doi:10.1007/bf02310555 · Cited by 43,931 · see citing works
“Stress: appraisal and coping,”
Folkman, S. (2013) · Encyclopedia of Behavioral Medicine · doi:10.1007/978-1-4419-1005-9_215 · Cited by 27,833 · see citing works
(1988) · Cited by 4,111 · see citing works
The expanding universe of T-cell subsets: Th1, Th2 and more
Mosmann, T. R., & Sad, S. (1996) · Immunology Today · doi:10.1016/0167-5699(96)80606-2 · Cited by 3,603 · see citing works
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., & Zeiher, A. M. (1999) · Nature · doi:10.1038/21224 · Cited by 3,591 · see citing works
Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P. M., & Meaney, M. J. (1997) · Science · doi:10.1126/science.277.5332.1659 · Cited by 3,170 · see citing works
The Instructive Role of Innate Immunity in the Acquired Immune Response
Fearon, D. T., & Locksley, R. M. (1996) · Science · doi:10.1126/science.272.5258.50 · Cited by 1,718 · see citing works
Psychological Stress and Susceptibility to the Common Cold
Cohen, S., Tyrrell, D. A. J., & Smith, A. P. (1991) · New England Journal of Medicine · doi:10.1056/nejm199108293250903 · Cited by 1,712 · see citing works
Self-citation(1995) · Cited by 1,270 · see citing works
Human TH1 and TH2 subsets: doubt no more
Romagnani, S. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90120-i · Cited by 1,096 · see citing works
Induction of TH1 and TH2 responses: a key role for the ‘natural’ immune response?
Romagnani, S. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90083-j · Cited by 780 · see citing works
Prescott, S. L., Macaubas, C., Holt, B. J., Smallacombe, T. B., Loh, R., Sly, P. D., & Holt, P. G. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.10.4730 · Cited by 778 · see citing works
Vallée, M., Mayo, W., Dellu-Hagedorn, F., Moal, M. L., Simon, H., & Maccari, S. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02626.1997 · Cited by 772 · see citing works
Relationships between perceived stress and health behaviors in a sample of working adults
Ng, D. M., & Jeffery, R. W. (2003) · Health Psychology · doi:10.1037/0278-6133.22.6.638 · Cited by 663 · see citing works
The Social Psychology of Health.
Gold, D. T., Spacapan, S., & Oskamp, S. (1990) · Contemporary Sociology A Journal of Reviews · doi:10.2307/2073512 · Cited by 644 · see citing works
Self-citationRobinson, D. S., Hamid, Q. A., Bentley, A. M., Ying, S., KAY, A., & Durham, S. R. (1993) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(93)90175-f · Cited by 576 · see citing works
Review of psychosocial stress and asthma: an integrated biopsychosocial approach
Wright, R., Rodriguez, M. S., & Cohen, S. (1998) · Thorax · doi:10.1136/thx.53.12.1066 · Cited by 535 · see citing works
Self-citationGlucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro
Ramírez, F., Fowell, D. J., Puklavec, M. J., Simmonds, S. J., & Mason, D. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.7.2406 · Cited by 483 · see citing works
Psychological Stress, Cytokine Production, and Severity of Upper Respiratory Illness
Cohen, S., Doyle, W. J., & Skoner, D. P. (1999) · Psychosomatic Medicine · doi:10.1097/00006842-199903000-00009 · Cited by 356 · see citing works
Self-citationPerceived stress, quitting smoking, and smoking relapse.
Cohen, S., & Lichtenstein, E. (1990) · Health Psychology · doi:10.1037//0278-6133.9.4.466 · Cited by 350 · see citing works
Self-citationGold, D. R., Burge, H. A., Carey, V. J., Milton, D. K., Platts‐Mills, T. A. E., & Weiss, S. T. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.1.9807104 · Cited by 299 · see citing works
Self-citationChapman, M. D., Aalberse, R. C., Brown, M. J., & Platts‐Mills, T. A. E. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.3.812 · Cited by 297 · see citing works
Parental Stress as a Predictor of Wheezing in Infancy: A Prospective Birth-Cohort Study
Wright, R. J., Cohen, S., CAREY, V. J., Weiss, S. T., & Gold, D. R. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.3.2102016 · Cited by 272 · see citing works
Self-citationFryer, A. A., Bianco, A., Hepple, M., JONES, P. W., Strange, R. C., & Spiteri, M. A. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.5.9903006 · Cited by 260 · see citing works
Chrousos, G. P. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2000.110163 · Cited by 258 · see citing works
Individual Differences in Cellular Immune Response to Stress
Manuck, S. B., Cohen, S., Rabin, B. S., Muldoon, M. F., & Bachen, E. A. (1991) · Psychological Science · doi:10.1111/j.1467-9280.1991.tb00110.x · Cited by 227 · see citing works
Self-citationBusse, W. W., & Rosenwasser, L. J. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.158 · Cited by 177 · see citing works
Wu, C. Y., Sarfati, M., Heusser, C., Fournier, S., Rubio, M., Peleman, R. A., & Delespesse, G. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115092 · Cited by 174 · see citing works
Aeroallergen Sensitization Can Occur during Fetal Life
Piccinni, M., Mecacci, E., Sampognaro, S., Manetti, R., Parronchi, P., Maggi, E., & Romagnani, S. (2009) · International Archives of Allergy and Immunology · doi:10.1159/000236541 · Cited by 161 · see citing works
Okumura, S., Kashiwakura, J., Tomita, H., Matsumoto, K., Nakajima, T., Saito, H., & Okayama, Y. (2003) · Blood · doi:10.1182/blood-2002-12-3929 · Cited by 152 · see citing works
Drost, E., & MacNee, W. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200202)32:2 · Cited by 135 · see citing works
TNF-α contributes to the development of allergic rhinitis in mice
Iwasaki, M., Saito, K., Takemura, M., Sekikawa, K., Fujii, H., Yamada, Y., Wada, H., Mizuta, K., Seishima, M., & Ito, Y. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.1554 · Cited by 134 · see citing works
Oxidative damage of nuclear DNA in liver of rats exposed to psychological stress.
Adachi, S., Kawamura, K.-I., & Takemoto, K. (1993) · PubMed · Cited by 133 · see citing works
Monoclonal antibodies to the major feline allergen Fel d I
de Groot, H., van Swieten, P., van Leeuwen, J., Lind, P., & Aalberse, R. C. (1988) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(88)90079-6 · Cited by 128 · see citing works
Adrenergic Blockade Ameliorates Cellular Immune Responses to Mental Stress in Humans
Bachen, E. A., Manuck, S. B., Cohen, S., Muldoon, M. F., Raible, R. J., Herbert, T. B., & Rabin, B. S. (1995) · Psychosomatic Medicine · doi:10.1097/00006842-199507000-00008 · Cited by 122 · see citing works
Self-citationThe Relationship Between Parental and Children's Serum IgE and Asthma
Burrows, B. A., Martínez, F. D., Cline, M. G., et al. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.5.7582283 · Cited by 98 · see citing works
Holgate, S. T. (1997) · Public Health · doi:10.1016/s0033-3506(97)00072-3 · Cited by 82 · see citing works
Children at risk for asthma: Home allergen levels, lymphocyte proliferation, and wheeze
Finn, P. W., Boudreau, J. O., He, H., Wang, Y., Chapman, M. D., Vincent, C., Burge, H. A., Weiss, S. T., Perkins, D. L., & Gold, D. R. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2000.106546 · Cited by 81 · see citing works
Self-citationLewis, S., Weiss, S. T., Platts‐Mills, T. A. E., Syring, M., & Gold, D. R. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.113523 · Cited by 79 · see citing works
Self-citationDevelopmental Change in Infant Cortisol and Behavioral Response to Inoculation
Ramsay, D. S., & Lewis, M. (1994) · Child Development · doi:10.1111/j.1467-8624.1994.tb00831.x · Cited by 78 · see citing works
Genes, oxidative stress, and the risk of chronic obstructive pulmonary disease
Koyama, H., & Geddes, D. M. (1998) · Thorax · doi:10.1136/thx.53.2008.s10 · Cited by 66 · see citing works
Glosli, H., Tronstad, K. J., Wergedal, H., Müller, F., Svardal, A. M., Aukrust, P., Berge, R. K., & Prydz, H. (2002) · The FASEB Journal · doi:10.1096/fj.01-0948fje · Cited by 53 · see citing works
Psychological stress in humans and susceptibility to the common cold
Cohen, S., Tyrrell, D. A. J., & Smith, A. P. (1997) · International Universities Press eBooks · Cited by 49 · see citing works
Self-citationKosugi, H., ENOMOTO, H., ISHIZUKA, Y., et al. (1994) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.17.1645 · Cited by 48 · see citing works
Immune mechanisms of childhood asthma
Donovan, C., & Finn, P. W. (1999) · Thorax · doi:10.1136/thx.54.10.938 · Cited by 46 · see citing works
Self-citationCytokines as mediators in the regulation of the hypothalamic-pituitary-adrenocortical function
Fukata, J., Imura, H., & Nakao, K. (1994) · Journal of Endocrinological Investigation · doi:10.1007/bf03347705 · Cited by 43 · see citing works
Allergen-induced cytokine production, atopic disease, IgE, and wheeze in children
Contreras, J. G., Ly, N. P., Gold, D. R., et al. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.08.036 · Cited by 43 · see citing works
Self-citationClassical conditioning of oxidative DNA damage in rats
Irie, M., Asami, S., Nagata, S., Miyata, M., & Kasai, H. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01194-0 · Cited by 39 · see citing works
Allergen Recognition in the Origin of Asthma
Holt, P. G., Yabuhara, A., Prescott, S. L., Venaille, T. J., Macaubas, C., Holt, B. J., Björkstén, B., & Sly, P. D. (2007) · Novartis Foundation symposium · doi:10.1002/9780470515334.ch3 · Cited by 34 · see citing works
Analysis of T-cell activation after bronchial allergen challenge in patients with atopic asthma
Lara-Marquez, M. L., Deykin, A., Krinzman, S. J., et al. (1998) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(98)70180-0 · Cited by 30 · see citing works
Endogenous glucocorticoids and antigen‐induced acute and late phase pulmonary responses
Peebles, S., Togias, Bickel, et al. (2000) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2000.00890.x · Cited by 28 · see citing works
Role of TNF- α and its 55 and 75 kDa receptors in bronchial hyperreactivity
Halász, A., Cserhati, E., Magyar, P., et al. (2002) · Respiratory Medicine · doi:10.1053/rmed.2001.1256 · Cited by 21 · see citing works
Kim, M. H., & Agrawal, D. K. (2002) · Journal of Asthma · doi:10.1081/jas-120004037 · Cited by 9 · see citing works
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- Authors
- Wright, R. J., Finn, P., Contreras, J. P., Cohen, S., Wright, R. O., Staudenmayer, J., Wand, M., Perkins, D., Weiss, S. T., & Gold, D. R.
- Affiliations
- Brigham and Women's Hospital (US)
- Carnegie Mellon University (US)
- University of Massachusetts Amherst (US)
- UNSW Sydney (AU)
- ORCID
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2004-06
- Volume
- 113
- Issue
- 6
- Pages
- 1051-1057
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W1980215785
- Cited by
- 256
- References
- 53
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 8 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 16 · 2017: 10 · 2016: 11 · 2015: 15 · 2014: 10 · 2013: 11 · 2012: 20
- FWCI
- 10.69
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- KiltHub Repository (submittedVersion)
- Scholarworks (University of Massachusetts Amherst) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (submittedVersion)
- KiltHub Repository
- Funders
- National Heart, Lung, and Blood Institute (K08HL004187, K08 HL04187)
- National Institute of Allergy and Infectious Diseases (R01 AI/EH 35786)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- caregiver stress, psychological stress, childhood atopy, serum IgE, Dermatophagoides farinae, Bla g 2, cytokines, TNF-α, interferon-gamma, IL-10, IL-13, allergic asthma, birth cohort
- MeSH terms
- Allergens, Chronic Disease, Cysteine Endopeptidases, Female, Humans, Hypersensitivity, Immunoglobulin E, Infant, Interferon-gamma, Lymphocyte Activation, Male, Stress, Psychological, Tumor Necrosis Factor-alpha, Logistic Models, Cytokines, Caregivers, Antigens, Dermatophagoides, Antigens, Plant, Arthropod Proteins
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