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Cited by 75Dermatology and Skin DiseasesContact Dermatitis and AllergiesPsoriasis: Treatment and Pathogenesis

Cytokine-Mediated Crosstalk Between Keratinocytes and T Cells in Atopic Dermatitis

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Humeau, Mélanie, Boniface, Katia, Bodet, Charles·2022·Frontiers in Immunology
DOI 10.3389/fimmu.2022.801579PMC PMC9022745
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Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by barrier dysfunction, dysregulated immune response, and dysbiosis with increased Staphylococcus aureus colonization. Infiltration of various T helper cell subsets into lesional skin and subsequent cytokine release are a hallmark of AD. Release of cytokines by both T cells and keratinocytes plays a key role in skin inflammation and drives many AD features. This review aims to discuss cytokine-mediated crosstalk between T cells and keratinocytes in AD pathogenesis and the potential impact of virulence factors produced by Staphylococcus aureus on these interactions.

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  • HDM extract is a clinically relevant allergen that triggers type 2-associated inflammatory responses in human skin.

    “To further evaluate its disease relevance, VSAs were challenged with HDM extract, a clinically relevant allergen that triggers type 2-associated inflammatory responses in human skin 44 .”

    From Vascularized human skin assembloids model compartmental skin organization and immune responsiveness in vitro (2026) · cites this paper as [44]

    The Introduction (page unavailable) describes environmental allergens as factors in atopic dermatitis and identifies a strong type 2 response in affected skin. It does not identify house dust mite (HDM) extract or say that HDM extract triggers that response in human skin; searches for HDM, house dust mite, and Dermatophagoides did not find such a passage. (LLM, conf=0.83)

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Authors
Humeau, M., Boniface, K., & Bodet, C.
Affiliations
  • Université de Poitiers (FR)
  • Centre National de la Recherche Scientifique (FR)
Corresponding author
Bodet, Charles
ORCID
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2022-04-07
Volume
13
Pages
801579-801579
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2022.801579
PMC
PMC9022745
OpenAlex
W4225777118
Cited by
75
References
11
Citations by year
2026: 19 · 2025: 17 · 2024: 17 · 2023: 19 · 2022: 3
FWCI
2.49
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords
atopic dermatitis, keratinocytes, T cells, cytokine crosstalk, T helper cells, skin inflammation, Staphylococcus aureus, bacterial virulence factors, skin barrier dysfunction, immune dysregulation, skin microbiome
MeSH terms
Dermatitis, Atopic, Humans, Staphylococcal Infections, Staphylococcus aureus, Keratinocytes, Cytokines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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