Cited by 319Dermatology and Skin DiseasesGenetic Associations and EpidemiologyAsthma and respiratory diseases

A common variant on chromosome 11q13 is associated with atopic dermatitis

Esparza-Gordillo, Jorge, Weidinger, Stephan, Fölster-Holst, Regina, Bauerfeind, Anja, Ruschendorf, Franz, Patone, Giannino, Rohde, Klaus, Marenholz, Ingo +19 more·2009·Nature Genetics

Abstract

We conducted a genome-wide association study in 939 individuals with atopic dermatitis and 975 controls as well as 270 complete nuclear families with two affected siblings. SNPs consistently associated with atopic dermatitis in both discovery sets were then investigated in two additional independent replication sets totalling 2,637 cases and 3,957 controls. Highly significant association was found with allele A of rs7927894 on chromosome 11q13.5, located 38 kb downstream of C11orf30 (P(combined) = 7.6 x 10(-10)). Approximately 13% of individuals of European origin are homozygous for rs7927894[A], and their risk of developing atopic dermatitis is 1.47 times that of noncarriers.

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Crossref · 10.1038/ng.347

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Authors
Esparza-Gordillo, J., Weidinger, S., Fölster-Holst, R., Bauerfeind, A., Ruschendorf, F., Patone, G., Rohde, K., Marenholz, I., Schulz, F., Kerscher, T., Hubner, N., Wahn, U., Schreiber, S., Franke, A., Vogler, R., Heath, S., Baurecht, H., Novak, N., Rodriguez, E., Illig, T., Lee-Kirsch, M.-A., Ciechanowicz, A., Kurek, M., Piskackova, T., Macek, M., Lee, Y.-A., & Ruether, A.
Affiliations
  • Charité – Universitätsmedizin Berlin (DE)
  • Helmholtz Munich (DE)
  • Max Delbrück Center (DE)
  • Christian-Albrechts-Universität zu Kiel (DE)
  • University of Bonn (DE)
  • Pomeranian Medical University (PL)
  • Charles University (CZ)
Corresponding author
Lee, Young-Ae
Venue
Nature Genetics
Published
2009-04-06
Volume
41
Issue
5
Pages
596-601
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
OpenAlex
W2157087957
Cited by
317
References
49
Citations by year
2026: 4 · 2025: 2 · 2024: 7 · 2023: 9 · 2022: 15 · 2021: 11 · 2020: 25 · 2019: 16 · 2018: 13 · 2017: 19 · 2016: 17 · 2015: 37 · 2014: 23 · 2013: 29 · 2012: 27
FWCI
37.63
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
  • mediaTUM (Technical University of Munich) (submittedVersion)
  • Site cant be reached (submittedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Keywords
atopic dermatitis, chromosome 11q13, genetic susceptibility, single nucleotide polymorphisms, genome-wide association study, Crohn's disease, homozygosity
MeSH terms
Adolescent, Chromosomes, Human, Pair 11, Dermatitis, Atopic, Female, Humans, Male, Genetic Variation, Linkage Disequilibrium, Genome, Human, Case-Control Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Young Adult

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