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Cited by 146Dermatology and Skin DiseasesContact Dermatitis and AllergiesAsthma and respiratory diseases

Does “autoreactivity” play a role in atopic dermatitis?

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Tang, Ting Seng, Bieber, Thomas, Williams, Hywel C.·2012·Journal of Allergy and Clinical Immunology
DOI 10.1016/j.jaci.2012.02.002
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Abstract

The role of autoimmunity in atopic dermatitis (AD) is unclear. We sought to critically examine the occurrence, correlation with severity, and possible causative role of autoreactivity in patients with AD. Our systematic review of studies identified from MEDLINE included 31 experiments that described autoreactivity in patients with AD. We defined autoreactivity as in vitro or in vivo evidence of immune response to autologous human, generic human, or recombinant human proteins or other tissue/cellular components. Autoreactivity prevalence in patients with AD ranged from 23% to 91% in 14 studies involving 2644 participants, although it did not appear to vary with age, sex, or disease duration. In contrast to studies of AD, IgE autoreactivity was not found in healthy subjects or in those with allergic rhinoconjunctivitis, psoriasis, systemic lupus erythematosus, or other inflammatory diseases (8 studies of 816 participants). Two reports found a positive correlation between autoreactivity and AD severity. We suggest that autoreactivity might be playing a causative role in AD based on the magnitude and specificity of the associations found; plausible mechanisms through IgE autoantibodies, IgG autoantibodies, and T(H)1 autoreactivity; and experimental elicitation of eczematous lesions after provocation. Whether autoantibodies contribute to AD chronicity now needs to be examined in longitudinal studies.

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  • TH2 immune polarization is accompanied by IgE sensitization to environmental allergens and self proteins and has a key role in atopic disorders.

    “T helper 2 (TH2) immune polarization is accompanied by IgE sensitization to environmental allergens and self proteins and has a key role in atopic disorders101,257.”

    From Atopic dermatitis: an expanding therapeutic pipeline for a complex disease (2022) · cites this paper as [101]

    The Figure 3 caption (Clinical and research implications; page unavailable) describes a proposed mechanism in atopic dermatitis in which a TH2 response accompanies IgE directed against self-proteins. The paper also discusses IgE responses to environmental allergens, but its Abstract says the role of autoreactivity is unclear and reports no IgE autoreactivity in subjects with allergic rhinoconjunctivitis. It therefore does not establish the claimed key role of this combined sensitization across atopic disorders. (LLM, conf=0.88)

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  • IgE responses against environmental allergens and self proteins correlate with cutaneous inflammation and overall AD severity.

    “A significant part of the sensitization process leading to the generation of IgE responses against environmental allergens (including food allergens)100 as well as against self proteins101 correlates with cutaneous inflammation and overall severity102,103.”

    From Atopic dermatitis: an expanding therapeutic pipeline for a complex disease (2022) · cites this paper as [101]

    The ‘How common is autoreactivity in patients with AD?’ section reports correlations between autoreactivity and AD severity, although only two of five analyses found statistically significant correlations. The paper’s discussion of self-protein sensitization also links it to skin inflammation. It does not establish the same severity correlation for IgE responses to environmental allergens; the Abstract says their role in AD persistence is unclear. Page numbers are unavailable in our copy. (LLM, conf=0.85)

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Cites

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Research works printed but not linked: 8

  1. Fluckiger S, Fijten H, Whitley P, Blaser K, Crameri R. Cyclophilins, a new family of cross-reactive allergens. Eur J Immunol 2002;32:10-7.
  2. Mittermann I, Aichberger K, B€ under R, Mothes N, Renz H, Valenta R. Autoimmu- nity and atopic dermatitis. Curr Opin Allergy Clin Immunol 2004;4:367-71.
  3. Kikuchi M, Nakao M, Inoue Y, Matsunaga K, Shichijo S, Yamana H, et al. Iden- tification of a SART-1-derived peptide capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes. Int J Cancer 1999;81:459-66.
  4. Ramakrishna V, Negri DR, Brusic V, Fontanelli R, Canevari S, Bolis G, et al. Gen- eration and phenotypic characterization of new human ovarian cancer cell lines with the identification of antigens potentially recognizable by HLA-restricted cy- totoxic T cells. Int J Cancer 1997;73:143-50.
  5. E25. Ogawa Y, Sugiura K, Watanabe A, Kunimatsu M, Mishima M, Tomita Y, et al. Autoantigenicity of DFS70 is restricted to the conformational epitope of C-termi- nal alpha-helical domain. J Autoimmun 2004;23:221-31.
  6. E27. Seiberler S, Natter S, Hufnagl P, Binder BR, Valenta R. Characterization of IgE- reactive autoantigens in atopic dermatitis. 2. A pilot study on IgE versus IgG subclass response and seasonal variation of IgE autoreactivity. Int Arch Allergy Immunol 1999;120:117-25.
  7. E28. Tada J, Toi Y, Yoshioka T, Fujiwara H, Arata J. Antinuclear antibodies in pa- tients with atopic dermatitis and severe facial lesions. Dermatology 1994;189: 38-40.
  8. E31. Valenta R, Natter S, Seiberler S, Wichlas S, Maurer D, Hess M, et al. Molecular characterization of an autoallergen, Hom s 1, identified by serum IgE from atopic dermatitis patients. J Invest Dermatol 1998;111:1178-83.

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Authors
Tang, T. S., Bieber, T., & Williams, H. C.
Affiliations
  • University of Nottingham (GB)
  • University of Bonn (DE)
Corresponding author
Tang, Ting Seng
ORCID
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2012-05
Volume
129
Issue
5
Pages
1209-1215.e2
ISSN
0091-6749 (ISSN-L)
DOI
10.1016/j.jaci.2012.02.002
OpenAlex
W2016896826
Cited by
146
References
54
Citations by year
2026: 2 · 2025: 2 · 2024: 6 · 2023: 11 · 2022: 5 · 2021: 13 · 2020: 10 · 2019: 13 · 2018: 8 · 2017: 15 · 2016: 17 · 2015: 14 · 2014: 16 · 2013: 9 · 2012: 4
FWCI
17.19
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Allergy and Clinical Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute for Health and Care Research (NF-SI-0611-10246)
Topics
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Keywords
atopic dermatitis, autoreactivity, autoimmunity, autoantibodies, IgE autoantibodies, IgG autoantibodies, disease severity, eczema pathogenesis
MeSH terms
Autoantibodies, Autoantigens, Dermatitis, Atopic, Humans, Immunoglobulin E, Immunoglobulin G, United States, Autoimmunity, Prevalence, Disease Progression, Evidence-Based Medicine, Th1-Th2 Balance

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