The DOI matches its Crossref record; 142 of the 142 references it cites were found in a registry or an index.
Chronic rhinosinusitis pathogenesis
Open accessAbstract
There are a variety of medical conditions associated with chronic sinonasal inflammation, including chronic rhinosinusitis (CRS) and cystic fibrosis. In particular, CRS can be divided into 2 major subgroups based on whether nasal polyps are present or absent. Unfortunately, clinical treatment strategies for patients with chronic sinonasal inflammation are limited, in part because the underlying mechanisms contributing to disease pathology are heterogeneous and not entirely known. It is hypothesized that alterations in mucociliary clearance, abnormalities in the sinonasal epithelial cell barrier, and tissue remodeling all contribute to the chronic inflammatory and tissue-deforming processes characteristic of CRS. Additionally, the host innate and adaptive immune responses are also significantly activated and might be involved in pathogenesis. Recent advancements in the understanding of CRS pathogenesis are highlighted in this review, with special focus placed on the roles of epithelial cells and the host immune response in patients with cystic fibrosis, CRS without nasal polyps, or CRS with nasal polyps.
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Cites
European Position Paper on Rhinosinusitis and Nasal Polyps 2020
Fokkens, W. J., Lund, V. J., Hopkins, C., Hellings, P. W., Kern, R., Reitsma, S., Toppila-Salmi, S., Bernal-Sprekelsen, M., Mullol, J., Alobid, I., et al. (2020) · Rhinology journal · doi:10.4193/rhin20.600 · Cited by 5,882
Self-citationIvanov, I. I., Frutos, R. D. L., Manel, N., Yoshinaga, K., Rifkin, D. B., Sartor, R. B., Finlay, B. B., & Littman, D. R. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.09.009 · Cited by 1,770
Mjösberg, J. M., Trifari, S., Crellin, N. K., Peters, C. P., van Drunen, C. M., Piet, B., Fokkens, W. J., Cupedo, T., & Spits, H. (2011) · Nature Immunology · doi:10.1038/ni.2104 · Cited by 1,166
Protease-Activated Receptors: Contribution to Physiology and Disease
OSSOVSKAYA, V. S., & BUNNETT, N. W. (2004) · Physiological Reviews · doi:10.1152/physrev.00028.2003 · Cited by 1,078
Mucus clearance as a primary innate defense mechanism for mammalian airways
Knowles, M. R., & Boucher, R. C. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215217 · Cited by 1,054
A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia
Button, B., Cai, L.-H., Ehre, C., Kesimer, M., Hill, D. B., Sheehan, J. K., Boucher, R. C., & Rubinstein, M. (2012) · Science · doi:10.1126/science.1223012 · Cited by 863
Differentiation of chronic sinus diseases by measurement of inflammatory mediators
Van Zele, T., Claeys, S., Gevaert, P., Van Maele, G., Holtappels, G., Van Cauwenberge, P., & Bachert, C. (2006) · Allergy · doi:10.1111/j.1398-9995.2006.01225.x · Cited by 774
The airway epithelium: soldier in the fight against respiratory viruses
Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655
Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease
Zhang, N., Van Zele, T., Perez-Novo, C., Van Bruaene, N., Holtappels, G., DeRuyck, N., Van Cauwenberge, P., & Bachert, C. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.07.008 · Cited by 620
Production of β-defensins by human airway epithelia
Singh, P. K., Jia, H. P., Wiles, K., Hesselberth, J., Liu, L., Conway, B.-A. D., Greenberg, E. P., Valore, E. V., Welsh, M. J., Ganz, T., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14961 · Cited by 579
Cited by
International consensus statement on allergy and rhinology: rhinosinusitis 2021
Orlandi, R. R., Kingdom, T. T., Smith, T. L., Bleier, B., DeConde, A., Luong, A. U., Poetker, D. M., Soler, Z., Welch, K. C., Wise, S. K., et al. (2021) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22741 · Cited by 959
Self-citation
Metadata
- Authors
- Stevens, W. W., Lee, R. J., Schleimer, R. P., & Cohen, N. A.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 136
- Issue
- 6
- Pages
- 1442-1453
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2182263134
- Cited by
- 388
- References
- 142
- FWCI
- 20.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Stevens, W. W., Lee, R. J., Schleimer, R. P., & Cohen, N. A. (2015). Chronic rhinosinusitis pathogenesis. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2015.10.009
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
