The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Production of β-defensins by human airway epithelia
Open accessAbstract
Human β-defensins (HBDs) are antimicrobial peptides that may play a role in mucosal defense. Diminished activity of these peptides has been implicated in the pathogenesis of cystic fibrosis (CF) lung disease. We show that HBD-1 and HBD-2 mRNAs are expressed in excised surface and submucosal gland epithelia from non-CF and CF patients. The pro-inflammatory cytokine interleukin-1β stimulated the expression of HBD-2 but not HBD-1 mRNA and peptide in primary cultures of airway epithelia. HBD-1 was found in bronchoalveolar lavage (BAL) fluid from normal volunteers, CF patients, and patients with inflammatory lung diseases, whereas HBD-2 was detected in BAL fluid from patients with CF or inflammatory lung diseases, but not in normal volunteers. Both HBD-1 and HBD-2 were found in BAL fluid in concentrations of several ng/ml, and both recombinant peptides showed salt-sensitive bactericidal activity. These data suggest that in the lung HBD-2 expression is induced by inflammation, whereas HBD-1 may serve as a defense in the absence of inflammation.
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Citations
Cites
A peptide antibiotic from human skin
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Human β-Defensin-1 Is a Salt-Sensitive Antibiotic in Lung That Is Inactivated in Cystic Fibrosis
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Cystic Fibrosis Airway Epithelia Fail to Kill Bacteria Because of Abnormal Airway Surface Fluid
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Self-citationDefensins: Antimicrobial and Cytotoxic Peptides of Mammalian Cells
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Self-citationHuman beta-defensin-1: an antimicrobial peptide of urogenital tissues.
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Self-citationWidespread expression of beta‐defensin hBD‐1 in human secretory glands and epithelial cells
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hBD‐1: a novel β‐defensin from human plasma
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Differentiated structure and function of cultures from human tracheal epithelium
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Somatic Mutations in Paroxysmal Nocturnal Hemoglobinuria: A Blessing in Disguise?
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Cited by
Antimicrobial peptides of multicellular organisms
Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Isolation and Characterization of Human μ-Defensin-3, a Novel Human Inducible Peptide Antibiotic
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Cationic peptides: effectors in innate immunity and novel antimicrobials
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The airway epithelium: soldier in the fight against respiratory viruses
Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655
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Metadata
- Authors
- Singh, P. K., Jia, H. P., Wiles, K., Hesselberth, J., Liu, L., Conway, B.-A. D., Greenberg, E. P., Valore, E. V., Welsh, M. J., Ganz, T., Tack, B. F., & McCray, P. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-12-08
- Volume
- 95
- Issue
- 25
- Pages
- 14961-14966
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2136538608
- Cited by
- 579
- References
- 26
- FWCI
- 25.46
- Type
- journal article
- Language
- en
- Open access
- green
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- Singh, P. K., Jia, H. P., Wiles, K., Hesselberth, J., Liu, L., Conway, B.-A. D., Greenberg, E. P., Valore, E. V., Welsh, M. J., Ganz, T., Tack, B. F., & McCray, P. B. (1998). Production of β-defensins by human airway epithelia. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.25.14961
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
