The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Human IgE-independent systemic anaphylaxis
Open accessAbstract
Anaphylaxis is a rapidly developing, life-threatening, generalized or systemic allergic reaction that is classically elicited by antigen (Ag) crosslinking of Ag-specific IgE bound to the high affinity IgE receptor, FcεRI, on mast cells and basophils. This initiates signals that induce cellular degranulation, with release and secretion of vasoactive mediators, enzymes, and cytokines. IgE-independent mechanisms of anaphylaxis, however, have been clearly demonstrated in experimental animals. These include IgG-dependent anaphylaxis, which involves the triggering of mediator release by IgG/antigen complex crosslinking of FcγRs on macrophages, basophils and neutrophils; anaphylaxis mediated by the binding of complement-derived peptides, C3a and C5a, to their receptors on mast cells, basophils and other myeloid cells; and direct activation of mast cells by drugs that interact with receptors on these cells. Here, we review the mechanisms involved in these IgE-independent forms of anaphylaxis and the clinical evidence for their human relevance. We conclude that this evidence supports the existence of all three IgE-independent mechanisms as important causes of human disease, although practical and ethical considerations preclude their demonstration to the degree of certainty possible with animal models. Further, we cite evidence that different clinical situations can suggest different mechanisms as having a primal role in anaphylaxis and that IgE-dependent and distinct IgE-independent mechanisms can act together to increase anaphylaxis severity. As specific agents become available that can interfere with mechanisms involved in the different types of anaphylaxis, recognition of specific types of anaphylaxis is likely to become important for optimal prophylaxis and therapy.
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Cites
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Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System
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Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis
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Cited by
Mast Cells in Inflammation and Disease: Recent Progress and Ongoing Concerns
Galli, S. J., Gaudenzio, N., & Tsai, M. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-071719-094903 · Cited by 367
Defining baseline variability of serum tryptase levels improves accuracy in identifying anaphylaxis
Mateja, A., Wang, Q., Chovanec, J., Kim, J., Wilson, K. J., Schwartz, L. B., Glover, S. C., Carter, M. C., Metcalfe, D. D., Brittain, E., et al. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.08.007 · Cited by 91
Vitte, J., Sabato, V., Tacquard, C., Garvey, L. H., Michel, M., Mertes, P.-M., Ebo, D. G., Schwartz, L. B., & Castells, M. C. (2021) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2021.03.011 · Cited by 79
New Biomarkers in Anaphylaxis (Beyond Tryptase)
Galvan-Blasco, P., Gil-Serrano, J., & Sala-Cunill, A. (2022) · Current Treatment Options in Allergy · doi:10.1007/s40521-022-00326-1 · Cited by 19
Mechanisms of anaphylaxis beyond classically mediated antigen- and IgE-induced events
Lieberman, P. (2017) · Annals of Allergy, Asthma & Immunology · doi:10.1016/j.anai.2017.01.009 · Cited by 11
Metadata
- Authors
- Finkelman, F. D., Khodoun, M. V., & Strait, R.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 137
- Issue
- 6
- Pages
- 1674-1680
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2343006138
- Cited by
- 299
- References
- 52
- FWCI
- 14.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Finkelman, F. D., Khodoun, M. V., & Strait, R. (2016). Human IgE-independent systemic anaphylaxis. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2016.02.015
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