Allergic reactions and anaphylaxis to LNP-based COVID-19 vaccines
Open accessAbstract
Mortality from coronavirus disease 2019 (COVID-19) in populations at high risk, such as the elderly, certain ethnic groups (e.g., Black/African American, and Hispanic/Latino persons), obese individuals, and those with endothelial dysfunction is substantial. While treatment options are limited, vaccination against SARS-CoV-2, the virus that causes COVID-19, is the most important global strategy in controlling the pandemic. Thus, two lipid nanoparticle (LNP)-based mRNA vaccines (Pfizer-BioNTech and Moderna) against SARS-CoV-2 have already received emergency use authorization by the US Food and Drug Administration (FDA).
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- Authors
- Moghimi, S. M.
- Affiliations
- Newcastle University (GB)
- Corresponding author
- Moghimi, S. Moein
- ORCID
- Moghimi, S. Moein
- Venue
- Molecular Therapy
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 29
- Issue
- 3
- Pages
- 898-900
- ISSN
- 1525-0016 (ISSN-L)
- PMC
- PMC7862013
- OpenAlex
- W3126797562
- Cited by
- 150
- References
- 19
- Citations by year
- 2026: 12 · 2025: 20 · 2024: 33 · 2023: 33 · 2022: 32 · 2021: 20
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Molecular Therapy (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
- Keywords
- allergic reactions, anaphylaxis, COVID-19 vaccines, SARS-CoV-2, BNT162b2, Moderna vaccine, vaccine safety, emergency use authorization
- MeSH terms
- COVID-19, SARS-CoV-2, COVID-19 Vaccines, mRNA Vaccines, BNT162 Vaccine, 2019-nCoV Vaccine mRNA-1273, Amino Alcohols, Anaphylaxis, Decanoates, Excipients, Humans, Liposomes, Polyethylene Glycols, Vaccines, Synthetic, Mass Vaccination, Nanoparticles
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