Adverse reactions to drugs and biologics in patients with clonal mast cell disorders: A Work Group Report of the Mast Cells Disorder Committee, American Academy of Allergy, Asthma & Immunology
Open accessAbstract
Providers caring for patients with mastocytosis are tasked with the decision to consider therapeutic options. This can come with some trepidation because information available in the public domain lists numerous mast cell (MC) activators based on data that do not discriminate between primates, rodents, and MC lines; do not consider dosage; and do not take into account previous exposure and resultant clinical findings. This being said, there is support in the literature for an enhanced MC response in some patients with mastocytosis and in cases in which there is a greater incidence of adverse reactions associated with certain antigens, such as venoms and drugs. Thus this report provides a comprehensive guide for those providers who must decide on therapeutic options in the management of patients with clonal MC disease.
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Patients with mixed MCAS are at high risk for developing recurrent life-threatening anaphylaxis, particularly after Hymenoptera stings, and possibly after exposure to food, drugs, and other allergens.
“thus, they are at high risk for developing recurrent life-threatening anaphylaxis, particularly after Hymenoptera stings, 23,100-102 but they might also be after exposure to food, drugs, and other allergens. 103-105”
From Selecting the Right Criteria and Proper Classification to Diagnose Mast Cell Activation Syndromes: A Critical Review (2021) · cites this paper as [105]
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Gülen, T., Akin, C., Bonadonna, P., Siebenhaar, F., Broesby-Olsen, S., Brockow, K., Niedoszytko, M., Nedoszytko, B., Oude Elberink, H. N. G., Butterfield, J. H., et al. (2021) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2021.06.011 · Cited by 83 · see citing works
“These patients may have a combination of primary and secondary MCAS (so-called mixed MCAS)(99); thus, they are at high risk for developing recurrent life-threatening anaphylaxis, particularly after Hymenoptera stings,(23,100-102) but they might also be after exposure to food, drugs, and other allergens.(103-105) Mast…”
BackgroundSelf-citationMast cell activation syndromes: Collegium Internationale Allergologicum update 2022
Valent, P., Hartmann, K., Bonadonna, P., Niedoszytko, M., Triggiani, M., Arock, M., & Brockow, K. (2022) · International Archives of Allergy and Immunology · doi:10.1159/000524532 · Cited by 55 · see citing works
Self-citationClonal mast cell disorders and hereditary α-tryptasemia as risk factors for anaphylaxis
Kačar, M., Rijavec, M., Šelb, J., & Korošec, P. (2023) · Clinical & Experimental Allergy · doi:10.1111/cea.14264 · Cited by 37 · see citing works
- Authors
- Carter, M. C., Metcalfe, D. D., Matito, A., Escribano, L., Butterfield, J. H., Schwartz, L. B., Bonadonna, P., Zanotti, R., Triggiani, M., Castells, M., & Brockow, K.
- Affiliations
- National Institutes of Health (US)
- Hospital Virgen del Valle (ES)
- Mayo Clinic (US)
- Virginia Commonwealth University (US)
- Azienda Ospedaliera Universitaria Integrata Verona (IT)
- University of Salerno (IT)
- Brigham and Women's Hospital (US)
- Technical University of Munich (DE)
- Corresponding author
- Carter, Melody C.
- ORCID
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 143
- Issue
- 3
- Pages
- 880-893
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2902984162
- Cited by
- 72
- References
- 156
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 9 · 2023: 13 · 2022: 10 · 2021: 17 · 2020: 3 · 2019: 7 · 2014: 1
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion, public-domain)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, public-domain)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Funders
- Division of Intramural Research of the National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Keywords
- mastocytosis, clonal mast cell disorders, adverse drug reactions, biologic therapy, venom hypersensitivity, drug hypersensitivity, mast cell mediators
- MeSH terms
- Anaphylaxis, Anesthetics, Animals, Anti-Inflammatory Agents, Non-Steroidal, Anti-Bacterial Agents, Antibodies, Monoclonal, Biological Products, Contrast Media, Desensitization, Immunologic, Drug Hypersensitivity, Humans, Hymenoptera, Mastocytosis, Vaccines, Venoms
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