Cited by 72Mast cells and histamineDrug-Induced Adverse ReactionsFood Allergy and Anaphylaxis Research

Adverse reactions to drugs and biologics in patients with clonal mast cell disorders: A Work Group Report of the Mast Cells Disorder Committee, American Academy of Allergy, Asthma & Immunology

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Carter, Melody C., Metcalfe, Dean D., Matito, Almudena, Escribano, Luis, Butterfield, Joseph H., Schwartz, Lawrence B., Bonadonna, Patrizia, Zanotti, Roberta +3 more·2019·Journal of Allergy and Clinical Immunology

Abstract

Providers caring for patients with mastocytosis are tasked with the decision to consider therapeutic options. This can come with some trepidation because information available in the public domain lists numerous mast cell (MC) activators based on data that do not discriminate between primates, rodents, and MC lines; do not consider dosage; and do not take into account previous exposure and resultant clinical findings. This being said, there is support in the literature for an enhanced MC response in some patients with mastocytosis and in cases in which there is a greater incidence of adverse reactions associated with certain antigens, such as venoms and drugs. Thus this report provides a comprehensive guide for those providers who must decide on therapeutic options in the management of patients with clonal MC disease.

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Registry

Crossref · 10.1016/j.jaci.2018.10.063

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156 of 156 references verified0 citation errors · 0 not checkable

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  • Patients with mixed MCAS are at high risk for developing recurrent life-threatening anaphylaxis, particularly after Hymenoptera stings, and possibly after exposure to food, drugs, and other allergens.

    “thus, they are at high risk for developing recurrent life-threatening anaphylaxis, particularly after Hymenoptera stings, 23,100-102 but they might also be after exposure to food, drugs, and other allergens. 103-105”

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Authors
Carter, M. C., Metcalfe, D. D., Matito, A., Escribano, L., Butterfield, J. H., Schwartz, L. B., Bonadonna, P., Zanotti, R., Triggiani, M., Castells, M., & Brockow, K.
Affiliations
  • National Institutes of Health (US)
  • Hospital Virgen del Valle (ES)
  • Mayo Clinic (US)
  • Virginia Commonwealth University (US)
  • Azienda Ospedaliera Universitaria Integrata Verona (IT)
  • University of Salerno (IT)
  • Brigham and Women's Hospital (US)
  • Technical University of Munich (DE)
Corresponding author
Carter, Melody C.
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2019-03
Volume
143
Issue
3
Pages
880-893
ISSN
0091-6749 (ISSN-L)
OpenAlex
W2902984162
Cited by
72
References
156
Citations by year
2026: 4 · 2025: 8 · 2024: 9 · 2023: 13 · 2022: 10 · 2021: 17 · 2020: 3 · 2019: 7 · 2014: 1
FWCI
0.69
Type
journal article
Language
en
Locations
  • Journal of Allergy and Clinical Immunology (publishedVersion, public-domain)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, public-domain)
  • mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
  • INFM-OAR (INFN Catania) (submittedVersion, other-oa)
Funders
  • Division of Intramural Research of the National Institute of Allergy and Infectious Diseases
  • National Institutes of Health
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
  • Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
  • Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
Keywords
mastocytosis, clonal mast cell disorders, adverse drug reactions, biologic therapy, venom hypersensitivity, drug hypersensitivity, mast cell mediators
MeSH terms
Anaphylaxis, Anesthetics, Animals, Anti-Inflammatory Agents, Non-Steroidal, Anti-Bacterial Agents, Antibodies, Monoclonal, Biological Products, Contrast Media, Desensitization, Immunologic, Drug Hypersensitivity, Humans, Hymenoptera, Mastocytosis, Vaccines, Venoms

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