Drug allergy in mast cell disease
Abstract
PURPOSE OF REVIEW: Mastocytosis in adults is associated with a history of anaphylaxis in 22-49%. In addition, monoclonal mast cell activation syndrome has been described presenting with anaphylaxis, especially in patients with hymenoptera venom anaphylaxis. Data on patients with drug hypersensitivity and mast cell diseases are scarce. RECENT FINDINGS: Drugs are elicitors of anaphylaxis in patients with mastocytosis. Drug hypersensitivity is only seldom described as associated with undetected mast cell disease in the literature. Together with a single-centred retrospective study, this data suggests that from all patients with drug-induced anaphylaxis, probably only a minority are associated with mast cell disease. Most of these cases in the literature are related to general anaesthesia. Thus, for patients with mastocytosis, general anaesthesia appears to be a procedure associated with risk of mast cell degranulation, and special precautions should be considered. SUMMARY: The association between immediate drug hypersensitivity and undetected mast cell diseases appears to be moderate, but nevertheless basal serum tryptase determination and examination for skin signs of mast cell disorders are recommended. An ongoing European multicenter study by the European Network for Drug Allergy will provide more information on this topic.
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Patients with mixed MCAS are at high risk for developing recurrent life-threatening anaphylaxis, particularly after Hymenoptera stings, and possibly after exposure to food, drugs, and other allergens.
“thus, they are at high risk for developing recurrent life-threatening anaphylaxis, particularly after Hymenoptera stings, 23,100-102 but they might also be after exposure to food, drugs, and other allergens. 103-105”
From Selecting the Right Criteria and Proper Classification to Diagnose Mast Cell Activation Syndromes: A Critical Review (2021) · cites this paper as [104]
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- Authors
- Brockow, K., & Bonadonna, P.
- Affiliations
- Helmholtz Munich (DE)
- Corresponding author
- Brockow, Knut
- Venue
- Current Opinion in Allergy & Clinical Immunology
- Published
- 2012-08
- Volume
- 12
- Issue
- 4
- Pages
- 354-360
- ISSN
- 1473-6322 (ISSN-L)
- 1528-4050
- OpenAlex
- W2039265769
- Cited by
- 57
- References
- 29
- Citations by year
- 2026: 1 · 2023: 2 · 2022: 2 · 2021: 7 · 2020: 1 · 2019: 5 · 2018: 7 · 2017: 6 · 2016: 2 · 2015: 9 · 2014: 8 · 2013: 6 · 2012: 1
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Site cant be reached (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Keywords
- drug hypersensitivity, mastocytosis, drug-induced anaphylaxis, general anesthesia, mast cell degranulation, serum tryptase
- MeSH terms
- Adult, Anaphylaxis, Anesthesia, General, Drug Hypersensitivity, European Union, Female, Humans, Male, Mastocytosis, Retrospective Studies, Skin, Multicenter Studies as Topic, Cell Degranulation, Tryptases
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