Cited by 65Lipoproteins and Cardiovascular HealthNatural Products and Biological ResearchCholesterol and Lipid Metabolism

Effects of Xuezhikang in patients with dyslipidemia: a multicenter, randomized, placebo-controlled study

Moriarty, Patrick M., Roth, Eli M., Karns, Adam, Ye, Ping, Zhao, Shui-Ping, Liao, Yuhua, Capuzzi, David M., Bays, Harold E. +12 more·2014·Journal of clinical lipidology

Abstract

Background Xuezhikang (XZK) is an extract of fermented red yeast rice that has lipid-lowering properties.Objective To evaluate the effects of XZK on lipids in subjects with dyslipidemia but no coronary heart disease.Methods A total of 116 adults with baseline non-high-density lipoprotein cholesterol (non-HDL-C) levels of approximately 208 mg/dL and low-density lipoprotein cholesterol (LDL-C) levels of approximately 175 mg/dL were randomized to either placebo or XZK 1200 or 2400 mg daily and treated for 12 weeks.Results A majority of the patients were white (53.4%) or Asian (37.1%). Daily XZK 1200 mg and 2400 mg for 4 to 12 weeks resulted in statistically significant (P < .001) and clinically meaningful decreases in non-HDL-C (∼24% reduction) and LDL-C (∼27% reduction) compared with placebo. XZK treatment at either dose enabled approximately 50% of subjects to reduce their LDL-C levels by ≥ 30%. Doubling the XZK daily dose from 1200 to 2400 mg at treatment week 8 caused an additional 4.6% reduction in LDL-C. Significant benefits were also observed across secondary efficacy variables, including total cholesterol (TC), apolipoprotein B (Apo B), triglycerides, HDL-C, the TC/HDL-C ratio, and the Apo B/Apo A-I ratio, at treatment week 8 or 12. XZK was safe and well tolerated. Safety and tolerability profiles were similar across treatment groups. Most adverse events were gastrointestinal. No subject experienced myopathy or markedly elevated liver transaminases or creatine kinase.Conclusion Xuezhikang significantly reduced non-HDL-C and LDL-C, and was well tolerated. Further, longer-term studies in more diverse patient populations are needed to corroborate these findings.

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Crossref · 10.1016/j.jacl.2014.09.002

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  • For all previously mentioned studies, there were no safety concerns.

    “For all previously mentioned studies, there were no safety concerns (80,126-130).”

    From The Role of Nutraceuticals in Statin Intolerant Patients (2018) · cites this paper as [129]

  • In studies with xuezhikang, 1,200 and 2,400 mg/day for 4 to 12 weeks in subjects with dyslipidemia but no coronary heart disease resulted in significant decreases in non-HDL cholesterol of about 24% and LDL-C of about 27% compared with placebo.

    “for 4 to 12 weeks in subjects with dyslipidemia but no coronary heart disease resulted in significant (p < 0.001) and clinically meaningful decreases in nonhigh-density lipoprotein cholesterol (HDL-C) (w24% reduction) and LDL-C (w27% reduction) compared with placebo (129)”

    From The Role of Nutraceuticals in Statin Intolerant Patients (2018) · cites this paper as [129]

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Authors
Moriarty, P. M., Roth, E. M., Karns, A., Ye, P., Zhao, S.-P., Liao, Y., Capuzzi, D. M., Bays, H. E., Zhang, F., Liu, S., Reichman, A. J., Brusco, O. A., Lu, G., Lerman, S., Duan, Z., Guo, S., Liu, P. L., Zhao, J., Zhang, Y., & Li, S.
Affiliations
  • University of Kansas (US)
  • Sterling Research Group (US)
  • Chinese PLA General Hospital (CN)
  • Second Xiangya Hospital of Central South University (CN)
  • Wuhan Union Hospital (CN)
  • Thomas Jefferson University (US)
  • Louisville Metabolic and Atherosclerosis Research Center (US)
  • Jiangsu Province Hospital (CN)
  • Shanghai First People's Hospital (CN)
  • Clinical Trial Network (US)
  • Texas A&M University (US)
  • Memorial Regional Hospital (US)
  • Peking University (CN)
Corresponding author
Li, Simon
Venue
Journal of clinical lipidology
Publisher
Elsevier BV
Published
2014-11
Volume
8
Issue
6
Pages
568-575
ISSN
  • 1876-4789 (ISSN-L)
  • 1933-2874
OpenAlex
W2064006730
Cited by
65
References
25
Citations by year
2026: 5 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 3 · 2017: 10 · 2016: 6 · 2015: 3 · 2014: 1
FWCI
6.61
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of clinical lipidology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • WPU
  • Luye Pharma Group
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Surgery › Natural Products and Biological Research
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords
Xuezhikang, red yeast rice extract, dyslipidemia, LDL cholesterol, non-HDL cholesterol, hypolipidemic effect, apolipoprotein B, triglycerides, HDL cholesterol, TC/HDL-C ratio, dose-response relationship, safety and tolerability, coronary heart disease prevention
MeSH terms
Adult, Aged, Hypolipidemic Agents, Apolipoproteins A, Apolipoproteins B, Biological Products, China, Drugs, Chinese Herbal, Female, Gastrointestinal Diseases, Humans, Cholesterol, HDL, Cholesterol, LDL, Lovastatin, Male, Middle Aged, Placebos, Triglycerides, United States, Dyslipidemias

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