Effects of Xuezhikang in patients with dyslipidemia: a multicenter, randomized, placebo-controlled study
Abstract
Background Xuezhikang (XZK) is an extract of fermented red yeast rice that has lipid-lowering properties.Objective To evaluate the effects of XZK on lipids in subjects with dyslipidemia but no coronary heart disease.Methods A total of 116 adults with baseline non-high-density lipoprotein cholesterol (non-HDL-C) levels of approximately 208 mg/dL and low-density lipoprotein cholesterol (LDL-C) levels of approximately 175 mg/dL were randomized to either placebo or XZK 1200 or 2400 mg daily and treated for 12 weeks.Results A majority of the patients were white (53.4%) or Asian (37.1%). Daily XZK 1200 mg and 2400 mg for 4 to 12 weeks resulted in statistically significant (P < .001) and clinically meaningful decreases in non-HDL-C (∼24% reduction) and LDL-C (∼27% reduction) compared with placebo. XZK treatment at either dose enabled approximately 50% of subjects to reduce their LDL-C levels by ≥ 30%. Doubling the XZK daily dose from 1200 to 2400 mg at treatment week 8 caused an additional 4.6% reduction in LDL-C. Significant benefits were also observed across secondary efficacy variables, including total cholesterol (TC), apolipoprotein B (Apo B), triglycerides, HDL-C, the TC/HDL-C ratio, and the Apo B/Apo A-I ratio, at treatment week 8 or 12. XZK was safe and well tolerated. Safety and tolerability profiles were similar across treatment groups. Most adverse events were gastrointestinal. No subject experienced myopathy or markedly elevated liver transaminases or creatine kinase.Conclusion Xuezhikang significantly reduced non-HDL-C and LDL-C, and was well tolerated. Further, longer-term studies in more diverse patient populations are needed to corroborate these findings.
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For all previously mentioned studies, there were no safety concerns.
“For all previously mentioned studies, there were no safety concerns (80,126-130).”
From The Role of Nutraceuticals in Statin Intolerant Patients (2018) · cites this paper as [129]
In studies with xuezhikang, 1,200 and 2,400 mg/day for 4 to 12 weeks in subjects with dyslipidemia but no coronary heart disease resulted in significant decreases in non-HDL cholesterol of about 24% and LDL-C of about 27% compared with placebo.
“for 4 to 12 weeks in subjects with dyslipidemia but no coronary heart disease resulted in significant (p < 0.001) and clinically meaningful decreases in nonhigh-density lipoprotein cholesterol (HDL-C) (w24% reduction) and LDL-C (w27% reduction) compared with placebo (129)”
From The Role of Nutraceuticals in Statin Intolerant Patients (2018) · cites this paper as [129]
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- Authors
- Moriarty, P. M., Roth, E. M., Karns, A., Ye, P., Zhao, S.-P., Liao, Y., Capuzzi, D. M., Bays, H. E., Zhang, F., Liu, S., Reichman, A. J., Brusco, O. A., Lu, G., Lerman, S., Duan, Z., Guo, S., Liu, P. L., Zhao, J., Zhang, Y., & Li, S.
- Affiliations
- University of Kansas (US)
- Sterling Research Group (US)
- Chinese PLA General Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- Wuhan Union Hospital (CN)
- Thomas Jefferson University (US)
- Louisville Metabolic and Atherosclerosis Research Center (US)
- Jiangsu Province Hospital (CN)
- Shanghai First People's Hospital (CN)
- Clinical Trial Network (US)
- Texas A&M University (US)
- Memorial Regional Hospital (US)
- Peking University (CN)
- Corresponding author
- Li, Simon
- ORCID
- Venue
- Journal of clinical lipidology
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 8
- Issue
- 6
- Pages
- 568-575
- ISSN
- 1876-4789 (ISSN-L)
- 1933-2874
- OpenAlex
- W2064006730
- Cited by
- 65
- References
- 25
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 3 · 2017: 10 · 2016: 6 · 2015: 3 · 2014: 1
- FWCI
- 6.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of clinical lipidology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- WPU
- Luye Pharma Group
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- Xuezhikang, red yeast rice extract, dyslipidemia, LDL cholesterol, non-HDL cholesterol, hypolipidemic effect, apolipoprotein B, triglycerides, HDL cholesterol, TC/HDL-C ratio, dose-response relationship, safety and tolerability, coronary heart disease prevention
- MeSH terms
- Adult, Aged, Hypolipidemic Agents, Apolipoproteins A, Apolipoproteins B, Biological Products, China, Drugs, Chinese Herbal, Female, Gastrointestinal Diseases, Humans, Cholesterol, HDL, Cholesterol, LDL, Lovastatin, Male, Middle Aged, Placebos, Triglycerides, United States, Dyslipidemias
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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