The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Magnetic resonance imaging (MRI) measurement of hippocampal volume in posttraumatic stress disorder: A meta-analysis
Abstract
Background Studies in animals showed that the hippocampus, a brain area involved in learning and memory, is sensitive to stress. Although several MRI studies showed smaller hippocampal volume in adults with chronic PTSD, others did not show significant differences from controls. These studies are typified by small sample sizes which may limit the ability to show significant differences. We therefore performed a meta-analytic study of all of these studies to clarify the role of hippocampal structural changes in subjects with PTSD. Methods Nine studies with a total of 133 adult subjects with chronic PTSD, 148 healthy controls, and 53 traumatized controls were included in the meta-analysis. Results There was significantly smaller volume in both right and left hippocampi in adult subjects with chronic PTSD in comparison with both healthy controls and traumatized controls. Conclusion These findings are consistent with smaller hippocampal volume in adult subjects with chronic PTSD.
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“Smaller hipocampal volume MRI: Villarreal et al. (2002); Hedges et al. (2003); Kitayama et al. (2005); Pavić et al. (2007); Morey et al. (2012)”
From Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex (2019) · cites this paper as Kitayama et al. (2005)
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The Neurocircuitry of Fear, Stress, and Anxiety Disorders
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A meta-analysis of structural brain abnormalities in PTSD
KARL, A., SCHAEFER, M., MALTA, L., DORFEL, D., ROHLEDER, N., & WERNER, A. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.03.004 · Cited by 881
Metadata
- Authors
- Kitayama, N., Vaccarino, V., Kutner, M., Weiss, P., & Bremner, J. D.
- Affiliations
- Emory University (US)
- Corresponding author
- Kitayama, Noriyuki
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2005-09
- Volume
- 88
- Issue
- 1
- Pages
- 79-86
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2145267709
- Cited by
- 423
- References
- 49
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 16 · 2023: 13 · 2022: 16 · 2021: 13 · 2020: 20 · 2019: 22 · 2018: 24 · 2017: 28 · 2016: 27 · 2015: 26 · 2014: 29 · 2013: 36 · 2012: 19
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- post-traumatic stress disorder, hippocampal volume, hippocampal atrophy, chronic PTSD, brain structural changes, trauma exposure, hippocampus
- MeSH terms
- Adult, Chronic Disease, Dominance, Cerebral, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Reference Values, Stress Disorders, Post-Traumatic
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