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Cited by 35Medication Adherence and ComplianceTreatment of Major DepressionMental Health Treatment and Access

An assessment of patient preference and adherence to treatment with Wellbutrin SR: A web-based survey

Granger, Arthur L., Fehnel, Sheri E., Hogue, Susan L., Bennett, Lee, Edin, Heather M.·2006·Journal of Affective Disorders
DOI 10.1016/j.jad.2005.08.018
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Abstract

Background Research has shown that lack of treatment adherence is a serious problem, especially among patients with psychiatric disorders. The current study was conducted to assess adherence and patient preference among individuals taking Wellbutrin SR (bupropion) for depression, as well as their interest in a once-daily formulation of bupropion.Methods A 20-item web-based survey was administered to 527 individuals (276 men and 251 women) recruited through an online panel. All participants were at least 18 years of age, diagnosed with major depressive disorder, and had been taking Wellbutrin SR for at least 6 weeks. Survey items addressed treatment regimen, adherence, satisfaction with Wellbutrin SR, and interest in a once-daily formulation of bupropion.Results The majority of respondents reported taking Wellbutrin SR twice a day (67%). Only 15% of once-daily users were nonadherent compared to 37% of twice-daily users and 65% of thrice-daily users. The most common reason reported for missing a dose of Wellbutrin SR was simply forgetting to take it (49% of twice-daily users and 65% of thrice-daily users). Results indicated that 77% of twice-daily users and 94% of thrice-daily users were interested in a once-daily formula.Conclusions A reduction in dosing frequency is favored by Wellbutrin SR users and likely to improve their adherence to treatment. Because greater adherence has been shown to facilitate symptom relief, improvements in quality of life, and reductions in healthcare expenses, the results of this study support the value of the recently released once-daily formulation, Wellbutrin XL.

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  • Medical studies have shown that adherence is associated with better outcomes, regardless of whether patients received placebo or active interventions.

    “Medical studies have shown that adherence is associated with better outcomes, regardless of whether patients received placebo or active interventions [78,79].”

    From A Systematic Review of the Impact of Adherence on the Effectiveness of e-Therapies (2011) · cites this paper as [79]

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Authors
Granger, A. L., Fehnel, S. E., Hogue, S. L., Bennett, L., & Edin, H. M.
Affiliations
  • RTI Health Solutions (US)
  • GlaxoSmithKline (United States) (US)
Corresponding author
Granger, Arthur L.
ORCID
Fehnel, Sheri E.
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
2006-02
Volume
90
Issue
2-3
Pages
217-221
ISSN
0165-0327 (ISSN-L)
DOI
10.1016/j.jad.2005.08.018
OpenAlex
W2127077956
Cited by
35
References
22
Citations by year
2026: 1 · 2024: 1 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 5 · 2012: 3
FWCI
1.18
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Affective Disorders (publishedVersion)
  • PubMed (publishedVersion)
Funders
GlaxoSmithKline
Topics
  • Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Keywords
bupropion, medication adherence, patient preferences, major depressive disorder, dosing frequency, once-daily formulation, medication satisfaction, dose skipping
MeSH terms
Adult, Aged, Delayed-Action Preparations, Depressive Disorder, Drug Administration Schedule, Female, Health Surveys, Humans, Male, Middle Aged, Patient Compliance, Quality of Life, Bupropion, Patient Satisfaction, Antidepressive Agents, Second-Generation

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