Sociodemographic and clinical predictors of compliance with antidepressants for depressive disorders: systematic review of observational studies
Open accessAbstract
BACKGROUND: The literature shows that compliance with antidepressant treatment is unsatisfactory. Several personal and disease-related variables have been shown to be related to compliance behavior. The objective of this study was to review the literature about sociodemographic and clinical predictors of compliance in patients with depressive disorders. METHODS: The Medline, Embase, Cochrane Central, PsycInfo, and Cinahl databases were searched until May 2012. Studies that analyzed sociodemographic and clinical predictors or correlates of compliance in patients with depressive disorder were included. A quantitative synthesis was not performed because of the heterogeneity and availability of the data reported. For similar reasons, the results were not classified according to the different phases of treatment. The search was limited to studies published in English and Spanish. RESULTS: Thirty-two studies fulfilled the inclusion criteria. The most consistent associations with compliance were found for age (older patients showed more compliance) and race (white patients were more likely to adhere to treatment than minority ethnic groups). Few studies assessed clinical factors, and the most plausible predictors of compliance were certain comorbidities and substance abuse. Severity of depression did not play an important role in predicting compliance. CONCLUSION: The impact of the variables studied on compliance behavior appeared to be inconsistent. Identifying potential predictors of compliance with antidepressant treatment is important, both for the routine practice of the mental health professional and for refining interventions to enhance adherence and target them to specific populations at risk of noncompliance.
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Written from the paper’s full text.
TL;DR
This systematic review of 32 observational studies found that older age and white race were the most consistent sociodemographic correlates of better antidepressant compliance, while clinical predictors were less studied and inconsistent. Overall, the evidence did not identify a stable set of predictors, and the authors call for more research on mediators and targeted adherence interventions.
Key findings
- Across 32 included studies, older age was generally associated with better adherence; about 60% of adherence studies assessing age found significant positive associations, and some discontinuation studies found older age linked to lower rates or longer time to stopping treatment.
- Race was consistently associated with compliance: white patients were more likely to adhere, and Hispanic patients showed the poorest adherence when multiple ethnic groups were compared.
- Clinical factors were assessed less often. Substance abuse predicted nonadherence in all three studies that examined it; medical comorbidity showed mixed directions; depression severity was generally not a significant predictor.
- Other sociodemographic factors, including gender, education, marital/living status, income, and employment, had mixed or few significant findings, and the review concluded that associations were inconsistent overall.
Methods
- The authors searched Medline, Embase, Cochrane Central, PsycInfo, and Cinahl from January 1990 to May 2012, limited to English and Spanish publications, and included observational studies of adults or elderly patients with a depressive disorder diagnosed by a health care provider or researchers.
- Studies were included if they analyzed sociodemographic or clinical predictors/correlates of compliance with antidepressants; exclusions included bipolar or psychotic disorders, depression only alongside a medical illness, or antidepressant use without a reported diagnosis.
- After removing duplicates, 1690 references were screened, 120 were selected by title/abstract, and 34 references yielded 32 studies. Data were extracted on sample, design, predictors, follow-up, compliance definition and assessment, and statistical methods; results were summarized narratively and classified as discontinuation versus nonadherence because heterogeneity prevented quantitative pooling.
Limitations
- The paper states that no quantitative synthesis was performed because of heterogeneity in statistical methods and predictors, that results could not be classified by treatment phase or follow-up duration because most studies used periods longer than 3 months without distinguishing acute from continuation phases, that only observational studies were included, and that the search was restricted to English and Spanish.
- Evident from the text: few studies assessed clinical predictors, compliance was measured in varied ways (self-report, prescription fills, Medication Event Monitoring System, physician rating), and some significant findings came from single studies or lacked reported numeric results, limiting certainty.
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Integrity signals
Registry
Cites
Statistics
Claims the paper makes
0 of 68 cited sources checked · 0 supported · 0 flagged
- Findingreasoning
Severity of depression did not play an important role in predicting compliance.
“Severity of depression did not play an important role in predicting compliance.”
- Also stated in: § Discussion · plain
“severity of depression by itself is not a significant predictor of compliance behavior”
Quote in the paperSubstantial claim - Also stated in: § Discussion · plain
- Findingcitation
Olfson et al found that individuals with 12 years of education or less showed higher rates of discontinuation than those with more than 12 years.
“Olfson et al found a significant result, ie, individuals with 12 years of education or less showed higher rates of discontinuation than those with more than 12 years.36”
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- Findingown data
White patients were more likely to adhere to antidepressant treatment than minority ethnic groups.
“race (white patients were more likely to adhere to treatment than minority ethnic groups)”
- Also stated in: § Predictors of treatment nonadherence · plain
“white patients were significantly more likely to adhere to treatment”
Quote in the paperSubstantial claim - Also stated in: § Predictors of treatment nonadherence · plain
- Findingcitation
Olfson et al found that participants with fair or poor mental health status discontinued more at 3 months than those with excellent or good status.
“Olfson et al found that participants with fair or poor mental health status discontinued more at 3 months than those with excellent or good status.36”
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- Findingown data
Seven studies provided data about treatment discontinuation.
“Seven studies offered data about treatment discontinuation.”
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- Findingcitation
Bull et al found that separate or divorced patients and those whose spouses had died discontinued significantly more often than married patients.
“Bull et al found that separate or divorced patients and those whose spouses had died discontinued significantly more often than married patients.24”
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- Findingown data
Certain comorbidities and substance abuse were the most plausible clinical predictors of compliance.
“the most plausible predictors of compliance were certain comorbidities and substance abuse”
Quote in the paperSubstantial claim - Findingcitation
The three studies that assessed severity did not find statistically significant associations with discontinuation of treatment.
“The three studies that assessed severity did not find statistically significant associations with discontinuation of treatment.24,41,47”
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- Findingown data
The impact of the studied variables on compliance behavior appeared inconsistent.
“The impact of the variables studied on compliance behavior appeared to be inconsistent.”
- Also stated in: § Discussion · plain
“The results of this review show inconsistent associations between the predictors studied and compliance with antidepressants.”
Quote in the paperSubstantial claim - Also stated in: § Discussion · plain
- Findingcitation
Hung et al found that individuals with chronic depression showed lower rates of discontinuation than those without the condition.
“Hung et al found that individuals with chronic depression showed lower rates of discontinuation than those without the condition.47”
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- Findingcitation
Bull et al found that improvement, and not level of depression, predicted an adequate treatment duration.
“Bull et al found that it was improvement, and not level of depression, that predicted an adequate treatment duration.24”
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- Findingown data
Thirty-two studies met the inclusion criteria for the review.
“Thirty-two studies fulfilled the inclusion criteria.”
- Also stated in: § Results · plain
“34 were finally included, comprising 32 studies”
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- Findingcitation
Olfson et al found that patients with low incomes discontinued significantly more often than those with high incomes.
“Only Olfson et al assessed income status and found that patients with low incomes discontinued significantly more often than those with high incomes.36”
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- Findingown data
Older patients showed greater compliance with antidepressant treatment.
“The most consistent associations with compliance were found for age (older patients showed more compliance)”
- Also stated in: § Predictors of treatment nonadherence · plain
“increasing age was associated with better adherence”
Quote in the paperSubstantial claim - Also stated in: § Predictors of treatment nonadherence · plain
- Findingcitation
Wu et al reported a longer time to discontinuation in Caucasians versus African-American patients.
“Wu et al reported a longer time to discontinuation in Caucasians versus African-American patients.42”
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- Findingcitation
Akincigil et al found that patients with an income level lower than $50,000 had a lower rate of adherence compared with those above that level.
“Akincigil et al found that patients with an income level lower than $50,000 had a lower rate of adherence compared with those above that level.22”
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Yeh et al found a statistically significant linear inverse relationship between income and adherence.
“Ye h et al found a statistically significant linear inverse relationship between income and adherence.48”
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Roca et al found that living alone was significantly related to poor adherence.
“only Roca et al found a statistically significant association, ie, living alone was significantly related to poor adherence.45”
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- Findingcitation
Four of six studies showed that white patients were significantly more likely to adhere to treatment.
“Four of them showed that white patients were significantly more likely to adhere to treatment.31,34,35,42”
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- Findingcitation
Of ten studies that assessed severity of depression, only Roca et al and Russell et al found that it was related to worse adherence.
“Of ten studies that assessed the influence of severity of depression,20,21,23,32,43,44,45,48–50 only Roca et al and Russell et al found that it was related to worse adherence.45,50”
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- Findingcitation
Burra et al found that patients who had not completed post-secondary education showed lower rates of adherence compared with those above that educational level.
“Burra et al found that patients who had not completed post-secondary education showed lower rates of adherence compared with those above that educational level.43”
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- Findingreasoning
Medical comorbidities relate significantly to both good and poor adherence in the studies included.
“Medical comorbidities have been shown to relate significantly to both good and poor adherence in the studies included.”
Quote in the paperSubstantial claim - Findingnone given
In all remaining studies, increasing age was associated with better adherence.
“In all the remaining studies, increasing age was associated with better adherence.”
Quote in the paperNot a substantial claim - Findingcitation
Another study found that women were more adherent than men, but only among users of selective serotonin uptake inhibitors.
“Another study also found that women were more adherent than men, but only among users of selective serotonin uptake inhibitors.46”
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- Findingcitation
Crown et al found that major depression disorder and neurotic depression related independently to worse adherence.
“only Crown et al found statistically significant associations, ie, major depression disorder and neurotic depression related independently to worse adherence.26”
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- Findingcitation
Maidment et al found that higher impairment predicted better adherence.
“Maidment et al found that higher impairment predicted better adherence.49”
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- Findingown data
Low educational level is not an important independent predictor of compliance with antidepressant treatment.
“results of the studies included here suggest that this is not an important independent predictor of compliance with antidepressant treatment”
Quote in the paperSubstantial claim - Findingcitation
When more than two ethnic categories were compared, Hispanic patients showed the worst adherence rates.
“When more than two ethnic categories were compared, Hispanic patients showed the worst adherence rates.31,35”
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- Findingcitation
Substance abuse was a significant predictor of nonadherence in the three studies that assessed this.
“Regarding psychiatric comorbidities, substance abuse was a significant predictor of nonadherence in the three studies that assessed this.22,25,35”
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Ayalon et al found that cognitive limitation was related to unintentional nonadherence in a sample of African-American and Hispanic patients.
“Ayalon et al, in a sample of African-American and Hispanic patients, found that cognitive limitation was related to unintentional nonadherence,23”
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- Findingcitation
None of the five studies that assessed previous history of depressive episodes found a statistically significant relationship with adherence.
“None of the five studies that assessed previous history of depressive episodes found a statistically significant relationship with adherence.20,27,39,44,45”
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- Premisecitation
Studies that analyzed concordance between different methods of assessing adherence reported acceptable correlations between them.
“Studies that have analyzed the concordance between these different methods of assessing adherence have reported acceptable correlations between them.14–16”
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Up to 42% of patients discontinue antidepressant treatment after 12 weeks.
“Up to 42% of patients discontinue treatment after 12 weeks,5”
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- Premisecitation
Patient adherence with antidepressants is unsatisfactory, especially for long-term maintenance treatment.
“several clinical studies have shown that patient adherence with antidepressants is quite unsatisfactory, specifically with regard to long-term maintenance treatment.”
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- Premisecitation
Partial compliance with antidepressants has been estimated at 45%.
“partial compliance has been estimated to be 45%.10”
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- Premisecitation
Reasons for noncompliance include factors related to patient or treatment characteristics and to patient-physician interaction.
“Reasons for noncompliance include a wide range of factors, related to patient or treatment characteristics, as well as to patient-physician interaction.11,12”
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- Interpretationreasoning
The attribution of higher noncompliance in women as previously reported cannot be sustained.
“it appears that the attribution of higher noncompliance in women as previously reported cannot be sustained.11,59”
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- Interpretationreasoning
The effect of age on adherence seemed more intense in studies that measured age categorically than in those that included age as a continuous variable, suggesting a nonlinear association.
“This effect seemed to be more intense in those studies that measured age categorically than in those which included age as a continuous variable, suggesting a nonlinear association between both factors.”
Quote in the paperNot a substantial claim - Interpretationcitation
The course of symptoms, rather than the severity level at any moment during treatment, is more likely to predict nonadherence.
“The course of symptoms, rather than the severity level at any moment during treatment, is more likely to predict nonadherence, and several studies have shown that both improvement in symptoms and lack of treatment efficacy may be responsible for poor compliance.8,60,61”
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- Interpretationcitation
The better adherence observed in older people was independent of the effect of the number of comorbidities and/or medications taken.
“the better adherence observed in older people was independent of the effect of the number of comorbidities and/or medications taken.22,25,26,34,42”
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- Classified as probably not a substantial claim. 6
- May combine two claims. 18
Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
Findingnone givenTwenty-five studies assessed adherence with antidepressants.
“Twenty-five studies assessed adherence with antidepressants”
Quote in the paperNot a substantial claimMay combine two claims.
FindingcitationOlfson et al found that Hispanic patients, but not black or other minorities, showed higher discontinuation rates than white patients.
“Olfson et al found that Hispanic patients (but not black or other minorities) showed higher discontinuation rates than white patients.36”
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FindingcitationOnly Woolley et al found a significant gender effect, with men being significantly more likely to discontinue treatment.
“Only Woolley et al found a significant effect, with men being significantly more likely to discontinue with treatment.41”
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FindingcitationDemyttenaere et al found an interaction between gender and functional improvement: risk of discontinuation for women was related to improvement in family functioning, while for men it was related to improvements in occupational, social, and family functioning.
“Demyttenaere et al found an interaction between gender and functional improvement, in that the risk of discontinuation for women related to improvement in family functioning, while in men it was related to improvements in occupational, social, and family functioning.18”
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FindingcitationOlder age was associated with both lower rates of and a longer time to discontinuation.
“Older age was associated with both lower rates41 and a longer time42 to discontinuation.”
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FindingcitationSanglier et al found an interaction between age and antidepressant dispensing year: before 2006 older adults were more likely to discontinue, but after that year the opposite was found.
“Sanglier et al found an interaction between age and antidepressant dispensing year, in that before 2006, older adults were more likely to discontinue than younger ones, but the opposite was found after that year.37”
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FindingcitationFive studies obtained statistically significant differences favoring women for adherence, while in one study women were almost twice as likely as men to be nonadherent.
“five obtained statistically significant differences favoring women,26,27,35,43,45 while in one study women were almost twice as likely as men to be nonadherent.28”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe results indicate better adherence for women, but most studies did not find a statistically significant relationship.
“Regarding gender, the results indicate better adherence for women, but most studies did not find a statistically significant relationship.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
FindingcitationRoca et al found that those with a lower educational level showed poor adherence, but the article did not report how this variable was measured or the numeric results.
“Roca et al found that those with a lower educational level showed poor adherence, but the article did not report how this variable was measured or the numeric results.45”
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Findingown dataAll studies except three offered data on age, and 13 found statistically significant associations.
“All studies except three32,45,50 offered data on age, and 13 found statistically significant associations.20,22,25–28,33–35,37,38,40,42”
Quote in the paperNot a substantial claimMay combine two claims.
FindingcitationComorbid anxiety disorders, except post-traumatic stress disorder, were significantly related to better adherence in two studies, but another three studies did not show statistically significant results.
“Comorbid anxiety disorders (except post-traumatic stress disorder, which predicted worse adherence in Pfeiffer et al)35 was significantly related to better adherence in two studies,35,42 but another three studies did not show statistically significant results.22,25,26,31”
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FindingcitationRoca et al found that unemployed participants showed lower adherence rates, but descriptive data and statistical tests were not reported.
“Only Roca et al,45 of six studies,20,27,28,43,45,48 obtained a statistically significant effect for employment status, with unemployed participants showing lower adherence rates, and once again, descriptive data and statistical tests were not reported.”
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FindingcitationRegarding medical comorbidities, the direction of the significant relationship was inconsistent across studies; three obtained better adherence for patients with a higher number of comorbid diseases, while another three found the opposite result.
“Regarding medical comorbidities, the direction of the significant relationship was inconsistent across studies; three of them obtained better adherence for patients with a higher number of comorbid diseases,25,40,42 while another three found the opposite result.22,26,45”
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FindingcitationTen studies assessed psychiatric and/or medical comorbidities, and seven found significant associations with adherence.
“Ten studies assessed psychiatric and/or medical comorbidities,22,25,26,31,34,35,40,42,45,46 and seven found significant associations with adherence.22,25,26,35,40,42,45”
Quote in the paperNot a substantial claimMay combine two claims.
FindingcitationRoca et al found a statistically significant relationship between perceived health status and/or health-related quality of life and adherence, with better mental and physical health in adherent patients.
“Only Roca et al,45 out of four studies,23,31,39,45 obtained a statistically significant relationship between perceived health status and/or health-related quality of life and adherence, with better mental and physical health in adherent patients.”
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Study design and conductown dataThe two studies with the smallest sample sizes (30 and 22 subjects) did not yield statistically significant results for any variables analyzed and were excluded from the counting of results to limit the analysis to studies with acceptable statistical power.
“Given that the two studies29,30 with the smallest sample sizes (30 and 22 subjects) did not yield statistically significant results for any of the variables analyzed, they are not considered in the counting of results, in order to limit the exposition to a group of studies with acceptable statistical power.”
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PremisecitationOther variables related to nonadherence include perceived lack of efficacy, poor instructions, lack of information about the condition and its treatment, poly-prescribing, and a difficult dosing regimen.
“Other variables that have been related to nonadherence are perceived lack of efficacy, poor instructions, lack of information about the condition and its treatment, “poly-prescribing”, or a difficult dosing regimen.13”
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PremisecitationIf guideline recommendations for antidepressant treatment were followed exactly, the overall burden of depression could be reduced by approximately 28%.
“if guideline recommendations about antidepressant treatment were followed exactly, the overall burden of depression (measured by disability-adjusted life-years) could be reduced by approximately 28%.9”
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Study design and conductreasoningResults could not be classified according to follow-up duration because most studies used periods longer than 3 months without differentiating acute and continuation phases, and cross-sectional studies included patients with different time frames since treatment onset.
“we could not classify the results according to the follow-up duration of the studies because most of them used periods longer than 3 months without differentiating between acute and continuation phases, and cross-sectional studies included patients with different time frames since the onset of treatment.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenThe bibliographic search was restricted to studies published in English or Spanish.
“the bibliographic search was restricted to studies in English or Spanish.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim. May combine two claims.
Study design and conductreasoningA limitation is the lack of a quantitative synthesis of results, because the included studies showed considerable heterogeneity in statistical methods and predictors assessed, prompting a narrative presentation.
“An important limitation is the lack of a quantitative synthesis of results, but the fact that the studies included showed considerable heterogeneity in the statistical methods used and the predictors assessed prompted us to show the results in a narrative manner.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim.
Study design and conductcitationAnalyses were limited to observational studies because compliance rates and risk factors could differ in naturalistic studies and clinical trials.
“we have limited the analyses to observational studies because some authors have argued that compliance rates and risk factors could be different in naturalistic studies and clinical trials.59”
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The paper relies on this without support.
In research on compliance with antidepressant medications, sociodemographic and disease-related variables have received less attention than more modifiable factors such as treatment characteristics or patient attitudes, beliefs, and preferences.
“In the research on variables that influence compliance with antidepressant medications, sociodemographic and disease-related variables have received less attention than more modifable factors, such as treatment characteristics (number and frequency of doses, type of drug, or quality of follow-up care) or patient attitudes, beliefs, and preferences concerning the disease and its treatment.”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Gender analysis counts two reports as separate studies
MinorThe six citations represent only five studies because references 17 and 18 report the same study. The stated count of six studies is therefore inconsistent with the paper's account of its references.
“Six studies offered data about gender differences for dis-continuation.17,18,24,36,41,42”
“one study was reported in two references,17,18”
Cites
(1996) · Cited by 6,884 · see citing works
(1980) · Postgraduate Medical Journal · doi:10.1136/pgmj.56.657.530 · Cited by 1,829 · see citing works
Haynes, R. B., Taylor, D. W., & Sackett, D. L. (1979) · DigitalGeorgetown (Georgetown University Library) · Cited by 1,627 · see citing works
PRACTICE GUIDELINE FOR THE Treatment of Patients With Major Depressive Disorder
Gelenberg, A. J., Freeman, P. B., Markowitz, J. C., Rosenbaum, J. F., Thase, M. E., Trivedi, M. H., & Rhoads, R. S. (2010) · Cited by 1,372 · see citing works
The National Collaborating Centre for Mental Health
Kendall, T., & Pilling, S. (2004) · UCL Discovery (University College London) · Cited by 840 · see citing works
Multiple recurrences of major depressive disorder
Solomon, D. A., Keller, M. B., Leon, A. C., Mueller, T. I., Lavori, P. W., Shea, M. T., Coryell, W., Warshaw, M., Turvey, C., Maser, J. D., et al. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.2.229 · Cited by 835 · cited 1× · see citing works
“Furthermore, approximately 50% of patients experience recurrence, and the probability of another depressive episode increases with each case of recurrence.(4) Therefore, for many patients, depression presents as a chronic disorder that requires lifelong antidepressant treatment to Dovepress”
BackgroundSirey, J. A., Bruce, M. L., Alexopoulos, G. S., Perlick, D. A., Friedman, S. J., & Meyers, B. S. (2001) · Psychiatric Services · doi:10.1176/appi.ps.52.12.1615 · Cited by 796 · cited 6× · see citing works
“48 Only Roca et al, 45 of six studies, 20,27,28,43,45,48 obtained a statistically significant effect for employment status, with unemployed participants showing lower adherence rates, and once again, descriptive data and statistical tests were not reported.”
InfluentialCooper, L. A., Gonzales, J. J., Gallo, J. J., Rost, K. M., Meredith, L. S., Rubenstein, L. V., Wang, N.-Y., & Ford, D. E. (2003) · Medical Care · doi:10.1097/01.mlr.0000053228.58042.e4 · Cited by 651 · cited 1× · see citing works
“55,56 Low educational level has been considered to be a potential risk factor for poor adherence, because individuals with less education may have more difficulty in understanding treatment regimens, medical recommendations, or the nature of the disease from which they suffer.”
Sobocki, P., Jönsson, B., Angst, J., & Rehnberg, C. (2006) · PubMed · Cited by 533 · see citing works
Continuity of antidepressant treatment for adults with depression in the United States
Olfson, M., Marcus, S. C., Tedeschi, M., & Wan, G. J. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.101 · Cited by 392 · cited 10× · see citing works
“42 Four studies assessed the effect of educational level on discontinuation, 24,36,41,47 and only Olfson et al found a significant result, ie, individuals with 12 years of education or less showed higher rates of discontinuation than those with more than 12 years.”
InfluentialDiscontinuation of Use and Switching of Antidepressants
Bull, S. A., Hu, X. H., Hunkeler, E. M., Lee, J. Y., Ming, E. E., Markson, L. E., & FIREMAN, B. H. (2002) · JAMA · doi:10.1001/jama.288.11.1403 · Cited by 357 · cited 9× · see citing works
“42 Four studies assessed the effect of educational level on discontinuation, 24,36,41,47 and only Olfson et al found a significant result, ie, individuals with 12 years of education or less showed higher rates of discontinuation than those with more than 12 years.”
InfluentialEthnicity and Preferences for Depression Treatment
Givens, J. L., Houston, T. K., Van Voorhees, B. W., Ford, D. E., & Cooper, L. A. (2007) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2006.11.002 · Cited by 330 · cited 1× · see citing works
“55,56 Low educational level has been considered to be a potential risk factor for poor adherence, because individuals with less education may have more difficulty in understanding treatment regimens, medical recommendations, or the nature of the disease from which they suffer.”
Continuity of Antidepressant Treatment for Adults With Depression in the United States
Ballenger, J. C. (2007) · Yearbook of Psychiatry and Applied Mental Health · doi:10.1016/s0084-3970(08)70480-8 · Cited by 309 · see citing works
Aikens, J. E. (2005) · The Annals of Family Medicine · doi:10.1370/afm.238 · Cited by 273 · cited 1× · see citing works
“26 Of ten studies that assessed the influence of severity of depression, 20,21,23,32,43,44,45,48–50 only Roca et al and Russell et al found that it was related to worse adherence.”
The Burden of Major Depression Avoidable by Longer-term Treatment Strategies
Vos, T., Haby, M. M., Barendregt, J. J., Kruijshaar, M., Corry, J., & Andrews, G. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.11.1097 · Cited by 213 · cited 1× · see citing works
“It has been argued that if guideline recommendations about antidepressant treatment were followed exactly, the overall burden of depression (measured by disability-adjusted lifeyears) could be reduced by approximately 28%.(9) However, several clinical studies have shown that patient adherence with antidepressants is q…”
BackgroundDemyttenaere, K., Enzlin, P., Dewé, W., Boulanger, B., Bie, J. D., Troyer, W. D., & Mesters, P. (2001) · PubMed · Cited by 204 · see citing works
Jimenez, D. E., Bartels, S. J., Cárdenas, V., Dhaliwal, S. S., & Alegria, M. M. (2011) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e318227f876 · Cited by 204 · cited 1× · see citing works
“53,54 It has been shown that African-American and Hispanic patients, compared with white patients, find antidepressants less acceptable, and are less likely to believe that medications are effective and that depression is biologically based, and more likely to believe that antidepressants are…”
Shi, L., Liu, J., Fonseca, V., Walker, P., Kalsekar, A., & Pawaskar, M. (2010) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-8-99 · Cited by 177 · cited 1× · see citing works
“16 As part of a wider review concerning predictors of compliance with antidepressant medications, the aim of this study was to review the literature on sociodemographic and clinical (disease-related) predictors or correlates of compliance with antidepressants in patients with depressive disorders.”
Adherence to Antidepressant Treatment Among Privately Insured Patients Diagnosed With Depression
Akıncıgil, A., Bowblis, J. R., Levin, C. A., Walkup, J. T., Jan, S., & Crystal, S. (2007) · Medical Care · doi:10.1097/01.mlr.0000254574.23418.f6 · Cited by 162 · cited 9× · see citing works
“22,25,26,35,40,42,45 Regarding medical comorbidities, the direction of the significant relationship was inconsistent across studies; three of them obtained better adherence for patients with a higher number of comorbid diseases, 25,40,42 while another three found the opposite result.”
InfluentialCompliance during treatment with antidepressants
Demyttenaere, K. (1997) · Journal of Affective Disorders · doi:10.1016/s0165-0327(96)00095-x · Cited by 149 · cited 2× · see citing works
“11,12 Adverse effects of medications have been shown to play an important role in treatment discontinuation and adherence, although the introduction of new-generation antidepressants with fewer side effects has, to some extent, overcome this problem.”
Effects of Pharmaceutical Promotion on Adherence to the Treatment Guidelines for Depression
Donohue, J. M., Berndt, E. R., Rosenthal, M. B., Epstein, A. M., & Frank, R. G. (2004) · Medical Care · doi:10.1097/00005650-200412000-00004 · Cited by 147 · cited 4× · see citing works
“20,27,39,44,45 Ten studies assessed psychiatric and/or medical comorbidities, 22,25,26,31,34,35,40,42,45,46 and seven found significant associations with adherence.”
InfluentialNon-adherence with psychotropic medications in the general population
Bulloch, A. G. M., & Patten, S. B. (2009) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-009-0041-5 · Cited by 129 · cited 1× · see citing works
“Up to 42% of patients discontinue treatment after 12 weeks,(5) and partial compliance has been estimated to be 45%.(10) Reasons for noncompliance include a wide range of factors, related to patient or treatment characteristics, as well as to patient-physician interaction.”
BackgroundSirey, J. A., BRUCE, M. L., Alexopoulos, S., PERLICK, D. A., Friedman, S., & Meyers, S. L. (2001) · Cited by 118 · see citing works
Maidment, R., Livingston, G., & Katona, C. (2002) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.688 · Cited by 116 · cited 3× · see citing works
“49 Regarding race, the results are consistent, with higher compliance by white patients, and Hispanic patients showing the poorest adherence.”
Voils, C. I., Steffens, D. C., Bosworth, H. B., & Flint, E. P. (2005) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200502000-00010 · Cited by 113 · cited 3× · see citing works
“Twelve used retrospective designs, nine were cross-sectional studies, and four used prospective designs.(20,32,39,44) Ten studies used self-report measures, 13 used prescription fills data, one used the Medication Event Monitoring System,(44) and one used a physicianrated measure.”
BackgroundMethodResultInfluentialAdherence to Depression Treatment in Older Adults: A Narrative Review
Zivin, K., & Kales, H. C. (2008) · Drugs & Aging · doi:10.2165/00002512-200825070-00003 · Cited by 110 · cited 1× · see citing works
“51,52 Alternatively, it could be argued that the higher number of comorbidities and prescribed medications could make older people more accustomed to taking them, leading to better adherence.”
Risk factors and predictors of compliance in depression
Demyttenaere, K. (2003) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(03)00095-6 · Cited by 107 · cited 2× · see citing works
“8 For the purposes of this work, we will refer to “nonadherence” as partial compliance (missed doses) and to “discontinuation” as definitely discontinuing the medication.”
Out-patient Compliance with Antidepressant Medication
Myers, E. D., & Branthwaite, A. (1992) · The British Journal of Psychiatry · doi:10.1192/bjp.160.1.83 · Cited by 94 · see citing works
Kwon, A., Bungay, K. M., Pei, Y., Rogers, W. H., Wilson, I. B., Zhou, Q., & Adler, D. A. (2003) · Medical Care · doi:10.1097/01.mlr.0000053019.79054.b6 · Cited by 93 · see citing works
Predictors of Self-Reported Antidepressant Adherence
Burra, T. A., Chen, E., McIntyre, R. S., Grace, S. L., Blackmore, E. R., & Stewart, D. E. (2007) · Behavioral Medicine · doi:10.3200/bmed.32.4.127-134 · Cited by 86 · cited 4× · see citing works
“43 Roca et al found that those with a lower educational level showed poor adherence, but the article did not report how this variable was measured or the numeric results.”
InfluentialAdherence to Antidepressant Medications in Black and Latino Elderly Patients
Ayalon, L., Areán, P. A., & Alvidrez, J. (2005) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200507000-00005 · Cited by 86 · cited 6× · see citing works
“Ayalon et al, in a sample of African-American and Hispanic patients, found that cognitive limitation was related to unintentional nonadherence, 23 while Maidment et al found that higher impairment predicted better adherence.”
InfluentialBosworth, H. B., Voils, C. I., Potter, G. G., & Steffens, D. C. (2007) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1852 · Cited by 74 · cited 1× · see citing works
“Depression in older adults is less well understood and presents unique clinical challenges, including more comorbidities and prescribed medications, and therefore it has been argued that the complexity of their treatment regimens along with other characteristics of aging, such as cognitive impairment, might act as bar…”
Brook, O. H., van Hout, H. P. J., Stalman, W. A. B., & de Haan, M. (2006) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000246217.34024.53 · Cited by 69 · see citing works
Six-month compliance with antidepressant medication in the treatment of major depressive disorder
Demyttenaere, K., Albert, A., Mesters, P., Dewé, W., Bruyckere, K. D., & Sangeleer, M. (2008) · International Clinical Psychopharmacology · doi:10.1097/yic.0b013e3282f1c1d8 · Cited by 65 · cited 1× · see citing works
“8,60,61 Medical comorbidities have been shown to relate significantly to both good and poor adherence in the studies included.”
The 5-Factor Model of Personality and Antidepressant Medication Compliance
Cohen, N. L., Ross, E. C., Bagby, R. M., Farvolden, P., & Kennedy, S. H. (2004) · The Canadian Journal of Psychiatry · doi:10.1177/070674370404900205 · Cited by 62 · cited 3× · see citing works
“26 Of ten studies that assessed the influence of severity of depression, 20,21,23,32,43,44,45,48–50 only Roca et al and Russell et al found that it was related to worse adherence.”
Medication beliefs and adherence to antidepressants in primary care
Russell, J., & Kazantzis, N. (2008) · PubMed · doi:10.26181/22201684 · Cited by 52 · see citing works
Demyttenaere, K., Enzlin, P., Dewé, W., Boulanger, B., Bie, J. D., Troyer, W. D., & Mesters, P. (2001) · PubMed · Cited by 51 · see citing works
Sher, I., McGinn, L., Sirey, J. A., & Meyers, B. (2005) · Psychiatric Services · doi:10.1176/appi.ps.56.5.564 · Cited by 50 · see citing works
Comparing Antidepressant Treatment Patterns in Older and Younger Adults: A Claims Database Analysis
Sanglier, T., Saragoussi, D., Milea, D., Auray, J., Valuck, R. J., & Tournier, M. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03457.x · Cited by 47 · cited 7× · see citing works
“37,41,42 Older age was associated with both lower rates 41 and a longer time 42 to discontinuation.”
InfluentialVoils, C. I. (2005) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.13.2.157 · Cited by 46 · see citing works
Somatoform Symptoms and Treatment Nonadherence in Depressed Family Medicine Outpatients
Keeley, R. D. (2000) · Archives of Family Medicine · doi:10.1001/archfami.9.1.46 · Cited by 44 · see citing works
Noncompliance with antidepressants
Demyttenaere, K. (1998) · International Clinical Psychopharmacology · doi:10.1097/00004850-199802002-00004 · Cited by 43 · cited 3× · see citing works
“Secondly, because predictors of compliance are not the same in different treatment phases, 59 we could not classify the results according to the follow-up duration of the studies because most of them used periods longer than 3 months without differentiating between acute and continuation phases,…”
Wu, C., Erickson, S. R., Piette, J. D., & Balkrishnan, R. (2011) · Research in Social and Administrative Pharmacy · doi:10.1016/j.sapharm.2011.04.002 · Cited by 42 · cited 9× · see citing works
“22,25,26,35,40,42,45 Regarding medical comorbidities, the direction of the significant relationship was inconsistent across studies; three of them obtained better adherence for patients with a higher number of comorbid diseases, 25,40,42 while another three found the opposite result.”
InfluentialBenzodiazepines and Adequacy of Initial Antidepressant Treatment for Depression
Pfeiffer, P. N., Ganoczy, D. A., Zivin, K., & Valenstein, M. M. (2011) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318217b4c4 · Cited by 39 · cited 4× · see citing works
“22,25,35 Comorbid anxiety disorders (except post-traumatic stress disorder, which predicted worse adherence in Pfeiffer et al) 35 was significantly related to better adherence in two studies, 35,42 but another three studies did not show statistically significant results.”
InfluentialPractice Guideline for the Treatment of Patients With Major Depressive Disorder, 2nd ed.
Passmore, T. A., & Lewy, A. J. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n0416a · Cited by 36 · cited 1× · see citing works
“Up to 42% of patients discontinue treatment after 12 weeks, 5 and partial compliance has been estimated to be 45%.”
Granger, A. L., Fehnel, S. E., Hogue, S. L., Bennett, L., & Edin, H. M. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.08.018 · Cited by 35 · cited 2× · see citing works
“48 Only Roca et al, 45 of six studies, 20,27,28,43,45,48 obtained a statistically significant effect for employment status, with unemployed participants showing lower adherence rates, and once again, descriptive data and statistical tests were not reported.”
Compliance and acceptance in antidepressant treatment
Demyttenaere, K. (2001) · International Journal of Psychiatry in Clinical Practice · doi:10.1080/13651500152048423 · Cited by 35 · cited 5× · see citing works
“17,18,24,36,41,42 Only Woolley et al found a significant effect, with men being significantly more likely to discontinue with treatment.”
InfluentialIbrahim, S. A., Zhang, A. Y., Mercer, M. B., Baughman, M., & Kwoh, C. K. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.12.1318 · Cited by 32 · cited 1× · see citing works
“53,54 It has been shown that African-American and Hispanic patients, compared with white patients, find antidepressants less acceptable, and are less likely to believe that medications are effective and that depression is biologically based, and more likely to believe that antidepressants are…”
Economic Impact of Patient Adherence with Antidepressant Therapy Within a Managed Care Organization
White, T., Vanderplas, A. M., Ory, C., Dezii, C. M., & Chang, E. Y. (2003) · Disease Management & Health Outcomes · doi:10.2165/00115677-200311120-00006 · Cited by 30 · cited 2× · see citing works
“20,27,39,44,45 Ten studies assessed psychiatric and/or medical comorbidities, 22,25,26,31,34,35,40,42,45,46 and seven found significant associations with adherence.”
Woolley, S. B., Fredman, L., Goethe, J. W., Lincoln, A. K., & Heeren, T. (2010) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181fc343b · Cited by 29 · cited 8× · see citing works
“41 Demyttenaere et al found an interaction between gender and functional improvement, in that the risk of discontinuation for women related to improvement in family functioning, while in men it was related to improvements in occupational, social, and family functioning.”
InfluentialMcLaughlin, T., Hogue, S., & Stang, P. (2007) · American Journal of Therapeutics · doi:10.1097/01.mjt.0000208273.80496.3f · Cited by 28 · cited 1× · see citing works
“Twelve used retrospective designs, 22,25–27, 31,33–35, 37”
Hung, C., Wang, S., Liu, C.-Y., Hsu, S., & Yang, C. (2010) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2010.08.005 · Cited by 26 · cited 7× · see citing works
“42 Four studies assessed the effect of educational level on discontinuation, 24,36,41,47 and only Olfson et al found a significant result, ie, individuals with 12 years of education or less showed higher rates of discontinuation than those with more than 12 years.”
InfluentialLong-Term Costs of Treatment for Depression: Impact of Drug Selection and Guideline Adherence
Crown, W. H., Treglia, M., Meneades, L. M., & White, A. (2001) · Value in Health · doi:10.1046/j.1524-4733.2001.44084.x · Cited by 25 · cited 7× · see citing works
“22,25,26,35,40,42,45 Regarding medical comorbidities, the direction of the significant relationship was inconsistent across studies; three of them obtained better adherence for patients with a higher number of comorbid diseases, 25,40,42 while another three found the opposite result.”
InfluentialStang, P., Suppapanaya, N., Hogue, S., Park, D., & Rigney, U. (2007) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e31802b59e4 · Cited by 22 · see citing works
Adherence to Medication in Depressive Patients
Roca, M., Armengol, S., Salvador‐Carulla, L., Monzón, S., Salvá, J., & Gili, M. (2011) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3182223af9 · Cited by 22 · cited 8× · see citing works
“48 Only Roca et al, 45 of six studies, 20,27,28,43,45,48 obtained a statistically significant effect for employment status, with unemployed participants showing lower adherence rates, and once again, descriptive data and statistical tests were not reported.”
InfluentialGuideline-concordant antidepressant use among patients with major depressive disorder
Chen, S.-Y., Hansen, R. A., Gaynes, B. N., Farley, J. F., MORRISSEY, J. P., & Maciejewski, M. L. (2010) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2010.03.007 · Cited by 22 · cited 6× · see citing works
“22,25,26,35,40,42,45 Regarding medical comorbidities, the direction of the significant relationship was inconsistent across studies; three of them obtained better adherence for patients with a higher number of comorbid diseases, 25,40,42 while another three found the opposite result.”
InfluentialYeh, M., Sung, S., Yorker, B. C., Sun, C.-C., & Kuo, Y.-L. (2008) · Issues in Mental Health Nursing · doi:10.1080/01612840802129038 · Cited by 20 · cited 4× · see citing works
“26 Of ten studies that assessed the influence of severity of depression, 20,21,23,32,43,44,45,48–50 only Roca et al and Russell et al found that it was related to worse adherence.”
InfluentialAwareness of hypertension and diabetes in the Hispanic community
Aranda, J. M., & Vazquez, R. (2004) · Clinical cornerstone · doi:10.1016/s1098-3597(04)80060-7 · Cited by 20 · cited 1× · see citing works
“57,58 However, results of the studies included here suggest that this is not an important independent predictor of compliance with antidepressant treatment, although it could interact negatively with other variables, such as patient attitudes or beliefs about treatment.”
Working with reactant patients: are we prescribing nonadherence?
Madsen, J. W., McQuaid, J. R., & Craighead, W. E. (2008) · Depression and Anxiety · doi:10.1002/da.20523 · Cited by 20 · cited 1× · see citing works
“26 Of ten studies that assessed the influence of severity of depression, 20,21,23,32,43,44,45,48–50 only Roca et al and Russell et al found that it was related to worse adherence.”
Townsend, M. S. (2011) · Nursing Clinics of North America · doi:10.1016/j.cnur.2011.05.011 · Cited by 13 · cited 1× · see citing works
“57,58 However, results of the studies included here suggest that this is not an important independent predictor of compliance with antidepressant treatment, although it could interact negatively with other variables, such as patient attitudes or beliefs about treatment.”
Canet, S. O., Martin, M., García-Lecina, R., Castro-Rodríguez, J. I., Font-Canal, T., Tintorer, D. L., Martín‐Lopez, L. M., & Flamarich, D. (2011) · Actas Españolas de Psiquiatría · Cited by 13 · see citing works
Adherence to Antidepressant Medications in Black and Latino Elderly Patients
Ayalon, L. (2005) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.13.7.572 · Cited by 13 · see citing works
Lin, H., Erickson, S. R., & Balkrishnan, R. (2011) · Health Outcomes Research in Medicine · doi:10.1016/j.ehrm.2011.06.003 · Cited by 12 · cited 5× · see citing works
“22,25,26,31 Cognitive limitations were assessed in two studies, with statistically significant results, but in opposite directions.”
InfluentialSomatoform Symptoms and Treatment Nonadherence in Depressed Family Medicine Outpatients
Keeley, R. (2000) · Archives of Family Medicine · doi:10.1001/archfami.9.1.54 · Cited by 11 · see citing works
Is customization in antidepressant prescribing associated with acute-phase treatment adherence?
Merrick, E. L., Hodgkin, D., Panas, L., Soumerai, S. B., & Ritter, G. A. (2011) · Journal of Pharmaceutical Health Services Research · doi:10.1111/j.1759-8893.2011.00068.x · Cited by 8 · cited 3× · see citing works
“20,27,39,44,45 Ten studies assessed psychiatric and/or medical comorbidities, 22,25,26,31,34,35,40,42,45,46 and seven found significant associations with adherence.”
An association between negatively biased response to neutral stimuli and antidepressant nonadherence
Keeley, R. D., Davidson, A. J., Crane, L. A., Matthews, B., & Pace, W. D. (2007) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2006.12.006 · Cited by 7 · see citing works
Medicine taking behaviour in depression – part 1
Feetam, C. (2009) · Progress in Neurology and Psychiatry · doi:10.1002/pnp.108 · Cited by 3 · see citing works
Medicine taking behaviour in depression – part 2
Feetam, C. (2009) · Progress in Neurology and Psychiatry · doi:10.1002/pnp.117 · Cited by 2 · see citing works
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Aljumah, K., & Hassali, M. A. (2015) · BMC Psychiatry · doi:10.1186/s12888-015-0605-8 · Cited by 125 · see citing works
“Adherence appears to be influenced by specific-concern beliefs and overuse beliefs about antidepressant medications, which is also consistent with findings from other studies [52, 53].”
ResultMood disorders medications: predictors of nonadherence – review of the current literature
Pompili, M., Venturini, P., Palermo, M., Stefani, H., Seretti, M. E., Lamis, D. A., Serafini, G., Amore, M., & Girardi, P. (2013) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2013.811976 · Cited by 120 · see citing works
Mechanisms of antidepressant resistance
El-Hage, W., Leman, S., Camus, V., & Belzung, C. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00146 · Cited by 111 · see citing works
Risk factors for non-adherence to antidepressant treatment in patients with mood disorders
Cuevas, C. D. L., Peñate, W., & Sanz, E. J. (2013) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-013-1582-9 · Cited by 87 · see citing works
Self-citationFactors predicting adherence to antidepressant treatment
Hung, C.-I. (2014) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000086 · Cited by 88 · see citing works
“Although some studies have reported that the severity of depression does not play an important role in predicting compliance [7], recent studies have reported that a greater severity of depression predicts nonadherence [6 & ,21 & ,22 & ].”
BackgroundResultSolmi, M., Miola, A., Croatto, G., Pigato, G., Favaro, A., Fornaro, M., Berk, M., Smith, L., Quevedo, J., Maes, M. H. J., et al. (2020) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2020-0935 · Cited by 88 · see citing works
ANTIDEPRESSANT ADHERENCE ACROSS DIVERSE POPULATIONS AND HEALTHCARE SETTINGS
Rossom, R. C., Shortreed, S. M., Coleman, K. J., Beck, A. L., Waitzfelder, B. E., Stewart, C. C., Ahmedani, B. K., Zeber, J. E., & Simon, G. E. (2016) · Depression and Anxiety · doi:10.1002/da.22532 · Cited by 79 · see citing works
Cuevas, C. D. L., de León, J., Peñate, W., & Betancort, M. (2017) · Patient Preference and Adherence · doi:10.2147/ppa.s133513 · Cited by 64 · see citing works
“22 Although previous research has shown direct associations between sociodemographic, 23,24 clinical, 23–26 attitudinal, 27,28 and perceived health control variables, 29,30 the mechanisms underlying these associations are still undetermined.”
Self-citationCuevas, C. D. L., y Revuelta, J. L. G. D. R., & Peñate, W. (2014) · Patient Preference and Adherence · doi:10.2147/ppa.s73029 · Cited by 56 · see citing works
“Review of the literature on predictors of compliance with psychiatric treatment prescribed has shown the inconsistency of sociodemographic and clinical variables.(14)”
BackgroundSelf-citationAntidepressant Self-Discontinuation: Results From the Collaborative Psychiatric Epidemiology Surveys
Samples, H., & Mojtabai, R. (2015) · Psychiatric Services · doi:10.1176/appi.ps.201400021 · Cited by 45 · see citing works
Cuevas, C. D. L., Peñate, W., & Sanz, E. J. (2014) · BMC Psychiatry · doi:10.1186/s12888-014-0324-6 · Cited by 47 · see citing works
Self-citationDeterminants of suboptimal medication adherence in patients with a major depressive episode
Baeza‐Velasco, C., Olié, É., Béziat, S., Guillaume, S., & Courtet, P. (2018) · Depression and Anxiety · doi:10.1002/da.22852 · Cited by 38 · see citing works
Chong, W. W., Aslani, P., & Chen, T. F. (2013) · Patient Preference and Adherence · doi:10.2147/ppa.s48486 · Cited by 37 · see citing works
“A number of factors have been identified as contributing to antidepressant medication nonadherence, including stigma associated with depression, clinical factors such as substance abuse and presence of comorbidities, side effects of antidepressants, and patients’ beliefs about antidepressant medications.(3,7,8) Effect…”
BackgroundTraining to Use Motivational Interviewing Techniques for Depression: A Cluster Randomized Trial
Keeley, R. D., Burke, B. L., Brody, D. S., Dimidjian, S., Engel, M., Emsermann, C. B., deGruy, F. V., Thomas, M., Moralez, E. A., Koester, S. K., et al. (2014) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.2014.05.130324 · Cited by 38 · see citing works
Positive psychological determinants of treatment adherence among primary care patients
Nsamenang, S. A., & Hirsch, J. K. (2015) · Primary Health Care Research & Development · doi:10.1017/s1463423614000292 · Cited by 35 · see citing works
“Most previous research on treatment adherence has focused on patient demographic and socioeconomic factors (Rivero-Santana et al., 2013), whereas our study focuses on psychological and motivational factors.”
BackgroundCuevas, C. D. L., & Peñate, W. (2015) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2487 · Cited by 32 · see citing works
“Review of the literature on predictors of adherence with psychiatric treatment prescribed has shown the inconsistency of socio-demographic and clinical variables (Rivero-Santana et al., 2013; De las Cuevas et al., 2014a, 2014b, 2014c).”
BackgroundSelf-citationAljumah, K., Hassali, M. A., Tahir, K. E., & Al Qhatani, D. (2014) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s71697 · Cited by 27 · see citing works
“Certain factors have been identified as predictors of adherence to antidepressant medication, including sociodemographic factors, educational level, clinical factors (eg, severity of symptoms), quality of life, and side effects.(6,9) In addition, evidence showed that patients’ beliefs about antidepressant medication c…”
InfluentialPedrosa-Naudín, M. A., Gutiérrez-Abejón, E., Herrera-Gómez, F., Fernández-Lázaro, D., & Álvarez, F. J. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122696 · Cited by 31 · see citing works
Pillai, A., Keyes, K. M., & Susser, E. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248641 · Cited by 26 · see citing works
Antidepressant medication treatment patterns in Asian patients with major depressive disorder
Haro, J. M., Novick, D., Montgomery, W. S., Moneta, V., Peng, X., & Brugnoli, R. (2015) · Patient Preference and Adherence · doi:10.2147/ppa.s68432 · Cited by 20 · see citing works
“In many patients, MDD requires long-term antidepressant treatment to prevent relapse, making adherence with therapy a crucial factor in relapse prevention.(1) Clinical guidelines recommend several months of antidepressant maintenance treatment for MDD; for example, 6 months of treatment are recommended in the National…”
Influentialde León, J., & Cuevas, C. D. L. (2017) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000675 · Cited by 19 · see citing works
Self-citationGender Differences in Brain-Heart Connection
Trevisan, C., Sergi, G., & Maggi, S. (2020) · Springer eBooks · doi:10.1007/978-3-030-28008-6_61 · Cited by 20 · see citing works
Bennett, B., Sharma, M., Bennett, R., Mawson, A. R., Buxbaum, S. G., & Sung, J. H. (2018) · Journal of Caring Sciences · doi:10.15171/jcs.2018.001 · Cited by 16 · see citing works
Pauly, A., Wolf, C., Mayr, A. J., Lenz, B., Kornhuber, J., & Friedland, K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139302 · Cited by 16 · see citing works
“The few studies investigating the impact of gender on adherence provide inconsistent results with a slight trend towards women being more adherent [36].”
Exploring Antidepressant Adherence at a Student-Run Free Mental Health Clinic
Mann, C. L., Rifkin, R. A., Nabel, E. M., Thomas, D. C., Meah, Y. S., & Katz, C. L. (2018) · Community Mental Health Journal · doi:10.1007/s10597-018-0301-5 · Cited by 11 · see citing works
Cooper, D. C., TRIVEDI, R. B., Nelson, K. M., Reiber, G. E., Eugenio, E. C., Beaver, K. A., & Fan, V. S. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12849 · Cited by 15 · see citing works
del Pino‐Sedeño, T., Infante‐Ventura, D., Hernández-González, D., González‐Hernández, Y., de León, B. G., Rivero‐Santana, A., Hurtado, I., & Acosta, F. J. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1327155 · Cited by 13 · see citing works
Ormsby, S., Smith, C. A., Dahlen, H. G., Hay, P., & Lind, J. M. (2016) · Trials · doi:10.1186/s13063-016-1204-9 · Cited by 13 · see citing works
“Treatment compliance is also an issue, with 45 % partially [26] and 42 % completely discontinuing medication within the first 3 months [27, 28], due in part to unwanted adverse effects [27, 29].”
BackgroundInfante‐Ventura, D., Rodriguez-Díaz, B., Bello, M. Á. G., Valcárcel‐Nazco, C., Estupiñán‐Romero, F., Acosta, F. J., de León, B. G., Hurtado, I., & del Pino‐Sedeño, T. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119443 · Cited by 11 · see citing works
Cuevas, C. D. L., & de León, J. (2020) · Patient Preference and Adherence · doi:10.2147/ppa.s242693 · Cited by 11 · see citing works
Self-citationBenatti, B., Girone, N., Conti, D., Cocchi, M., Achilli, F., Leo, S., Putti, G., Bosi, M. F., & Dell’Osso, B. M. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20031994 · Cited by 10 · see citing works
“Previous research has described a lower level of education as a risk factor for nonadherence to medication and psychoeducation groups [28,50].”
BackgroundEshtehardi, S. S., Taylor, A., Chen, T. A., de Dios, M. A., Correa-Fernández, V., Kendzor, D. E., Businelle, M. S., & Reitzel, L. R. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18157958 · Cited by 10 · see citing works
Jeżuchowska, A., Cybulska, A. M., Rachubińska, K., Skonieczna‐Żydecka, K., Reginia, A., Pańczyk, M., Ćwiek, D., Grochans, E., & Schneider-Matyka, D. (2024) · Healthcare · doi:10.3390/healthcare12232484 · Cited by 7 · see citing works
Mohammadjafari, A., Tabatabaee, M., Sharifi, V., Masouleh, F. A., & Abolhassani, F. (2021) · Iranian Journal of Psychiatry and Behavioral Sciences · doi:10.5812/ijpbs.115045 · Cited by 5 · see citing works
Gender Differences in Brain-Heart Connection
Trevisan, C., Sergi, G., & Maggi, S. (2020) · Springer eBooks · doi:10.1007/978-3-319-90305-7_61-1 · Cited by 5 · see citing works
Lauzier, S., Kadachi, H., Moisan, J., Vanasse, A., LESAGE, A. D., Fleury, M., & Grégoire, J. (2018) · The Canadian Journal of Psychiatry · doi:10.1177/0706743718760290 · Cited by 5 · see citing works
On-Site Prescription Dispensing Improves Antidepressant Adherence among Uninsured Depressed Patients
Powell, S. K., Gibson, C. L., Okoroafor, I., Hernandez-Antonio, J., Nabel, E. M., Meah, Y. S., & Katz, C. L. (2021) · Psychiatric Quarterly · doi:10.1007/s11126-021-09885-z · Cited by 3 · see citing works
Engagement among Minority Patients in Collaborative Care Management for Depression
Rs, D., Njeru, J. W., & Angstman, K. B. (2015) · Cited by 4 · see citing works
Antidepressant adherence in United States active duty Army Soldiers: A small descriptive study
Gallagher, S. P., Insel, K. C., Badger, T. A., & Reed, P. G. (2018) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2018.06.002 · Cited by 3 · see citing works
Treatment Satisfaction Among Patients Taking Antidepressant Medication
Hidalgo, J. D. L.-T., Gallardo, Y. L., Martínez, I. P., Campo, J. M. D. C.-D., Ferrer, A. V., & Rayo, S. M. (2015) · Community Mental Health Journal · doi:10.1007/s10597-015-9865-5 · Cited by 3 · see citing works
Satisfacción con el tratamiento antidepresivo: validación del cuestionario "ESTA"
Hidalgo, J. D. L.-T., Gallardo, Y. L., Martínez, I. P., Campo, J. M. D. C.-D., Ferrer, A. V., & Rayo, S. M. (2013) · Revista Española de Salud Pública · doi:10.4321/s1135-57272013000600006 · Cited by 3 · see citing works
Can dissociative amnesia be a residual symptom of prolonged complex post-traumatic stress disorder?
Metin, İ. Ç., Yıldırım, S., & Karahan, A. (2024) · Annals of General Psychiatry · doi:10.1186/s12991-024-00536-8 · Cited by 2 · see citing works
“The doctor-patient relationship plays an essential role in this process, as factors like inadequate patient education, inappropriate medication prescriptions, insufficient dosages, communication style, and lack of follow-up care remain within the physician’s control [24].”
Prospective study of variables associated with nonadherence to psychotherapy
Acosta, F. J., Ramallo‐Fariña, Y., Ruiz, L., Gómez, S., Hernández, A. N. G., Quesada, I., Lastra, C., & Calviño, M. J. (2019) · Journal of Mental Health · doi:10.1080/09638237.2019.1581346 · Cited by 2 · see citing works
Alcalde, E., Rouquette, A., Wiernik, E., & Rigal, L. (2024) · International Journal of Social Psychiatry · doi:10.1177/00207640241237714 · Cited by 1 · see citing works
“Other potential explanations are that socially disadvantaged groups may have poorer treatment engagement (Rivero-Santana et al., 2013) or may not be treated as comprehensively or assertively due to clinicians bias and social distance (Garb, 1997; Salmon et al., 2004).”
Kovachy, B., Chang, T. E., Vogeli, C., Tolland, S., Garrels, S., Forester, B. P., & Fung, V. (2023) · Healthcare · doi:10.1016/j.hjdsi.2023.100676 · Cited by 1 · see citing works
de León, B. G., del Pino‐Sedeño, T., Serrano-Pérez, P., Rodríguez‐Alvarez, C., Bejarano‐Quisoboni, D., & Trujillo‐Martín, M. M. (2021) · Research Square · doi:10.21203/rs.3.rs-887776/v1 · Cited by 1 · see citing works
Jeżuchowska, A., Cybulska, A. M., Rachubińska, K., Reginia, A., Pańczyk, M., Ćwiek, D., Grochans, E., & Schneider-Matyka, D. (2024) · Research Square · doi:10.21203/rs.3.rs-4648228/v1
Dhungana, S., Rijal, R., Regmi, B. U., Bajracharya, J. S., Sharma, S., Singh, S. K., Karn, N., & Chapagai, M. (2023) · PLoS ONE · doi:10.1371/journal.pone.0281366
“Many patients with depressive disorders do not achieve full remission despite taking prescription antidepressants and almost half of these patients have recurrent episodes over time [7].”
BackgroundDepressive and Anxiety Symptoms and Disorders
Dorfman, C. S., Arrato, N. A., Arthur, S. S., & Andersen, B. (2021) · Common Issues in Breast Cancer Survivors · doi:10.1007/978-3-030-75377-1_12
ความรวมมอในการใชยาและปจจยทเกยวของของผสงอายโรคซมเศรา ณ โรงพยาบาลจฬาลงกรณ
ใจปินตา, ฐ., & ตั้งวงษ์ไชย, ส. (2021) · doi:10.58837/chula.the.2021.1079
Vásquez, A. U., García, J. R. G., Dominguez, G. I. M., Sánchez, L. M. M., & Ospina-Sánchez, J. P. (2017) · Archivos de Medicina (Manizales) · doi:10.30554/archmed.17.1.1783.2017
In depression, increased psychological reactance is associated with poorer treatment compliance
Jaeger, S. (2015) · Evidence-Based Nursing · doi:10.1136/eb-2014-102052
Lühike ülevaade mõningatest antidepressantide kliinilist efektiivsust mõjustavatest teguritest
Pokk, P. (2014) · Ajakirjad. Journals by UT · doi:10.15157/ea.v0i0.11732
- Authors
- Perestelo-Perez, L., Perestelo-Perez, Perez-Ramos, Serrano-Aguilar, & Cuevas, D. L.
- Affiliations
- Servicio Canario de la Salud (ES)
- Venue
- Patient Preference and Adherence
- Publisher
- Informa UK Limited
- Published
- 2013-03
- Volume
- 7
- Pages
- 151
- ISSN
- 1177-889X (ISSN-L)
- PMC
- PMC3592507
- OpenAlex
- W2088133869
- Semantic Scholar
- 49cbdc9a99f70a98ce539d0246df013e91457a18
- Cited by
- 54
- References
- 69
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 4 · 2022: 1 · 2021: 7 · 2020: 4 · 2019: 1 · 2018: 5 · 2017: 3 · 2016: 2 · 2015: 7 · 2014: 9 · 2013: 5
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Patient Preference and Adherence (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Funders
- Instituto de Salud Carlos III
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- antidepressant adherence, medication adherence, depressive disorders, sociodemographic predictors, clinical predictors, age, race, ethnic minorities, comorbidities, substance abuse, depression severity
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