Acute exercise reduces the effects of a 35% CO2 challenge in patients with panic disorder
Abstract
Background Chronic exercise has been shown to have therapeutic effects in panic disorder (PD). The mechanism of these effects is unknown. Acute exercise reduces the effect of a panic challenge in healthy volunteers. Such an effect has not yet been demonstrated in PD patients. The present study aimed at exploring the antipanic effects of acute exercise on a 35% CO2 panic provocation in treatment-naïve PD patients to further elucidate the mechanisms of the beneficial effects of exercise on panic.Methods Eighteen PD patients performed either moderate/hard exercise or very-light exercise before a 35% CO2 challenge in a randomized, between-group design. The reactivity to CO2 was assessed with the Visual Analogue Anxiety Scale and the DSM-IV Panic Symptom List.Results Panic reactions to CO2 were smaller in patients that performed moderate/hard exercise in contrast to those that performed very-light exercise. Increments in both measurements and panic rates were consistently reduced by intense exercise.Limitations Since this study focuses on the acute effects of exercise on CO2 sensitivity in patients with PD, the results of repetitive exercise sessions on the rate of spontaneous panic attacks and overall symptoms are warranted. The small sample size and other limitations are addressed.Conclusions Exercise reduced the panicogenic effects of a CO2 challenge. In addition to its therapeutic potential, exercise may also be useful as a laboratory maneuver with heuristic value in experimental research into the mechanisms of antipanic treatment.
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A small study (N = 18) demonstrated less panic reactions to CO2 in patients who performed moderate-to-vigorous intensity exercise compared with those who performed very light intensity activity.
“A small study (N = 18) tested a dose-response relationship by comparing the anxiolytic impact of varying intensity exercise and demonstrated that there were less panic reactions to CO2 in patients that performed moderate-to-vigorous intensity in contrast to those who performed very light intensity activity [96].”
From Moving to Beat Anxiety: Epidemiology and Therapeutic Issues with Physical Activity for Anxiety (2018) · cites this paper as [96]
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- Authors
- Esquivel, G., Díaz-Galvis, J., Schruers, K., Berlanga, C., Lara-Muñoz, C., & Griez, E.
- Affiliations
- Maastricht University (NL)
- Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (MX)
- Corresponding author
- Esquivel, Gabriel
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 107
- Issue
- 1-3
- Pages
- 217-220
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2061174407
- Cited by
- 75
- References
- 18
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 7 · 2014: 2 · 2013: 7 · 2012: 5
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- panic disorder, acute exercise, CO2 challenge, hypercapnia, panic attacks, exercise intensity, treatment-naive patients
- MeSH terms
- Adult, Carbon Dioxide, Exercise Therapy, Physical Exertion, Female, Humans, Lactates, Male, Psychiatric Status Rating Scales, Exercise, Panic Disorder, Treatment Outcome, Diagnostic and Statistical Manual of Mental Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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