Cited by 205Fatty Acid Research and HealthParkinson's Disease Mechanisms and TreatmentsTreatment of Major Depression

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Depression in Parkinson’s Disease: A Double-Blind, Randomized, Placebo-Controlled Pilot Study of Omega-3 Fatty-Acid Supplementation

da Silva, Ticyana Moralez, Munhoz, Renato Puppi, Alvarez, Cristiano, Naliwaiko, Katya, Kiss, Ágata, Andreatini, Roberto, Ferraz, Anete Curte·2008·Journal of Affective Disorders

DOI 10.1016/j.jad.2008.03.008

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Abstract

Background Effect of fish oil supplementation in parkinsonian patients with depression measured by Montgomery-Asberg Rating Scale (MADRS), the Clinical Global Impressions Scale (CGI) and Beck Depression Inventory (BECK).Method Double-blind, placebo-controlled study analyzed depression in 31 patients with Parkinson's Disease and Major Depression (DSM-IV). The patients were double-blind separated in 2 groups that received fish oil (containing omega-3 fatty acids) or mineral oil capsules for 3 months; each group was separated in 2 new groups: one taking antidepressant medication and another one not taking it.Results 29 patients completed the 12-week trial, 58% were female and the mean age was 64.4 years old. Patients supplemented with fish oil showed a significant decrease in MADRS and CGI-Depression scores, and there was no difference among groups in BDI. 14 patients (42%) met criteria for > or = 50% reduction in MADRS score, 7 patients (22%) met criteria for remission (final MADRS total score < or = 12), and 2 patients (6%) discontinued supplementation of fish oil. HPLC analysis of fatty-acid profile showed increase of omega-3 fatty acid in the erythrocyte membrane of patients taking fish oil.Conclusion These results reveal that PD patients taking fish oil, with or without antidepressants, presented improvement in depressive symptoms and indicate that the intake of omega-3 can be used with an antidepressant effect or as adjuvant therapy with some other medication. This is a first pilot study with parkinsonian patients and omega-3 supplementation and requires replication in a larger sample.

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“In fact, a recent RCT has clearly demonstrated the efficacy and safety of omega-3 fatty acid as augmentation treatment or monotherapy for treating depression in PD patients.(5) Preliminary studies also suggest that repetitive transcranial magnetic stimulation (rTMS) may be effective for treating depression in PD patie…”
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Quintana, D. C., Calzado, Y. R., Cuevas, V. M., Ferreiro, R. M., & Valmaña, M. D. L. A. (2010) · Revista cubana de farmacia
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Omega-3 Fatty Acids for Major Depressive Disorder: A Systematic Review
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LoBuono, D. L. (2020) · Digital Commons - URI (University of Rhode Island) · doi:10.23860/diss-lobuono-dara-2020
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The role of polyunsaturated fatty acids: The possibility of diet intervention in Parkinson's disease
Tang, H., Chen, S., Liu, H., & Chen, X. (2023) · MEDS Public Health and Preventive Medicine · doi:10.23977/phpm.2023.030606
“The findings suggested that ω-3 may be employed as an additional therapy since it alleviated depression symptoms in PD patients regardless of whether they were taking antidepressants [70].”
Background
Bioprospecting Nutraceuticals for Human Welfare
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Levant, B. (2025) · Springer eBooks · doi:10.1007/978-3-031-84200-9_19
Additional file 1 of Isotope-reinforced polyunsaturated fatty acids improve Parkinson’s disease-like phenotype in rats overexpressing α-synuclein
Beal, M. F., Chiluwal, J., Calingasan, N. Y., Milne, G. L., Shchepinov, M. S., & Tapias, V. (2020) · Figshare · doi:10.6084/m9.figshare.13467573
Additional file 2 of A scoping review of over-the-counter products for depression, anxiety and insomnia in older people
Frost, R., Mathew, S., Thomas, V., Uddin, S., Salame, A., Vial, C., Cohen, T., Bhamra, S. K., Bazo‐Alvarez, J. C., Bhanu, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26752069
Additional file 1 of A scoping review of over-the-counter products for depression, anxiety and insomnia in older people
Frost, R., Mathew, S., Thomas, V., Uddin, S., Salame, A., Vial, C., Cohen, T., Bhamra, S. K., Bazo‐Alvarez, J. C., Bhanu, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26752066

Authors: da Silva, T. M., Munhoz, R. P., Alvarez, C., Naliwaiko, K., Kiss, Á., Andreatini, R., & Ferraz, A. C.
Affiliations: Hospital de Clínicas Universidade Federal do Paraná (BR)
Universidade Federal do Paraná (BR)
Corresponding author: Ferraz, Anete Curte
ORCID: Munhoz, Renato Puppi
Naliwaiko, Katya
Andreatini, Roberto
Venue: Journal of Affective Disorders
Publisher: Elsevier BV
Published: 2008-12
Volume: 111
Issue: 2-3
Pages: 351-359
ISSN: 0165-0327 (ISSN-L)
DOI: 10.1016/j.jad.2008.03.008
OpenAlex: W2034824946
Cited by: 205
References: 54
Citations by year: 2026: 7 · 2025: 10 · 2024: 14 · 2023: 13 · 2022: 11 · 2021: 13 · 2020: 13 · 2019: 11 · 2018: 4 · 2017: 14 · 2016: 12 · 2015: 15 · 2014: 13 · 2013: 15 · 2012: 9
FWCI: 9.86
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Affective Disorders (publishedVersion)
PubMed (publishedVersion)
Funders: Universidade Federal do Paraná
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: Parkinson's disease, depression, omega-3 fatty acids, fish oil supplementation, major depressive disorder, depression remission
MeSH terms: Aged, Antidepressive Agents, Antiparkinson Agents, Brazil, Combined Modality Therapy, Depressive Disorder, Major, Major Depressive Disorder, Double-Blind Method, Female, Humans, Levodopa, Male, Middle Aged, Mineral Oil, Parkinson Disease, Personality Inventory, Pilot Projects, Placebos, Psychiatric Status Rating Scales, Fatty Acids, Omega-3, Comorbidity, Treatment Outcome, Dietary Supplements

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Depression in Parkinson’s Disease: A Double-Blind, Randomized, Placebo-Controlled Pilot Study of Omega-3 Fatty-Acid Supplementation

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