The DOI matches its Crossref record; 53 of the 54 references it cites were found in a registry or an index.
Depression in Parkinson’s Disease: A Double-Blind, Randomized, Placebo-Controlled Pilot Study of Omega-3 Fatty-Acid Supplementation
Abstract
Background Effect of fish oil supplementation in parkinsonian patients with depression measured by Montgomery-Asberg Rating Scale (MADRS), the Clinical Global Impressions Scale (CGI) and Beck Depression Inventory (BECK).Method Double-blind, placebo-controlled study analyzed depression in 31 patients with Parkinson's Disease and Major Depression (DSM-IV). The patients were double-blind separated in 2 groups that received fish oil (containing omega-3 fatty acids) or mineral oil capsules for 3 months; each group was separated in 2 new groups: one taking antidepressant medication and another one not taking it.Results 29 patients completed the 12-week trial, 58% were female and the mean age was 64.4 years old. Patients supplemented with fish oil showed a significant decrease in MADRS and CGI-Depression scores, and there was no difference among groups in BDI. 14 patients (42%) met criteria for > or = 50% reduction in MADRS score, 7 patients (22%) met criteria for remission (final MADRS total score < or = 12), and 2 patients (6%) discontinued supplementation of fish oil. HPLC analysis of fatty-acid profile showed increase of omega-3 fatty acid in the erythrocyte membrane of patients taking fish oil.Conclusion These results reveal that PD patients taking fish oil, with or without antidepressants, presented improvement in depressive symptoms and indicate that the intake of omega-3 can be used with an antidepressant effect or as adjuvant therapy with some other medication. This is a first pilot study with parkinsonian patients and omega-3 supplementation and requires replication in a larger sample.
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“Interestingly, in a clinical study where PD patients were taking fish oil (a great source of ω3) with or without antidepressants presented improvements in depressive symptoms [450].”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [450]
Citations
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Items 201–205 of 205
Wu, J., Wang, C., Wang, Y., Xue, C., Wang, Y., Zhang, L., Abdelnaby, T., El-Waseif, M., & Zhang, T. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.108174
Lee, J. Y., Lim, L. W. C., Wong, C.-Y., Koh, R. Y., Lim, C. L., Kok, Y.-Y., & Chye, S. M. (2026) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273403412251202093934
The Emerging Parkinson's Disease Oxylipin‐Ome
Kelliher, J. C., & Fanning, S. (2026) · Advanced Science · doi:10.1002/advs.202522997
“PUFA supplementation was associated with reduced inflammation and depressive symptoms and increased antioxidant capacity in PD [ 196, 199, 200 ].”
Maladie de Parkinson et dépression
Laurencin, C., Prange, S., & Thobois, S. (2026) · Encyclopédie médico-chirurgicale. Neurologie · doi:10.1016/s0246-0378(26)51232-6
Neuroprotective diets and their synergy with (PD) pharmacotherapy
Fathy, H. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-54032-5.00009-7
Metadata
- Authors
- da Silva, T. M., Munhoz, R. P., Alvarez, C., Naliwaiko, K., Kiss, Á., Andreatini, R., & Ferraz, A. C.
- Affiliations
- Hospital de Clínicas Universidade Federal do Paraná (BR)
- Universidade Federal do Paraná (BR)
- Corresponding author
- Ferraz, Anete Curte
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 111
- Issue
- 2-3
- Pages
- 351-359
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2034824946
- Cited by
- 205
- References
- 54
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 14 · 2023: 13 · 2022: 11 · 2021: 13 · 2020: 13 · 2019: 11 · 2018: 4 · 2017: 14 · 2016: 12 · 2015: 15 · 2014: 13 · 2013: 15 · 2012: 9
- FWCI
- 9.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universidade Federal do Paraná
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- Parkinson's disease, depression, omega-3 fatty acids, fish oil supplementation, major depressive disorder, depression remission
- MeSH terms
- Aged, Antidepressive Agents, Antiparkinson Agents, Brazil, Combined Modality Therapy, Depressive Disorder, Major, Major Depressive Disorder, Double-Blind Method, Female, Humans, Levodopa, Male, Middle Aged, Mineral Oil, Parkinson Disease, Personality Inventory, Pilot Projects, Placebos, Psychiatric Status Rating Scales, Fatty Acids, Omega-3, Comorbidity, Treatment Outcome, Dietary Supplements
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