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Depression in Parkinson’s Disease: A Double-Blind, Randomized, Placebo-Controlled Pilot Study of Omega-3 Fatty-Acid Supplementation
Abstract
Background Effect of fish oil supplementation in parkinsonian patients with depression measured by Montgomery-Asberg Rating Scale (MADRS), the Clinical Global Impressions Scale (CGI) and Beck Depression Inventory (BECK).Method Double-blind, placebo-controlled study analyzed depression in 31 patients with Parkinson's Disease and Major Depression (DSM-IV). The patients were double-blind separated in 2 groups that received fish oil (containing omega-3 fatty acids) or mineral oil capsules for 3 months; each group was separated in 2 new groups: one taking antidepressant medication and another one not taking it.Results 29 patients completed the 12-week trial, 58% were female and the mean age was 64.4 years old. Patients supplemented with fish oil showed a significant decrease in MADRS and CGI-Depression scores, and there was no difference among groups in BDI. 14 patients (42%) met criteria for > or = 50% reduction in MADRS score, 7 patients (22%) met criteria for remission (final MADRS total score < or = 12), and 2 patients (6%) discontinued supplementation of fish oil. HPLC analysis of fatty-acid profile showed increase of omega-3 fatty acid in the erythrocyte membrane of patients taking fish oil.Conclusion These results reveal that PD patients taking fish oil, with or without antidepressants, presented improvement in depressive symptoms and indicate that the intake of omega-3 can be used with an antidepressant effect or as adjuvant therapy with some other medication. This is a first pilot study with parkinsonian patients and omega-3 supplementation and requires replication in a larger sample.
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“Interestingly, in a clinical study where PD patients were taking fish oil (a great source of ω3) with or without antidepressants presented improvements in depressive symptoms [450].”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [450]
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1 of the 54 references couldn’t be matched to a known paper.
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Sorted by citations
Omega-3 polyunsaturated fatty acids and their health benefits
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“Da Silva et al. (2008)9 conducted a randomized, double-blind, placebo-controlled 12-week study of omega-3 fatty-acids for the treatment of a major depressive episode (DSM-IV) in PD. Thirty-one subjects were randomized to receive omega-3 (each capsule containing 180 mg eicosapentaenoic acid [EPA]…”
MethodNeuropsychiatric symptoms in Parkinson's disease
Aarsland, D., Marsh, L., & Schrag, A. (2009) · Movement Disorders · doi:10.1002/mds.22589 · Cited by 320
“A small placebo-controlled pilot trial recently reported significantly greater improvement of depression in patients treated with omega-3 fatty-acid supplementation.(46) Bright light therapy has also been reported to be slightly superior to placebo (with less bright light) in a trial.”
BackgroundSignificance of long chain polyunsaturated fatty acids in human health
Zárate, R., el Jaber-Vazdekis, N., Tejera, N., Pérez, J. A., & Rodríguez, C. (2017) · Clinical and Translational Medicine · doi:10.1186/s40169-017-0153-6 · Cited by 573
“However, when the patients were evaluated for depression symptoms using the Montgomery–Asberg Scale, it was observed that after 3-month supplementation, fish oil groups, taking or not antidepressant medication, exhibited a reduction in depression symptoms when compared to mineral oil groups [128].”
MethodA meta-analytic review of polyunsaturated fatty acid compositions in patients with depression
Lin, P.-Y., Huang, S.-Y., & Su, K.-P. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.018 · Cited by 530
Metadata
- Authors
- da Silva, T. M., Munhoz, R. P., Alvarez, C., Naliwaiko, K., Kiss, Á., Andreatini, R., & Ferraz, A. C.
- Affiliations
- Hospital de Clínicas Universidade Federal do Paraná (BR)
- Universidade Federal do Paraná (BR)
- Corresponding author
- Ferraz, Anete Curte
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 111
- Issue
- 2-3
- Pages
- 351-359
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2034824946
- Cited by
- 205
- References
- 54
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 14 · 2023: 13 · 2022: 11 · 2021: 13 · 2020: 13 · 2019: 11 · 2018: 4 · 2017: 14 · 2016: 12 · 2015: 15 · 2014: 13 · 2013: 15 · 2012: 9
- FWCI
- 9.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universidade Federal do Paraná
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- Parkinson's disease, depression, omega-3 fatty acids, fish oil supplementation, major depressive disorder, depression remission
- MeSH terms
- Aged, Antidepressive Agents, Antiparkinson Agents, Brazil, Combined Modality Therapy, Depressive Disorder, Major, Major Depressive Disorder, Double-Blind Method, Female, Humans, Levodopa, Male, Middle Aged, Mineral Oil, Parkinson Disease, Personality Inventory, Pilot Projects, Placebos, Psychiatric Status Rating Scales, Fatty Acids, Omega-3, Comorbidity, Treatment Outcome, Dietary Supplements
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